Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 286, Issue 2 55-2, 2004, Pages

  Madden, C J ^a   Morrison, S F ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Febrile; Glutamate; Medial preoptic area; Sympathetic; Thermoregulation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; AMINO ACID RECEPTOR; CHLORALOSE; KYNURENIC ACID; MUSCIMOL; PROSTAGLANDIN; PROSTAGLANDIN E2; URETHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN REGION; BROWN ADIPOSE TISSUE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEART RATE; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; MEDIAL PREOPTIC AREA; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; SYMPATHETIC NERVE; THERMOGENESIS;

EID: 0942298212     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00515.2003     Document Type: Article

References (33)

1. Amir S and Schiavetto A. Injection of prostaglandin E2 into the anterior hypothalamic preoptic area activates brown adipose tissue thermogenesis in the rat. Brain Res 528: 138-142, 1990.
2. Bacon SJ, Zagon A, and Smith AD. Electron microscopic evidence of a monosynaptic pathway between cells in the caudal raphe nuclei and sympathetic preganglionic neurons in the rat spinal cord. Exp Brain Res 79: 589-602, 1990.
3. Bamshad M, Song CK, and Bartness TJ. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276: R1569-R1578, 1999.
4. Cano G, Passerin AM, Schiltz JC, Card JP, Morrison SF, and Sved AF. Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J Comp Neurol 460: 303-326, 2003.
5. Cao WH and Morrison SF. Disinhibition of rostral raphe pallidus neurons increases cardiac sympathetic nerve activity and heart rate. Brain Res 980: 1-10, 2003.
6. Cao WH and Morrison SF. Glutamate receptors in the raphe pallidus mediate brown adipose tissue thermogenesis evoked by activation of dorsomedial hypothalamic neurons (Abstract), FASEB J 17: 63.13, 2003.
7. Chen XM, Hosono T, Yoda T, Fukuda Y, and Kanosue K. Efferent projection from the preoptic area for the control of non-shivering thermogenesis in rats. J Physiol 512: 883-892, 1998.
8. Chen XM, Nishi M, Taniguchi A, Nagashima K, Shibata M, and Kanosue K. The caudal periaqueductal gray participates in the activation of brown adipose tissue in rats. Neurosci Lett 331: 17-20, 2002.
9. Da Silva LG, de Menezes RC, Souza dos Santos RA, Campagnole-Santos MJ, and Peliky Fontes MA. Role of periaqueductal gray on the cardiovascular response evoked by disinhibition of the dorsomedial hypothalamus. Brain Res 984: 206-214, 2003.
10. Ek M, Arias C, Sawchenko P, and Ericsson-Dahlstrand A. Distribution of the EP3 prostaglandin E(2) receptor subtype in the rat brain: relationship to sites of interleukin-1-induced cellular responsiveness. J Comp Neurol 428: 5-20, 2000.
11. Feldberg W and Saxena PN. Further studies on prostaglandin E 1 fever in cats. J Physiol 219: 739-745, 1971.
12. Hermann DM, Luppi PH, Peyron C, Hinckel P, and Jouvet M. Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars alpha demonstrated by iontophoretic application of choleratoxin (subunit b). J Chem Neuroanat 13: 1-21, 1997.
13. Imai-Matsumura K and Nakayama T. The central efferent mechanism of brown adipose tissue thermogenesis induced by preoptic cooling. Can J Physiol Pharmacol 65: 1299-1303, 1987.
14. Loewy AD. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res 222: 129-133, 1981.
15. Madden CJ and Morrison SF. Excitatory amino acid receptor activation in the raphe pallidus area mediates prostaglandin-evoked thermogenesis. Neuroscience 122: 5-15, 2003.
16. Morimoto A, Murakami N, Nakamori T, and Watanabe T. Multiple control of fever production in the central nervous system of rabbits. J Physiol 397: 269-280, 1988.
17. Morrison SF. Raphe pallidus neurons mediate prostaglandin E2-evoked increases in brown adipose tissue thermogenesis. Neuroscience 121: 17-24, 2003.
18. Morrison SF, Sved AF, and Passerin AM. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276: R290-R297, 1999.
19. Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, Ichikawa A, and Negishi M. Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci Lett 260: 117-120, 1999.
20. Nakamura K, Matsumura K, Kaneko T, Kobayashi S, Katoh H, and Negishi M. The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci 22: 4600-4610, 2002.
21. Nogueira MI, de Rezende BD, do Vale LE, and Bittencourt JC. Afferent connections of the caudal raphe pallidus nucleus in rats: a study using the fluorescent retrograde tracers fluorogold and true-blue. Anat Anz 182: 35-45, 2000.
22. Oka T, Oka K, Scammell TE, Lee C, Kelly JF, Nantel F, Elmquist JK, and Saper CB. Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J Comp Neurol 428: 20-32, 2000.
23. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, and McKinley MJ. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110: 515-526, 2002.
24. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. Sydney, Australia: Academic, 1986.
25. Scammell TE, Griffin JD, Elmquist JK, and Saper CB. Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol Regul Integr Comp Physiol 274: R783-R789, 1998.
26. Soltis RP and DiMicco JA. Interaction of hypothalamic GABAA and excitatory amino acid receptors controlling heart rate in rats. Am J Physiol Regul Integr Comp Physiol 261: R427-R433, 1991.
27. Stitt JT. Prostaglandin E1 fever induced in rabbits. J Physiol 232: 163-179, 1973.
28. Stitt JT. Differential sensitivity in the sites of fever production by prostaglandin E1 within the hypothalamus of the rat. J Physiol 432: 99-110, 1991.
29. Thompson RH and Swanson LW. Organization of inputs to the dorsomedial nucleus of the hypothalamus: a reexamination with Fluorogold and PHAL in the rat. Brain Res Brain Res Rev 27: 89-118, 1998.
30. Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, Kobayashi T, Hizaki H, Tuboi K, Katsuyama M, Ichikawa A, Tanaka T, Yoshida N, and Narumiya S. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395: 281-284, 1998.
31. Williams JW, Rudy TA, Yaksh TL, and Viswanathan CT. An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia. Brain Res 120: 251-262, 1977.
32. Zaretskaia MV, Zaretsky DV, and DiMicco JA. Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett 340: 14, 2003.
33. Zaretskaia MV, Zaretsky DV, Shekhar A, and DiMicco JA. Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res 928: 113-125, 2002.