Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3209-3213

  Rodriguez, Alice L ^a   Williams, Richard ^a   Zhou, Ya ^a   Lindsley, Stacey R ^a   Le, Uyen ^a   Grier, Mark D ^a   David Weaver, C ^a   Jeffrey Conn, P ^a   Lindsley, Craig W ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Glutamate; Metabotropic; mGluR5

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST;

ALLOSTERISM; ARTICLE; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; IC 50;

ALLOSTERIC REGULATION; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INHIBITORY CONCENTRATION 50; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65749112588     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.110     Document Type: Article

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