The Differential Role of Prostaglandin E 2 Receptors in the CNS Response to Systemic Immune Challenge

Psychoneuroimmunology

Volumn , Issue , 2006, Pages 319-336

  Lazarus, Michael ^a   Saper, Clifford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882491612     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088576-3/50020-4     Document Type: Chapter

References (145)

1. Abe M., Oka T., Hori T., Takahashi S. Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. Brain Res. 2001, 916:41-49.
2. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., Kenny C.D., McGovern R.A., Chua S.C., Elmquist J.K., Lowell B.B. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
3. Batshake B., Nilsson C., Sundelin J. Molecular characterization of the mouse prostanoid EP1 receptor gene. Eur. J. Biochem. 1995, 231:809-814.
4. Beuckmann C.T., Fujimori K., Urade Y., Hayaishi O. Identifi cation of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. Neurochem. Res. 2000, 25:733-738.
5. Beuckmann C.T., Lazarus M., Gerashchenko D., Mizoguchi A., Nomura S., Mohri I., Uesugi A., Kaneko T., Mizuno N., Hayaishi O., Urade Y. Cellular localization of lipocalin-type prostaglandin D synthase â-trace in the central nervous system of the adult rat. J. Comp. Neurol. 2000, 428:62-78.
6. Blatteis C.M. Role of the OVLT in the febrile response to circulating pyrogens. Prog. Brain Res. 1992, 91:409-412.
7. Blatteis C.M., Bealer S.L., Hunter W.S., Llanos Q.J., Ahokas R.A., Mashburn T.A. Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res. Bull. 1983, 11:519-526.
8. Blatteis C.M., Sehic E., Li S. Afferent pathways of pyrogen signaling. Ann. N. Y. Acad. Sci. 1998, 856:95-107.
9. Bluthe R.M., Michaud B., Kelley K.W., Dantzer R. Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes. Neuroreport 1996, 7:2823-2827.
10. Breder C.D., Dewitt D., Kraig R.P. Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 1995, 355:296-315.
11. Breder C.D., Dinarello C.A., Saper C.B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 1988, 240:321-324.
12. Breder C.D., Hazuka C., Ghayur T., Klug C., Huginin M., Yasuda K., Teng M., Saper C.B. Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:11393-11397.
13. Breder C.D., Saper C.B. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res. 1996, 713:64-69.
14. Breder C.D., Smith W.L., Raz A., Masferrer J., Seibert K., Needleman P., Saper C.B. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J. Comp. Neurol. 1992, 322:409-438.
15. Breder C.D., Tsujimoto M., Terano Y., Scott D.W., Saper C.B. Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system. J. Comp. Neurol. 1993, 337:543-567.
16. Cano G., Passerin A.M., Schiltz J.C., Card J.P., Morrison S.F., Sved A.F. Anatomical substrates for the central control of sympathetic outfl ow to interscapular adipose tissue during cold exposure. J. Comp. Neurol. 2003, 460:303-326.
17. Canteras N.S., Simerly R.B., Swanson L.W. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 1994, 348:41-79.
18. Cao C., Matsumura K., Yamagata K., Watanabe Y. Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 1995, 697:187-196.
19. Cao C., Matsumura K., Yamagata K., Watanabe Y. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synt responsible for fever. Brain Res. 1996, 733:263-272.
20. Chan R.K., Brown E.R., Ericsson A., Kovacs K.J., Sawchenko P.E. A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 1993, 13:5126-5138.
21. Conti B., Tabarean I., Andrei C., Bartfai T. Cytokines and fever. Front. Biosci. 2004, 9:1433-1449.
22. Dantzer R., Konsman J.P., Bluthe R.M., Kelley K.W. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?. Auton. Neurosci. 2000, 85:60-65.
23. Ek M., Arias C., Sawchenko P., Ericsson-Dahlstrand A. Distribution of the EP3 prostaglandin E (2) receptor subtype in the rat brain: relationship to sites of interleukin-1-induced cellular responsiveness. J. Comp. Neurol. 2000, 428:5-20.
24. Ek M., Engblom D., Saha S., Blomqvist A., Jakobsson P.J., Ericsson-Dahlstrand A. Infl ammatory response: pathway across the blood-brain barrier. Nature 2001, 410:430-431.
25. Ek M., Kurosawa M., Lundeberg T., Ericsson A. Activation of vagal afferents after intravenous injection of interleukin-1beta: role of endogenous prostaglandins. J. Neurosci. 1998, 18:9471-9479.
26. Elmquist J.K., Breder C.D., Sherin J.E., Scammell T.E., Hickey W.F., Dewitt D., Saper C.B. Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J. Comp. Neurol. 1997, 381:119-129.
27. Elmquist J.K., Saper C.B. Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide. J. Comp. Neurol. 1996, 374:315-331.
28. Elmquist J.K., Scammell T.E., Jacobson C.D., Saper C.B. Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J. Comp. Neurol. 1996, 371:85-103.
29. Engblom D., Ek M., Andersson I.M., Saha S., Dahlstrom M., Jakobsson P.J., Ericsson-Dahlstrand A., Blomqvist A. Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis. J. Comp. Neurol. 2002, 452:205-214.
30. Engblom D., Ek M., Ericsson-Dahlstrand A., Blomqvist A. Activation of prostanoid EP (3) and EP (4) receptor mRNAexpressing neurons in the rat parabrachial nucleus by intravenous injection of bacterial wall lipopoly. J. Comp. Neurol. 2001, 440:378-386.
31. Engblom D., Ek M., Saha S., Ericsson-Dahlstrand A., Jakobsson P.J., Blomqvist A. Prostaglandins as infl ammatory messengers across the blood-brain barrier. J. Mol. Med. 2002, 80:5-15.
32. Engblom D., Saha S., Engstrom L., Westman M., Audoly L.P., Jakobsson P.J., Blomqvist A. Microsomal prostaglandin E synthase-1 is the central switch during immuneinduced pyresis. Nat. Neurosci. 2003, 6:1137-1138.
33. Ericsson A., Arias C., Sawchenko P.E. Evidence for an intramedullary prostaglandin-dependent mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. J. Neurosci. 1997, 17:7166-7179.
34. Ericsson A., Kovacs K.J., Sawchenko P.E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 1994, 14:897-913.
35. Fitzgerald K.A., O'Neill L.A.J. The role of the interleukin-1/Toll-like receptor superfamily in infl ammation and host defence. Microbes and Infection 2000, 2:933-943.
36. Gerozissis K., De Saint Hilaire Z., Orosco M., Rouch C., Nicolaidis S. Changes in hypothalamic prostaglandin E2 may predict the occurrence of sleep or wakefulness as assessed by parallel EEG and microdialysis in the rat. Brain Res. 1995, 689:239-244.
37. Goehler L.E., Gaykema R.P., Nguyen K.T., Lee J.E., Tilders F.J., Maier S.F., Watkins L.R. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J. Neurosci. 1999, 19:2799-2806.
38. Goldblatt M.W. Properties of human seminal plasma. J. Physiol. (Lond) 1935, 84:208-218.
39. Hashimoto M., Bando T., Iriki M., Hashimoto K. Effect of indomethacin on febrile response to recombinant human interleukin 1-alpha in rabbits. Am. J. Physiol. 1988, 255:R527-R533.
40. Hayaishi O., Huang Z.L. Role of orexin and prostaglandin E2 in activating histaminergic neurotransmission. Drug News Perspect. 2004, 17:105-109.
41. Hayaishi O., Urade Y. Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. Neuroscientist 2002, 8:12-15.
42. Herman J.P., Cullinan W.E. Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci. 1997, 20:78-84.
43. Hopkins S.J., Rothwell N.J. Cytokines and the nervous system I: expression and recognition. Trends Neurosci. 1995, 18:83-88.
44. Hori T., Oka T., Hosoi M., Abe M., Oka K. Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2. Ann. N. Y. Acad. Sci. 2000, 917:106-120.
45. Horn T., Wilkinson M.F., Landgraf R., Pittman Q.J. Reduced febrile responses to pyrogens after lesions of the hypothalamic paraventricular nucleus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1994, 267:R323-R328.
46. Hosoi M., Oka T., Abe M., Hori T., Yamamoto H., Mine K., Kubo C. Prostaglandin E (2) has antinociceptive effect through EP (1) receptor in the ventromedial hypothalamus in rats. Pain 1999, 83:221-227.
47. Hosoi M., Oka T., Hori T. Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in ra. Pain 1997, 71:303-311.
48. Huang Z.-L., Sato Y., Mochizuki T., Okada T., Qu W.-M., Yamatodani A., Urade Y., Hayaishi O. Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. J. Neurosci. 2003, 23:5975-5983.
49. Ivanov A.I., Romanovsky A.A. Prostaglandin E2 as a mediator of fever: synthesis and catabolism. Front. Biosci. 2004, 9:1977-1993.
50. Ivanov A.I., Scheck A.C., Romanovsky A.A. Expression of genes controlling transport and catabolism of prostaglandin E2 in lipopolysaccharide fever. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 284:R698-R706.
51. Jakobsson P.J., Thoren S., Morgenstern R., Samuelsson B. Identifi cation of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:7220-7225.
52. Johnson R.W., von Borell E. Lipopolysaccharideinduced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J. Anim. Sci. 1994, 72:309-314.
53. Jones S.L. Descending control of nociception. Pain and headache 1992, vol. 12:203-295. Karger, Basel. P. L. Gildenberg (Ed.).
54. Kamei D., Yamakawa K., Takegoshi Y., Mikami-Nakanishi M., Nakatani Y., Oh-Ishi S., Yasui H., Azuma Y., Hirasawa N., Ohuchi K., Kawaguchi H., Ishikawa Y., Ishii T., Uematsu S., Akira S., Murakami M., Kudo I. Reduced pain hypersensitivity and infl ammation in mice lacking microsomal prostaglandin E synthase-1. J. Biol. Chem. 2004, 279:33684-33695.
55. Katsuura G., Arimura A., Koves K., Gottschall P.E. Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1 beta-induced ACTH release. Am. J. Physiol. 1990, 258:E163-E171.
56. Konsman J.P., Parnet P., Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 2002, 25:154-159.
57. Krueger J.M., Majde J.A. Humoral links between sleep and the immune system: research issues. Ann. N. Y. Acad. Sci. 2003, 992:9-20.
58. Krueger J.M., Obal F., Fang J., Kubota T., Taishi P. The role of cytokines in physiological sleep regulation. Ann. N. Y. Acad. Sci. 2001, 933:211-221.
59. Lacroix S., Vallieres L., Rivest S. C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type. J. Neuroimmunol. 1996, 70:163-179.
60. Lazarus M., Kubata B.K., Eguchi N., Fujitani Y., Urade Y., Hayaishi O. Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Arch. Biochem. Biophys. 2002, 397:336-341.
61. Lewandoski M. Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2001, 2:743-755.
62. Li S., Ballou L.R., Morham S.G., Blatteis C.M. Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta. Brain Res. 2001, 910:163-173.
63. Li S., Wang Y., Matsumura K., Ballou L.R., Morham S.G., Blatteis C.M. The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2-/-, but not in cyclooxygenase-1-/-mice. Brain Res. 1999, 825:86-94.
64. Lu J., Zhang Y.H., Chou T.C., Gaus S.E., Elmquist J.K., Shiromani P., Saper C.B. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J. Neurosci. 2001, 21:4864-4874.
65. Madden C.J., Morrison S.F. Excitatory amino acid receptor activation in the raphe pallidus area mediates prostaglandin-evoked thermogenesis. Neuroscience 2003, 122:5-15.
66. Madden C.J., Morrison S.F. Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286:R320-R325.
67. Maier S.F., Wiertelak E.P., Martin D., Watkins L.R. Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res. 1993, 623:321-324.
68. Matsumura H., Honda K., Choi W.S., Inoue S., Sakai T., Hayaishi O. Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. Proc. Natl. Acad. Sci. U.S.A. 1989, 86:5666-5669.
69. Matsumura H., Honda K., Goh Y., Ueno R., Sakai T., Inoue S., Hayaishi O. Awaking effect of prostaglandin E2 in freely moving rats. Brain Res. 1989, 481:242-249.
70. Matsumura K., Kobayashi S. Signaling the brain in infl ammation: the role of endothelial cells. Front. Biosci. 2004, 9:2819-2826.
71. Matsuoka Y., Furuyashiki T., Bito H., Ushikubi F., Tanaka Y., Kobayashi T., Muro S., Satoh N., Kayahara T., Higashi M., Mizoguchi A., Shichi H., Fukuda Y., Nakao K., Narumiya S. Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice defi cient in prostaglandin E receptor EP1 and EP3 subtypes. Proc. Natl. Acad. Sci. U.S.A. 2003, 00:4132-4137.
72. Milton A.S., Wendlandt S. A possible role for prostaglandin E1 as a modulator for temperature regulation in the central nervous system of the cat. J. Physiol. 1970, 207:76P-77P.
73. Morrison S.F. Differential regulation of sympathetic out-fl ows to vasoconstrictor and thermoregulatory effectors. Ann. N. Y. Acad. Sci. 2001, 940:286-298.
74. Morrison S.F. Raphe pallidus neurons mediate prostaglandin E2-evoked increases in brown adipose tissue thermogenesis. Neuroscience 2003, 121:17-24.
75. Morrison S.F. Central pathways controlling brown adipose tissue thermogenesis. News Physiol. Sci. 2004, 19:67-74.
76. Mullington J.M., Hinze-Selch D., Pollmacher T. Mediators of infl ammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions. Ann. N. Y. Acad. Sci. 2001, 933:201-210.
77. Nakamori T., Morimoto A., Yamaguchi K., Watanabe T., Murakami N. Interleukin-1 beta production in the rabbit brain during endotoxin-induced fever. J. Physiol. 1994, 476:177-186.
78. Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Ichikawa A., Negishi M. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neuroscience Letters 1999, 260:117-120.
79. Nakamura K., Kaneko T., Yamashita Y., Hasegawa H., Katoh H., Negishi M. Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J. Comp. Neurol. 2000, 421:543-569.
80. Nakamura K., Matsumura K., Hubschle T., Nakamura Y., Hioki H., Fujiyama F., Boldogkoi Z., Konig M., Thiel H.-J., Gerstberger R., Kobayashi S., Kaneko T. Identifi cation of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J. Neurosci. 2004, 24:5370-5380.
81. Nakamura K., Matsumura K., Kaneko T., Kobayashi S., Katoh H., Negishi M. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J. Neurosci. 2002, 22:4600-4610.
82. Narumiya S., FitzGerald G.A. Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest 2001, 108:25-30.
83. Narumiya S., Sugimoto Y., Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 1999, 79:1193-1226.
84. Nguyen M., Camenisch T., Snouwaert J.N., Hicks E., Coffman T.M., Anderson P.A., Malouf N.N., Koller B.H. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 1997, 390:78-81.
85. O'Banion M.K. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit. Rev. Neurobiol. 1999, 13:45-82.
86. Oka K., Oka T., Hori T. Prostaglandin E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions. Brain Res. 1997, 767:92-99.
87. Oka K., Oka T., Hori T. PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1beta-induced fever in rats. Am. J. Physiol. 1998, 275:R1762-R1765.
88. Oka T., Aou S., Hori T. Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats: the possible involvement of EP3 receptors. Brain Res. 1994, 663:287-292.
89. Oka T., Hori T. EP1-receptor mediation of prostaglandin E2-induced hyperthermia in rats. Am. J. Physiol. 1994, 267:R289-R294.
90. Oka T., Hori T., Hosoi M., Oka K., Abe M., Kubo C. Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through different EP rece subtypes in rats. Brain Res. 1997, 771:278-284.
91. Oka T., Oka K., Hosoi M., Aou S., Hori T. The opposing effects of interleukin-1 beta microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats. Brain Res. 1995, 700:271-278.
92. Oka T., Oka K., Kobayashi T., Sugimoto Y., Ichikawa A., Ushikubi F., Narumiya S., Saper C.B. Characteristics of thermoregulatory and febrile responses in mice defi cient in prostaglandin EP1 and EP3 receptors. J. Physiol. (Lond) 2003, 551:945-954.
93. Oka T., Oka K., Saper C.B. Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats. Brain Res. 2003, 968:256-262.
94. Oka T., Oka K., Scammell T.E., Lee C., Kelly J.F., Nantel F., Elmquist J.K., Saper C.B. Relationship of EP (1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J. Comp. Neurol. 2000, 428:20-32.
95. Parrott R.F., Vellucci S.V. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res. Bull. 1996, 41:97-103.
96. Quan N., Stern E.L., Whiteside M.B., Herkenham M. Induction of pro-infl ammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J. Neuroimmunol. 1999, 93:72-80.
97. Ram A., Pandey H.P., Matsumura H., Kasahara-Orita K., Nakajima T., Takahata R., Satoh S., Terao A., Hayaishi O. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Res. 1997, 751:81-89.
98. Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav. Immun. 2003, 17:13-19.
99. Rizvi T.A., Ennis M., Shipley M.T. Reciprocal connections between the medial preoptic area and the midbrain periaqueductal gray in rat: a WGA-HRP and PHA-L study. J. Comp. Neurol. 1992, 315:1-15.
100. Romanovsky A.A. Signaling the brain in the early sickness syndrome: are sensory nerves involved?. Front. Biosci. 2004, 9:494-504.
101. Romanovsky A.A., Ivanov A.I., Lenczowski M.J.P., Kulchitsky V.A., Van Dam A.M., Poole S., Homer L.D., Tilders F.J.H. Lipopolysaccharide transport from the peritoneal cavity to the blood: is it controlled by the vagus nerve?. Autonomic Neuroscience 2000, 85:133-140.
102. Romanovsky A.A., Sugimoto N., Simons C.T., Hunter W.S. The organum vasculosum laminae terminalis in immuneto-brain febrigenic signaling: a reappraisal of lesion experiments. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 285:R420-R428.
103. Saper C.B., Breder C.D. Endogenous pyrogens in the CNS: role in the febrile response. Prog. Brain Res. 1992, 93:419-429.
104. Saper C.B., Breder C.D. The neurologic basis of fever. N. Engl. J. Med. 1994, 330:1880-1886.
105. Saper C.B., Chou T.C., Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 2002, 36:199-211.
106. Saper C.B., Chou T.C., Scammell T.E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001, 24:726-731.
107. Saper C.B., Levisohn D. Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third vent (AV3V) region. Brain Res. 1983, 288:21-31.
108. Saper C.B., Swanson L.W., Cowan W.M. The efferent connections of the ventromedial nucleus of the hypothalamus of the rat. J. Comp. Neurol. 1976, 169:409-442.
109. Sawchenko P.E., Brown E.R., Chan R.K., Ericsson A., Li H.Y., Roland B.L., Kovacs K.J. The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog. Brain Res. 1996, 107:201-222.
110. Scammell T., Gerashchenko D., Urade Y., Onoe H., Saper C., Hayaishi O. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:7754-7759.
111. Scammell T.E., Arrigoni E., Thompson M.A., Ronan P.J., Saper C.B., Greene R.W. Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. J. Neurosci. 2003, 23:5762-5770.
112. Scammell T.E., Elmquist J.K., Griffi n J.D., Saper C.B. Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J. Neurosci. 1996, 16:6246-6254.
113. Scammell T.E., Griffi n J.D., Elmquist J.K., Saper C.B. Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am. J. Physiol. 1998, 274:R783-R789.
114. Schiltz J.C., Sawchenko P.E. Distinct brain vascular cell types manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults. J. Neurosci. 2002, 22:5606-5618.
115. Schiltz J.C., Sawchenko P.E. Signaling the brain in systemic infl ammation: the role of perivascular cells. Front. Biosci. 2003, 8:S1321-S1329.
116. Schneider A., Guan Y., Zhang Y., Magnuson M.A., Pettepher C., Loftin C.D., Langenbach R., Breyer R.M., Breyer M.D. Generation of a conditional allele of the mouse prostaglandin EP (4) receptor. Genesis 2004, 40:7-14.
117. Segi E., Sugimoto Y., Yamasaki A., Aze Y., Oida H., Nishimura T., Murata T., Matsuoka T., Ushikubi F., Hirose M. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-defi cient mice. Biochem. Biophys. Res. Commun. 1998, 246:7-12.
118. Sehic E., Hunter W.S., Ungar A.L., Blatteis C.M. Blockade of Kupffer cells prevents the febrile and preoptic prostaglandin E2 responses to intravenous lipopolysaccharide in guinea pigs. Ann. N. Y. Acad. Sci. 1997, 813:448-452.
119. Smith W.L., Dewitt D.L. Prostaglandin endoperoxide H synthases-1 and-2. Adv. Immunol. 1996, 62:167-215.
120. Stitt J.T. Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats. J. Physiol. 1985, 368:501-511.
121. Stitt J.T., Bernheim H.A. Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits. J. Appl. Physiol. 1985, 59:342-347.
122. Szekely M., Balasko M., Kulchitsky V.A., Simons C.T., Ivanov A.I., Romanovsky A.A. Multiple neural mechanisms of fever. Auton. Neurosci. 2000, 85:78-82.
123. Takahashi Y., Smith P., Ferguson A., Pittman Q.J. Circumventricular organs and fever. Am. J. Physiol. 1997, 273:R1690-R1695.
124. Tanaka M., McAllen R.M. A subsidiary fever center in the medullary raphe?. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289:R1592-R1598.
125. Tanioka T., Nakatani Y., Semmyo N., Murakami M., Kudo I. Molecular identifi cation of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 2000, 275:32775-32782.
126. Taogoshi T., Nomura A., Murakami T., Nagai J., Takano M. Transport of prostaglandin E1 across the blood-brain barrier in rats. J. Pharm. Pharmacol. 2005, 57:61-66.
127. Thoren S., Jakobsson P.J. Coordinate up-and downregulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. Eur. J. Biochem. 2000, 267:6428-6434.
128. Ushikubi F., Segi E., Sugimoto Y., Murata T., Matsuoka T., Kobayashi T., Hizaki H., Tuboi K., Katsuyama M., Ichikawa A., Tanaka T., Yoshida N., Narumiya S. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 1998, 395:281-284.
129. Van Dam A.M., Brouns M., Man A.H.W., Berkenbosch F. Immunocytochemical detection of prostaglandin E2 in microvasculature and in neurons of rat brain after administration of bacterial endotoxin. Brain Res. 1993, 613:331-336.
130. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 1971, 231:232-235.
131. Vane J.R., Botting R.M. The mechanism of action of aspirin. Thromb. Res. 2003, 110:255-258.
132. Vanegas H., Schaible H.-G. Descending control of persistent pain: inhibitory or facilitatory?. Brain Res. Rev. 2004, 46:295-309.
133. von Euler U.S. Über die spezifi sche blutdrucksenkende Substanz des menschlichen Prostata-und Samenblasensekretes. Klin. Wochenschrift. 1935, 14:1182-1183.
134. Wan W., Wetmore L., Sorensen C.M., Greenberg A.H., Nance D.M. Neural and biochemical mediators of endotoxin and stress-induced c-fos expression in the rat brain. Brain Res. Bull. 1994, 34:7-14.
135. Watkins L.R., Wiertelak E.P., Goehler L.E., Mooney-Heiberger K., Martinez J., Furness L., Smith K.P., Maier S.F. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 1994, 639:283-299.
136. Wicrtelak E.P., Smith K.P., Furness L., Mooney-Heiberger K., Mayr T., Maier S.F., Watkins L.R. Acute and conditioned hyperalgesic responses to illness. Pain 1994, 56:227-234.
137. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 1993, 11:371-386.
138. Yamagata K., Matsumura K., Inoue W., Shiraki T., Suzuki K., Yasuda S., Sugiura H., Cao C., Watanabe Y., Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J. Neurosci. 2001, 21:2669-2677.
139. Yoshida K., Konishi M., Nagashima K., Saper C.B., Kanosue K. Fos activation in hypothalamic neurons during cold or warm exposure: projections to periaqueductal gray matter. Neuroscience 2005, 133:1039-1046.
140. Yoshida K., Nakamura K., Matsumura K., Kanosue K., Konig M., Thiel H.J., Boldogkoi Z., Toth I., Roth J., Gerstberger R., Hubschle T. Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3. Eur. J. Neurosci. 2003, 18:1848-1860.
141. Yoshida Y., Matsumura H., Nakajima T., Mandai M., Urakami T., Kuroda K., Yoneda H. Prostaglandin E (EP) receptor subtypes and sleep: promotion by EP4 and inhibition by EP1/ EP2. Neuroreport 2000, 11:2127-2131.
142. Zhang J., Rivest S. Distribution, regulation and colocalization of the genes encoding the EP2-and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic infl amma. Eur. J. Neurosci. 1999, 11:2651-2668.
143. Zhang J., Rivest S. A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specifi c nuclei of the brain in response to circu interleukin-1beta. J. Neurochem. 2000, 74:2134-2145.
144. Zhang Y.H., Lu J., Elmquist J.K., Saper C.B. Specifi c roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J. Comp. Neurol. 2003, 463:3-12.
145. Zhang Y.-H., Lu J., Elmquist J.K., Saper C.B. Lipopolysaccharide activates specifi c populations of hypothalamic and brainstem neurons that project to the spinal cord. J. Neurosci. 1900, 20:6578-6586.