A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1β

Journal of Neurochemistry

Volumn 74, Issue 5, 2000, Pages 2134-2145

  Zhang, Ji ^a   Rivest, Serge ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Glucocorticoids; Immediate early genes; Immunocytochemistry; In situ hybridization histochemistry; Inflammation; Paraventricular nucleus of the hypothalamus; Proinflammatory cytokines; Prostaglandins

Indexed keywords

CORTICOSTERONE; INTERLEUKIN 1BETA; KETOROLAC; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; RECEPTOR SUBTYPE; ANTISERUM; INTERLEUKIN 1; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PROSTAGLANDIN E2 RECEPTOR, EP4 SUBTYPE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NUCLEUS; CATECHOLAMINE NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOCHEMISTRY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMEDIATE EARLY GENE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; MALE; MEDULLA OBLONGATA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SOLITARY TRACT NUCLEUS; ANIMAL; BLOOD; BRAIN; CYTOLOGY; DRUG EFFECT; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOLOGY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; GENE EXPRESSION; GENES, IMMEDIATE-EARLY; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNE SERA; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1; KETOROLAC; MALE; MEDULLA OBLONGATA; NEURONS; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E; TRANSCRIPTION, GENETIC;

EID: 0033624943     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742134.x     Document Type: Article

References (39)

1. Armstrong W. E. (1995) Hypothalamic supraoptic and paraventricular nuclei, in The Rat Nervous System (Paxinos G., ed), pp. 377-390. Academic Press, San Diego.
2. Barbanel G., Ixart G., Szafarczyk A., Malaval F., and Assenmacher I. (1990) Intrahypothalamic infusion of interleukin-1 β increases the release of corticotropin-releasing hormone (CRH 41) and adrenocorticotropic hormone (ACTH) in free-moving rats bearing a push-pull cannula in the median eminence. Brain Res. 516, 31-36.
3. Berkenbosch F., Oers J. V., Rey A. D., Tilders F., and Besedovsky H. (1987) Corticotropin-releasing factor producing neurons in the rat activated by interleukin-1. Science 238, 524-526.
4. Boie Y., Stocco R., Sawyer N., Slipetz D. M., Ungrin M. D., Neuschafer-Rube F., Puschel G. P., Metters K. M., and Abramovitz M. (1997) Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur. J. Pharmacol. 340, 227-241.
5. Buller K. M., Smith D. W., and Day T. A. (1999) Differential recruitment of hypothalamic neuroendocrine and ventrolateral medulla catecholamine cells by non-hypotensive and hypotensive hemorrhages. Brain Res. 834, 42-54.
6. Coleman R. A., Smith W. L., and Narumiya S. (1994) International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46, 205-229.
7. Cunningham E. T. and Sawchenko P. E. (1988) Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J. Comp. Neurol. 274, 60-76.
8. Cunningham E. T. Jr., Bohn M. C., and Sawchenko P. E. (1990) Organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J. Comp. Neurol. 292, 651-667.
9. Eguchi N., Hayashi H., Urade Y., Ito S., and Hayaishi O. (1988) Central action of prostaglandin E2 and its methyl ester in the induction of hyperthermia after their systemic administration in urethane-anesthetized rats. J. Pharmacol. Exp. Ther. 247, 671-679.
10. Elmquist J. K., Breder C. D., Sherin J. E., Scammell T. E., Hickey W. F., Dewitt D., and Saper C. B. (1997) Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J. Comp. Neurol. 381, 119-129.
11. Elmquist J. K., Scammell T. E., and Saper C. B. (1997) Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci. 20, 565-570.
12. Ericsson A., Ek M., and Lindefors N. (1995a) Distribution of prostaglandins E2 receptor (EP3 subtype) mRNA containing cells in the rat central nervous system. Soc. Neurosci. Abstr. 21, 98.
13. Ericsson A., Liu C., Hart R. P., and Sawchenko P. E. (1995b) Type-1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J. Comp. Neurol. 361, 681-698.
14. Gartside S. E., Suaud-Chagny M. F., and Tappaz M. (1995) Evidence that activation of the hypothalamo-pituitary-adrenal axis by electrical stimulation of the noradrenergic A1 group is not mediated by noradrenaline. Neuroendocrinology 62, 2-12.
15. Hosoi M., Oka T., and Hori T. (1997) Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats. Pain 71, 303-311.
16. Lacroix S. and Rivest S. (1997) Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins. J. Comp. Neurol. 387, 307-324.
17. Lacroix S. and Rivest S. (1998) Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain. J. Neurochem. 70, 452-466.
18. Lacroix S., Vallières L., and Rivest S. (1996) c-fos mRNA pattern and CRF neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type. J. Neuroimmunol. 70, 163-179.
19. Laflamme N. and Rivest S. (1999) Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor κBα within specific cellular populations of the rat brain. J. Neurochem. 73, 309-321.
20. Laflamme N., Lacroix S., and Rivest S. (1999) An essential role of interleukin-1 β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain harrier in response to a systemic and localized inflammation but not during endotoxemia. J. Neurosci. 19, 10923-10930.
21. Matsumura K., Cao C., Ozaki M., Morii H., Nakadate K., and Watanabe Y. (1998) Brain endothelial cells express cyclooxygenase-2 during lipopolysaccharide-induced fever: light and electron microscopic immunocytochemical studies. J. Neurosci. 18, 6279-6289.
22. Milbrandt J. (1988) Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1, 183-188.
23. Namba T., Sugimoto Y., Negishi M., Irie A., Ushikubi F., Kakizuka A., Ito S., Ichikawa A., and Narumiya S. (1993) Alternate splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 365, 166-170.
24. Narumiya S., Sugimoto Y., and Ushikubi F. (1999) Prostanoid receptors; structures, properties, and functions. Physiol. Rev. 79, 1193-1226.
25. Navarra P., Tsagarakis S., Faria M. S., Rees L. H., Besser G. M., and Grossman A. B. (1991) Interleukin-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology 128, 37-44.
26. Oka T. and Hori T. (1994) EPI-receptor mediation of prostaglandin E2-induced hyperthermia in rats. Am. J. Physiol. 267, R289-R294.
27. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
28. Plotsky P., Cunningham E. T. J., and Widmaier E. P. (1989) Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocr. Rev. 10, 437-458.
29. Rivest S. (1999) What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies. Mol. Psychiatry 4, 501-507.
30. Rivest S., Lacroix S., Vallières L., Nadeau S., Zhang J., and Laflamme N. (2000) How the blond talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc. Soc. Exp. Biol. Med. 223, 22-38.
31. Rivier C. and Vale W. (1991) Stimulatory effect of interleukin-1 on ACTH secretion in the rat: is it modulated by prostaglandins? Endocrinology 129, 384-388.
32. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., and Vale W. (1987) Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238, 522-524.
33. Sawchenko P. E., Brown E. R., Chan R. K. W., Ericsson A., Li H. Y., Roland B. L., and Kovacs K. J. (1996) The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog. Brain Res. 107, 201-222.
34. Scammell T. E., Elmquist J. K., Griffin J. D., and Saper C. B. (1996) Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J. Neurosci. 16, 6246-6254.
35. Smith D. W., Buller K. M., and Day T. A. (1995) Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell responses to systemic hypoxia. J. Neurosci. 15, 7979-7988.
36. Swanson L. W. (1992) Brain Maps: Structure of the Rat Brain. Elsevier, New York.
37. Turnbull A. V. and Rivier C. L. (1999) Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79, 1-71.
38. Ushikubi F., Segi E., Sugimoto Y., Murata T., Matsuoka T., Kobayashi T., Hizaki H., Tuboi K., Katsuyama M., Ichikawa A., Tanaka T., Yoshida N., and Narumiya S. (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395, 281-284.
39. 2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur. J. Neurosci. 11, 2651-2668.