Metabotropic glutamate receptor-1: A potential therapeutic target for the treatment of breast cancer

Breast Cancer Research and Treatment

Volumn 132, Issue 2, 2012, Pages 565-573

  Speyer, Cecilia L ^a,b   Smith, Jennifer S ^a,b,c   Banda, Malathi ^a,b   DeVries, John A ^a,b   Mekani, Tassia ^d   Gorski, David H ^a,b  

^a KARMANOS CANCER INSTITUTE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF MICHIGAN DEARBORN   (United States)

Author keywords

Apoptosis; Breast cancer; GRM1; mGluR1

Indexed keywords

ANTINEOPLASTIC AGENT; BAY 367620; METABOTROPIC RECEPTOR 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B BETA; QUISQUALIC ACID; RILUZOLE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CALCIUM TRANSPORT; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, NUDE; NAPHTHALENES; PHENOTYPE; QUISQUALIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; RILUZOLE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84859107394     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1624-x     Document Type: Article

References (34)

1. Coughlin SS, Ekwueme DU (2009) Breast cancer as aglobal health concern. Cancer Epidemiol 33(5):315-318
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71-96 (Pubitemid 351521864)
3. Kurebayashi J (2009) Possible treatment strategies for triplenegative breast cancer on the basis of molecular characteristics. Breast Cancer 16(4):275-280
4. Riggins RB, Schrecengost RS, Guerrero MS, Bouton AH (2007) Pathways totamoxifen resistance. Cancer Lett 256(1):1-24
5. Gajria D, Chandarlapaty S (2011) HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies. Expert Rev Anticancer Ther 11(2):263-275
6. Francesconi A, Duvoisin RM (1998) Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. J Biol Chem 273(10): 5615-5624 (Pubitemid 28124031)
7. Marinissen MJ, Gutkind JS (2001) G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22(7):368-376 (Pubitemid 32592476)
8. Pin JP, Duvoisin R (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34(1):1-26
9. Wang JQ, Tang Q, Parelkar NK, Liu Z, Samdani S, Choe ES, Yang L, Mao L (2004) Glutamate signaling toRas-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity. Mol Neurobiol 29(1):1-14 (Pubitemid 39118075)
10. Waters C, Pyne S, Pyne NJ (2004) The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin Cell Dev Biol 15(3):309-323 (Pubitemid 38581999)
11. Bruno V, Battaglia G, Copani A, D' Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F (2001) Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 21(9):1013-1033 (Pubitemid 32823739)
12. Festoff BW (1996) Amyotrophic lateral sclerosis: current and future treatment strategies. Drugs 51(1):28-44
13. Mills CD, Johnson KM, Hulsebosch CE (2002) Group Imetabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain. J Neurotrauma 19(1):23-42 (Pubitemid 34117094)
14. Ronesi JA, Huber KM (2008) Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J Neurosci 28(2):543-547
15. Ronesi JA, Huber KM (2008) Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse. Sci Signal 1(5):6
16. Endoh T (2004) Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. Brain Res 1024(1-2):212-224
17. Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF (2008) The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8(3):187-198 (Pubitemid 351688437)
18. Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M (2002) Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Aktmediated phosphorylation in breast cancer. Nat Med 8(10): 1136-1144 (Pubitemid 35175969)
19. Pollock PM, Cohen-Solal K, Sood R, Namkoong J, Martino JJ, Koganti A, Zhu H, Robbins C, Makalowska I, Shin SS, Marin Y, Roberts KG, Yudt LM, Chen A, Cheng J, Incao A, Pinkett HW, Graham CL, Dunn K, Crespo-Carbone SM, Mackason KR, Ryan KB, Sinsimer D, Goydos J, Reuhl KR, Eckhaus M, Meltzer PS, Pavan WJ, Trent JM, Chen S (2003) Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet 34(1):108-112 (Pubitemid 36548800)
20. Shin SS, Martino JJ, Chen S (2008) Metabotropic glutamate receptors (mGlus) and cellular transformation. Neuropharmacology 55(4):396-402
21. Shin SS, Namkoong J, Wall BA, Gleason R, Lee HJ, Chen S (2008) Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation. Pigment Cell Melanoma Res 21(3):368-378 (Pubitemid 351678078)
22. Miller RG, Mitchell JD, Lyon M, Moore DH (2003) Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Amyotroph Lateral Scler Other Motor Neuron Disord 4(3): 191-206 (Pubitemid 37184890)
23. Namkoong J, Shin SS, Lee HJ, Marin YE, Wall BA, Goydos JS, Chen S (2007) Metabotropic glutamate receptor 1and glutamate signaling in human melanoma. Cancer Res 67(5):2298-2305 (Pubitemid 46424250)
24. Marin YE, Namkoong J, Cohen-Solal K, Shin SS, Martino JJ, Oka M, Chen S (2006) Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon. Cell Signal 18(8):1279-1286 (Pubitemid 43674044)
25. Shin SS, Wall BA, Goydos JS, Chen S (2010) AKT2 is adownstream target of metabotropic glutamate receptor 1 (Grm1). Pigment Cell Melanoma Res 23(1):103-111
26. Ohtani Y, Harada T, Funasaka Y, Nakao K, Takahara C, Abdel- Daim M, Sakai N, Saito N, Nishigori C, Aiba A (2008) Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. Oncogene 27(57):7162-7170
27. Yip D, Le MN, Chan JL, Lee JH, Mehnert JA, Yudd A, Kempf J, Shih WJ, Chen S, Goydos JS (2009) A phase 0trial of riluzole in patients with resectable stage III and IV melanoma. Clin Cancer Res 15(11):3896-3902
28. Hou L, Klann E (2004) Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent longterm depression. J Neurosci 24(28):6352-6361 (Pubitemid 38944226)
29. Scartabelli T, Gerace E, Landucci E, Moroni F, Pellegrini- Giampietro DE (2008) Neuroprotection by group ImGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K-Akt signaling pathway: a novel postconditioning strategy? Neuropharmacology 55(4):509-516
30. Zhang RD, Fidler IJ, Price JE (1991) Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis 11(4): 204-215
31. Carroll FY, Stolle A, Beart PM, Voerste A, Brabet I, Mauler F, Joly C, Antonicek H, Bockaert J, Muller T, Pin JP, Prezeau L (2001) BAY36-7620: apotent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol 59(5): 965-973 (Pubitemid 32381574)
32. Noh KM, Hwang JY, Shin HC, Koh JY (2000) A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C. Neurobiol Dis 7(4):375-383
33. Khan AJ, Wall B, Ahlawat S, Green C, Schiff D, Mehnert JM, Goydos JS, Chen S, Haffty BG (2011) Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo. Clin Cancer Res 17(7):1807-1814
34. Kuperwasser C, Dessain S, Bierbaum BE, Garnet D, Sperandio K, Gauvin GP, Naber SP, Weinberg RA, Rosenblatt M (2005) A mouse model of human breast cancer metastasis to human bone. Cancer Res 65(14):6130-6138 (Pubitemid 40994398)