Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1575-1578

  Bennett, Chad E ^a   Burnett, Duane A ^a   Greenlee, William J ^a   Knutson, Chad E ^a   Korakas, Peter ^a   Li, Cheng ^a   Tulshian, Deen ^a   Wu, Wen Lian ^a   Bertorelli, Rosalia ^b   Fredduzzi, Silva ^b   Grilli, Mariagrazia ^b   Lozza, Gianluca ^b   Reggiani, Angelo ^b   Veltri, Alessio ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b San Raffaele Science Park   (Italy)

Author keywords

Fused tricyclic pyridones; GPCR; MGluR1 (metabotropic glutamate receptor 1); Neuropathic pain; Spinal nerve ligation (SNL)

Indexed keywords

4 CHLOROPYRIDINE DERIVATIVE; 4 CYCLOPROPYL AMINOPYRIDYL DERIVATIVE; 4 ETHYLAMINO DERIVATIVE; 4 METHOXYPHENYL DERIVATIVE; 4 METHOXYPYRIDINE DRIVATIVE; BENZTHIAZOLE; FLUORINE; GLUTAMATE RECEPTOR ANTAGONIST; ISOENZYME; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYLAMINOPYRIDYL DERIVATIVE; N,N DIMETHYLAMINO DERIVATIVE; PYRIDONYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

RATTUS;

EID: 84862826031     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.131     Document Type: Article

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