The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence

Microbes and Infection

Volumn 2, Issue 8, 2000, Pages 933-943

  Fitzgerald, Katherine A ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

IL 1R; Spatzle; TIR domain; Toll

Indexed keywords

ADAPTOR PROTEIN; CELL SURFACE RECEPTOR; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18 RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

BACTERIAL INFECTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST RESISTANCE; IMMUNE RESPONSE; INFLAMMATION; INJURY; NONHUMAN; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 0033925359     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)00396-8     Document Type: Review

References (68)

1. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood. 87:(6):1996;2095-2147.
2. Sims J.E., Gayle M.A., Slack J.L., Alderson M.R., Bird T.A., Giri J.G., Colotta F., Re F., Mantovani A., Shanebeck K., et al. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. USA. 90:(13):1993;6155-6159.
3. McMahan C.J., Slack J.L., Mosley B., Cosman D., Lupton S.D., Brunton L.L., Grubin C.E., Wignall J.M., Jenkins N.A., Brannan C.I., et al. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. Embo. J. 10:(10):1991;2821-2832.
4. Stylianou E., O'Neill L.A., Rawlinson L., Edbrooke M.R., Woo P., Saklatvala J. Interleukin 1 induces NF - κB through its type I but not its type II receptor in lymphocytes. J. Biol. Chem. 267:(22):1992;15836-15841.
5. Gay N.J., Keith F.J. Drosophila Toll and IL-1 receptor. Nature. 351:(6325):1991;355-356.
6. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., Hoffmann J.A. The dorsoventral regulatory gene cassette spatzle/Toll/ cactus controls the potent antifungal response in Drosophila adults. Cell. 86:(6):1996;973-983.
7. Burns K., Martinon F., Esslinger C., Pahl H., Schneider P., Bodmer J.L., Di Marco F., French L., Tschopp J. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273:(20):1998;12203-12209.
8. Wesche H., Henzel W.J., Shillinglaw W., Li S., Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity. 7:(6):1997;837-847.
9. Heguy A., Baldari C.T., Macchia G., Telford J.L., Melli M. Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction. J. Biol. Chem. 267:(4):1992;2605-2609.
10. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M., Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:(6755):1999;811-815.
11. Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:(5396):1998;2085-2088.
12. Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., Bazan J.F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA. 95:(2):1998;588-593.
13. Muzio M., Ni J., Feng P., Dixit V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 278:(5343):1997;1612-1615.
14. O'Neill L.A., Greene C. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J. Leukoc. Biol. 63:(6):1998;650-657.
15. Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem. 271:(8):1996;3967-3970.
16. Torigoe K., Ushio S., Okura T., Kobayashi S., Taniai M., Kunikata T., Murakami T., Sanou O., Kojima H., Fujii M., Ohta T., Ikeda M., Ikegami H., Kurimoto M. Purification and characterization of the human interleukin- 18 receptor. J. Biol. Chem. 272:(41):1997;25737-25742.
17. Bazan J.F., Timans J.C., Kastelein R.A. A newly defined interleukin-1? Nature. 379:(6566):1996;591-591.
18. Born T.L., Thomassen E., Bird T.A., Sims J.E. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273:(45):1998;29445-29450.
19. Hoshino K., Tsutsui H., Kawai T., Takeda K., Nakanishi K., Takeda Y., Akira S. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162:(9):1999;5041-5044.
20. Takeda K., Tsutsui H., Yoshimoto T., Adachi O., Yoshida N., Kishimoto T., Okamura H., Nakanishi K., Akira S. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8:(3):1998;383-390.
21. Lovenberg T.W., Crowe P.D., Liu C., Chalmers D.T., Liu X.J., Liaw C., Clevenger W., Oltersdorf T., De Souza E.B., Maki R.A. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). J. Neuroimmunol. 70:(2):1996;113-122.
22. Thomassen E., Renshaw B.R., Sims J.E. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 11:(6):1999;389-399.
23. Klemenz R., Hoffmann S., Werenskiold A.K. Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc. Natl. Acad. Sci. USA. 86:(15):1989;5708-5712.
24. Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor. FEBS Lett. 258:(2):1989;301-304.
25. Gayle M.A., Slack J.L., Bonnert T.P., Renshaw B.R., Sonoda G., Taguchi T., Testa J.R., Dower S.K., Sims J.E. Cloning of a putative ligand for the T1/ST2 receptor. J. Biol. Chem. 271:(10):1996;5784-5789.
26. Mitcham J.L., Parnet P., Bonnert T.P., Garka K.E., Gerhart M.J., Slack J.L., Gayle M.A., Dower S.K., Sims J.E. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. J. Biol. Chem. 271:(10):1996;5777-5783.
27. Coyle A.J., Lloyd C., Tian J., Nguyen T., Erikkson C., Wang L., Ottoson P., Persson P., Delaney T., Lehar S., Lin S., Poisson L., Meisel C., Kamradt T., Bjerke T., Levinson D., Gutierrez-Ramos J.C. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J. Exp. M. 190:(7):1999;895-902.
28. Carrie A., Jun L., Bienvenu T., Vinet M.C., Mc Donell N., Couvert P., Zemni R., Cardona A., Van Buggenhout G., Frints S., Hamel B., Moraine C., Ropers H.H., Strom T., Howell G.R., Whittaker A., Ross M.T., Kahn A., Fryns J.P., Beldjord C., Marynen P., Chelly J. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nat. Genet. 23:(1):1999;25-31.
29. Alcami A., Smith G.L. A soluble receptor for interleukin-1b encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Cell. 71:(1):1992;153-167.
30. Williams M.J., Rodriguez A., Kimbrell D.A., Eldon E.D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. Embo. J. 16:(20):1997;6120-6130.
31. Kuchenmeister M.K., Handel K., Schmidtott U., Roth S., Jackle H. Toll homologue expression in the beetle tribolium suggests a different mode of dorsoventral patterning than in drosophila embryos. Mech. Dev. 83:(1-2):1999;107-114.
32. Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S. TLR6: A novel member of an expanding toll-like receptor family. Gene. 231:(1-2):1999;59-65.
33. Chaudhary P.M., Ferguson C., Nguyen V., Nguyen O., Massa H.F., Eby M., Jasmin A., Trask B.J., Hood L., Nelson P.S. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi- gene receptor family in humans. Blood. 91:(11):1998;4020-4027.
34. Yang R.B., Mark M.R., Gray A., Huang A., Xie M.H., Zhang M., Goddard A., Wood W.I., Gurney A.L., Godowski P.J. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395:(6699):1998;284-288.
35. Kirschning C.J., Wesche H., Merrill A.Y., Restrothe M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. M. 188:(11):1998;2091-2097.
36. Medzhitov R., Preston-Hurlburt P., Janeway C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:(6640):1997;394-397.
37. Frantz S., Kobzik L., Kim Y.D., Fukazawa R., Medzhitov R., Lee R.T., Kelly R.A. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J. Clin. Invest. 104:(3):1999;271-280.
38. Harris N.L., Ronchese F. The role of B7 costimulation in T-cell immunity. Immunol. Cell. Biol. 77:(4):1999;304-311.
39. Ulevitch R.J., Tobias P.S. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr. Opin. Immunol. 11:(1):1999;19-22.
40. Qureshi S.T., Lariviere L., Leveque G., Clermont S., Moore K.J., Gros P., Malo D. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. M. 189:(4):1999;615-625.
41. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll- like receptor 4. J. Exp. M. 189:(11):1999;1777-1782.
42. Vogel S.N., Johnson D., Perera P.Y., Medvedev A., Lariviere L., Qureshi S.T., Malo D. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J. Immunol. 162:(10):1999;5666-5670.
43. Melchior F., Gerace L. Two-way trafficking with Ran. Trends Cell. Biol. 8:(5):1998;175-179.
44. Wong P.M., Kang A., Chen H., Yuan Q., Fan P., Sultzer B.M., Kan Y.W., Chung S.W. Lps (d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc. Natl. Acad. Sci. USA. 96:(20):1999;11543-11548.
45. Janeway C.A. Jr. Presidential Address to The American Association of Immunologists, The road less traveled by: the role of innate immunity in the adaptive immune response. J. Immunol. 161:(2):1998;539-544.
46. Heine H., Kirschning C.J., Lien E., Monks B.G., Rothe M., Golenbock D.T. Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J. Immunol. 162:(12):1999;6971-6975.
47. Yoshimura A., Lien E., Ingalls R.R., Tuomanen E., Dziarski R., Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:(1):1999;1-5.
48. Means T.K., Wang S., Lien E., Yoshimura A., Golenbock D.T., Fenton M.J. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163:(7):1999;3920-3927.
49. Hirschfeld M., Kirschning C.J., Schwandner R., Wesche H., Weis J.H., Wooten R.M., Weis J.J. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163:(5):1999;2382-2386.
50. Brightbill H.D., Libraty D.H., Krutzik S.R., Yang R.B., Belisle J.T., Bleharski J.R., Maitland M., Norgard M.V., Plevy S.E., Smale S.T., Brennan P.J., Bloom B.R., Godowski P.J., Modlin R.L. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 285:(5428):1999;732-736.
51. Anderson K.V., Schneider D.S., Morisato D., Jin Y., Ferguson E.L. Extracellular morphogens in Drosophila embryonic dorsal- ventral patterning. Cold Spring Harb. Symp. Quant. Biol. 57:1992;409-417.
52. Schneider D.S., Jin Y., Morisato D., Anderson K.V. A processed form of the Spatzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development. 120:(5):1994;1243-1250.
53. Lemosy E.K., Hong C.C., Hashimoto C. Signal transduction by a protease cascade. Trends Cell. Biol. 9:(3):1999;102-107.
54. Hoffmann J.A. Drosophila immunity. Trends Cell. Biol. 7:1997;309-316.
55. Levashina E.A., Langley E., Green C., Gubb D., Ashburner M., Hoffmann J.A., Reichhart J.M. Constitutive activation of toll-mediated antifungal defense in serpin- deficient Drosophila. Science. 285:(5435):1999;1917-1919.
56. Iwanaga S., Kawabata S., Muta T. New types of clotting factors, defense molecules found in horseshoe crab hemolymph: their structures and functions. J. Biochem. (Tokyo). 123:(1):1998;1-15.
57. Wright S.D., Toll. a new piece in the puzzle of innate immunity. J. Exp. M. 189:(4):1999;605-609.
58. Whitham S., Dinesh Kumar S.P., Choi D., Hehl R., Corr C., Baker B. The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell. 78:(6):1994;1101-1115.
59. Lawrence G.J., Finnegan E.J., Ayliffe M.A., Ellis J.G. The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N. Plant Cell. 7:(8):1995;1195-1206.
60. Botella M.A., Parker J.E., Frost L.N., Bittner-Eddy P.D., Beynon J.L., Daniels M.J., Holub E.B., Jones J.D. Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasitica avirulence determinants. Plant Cell. 10:(11):1998;1847-1860.
61. Parker J.E., Coleman M.J., SzabÚ V., Frost L.N., Schmidt R., Van Der Biezen E.A., Moores T., Dean C., Daniels M.J., Jones J.D. The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6. Plant Cell. 9:(6):1997;879-894.
62. Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., Nakanishi K., Akira S. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function. Immunity. 9:(1):1998;143-150.
63. Kawai T., Adachi O., Ogawa T., Takeda K., Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 11:(1):1999;115-122.
64. Medzhitov R., Preston Hurlburt P., Janeway C.A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:(6640):1997;394-397.
65. Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., Mantovani A., Rothe M., Muzio M., Arditi M. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274:(12):1999;7611-7614.
66. Liu H., Su Y.C., Becker E., Treisman J., Skolnik E.Y. A Drosophila TNF - receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Curr. Biol. 9:(2):1999;101-104.
67. Kopp E., Medzhitov R., Carothers J., Xiao C., Douglas I., Janeway C.A., Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 13:(16):1999;2059-2071.
68. Karin M. The beginning of the end: IkappaB kinase (IKK) and NF - κB activation. J. Biol. Chem. 274:(39):1999;27339-27342.