Cubyl amides: Novel P2X7 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3720-3723

  Gunosewoyo, Hendra ^a   Guo, Jun Liu ^b   Bennett, Maxwell R ^b   Coster, Mark J ^c   Kassiou, Michael ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

Author keywords

Microglia; P2X7 antagonists; Polycyclic benzamides; Rational drug design

Indexed keywords

ADAMANTANE DERIVATIVE; AMIDE; BENZAMIDE; BENZOIC ACID; CHLORO 5 METHOXYBENZOIC ACID; CUBYL AMIDE DERIVATIVE; IMIDE; N CUBAN 1 YLMETHYL BENZAMIDE DERIVATIVE; POLYCYCLIC HYDROCARBON; PROTEIN INHIBITOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X7 RECEPTOR; TRACER;

ANIMAL CELL; ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPOPHILICITY; MICROGLIA; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPINAL CORD; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BENZAMIDES; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; HUMANS; MICE; MICROGLIA; MODELS, CHEMICAL; MOLECULAR CONFORMATION; RATS; RECEPTORS, PURINERGIC P2; SPINAL CORD;

RATTUS;

EID: 44849144365     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.062     Document Type: Article

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