-
1
-
-
0037374817
-
Where a pill won't reach
-
R. Langer (2003) Where a pill won't reach. Scientific American 288 50-57.
-
(2003)
Scientific American
, vol.288
, pp. 50-57
-
-
Langer, R.1
-
2
-
-
0032580354
-
Drug delivery and targeting
-
R. Langer (1998) Drug delivery and targeting. Nature 392 5-10.
-
(1998)
Nature
, vol.392
, pp. 5-10
-
-
Langer, R.1
-
3
-
-
33751419875
-
Nanomedicine: Developing smarter therapeutic and diagnostic modalities
-
O.C. Farokhzad and R. Langer (2006) Nanomedicine: Developing smarter therapeutic and diagnostic modalities. Adv. Drug Deliv. Rev. 58 1456-1459.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 1456-1459
-
-
Farokhzad, O.C.1
Langer, R.2
-
4
-
-
0035937593
-
Polysaccharide colloidal particles as delivery systems for macromolecules
-
K.A. Janes, P. Calvo and M.J. Alonso (2001) Polysaccharide colloidal particles as delivery systems for macromolecules. Adv. Drug Deliv. Rev. 47 83-97.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.47
, pp. 83-97
-
-
Janes, K.A.1
Calvo, P.2
Alonso, M.J.3
-
5
-
-
0028657017
-
Enzymatic barriers for Gl peptide and protein delivery
-
F. Woodley (1994) Enzymatic barriers for Gl peptide and protein delivery. Crit. Rev. Ther. Drug Carrier Syst. 11 61-95.
-
(1994)
Crit. Rev. Ther. Drug Carrier Syst.
, vol.11
, pp. 61-95
-
-
Woodley, F.1
-
6
-
-
0028239031
-
Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs
-
X.H. Zhou (1994) Overcoming enzymatic and absorption barriers to non-parenterally administered protein and peptide drugs. J. Control. Release 29 239-252.
-
(1994)
J. Control. Release
, vol.29
, pp. 239-252
-
-
Zhou, X.H.1
-
7
-
-
0003444176
-
International Commission on Radiological Partition 23
-
New York: Pergamon Press
-
W.S. Snyder, M.J. Cook, E.S. Nassat, L.R. Karhausen, G.P. Howells and I.H. Tipton (1974) International Commission on Radiological Partition 23. Report of the Taskgroup on Reference Man New York: Pergamon Press 139.
-
(1974)
Report of the Taskgroup on Reference Man
, pp. 139
-
-
Snyder, W.S.1
Cook, M.J.2
Nassat, E.S.3
Karhausen, L.R.4
Howells, G.P.5
Tipton, I.H.6
-
8
-
-
0019903597
-
A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: Influence of feeding, prostaglandin, N-acetylcysteine and other agents
-
S. Kerss, A. Allen and A. Garner (1982) A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: Influence of feeding, prostaglandin, N-acetylcysteine and other agents. Clin. Sci. (Lond.) 63 187-195.
-
(1982)
Clin. Sci. (Lond.)
, vol.63
, pp. 187-195
-
-
Kerss, S.1
Allen, A.2
Garner, A.3
-
9
-
-
27144505483
-
Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane
-
Y. Aoki, M. Morishita, K. Asai, B. Akikusa, S. Hosoda and K. Takayama (2005) Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane. Pharm. Res. 22 1854-1862.
-
(2005)
Pharm. Res.
, vol.22
, pp. 1854-1862
-
-
Aoki, Y.1
Morishita, M.2
Asai, K.3
Akikusa, B.4
Hosoda, S.5
Takayama, K.6
-
10
-
-
0027538539
-
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin
-
M. Morishita, I. Morishita, K. Takayama, Y. Machida and T. Nagai (1993) Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol. Pharm. Bull. 16 68-72.
-
(1993)
Biol. Pharm. Bull.
, vol.16
, pp. 68-72
-
-
Morishita, M.1
Morishita, I.2
Takayama, K.3
Machida, Y.4
Nagai, T.5
-
11
-
-
0027988721
-
Effect of various protease inhibitors on the intestinal absorption and degradation of insulin in rats
-
A. Yamamoto, T. Taniguchi, K. Rikyuu, T. Tsuji, T. Fujita, M. Murakami, et al. (1994) Effect of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res. 11 1496-1500.
-
(1994)
Pharm. Res.
, vol.11
, pp. 1496-1500
-
-
Yamamoto, A.1
Taniguchi, T.2
Rikyuu, K.3
Tsuji, T.4
Fujita, T.5
Murakami, M.6
-
13
-
-
0024539595
-
Synthesis of palmitoyl derivatives of insulin and their biological activities
-
M. Hashimoto, K. Takada, Y. Kiso and S. Muranishi (1989) Synthesis of palmitoyl derivatives of insulin and their biological activities. Pharm. Res. 6 171-176.
-
(1989)
Pharm. Res.
, vol.6
, pp. 171-176
-
-
Hashimoto, M.1
Takada, K.2
Kiso, Y.3
Muranishi, S.4
-
16
-
-
0033456147
-
Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption enhancing mechanism of n-lauryl-b-D-maltopyranoside
-
T. Uchiyama, T. Sugiyama, Y.S. Quan, A. Kotani, N. Okada, T. Fujita, et al. (1999) Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: Their intestinal mucosal toxicity and absorption enhancing mechanism of n-lauryl-b-D-maltopyranoside. J. Pharm. Pharmacol. 51 1241-1250.
-
(1999)
J. Pharm. Pharmacol.
, vol.51
, pp. 1241-1250
-
-
Uchiyama, T.1
Sugiyama, T.2
Quan, Y.S.3
Kotani, A.4
Okada, N.5
Fujita, T.6
-
17
-
-
0030938926
-
Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
-
A. Fasano and S. Uzzau (1997) Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J. Clin. Invest 99 1158-1164.
-
(1997)
J. Clin. Invest
, vol.99
, pp. 1158-1164
-
-
Fasano, A.1
Uzzau, S.2
-
18
-
-
33646492929
-
Tight junction modulation and its relationship to drug delivery
-
N.N. Salama, N.D. Eddington and A. Fasano (2006) Tight junction modulation and its relationship to drug delivery. Adv. Drug Deliv. Rev. 58 15-28.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 15-28
-
-
Salama, N.N.1
Eddington, N.D.2
Fasano, A.3
-
19
-
-
12344312013
-
Quantitative estimation of the effects of bile salts surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model
-
E.M. Lane, C.M. O'Driscoll and O.I. Corrigan (2005) Quantitative estimation of the effects of bile salts surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. J. Pharm. Pharmacol. 57 169-175.
-
(2005)
J. Pharm. Pharmacol.
, vol.57
, pp. 169-175
-
-
Lane, E.M.1
O'Driscoll, C.M.2
Corrigan, O.I.3
-
20
-
-
0025095208
-
Biophysical model approaches to mechanistic transepithelial studies of peptides
-
N.F.H. Ho, J.S. Day, C.L. Barsuhn, P.S. Burton and T.J. Ranb (1990) Biophysical model approaches to mechanistic transepithelial studies of peptides. J. Control. Release 11 3-24.
-
(1990)
J. Control. Release
, vol.11
, pp. 3-24
-
-
Ho, N.F.H.1
Day, J.S.2
Barsuhn, C.L.3
Burton, P.S.4
Ranb, T.J.5
-
21
-
-
0037393955
-
Challenge for the oral delivery of macromolecules
-
M. Gordberg and I. Gomez-Orellana (2003) Challenge for the oral delivery of macromolecules. Nat. Rev. Drug Discov. 2 289-295.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 289-295
-
-
Gordberg, M.1
Gomez-Orellana, I.2
-
22
-
-
0026571249
-
(C) Means to Enhance Penetration: (2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity
-
E.S. Swenson and W.J. Curatolo (1992) (C) Means to Enhance Penetration: (2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8 39-92.
-
(1992)
Adv. Drug Deliv. Rev.
, vol.8
, pp. 39-92
-
-
Swenson, E.S.1
Curatolo, W.J.2
-
23
-
-
0028033391
-
Intestinal permeability enhancement: Efficacy, acute local toxicity and reversibility
-
E.S. Swenson, W.B. Milisen and W. Curatolo (1994) Intestinal permeability enhancement: Efficacy, acute local toxicity and reversibility. Pharm. Res. 11 1132-1142.
-
(1994)
Pharm. Res.
, vol.11
, pp. 1132-1142
-
-
Swenson, E.S.1
Milisen, W.B.2
Curatolo, W.3
-
24
-
-
0037124501
-
Effects of PEG conjugation on insulin properties
-
K.D. Hinds and S.W. Kim (2004) Effects of PEG conjugation on insulin properties. Adv. Drug Deliv. Rev. 54 505-530.
-
(2004)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 505-530
-
-
Hinds, K.D.1
Kim, S.W.2
-
25
-
-
0030457349
-
Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells
-
D. Shah and W.-C. Shen (1996) Transcellular delivery of an insulin-transferrin conjugate in enterocyte-like Caco-2 cells. J. Pharm. Sci. 85 1306-1311.
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 1306-1311
-
-
Shah, D.1
Shen, W.-C.2
-
26
-
-
0033771566
-
Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats
-
C.Q. Xia, J. Wang and W.-C. Shen (2000) Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats. J. Pharmacol. Exp. Ther. 295 594-600.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 594-600
-
-
Xia, C.Q.1
Wang, J.2
Shen, W.-C.3
-
27
-
-
33845220586
-
Synthesis and characterization of insulin−transferrin conjugates
-
N.J. Kavimandan, E. Losi, J.J. Wilson, J.S. Brodbelt and N.A. Peppas (2006) Synthesis and characterization of insulin−transferrin conjugates. Bioconjugate Chem. 7 1376-1384.
-
(2006)
Bioconjugate Chem.
, vol.7
, pp. 1376-1384
-
-
Kavimandan, N.J.1
Losi, E.2
Wilson, J.J.3
Brodbelt, J.S.4
Peppas, N.A.5
-
28
-
-
39049124118
-
Nanoparticle strategies for the oral delivery of insulin
-
C. Damge, C. Pinto and P. Maincent (2008) Nanoparticle strategies for the oral delivery of insulin. Expert Opin. Drug Deliv. 5 45-68.
-
(2008)
Expert Opin. Drug Deliv.
, vol.5
, pp. 45-68
-
-
Damge, C.1
Pinto, C.2
Maincent, P.3
-
29
-
-
44249095621
-
Developments in polymeric devices for oral insulin delivery
-
V.R. Babu, P. Patel, R.C. Mundargi, V. Rangaswamy and T.M. Aminabhavi (2008) Developments in polymeric devices for oral insulin delivery. Expert Opin. Drug Deliv. 5 403-415.
-
(2008)
Expert Opin. Drug Deliv.
, vol.5
, pp. 403-415
-
-
Babu, V.R.1
Patel, P.2
Mundargi, R.C.3
Rangaswamy, V.4
Aminabhavi, T.M.5
-
30
-
-
47049095564
-
Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation
-
C.B. Woitiski, R.A. Carvalho, A.J. Ribiero, R.J. Neufeld and F. Veiga (2008) Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation. BioDrugs 22 223-237.
-
(2008)
BioDrugs
, vol.22
, pp. 223-237
-
-
Woitiski, C.B.1
Carvalho, R.A.2
Ribiero, A.J.3
Neufeld, R.J.4
Veiga, F.5
-
31
-
-
36248965689
-
Current challenges in non-invasive insulin delivery systems: A comparative review
-
E.-S. Khafagy, M. Morishita, Y. Onuki and K. Takayama (2007) Current challenges in non-invasive insulin delivery systems: A comparative review. Adv. Drug Deliv. Rev. 59 1521-1546.
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 1521-1546
-
-
Khafagy, E.-S.1
Morishita, M.2
Onuki, Y.3
Takayama, K.4
-
32
-
-
63949086707
-
Methods for the preparation and manufacture of polymeric nanoparticles
-
C. Vauthier and K. Bouchemal (2009) Methods for the preparation and manufacture of polymeric nanoparticles. Pharm. Res. 26 1025-1058.
-
(2009)
Pharm. Res.
, vol.26
, pp. 1025-1058
-
-
Vauthier, C.1
Bouchemal, K.2
-
33
-
-
0028939209
-
Controlled drug delivery with nanoparticles: Current possibilities and future trends
-
P. Couvreur, C. Dubernet and F. Puisieux (1995) Controlled drug delivery with nanoparticles: Current possibilities and future trends. Eur. J. Pharm. Biopharm. 41 2-13.
-
(1995)
Eur. J. Pharm. Biopharm.
, vol.41
, pp. 2-13
-
-
Couvreur, P.1
Dubernet, C.2
Puisieux, F.3
-
34
-
-
0029833171
-
A new nanocapsule formulation with hydrophilic core: Application to the oral administration of salmon calcitonin in rats
-
H. Vranckx, M. Demoustier and M. Deleers (1996) A new nanocapsule formulation with hydrophilic core: Application to the oral administration of salmon calcitonin in rats. J. Pharm. Pharmacol. 42 345-347.
-
(1996)
J. Pharm. Pharmacol.
, vol.42
, pp. 345-347
-
-
Vranckx, H.1
Demoustier, M.2
Deleers, M.3
-
35
-
-
33645034817
-
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles
-
C. Pinto-Reis, R.J. Neufeld, A.J. Ribeiro and F. Veiga (2006) Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine 2 8-21.
-
(2006)
Nanomedicine
, vol.2
, pp. 8-21
-
-
Pinto-Reis, C.1
Neufeld, R.J.2
Ribeiro, A.J.3
Veiga, F.4
-
36
-
-
0031446134
-
poly(alkylcyanoacrylate) nanospheres for oral administration of insulin
-
C. Damge, H. Vranckx, P. Balschmidt and P. Couvreur (1997) poly(alkylcyanoacrylate) nanospheres for oral administration of insulin. J. Pharm. Sci. 86 1403-1409.
-
(1997)
J. Pharm. Sci.
, vol.86
, pp. 1403-1409
-
-
Damge, C.1
Vranckx, H.2
Balschmidt, P.3
Couvreur, P.4
-
38
-
-
11144279341
-
Oral and subcutaneous absorption of insulin poly(alkylcyanoacrylate) nanoparticles
-
M.S. Meisha, M.B. Sidhom and B. Fasipe (2005) Oral and subcutaneous absorption of insulin poly(alkylcyanoacrylate) nanoparticles. Int. J. Pharm. 288 289-293.
-
(2005)
Int. J. Pharm.
, vol.288
, pp. 289-293
-
-
Meisha, M.S.1
Sidhom, M.B.2
Fasipe, B.3
-
39
-
-
31544449136
-
Novel pH responsive polymethacrylic acid-chitosan-polyethylene glycol nanoparticles for oral peptide delivery
-
S. Sajeesh and C.P. Sharma (2006) Novel pH responsive polymethacrylic acid-chitosan-polyethylene glycol nanoparticles for oral peptide delivery. J. Biomed. Mater. Res. B Appl. Biomater. 76 298-305.
-
(2006)
J. Biomed. Mater. Res. B Appl. Biomater.
, vol.76
, pp. 298-305
-
-
Sajeesh, S.1
Sharma, C.P.2
-
41
-
-
0037161419
-
Preparation and characterization of pH-responsive poly(methacrylic acid-g-poly(ethylene glycol) nanospheres
-
D.N. Robinson and N.A. Peppas (2002) Preparation and characterization of pH-responsive poly(methacrylic acid-g-poly(ethylene glycol) nanospheres. Macromolecules 35 3668-3674.
-
(2002)
Macromolecules
, vol.35
, pp. 3668-3674
-
-
Robinson, D.N.1
Peppas, N.A.2
-
42
-
-
0036377191
-
Preparation and characterization of P(MAA-g-EG) nanospheres for protein delivery applications
-
M. Torres-Lugo and N.A. Peppas (2002) Preparation and characterization of P(MAA-g-EG) nanospheres for protein delivery applications. J. Nanoparticle Res. 4 73-81.
-
(2002)
J. Nanoparticle Res.
, vol.4
, pp. 73-81
-
-
Torres-Lugo, M.1
Peppas, N.A.2
-
43
-
-
0030949396
-
Biologically erodable microspheres as potential oral delivery systems
-
E. Mathiowitz, J.S. Jacob, Y.S. Jong, G.P. Carino, D.E. Chickering, D.E. Chaturvedi, et al. (1997) Biologically erodable microspheres as potential oral delivery systems. Nature 386 410-414.
-
(1997)
Nature
, vol.386
, pp. 410-414
-
-
Mathiowitz, E.1
Jacob, J.S.2
Jong, Y.S.3
Carino, G.P.4
Chickering, D.E.5
Chaturvedi, D.E.6
-
44
-
-
36549049905
-
Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres
-
S. Furtado, D. Abramson, R. Burrill, G. Olivier, C. Gourd, E. Bubbers, et al. (2008) Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int. J. Pharm. 347 149-155.
-
(2008)
Int. J. Pharm.
, vol.347
, pp. 149-155
-
-
Furtado, S.1
Abramson, D.2
Burrill, R.3
Olivier, G.4
Gourd, C.5
Bubbers, E.6
-
45
-
-
33746052131
-
Synthesis and characterization of PLGA nanoparticles
-
C.E. Astete and C.M. Sabliov (2006) Synthesis and characterization of PLGA nanoparticles. J. Biomater. Sci. Polymer. 17 247-289.
-
(2006)
J. Biomater. Sci. Polymer.
, vol.17
, pp. 247-289
-
-
Astete, C.E.1
Sabliov, C.M.2
-
46
-
-
38349154138
-
Nano/micro technologies for delivering macromolecular therapeutics using poly(d, l-lactide-co-glycolide) and its derivatives
-
R.C. Mundargi, V.R. Babu, V. Rangaswamy, P. Patel and T.M. Aminabhavi (2008) Nano/micro technologies for delivering macromolecular therapeutics using poly(d, l-lactide-co-glycolide) and its derivatives. J. Control. Release 125 193-209.
-
(2008)
J. Control. Release
, vol.125
, pp. 193-209
-
-
Mundargi, R.C.1
Babu, V.R.2
Rangaswamy, V.3
Patel, P.4
Aminabhavi, T.M.5
-
47
-
-
38749146888
-
Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery
-
S. Davaran, Y. Omidi, M.R. Rashidi, M. Anzabi, A. Shayanfar, S. Ghyasvand, et al. (2008) Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery. J. Bioactive Comp. Pol. 23 115-131.
-
(2008)
J. Bioactive Comp. Pol.
, vol.23
, pp. 115-131
-
-
Davaran, S.1
Omidi, Y.2
Rashidi, M.R.3
Anzabi, M.4
Shayanfar, A.5
Ghyasvand, S.6
-
48
-
-
0031783879
-
Chitosan and its use as a pharmaceutical excipient
-
L. Illum (1998) Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 15 1326-1331.
-
(1998)
Pharm. Res.
, vol.15
, pp. 1326-1331
-
-
Illum, L.1
-
49
-
-
0037027876
-
Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
-
Y. Pan, Y.-J. Li and H.-Y. Zhao (2002) Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm. 249 139-147.
-
(2002)
Int. J. Pharm.
, vol.249
, pp. 139-147
-
-
Pan, Y.1
Li, Y.-J.2
Zhao, H.-Y.3
-
50
-
-
9944239305
-
A study of insulin-chitosan complex nanoparticles used for oral administration
-
F. Cui, L. Zhang, J. Zheng and Y. Kawashima (2004) A study of insulin-chitosan complex nanoparticles used for oral administration. STP Pharma. 14 435-439.
-
(2004)
STP Pharma.
, vol.14
, pp. 435-439
-
-
Cui, F.1
Zhang, L.2
Zheng, J.3
Kawashima, Y.4
-
51
-
-
35549012407
-
Oral bioavailability of insulin contained in polysaccharide nanoparticles
-
B. Sarmento, A. Ribeiro and F. Veiga (2007) Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules 8 3054-3060.
-
(2007)
Biomacromolecules
, vol.8
, pp. 3054-3060
-
-
Sarmento, B.1
Ribeiro, A.2
Veiga, F.3
-
52
-
-
62849083225
-
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption
-
M.R. Rekha and C.P. Sharma (2009) Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J. Control. Release 135 144-151.
-
(2009)
J. Control. Release
, vol.135
, pp. 144-151
-
-
Rekha, M.R.1
Sharma, C.P.2
-
53
-
-
77953363802
-
N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a novel delivery system for Parathyroid Hormone-Related Protein 1-34
-
S.H. Zhao, X.T. Wu, W.C. Guo, Y.M. Du, L. Yu and J. Tang (2010) N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a novel delivery system for Parathyroid Hormone-Related Protein 1-34. Int. J. Pharm. 393 268-272.
-
(2010)
Int. J. Pharm.
, vol.393
, pp. 268-272
-
-
Zhao, S.H.1
Wu, X.T.2
Guo, W.C.3
Du, Y.M.4
Yu, L.5
Tang, J.6
-
54
-
-
77953364193
-
Effective protection and controlled release of insulin by cationic β-cyclodextrin polymers from alginate/chitosan nanoparticles
-
N. Zhang, J. Li, W. Jiang, C. Ren, J. Li, J. Xin, et al. (2010) Effective protection and controlled release of insulin by cationic β-cyclodextrin polymers from alginate/chitosan nanoparticles. Int. J. Pharm. 393 212-218.
-
(2010)
Int. J. Pharm.
, vol.393
, pp. 212-218
-
-
Zhang, N.1
Li, J.2
Jiang, W.3
Ren, C.4
Li, J.5
Xin, J.6
-
55
-
-
33745135423
-
Hydrogels in biology and medicine: From molecular principles to bionanotechnology
-
N.A. Peppas, J.Z. Hilt, A. Khademhosseini and R. Langer (2006) Hydrogels in biology and medicine: From molecular principles to bionanotechnology. Adv. Mater. 18 1345-1360.
-
(2006)
Adv. Mater.
, vol.18
, pp. 1345-1360
-
-
Peppas, N.A.1
Hilt, J.Z.2
Khademhosseini, A.3
Langer, R.4
-
56
-
-
0025037822
-
Mucolysis of the colonic mucus barrier by faecal proteinases: Inhibition by interacting polyacrylate
-
D.A. Hutton, J.P. Pearson, A. Allen and S.N.E. Foster (1990) Mucolysis of the colonic mucus barrier by faecal proteinases: Inhibition by interacting polyacrylate. Clin. Sci. (Lond.) 78 265-271.
-
(1990)
Clin. Sci. (Lond.)
, vol.78
, pp. 265-271
-
-
Hutton, D.A.1
Pearson, J.P.2
Allen, A.3
Foster, S.N.E.4
-
57
-
-
0028788346
-
Mucoadhesive polymers in the peroral peptide drug delivery: II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin
-
H.L. Lueßen, J.C. Verhoef, G. Borchard, C.-M. Lehr, A.G. de Boer and H.E. Junginger (1995) Mucoadhesive polymers in the peroral peptide drug delivery: II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin. Pharm. Res. 12 1293-1298.
-
(1995)
Pharm. Res.
, vol.12
, pp. 1293-1298
-
-
Lueßen, H.L.1
Verhoef, J.C.2
Borchard, G.3
Lehr, C.-M.4
de Boer, A.G.5
Junginger, H.E.6
-
58
-
-
33744910573
-
Preparation, characterization and enzyme inhibition of methylmethacrylate copolymer nanoparticles with different hydrophilic polymeric chains
-
F. Qian, F. Cui and C. Yin (2006) Preparation, characterization and enzyme inhibition of methylmethacrylate copolymer nanoparticles with different hydrophilic polymeric chains. Eur. Polym. J. 42 1653-1661.
-
(2006)
Eur. Polym. J.
, vol.42
, pp. 1653-1661
-
-
Qian, F.1
Cui, F.2
Yin, C.3
-
59
-
-
0033822911
-
Polycarbophil–cysteine conjugates as platforms for oral polypeptide delivery systems
-
A. Bernkop-Schnürch and S.C. Thaler (2000) Polycarbophil–cysteine conjugates as platforms for oral polypeptide delivery systems. J. Pharm. Sci. 89 901-909.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 901-909
-
-
Bernkop-Schnürch, A.1
Thaler, S.C.2
-
60
-
-
0035157888
-
Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase-N
-
A. Bernkop-Schnürch, H. Zarti and G.F. Walker (2001) Thiolation of polycarbophil enhances its inhibition of soluble and intestinal brush border membrane bound aminopeptidase-N. J. Pharm. Sci. 90 1907-1914.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 1907-1914
-
-
Bernkop-Schnürch, A.1
Zarti, H.2
Walker, G.F.3
-
61
-
-
0343150936
-
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
-
G. Borchard, H.L. Lueβen, A.G. de Boer, J.C. Verhoef, C.-M. Lehr and H.E. Junginger (1996) The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control. Release 39 131-138.
-
(1996)
J. Control. Release
, vol.39
, pp. 131-138
-
-
Borchard, G.1
Lueβen, H.L.2
de Boer, A.G.3
Verhoef, J.C.4
Lehr, C.-M.5
Junginger, H.E.6
-
62
-
-
0345055299
-
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
-
A.F. Kotzé, H.L. Lueßen, B.J. de Leeuw, A.G. de Boer, J.C. Verhoef and H.E. Junginger (1998) Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J. Control. Release 51 35-46.
-
(1998)
J. Control. Release
, vol.51
, pp. 35-46
-
-
Kotzé, A.F.1
Lueßen, H.L.2
de Leeuw, B.J.3
de Boer, A.G.4
Verhoef, J.C.5
Junginger, H.E.6
-
63
-
-
0028071051
-
Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
-
P. Artursson, T. Lindmark, S.S. Davis and L. Illum (1994) Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 11 1358-1361.
-
(1994)
Pharm. Res.
, vol.11
, pp. 1358-1361
-
-
Artursson, P.1
Lindmark, T.2
Davis, S.S.3
Illum, L.4
-
64
-
-
0027098054
-
Epithelial transport of drugs in cell culture. VII. Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells
-
E.K. Anderberg, C. Nystrom and P. Artursson (1992) Epithelial transport of drugs in cell culture. VII. Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. J. Pharm. Sci. 81 879-887.
-
(1992)
J. Pharm. Sci.
, vol.81
, pp. 879-887
-
-
Anderberg, E.K.1
Nystrom, C.2
Artursson, P.3
-
65
-
-
50249129610
-
Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells
-
A.M.M. Sadeghi, F.A. Dorkoosh and M.R. Avadi (2008) Permeation enhancer effect of chitosan and chitosan derivatives: Comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur. J. Pharm. Biopharm. 70 270-278.
-
(2008)
Eur. J. Pharm. Biopharm.
, vol.70
, pp. 270-278
-
-
Sadeghi, A.M.M.1
Dorkoosh, F.A.2
Avadi, M.R.3
-
66
-
-
0036692366
-
Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
-
I. Behrens, A.I. Pena, M.J. Alonso and T. Kissel (2002) Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport. Pharm. Res. 19 1185-1193.
-
(2002)
Pharm. Res.
, vol.19
, pp. 1185-1193
-
-
Behrens, I.1
Pena, A.I.2
Alonso, M.J.3
Kissel, T.4
-
67
-
-
0030465871
-
The intestinal uptake of particles and the implications for drug and antigen delivery
-
D.T. O'Hagan (1996) The intestinal uptake of particles and the implications for drug and antigen delivery. J. Anal. 189 477-482.
-
(1996)
J. Anal.
, vol.189
, pp. 477-482
-
-
O'Hagan, D.T.1
-
68
-
-
0029092672
-
Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
-
A.T. Florence, A.M. Hillery, N. Hussain and P.U. Jani (1995) Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate. J. Control. Release 36 39-46.
-
(1995)
J. Control. Release
, vol.36
, pp. 39-46
-
-
Florence, A.T.1
Hillery, A.M.2
Hussain, N.3
Jani, P.U.4
-
69
-
-
33751253462
-
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
-
A. des Rieux, V. Fievez, M. Garinot, Y.-J. Schneider and V. Préat (2006) Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. J. Control. Release 10 1-27.
-
(2006)
J. Control. Release
, vol.10
, pp. 1-27
-
-
des Rieux, A.1
Fievez, V.2
Garinot, M.3
Schneider, Y.-J.4
Préat, V.5
-
70
-
-
0023856501
-
New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier
-
C. Damge, C. Michel, M. Aprahamian and P. Couvreur (1988) New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes 37 246-251.
-
(1988)
Diabetes
, vol.37
, pp. 246-251
-
-
Damge, C.1
Michel, C.2
Aprahamian, M.3
Couvreur, P.4
-
71
-
-
0028837083
-
Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
-
L. Brannon-Peppas (1995) Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery. Int. J. Pharm. 116 1-9.
-
(1995)
Int. J. Pharm.
, vol.116
, pp. 1-9
-
-
Brannon-Peppas, L.1
-
72
-
-
0034580371
-
The manufacturing techniques of various drug loaded biodegradable poly (lactide-co-glycolide) (PLGA) devices
-
R.A. Jain (2000) The manufacturing techniques of various drug loaded biodegradable poly (lactide-co-glycolide) (PLGA) devices. Biomaterials 21 2475-2490.
-
(2000)
Biomaterials
, vol.21
, pp. 2475-2490
-
-
Jain, R.A.1
-
73
-
-
33745674687
-
Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems
-
C.P. Reis, R.J. Neufeld, A.J. Ribeiro and F. Veiga (2006) Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems. Nanomedicine 2 53-65.
-
(2006)
Nanomedicine
, vol.2
, pp. 53-65
-
-
Reis, C.P.1
Neufeld, R.J.2
Ribeiro, A.J.3
Veiga, F.4
-
74
-
-
79952920907
-
The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein loaded SLN prepared by the double emulsion process
-
R. Yang, R. Gao, F. Li, H. He and X. Tang (2011) The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein loaded SLN prepared by the double emulsion process. Drug Dev. Ind. Pharm. 37 139-148.
-
(2011)
Drug Dev. Ind. Pharm.
, vol.37
, pp. 139-148
-
-
Yang, R.1
Gao, R.2
Li, F.3
He, H.4
Tang, X.5
-
75
-
-
68549122512
-
Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
-
L. Yin, J. Ding, C. He, L. Cui, C. Tang and C. Yin (2009) Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 30 5691-5700.
-
(2009)
Biomaterials
, vol.30
, pp. 5691-5700
-
-
Yin, L.1
Ding, J.2
He, C.3
Cui, L.4
Tang, C.5
Yin, C.6
-
76
-
-
0032969652
-
Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract
-
S. Sakuma, R. Sudo, N. Suzuki, H. Kikuchi, M. Akashi and M. Hayashi (1999) Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract. Int. J. Pharm. 177 161-172.
-
(1999)
Int. J. Pharm.
, vol.177
, pp. 161-172
-
-
Sakuma, S.1
Sudo, R.2
Suzuki, N.3
Kikuchi, H.4
Akashi, M.5
Hayashi, M.6
-
77
-
-
2442672527
-
Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin
-
T. Morçöl, P. Nagappan, L. Nerenbaum, A. Mitchell and S.J.D. Bell (2004) Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin. Int. J. Pharm. 277 91-97.
-
(2004)
Int. J. Pharm.
, vol.277
, pp. 91-97
-
-
Morçöl, T.1
Nagappan, P.2
Nerenbaum, L.3
Mitchell, A.4
Bell, S.J.D.5
-
78
-
-
39749177298
-
Tricalcium phosphate delayed release formulation for oral delivery of insulin: A proof-of-concept study
-
W. Paul and C.P. Sharma (2008) Tricalcium phosphate delayed release formulation for oral delivery of insulin: A proof-of-concept study. J. Pharm. Sci. 97 875-882.
-
(2008)
J. Pharm. Sci.
, vol.97
, pp. 875-882
-
-
Paul, W.1
Sharma, C.P.2
-
80
-
-
77649265415
-
Fatty acid conjugated calcium phosphate nanoparticles for protein delivery
-
W. Paul and C.P. Sharma (2010) Fatty acid conjugated calcium phosphate nanoparticles for protein delivery. Int. J. Appl. Ceram. Technol. 7 129-138.
-
(2010)
Int. J. Appl. Ceram. Technol.
, vol.7
, pp. 129-138
-
-
Paul, W.1
Sharma, C.P.2
-
81
-
-
0018718071
-
Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats: Preliminary study
-
A. Hashimoto and J. Kawada (1979) Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats: Preliminary study. Endocrinol. Jpn. 26 337-344.
-
(1979)
Endocrinol. Jpn.
, vol.26
, pp. 337-344
-
-
Hashimoto, A.1
Kawada, J.2
-
82
-
-
0017339345
-
The gastro-intestinal absorption of liposomally entrapped insulin in normal rats
-
H.M. Patel and B. Ryman (1977) The gastro-intestinal absorption of liposomally entrapped insulin in normal rats. Biochem. Soc. Trans. 5 1054-1055.
-
(1977)
Biochem. Soc. Trans.
, vol.5
, pp. 1054-1055
-
-
Patel, H.M.1
Ryman, B.2
-
83
-
-
0019975988
-
Orally administered liposome-entrapped insulin in diabetic animals. A critical assessment
-
J.F. Arrieta-Molero, K. Aleck, M.K. Sinha, C.M. Brownscheilde, L.J. Shapiro and M.A. Sperling (1982) Orally administered liposome-entrapped insulin in diabetic animals. A critical assessment. Horm. Res. 16 249-256.
-
(1982)
Horm. Res.
, vol.16
, pp. 249-256
-
-
Arrieta-Molero, J.F.1
Aleck, K.2
Sinha, M.K.3
Brownscheilde, C.M.4
Shapiro, L.J.5
Sperling, M.A.6
-
84
-
-
0022337613
-
Protection of insulin from enzymatic degradation by its association to liposomes
-
C. Weingarten, A. Moufti, J. Delattre, F. Puisieux and P. Couvreur (1985) Protection of insulin from enzymatic degradation by its association to liposomes. Int. J. Pharm. 26 251-257.
-
(1985)
Int. J. Pharm.
, vol.26
, pp. 251-257
-
-
Weingarten, C.1
Moufti, A.2
Delattre, J.3
Puisieux, F.4
Couvreur, P.5
-
85
-
-
0019798817
-
Oral ingestion of insulin liposomes: Effects of the administration route
-
C. Weingarten, A. Moufti, J.F. Desjeux, T.T. Luong, G. Durand, J.P. Devissaguet, et al. (1981) Oral ingestion of insulin liposomes: Effects of the administration route. Life Sci. 28 2747-2752.
-
(1981)
Life Sci.
, vol.28
, pp. 2747-2752
-
-
Weingarten, C.1
Moufti, A.2
Desjeux, J.F.3
Luong, T.T.4
Durand, G.5
Devissaguet, J.P.6
-
86
-
-
0032769433
-
Folic acid-PEO acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents
-
K.E. Anderson, B.R. Stevenson and J.A. Rogers (1999) Folic acid-PEO acid-PEO-labeled liposomes to improve gastrointestinal absorption of encapsulated agents. J. Control. Release 60 189-198.
-
(1999)
J. Control. Release
, vol.60
, pp. 189-198
-
-
Anderson, K.E.1
Stevenson, B.R.2
Rogers, J.A.3
-
87
-
-
18044366409
-
A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery
-
M. Garcia-Fuentes, C. Prego, D. Torres and M.J. Alonso (2005) A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci. 25 133-143.
-
(2005)
Eur. J. Pharm. Sci.
, vol.25
, pp. 133-143
-
-
Garcia-Fuentes, M.1
Prego, C.2
Torres, D.3
Alonso, M.J.4
-
88
-
-
0037726624
-
Potentiality of double liposomes containing salmon calcitonin as an oral dosage form
-
K. Yamabe, Y. Kato, H. Onishi and Y. Machida (2003) Potentiality of double liposomes containing salmon calcitonin as an oral dosage form. J. Control. Release 89 429-436.
-
(2003)
J. Control. Release
, vol.89
, pp. 429-436
-
-
Yamabe, K.1
Kato, Y.2
Onishi, H.3
Machida, Y.4
-
91
-
-
18244365849
-
Protein drug stability: A formulation challenge
-
S. Frokjaer and D.E. Otzen (2005) Protein drug stability: A formulation challenge. Nat. Rev. 4 298-306.
-
(2005)
Nat. Rev.
, vol.4
, pp. 298-306
-
-
Frokjaer, S.1
Otzen, D.E.2
-
92
-
-
33947530087
-
Novel nanoparticles for oral insulin delivery via the paracellular pathway
-
H.S. Lin, C.-T. Chen, H.-F. Liang, A.R. Kulkarni, P.-W. Lee, C.-H. Chen and H.-W. Sung (2007) Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology 18 105102.
-
(2007)
Nanotechnology
, vol.18
, pp. 105102
-
-
Lin, H.S.1
Chen, C.-T.2
Liang, H.-F.3
Kulkarni, A.R.4
Lee, P.-W.5
Chen, C.-H.6
Sung, H.-W.7
-
93
-
-
33750008879
-
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery
-
S. Sajeesh and C.P. Sharma (2006) Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int. J. Pharm. 325 147-154.
-
(2006)
Int. J. Pharm.
, vol.325
, pp. 147-154
-
-
Sajeesh, S.1
Sharma, C.P.2
-
94
-
-
63849211819
-
Influence of food intake on the bioavailability and efficacy of oral calcitonin
-
M.A. Karsdal, I. Byrjalsen, M. Azira, M. Arnold, L. Choi, B.J. Rjis, et al. (2009) Influence of food intake on the bioavailability and efficacy of oral calcitonin. Br. J. Clin. Pharmacol. 67 413-420.
-
(2009)
Br. J. Clin. Pharmacol.
, vol.67
, pp. 413-420
-
-
Karsdal, M.A.1
Byrjalsen, I.2
Azira, M.3
Arnold, M.4
Choi, L.5
Rjis, B.J.6
-
95
-
-
60149089459
-
Barrier properties of mucus
-
R.A. Cone (2009) Barrier properties of mucus. Adv. Drug Deliv. Rev. 27 75-85.
-
(2009)
Adv. Drug Deliv. Rev.
, vol.27
, pp. 75-85
-
-
Cone, R.A.1
-
96
-
-
60149111908
-
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
-
S.K. Lai, Y.-Y. Wang and J. Hanes (2009) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv. Drug Deliv. Rev. 61 158-171.
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 158-171
-
-
Lai, S.K.1
Wang, Y.-Y.2
Hanes, J.3
-
97
-
-
7044270542
-
From mucins to mucus: Toward a more coherent understanding of this essential barrier
-
D.J. Thornton and J.K. Sheehan (2004) From mucins to mucus: Toward a more coherent understanding of this essential barrier. Proc. Am. Thorac. Soc. 1 54-61.
-
(2004)
Proc. Am. Thorac. Soc.
, vol.1
, pp. 54-61
-
-
Thornton, D.J.1
Sheehan, J.K.2
-
98
-
-
0032531083
-
MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-terminal cleavage
-
C. Wickström, J.R. Davies, G.V. Eriksen, E.C.I. Veerman and I. Carlstedt (1998) MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-terminal cleavage. Biochem. J. 334 685-693.
-
(1998)
Biochem. J.
, vol.334
, pp. 685-693
-
-
Wickström, C.1
Davies, J.R.2
Eriksen, G.V.3
Veerman, E.C.I.4
Carlstedt, I.5
-
99
-
-
0029841922
-
Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from goblet cells
-
H.W. Hovenberg, J.R. Davies and I. Carlstedt (1996) Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from goblet cells. Biochem. J. 318 319-324.
-
(1996)
Biochem. J.
, vol.318
, pp. 319-324
-
-
Hovenberg, H.W.1
Davies, J.R.2
Carlstedt, I.3
-
100
-
-
0021335513
-
Hydrodynamic properties of human cervical-mucus glycoproteins in 6M-guanidinium chloride
-
J.K. Sheehan and I. Carlstedt (1984) Hydrodynamic properties of human cervical-mucus glycoproteins in 6M-guanidinium chloride. Biochem. J. 217 93-101.
-
(1984)
Biochem. J.
, vol.217
, pp. 93-101
-
-
Sheehan, J.K.1
Carlstedt, I.2
-
101
-
-
0024461017
-
Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes
-
D.J. Thornton, D.F. Holmes, J.K. Sheehan and I. Carlstedt (1989) Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal. Biochem. 182 160-164.
-
(1989)
Anal. Biochem.
, vol.182
, pp. 160-164
-
-
Thornton, D.J.1
Holmes, D.F.2
Sheehan, J.K.3
Carlstedt, I.4
-
102
-
-
0023283990
-
Gastric emptying of nondigestible solids in the fasted dog
-
P. Gruber, A. Rubinstein, V.H. Li, P. Bass and J.R. Robinson (1987) Gastric emptying of nondigestible solids in the fasted dog. J. Pharm. Sci. 76 117-122.
-
(1987)
J. Pharm. Sci.
, vol.76
, pp. 117-122
-
-
Gruber, P.1
Rubinstein, A.2
Li, V.H.3
Bass, P.4
Robinson, J.R.5
-
103
-
-
0025846959
-
An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
-
C.-M. Lehr, F.G.J. Poelma, H.E. Junginger and J.J. Tukker (1991) An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop. Int. J. Pharm. 70 235-240.
-
(1991)
Int. J. Pharm.
, vol.70
, pp. 235-240
-
-
Lehr, C.-M.1
Poelma, F.G.J.2
Junginger, H.E.3
Tukker, J.J.4
-
104
-
-
29144461657
-
Polymeric nanoparticles for oral delivery of drugs and vaccines: A critical evaluation of in vivo studies
-
S.A. Galindo-Rodriguez, E. Allemann, H. Fessi and E. Doelker (2005) Polymeric nanoparticles for oral delivery of drugs and vaccines: A critical evaluation of in vivo studies. Crit. Rev. Ther. Drug Carr. Syst. 22 419-464.
-
(2005)
Crit. Rev. Ther. Drug Carr. Syst.
, vol.22
, pp. 419-464
-
-
Galindo-Rodriguez, S.A.1
Allemann, E.2
Fessi, H.3
Doelker, E.4
-
105
-
-
0032403467
-
Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract
-
G. Ponchel and J. Irache (1998) Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv. Drug Deliv. Rev. 34 191-219.
-
(1998)
Adv. Drug Deliv. Rev.
, vol.34
, pp. 191-219
-
-
Ponchel, G.1
Irache, J.2
-
106
-
-
33751253462
-
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
-
A. des Rieux, V. Fievez, M. Garinot, Y.J. Schneider and V. Préat (2006) Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. J. Control. Release 116 1-27.
-
(2006)
J. Control. Release
, vol.116
, pp. 1-27
-
-
des Rieux, A.1
Fievez, V.2
Garinot, M.3
Schneider, Y.J.4
Préat, V.5
-
107
-
-
0035937594
-
Mucoadhesive nanoparticulate systems for peptide drug delivery
-
H. Takeuchi, H. Yamamoto and Y. Kawashima (2001) Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv. Drug Del. Rev. 23 39-54.
-
(2001)
Adv. Drug Del. Rev.
, vol.23
, pp. 39-54
-
-
Takeuchi, H.1
Yamamoto, H.2
Kawashima, Y.3
-
108
-
-
44949187597
-
Thiolated chitosan coated poly hydroxyethyl methacrylate nanoparticles: Synthesis and characterization
-
F. Atyabi, F.A. Moghaddam, R. Dinarvand, M.J. Zohuriaan-Mehr and G. Ponchel (2008) Thiolated chitosan coated poly hydroxyethyl methacrylate nanoparticles: Synthesis and characterization. Carb. Pol. 74 59-67.
-
(2008)
Carb. Pol.
, vol.74
, pp. 59-67
-
-
Atyabi, F.1
Moghaddam, F.A.2
Dinarvand, R.3
Zohuriaan-Mehr, M.J.4
Ponchel, G.5
-
109
-
-
26644452975
-
Thiomers: A new generation of mucoadhesive polymers
-
A. Bernkop-Schnürch (2005) Thiomers: A new generation of mucoadhesive polymers. Adv. Drug Del. Rev. 57 1569-1582.
-
(2005)
Adv. Drug Del. Rev.
, vol.57
, pp. 1569-1582
-
-
Bernkop-Schnürch, A.1
-
110
-
-
15244340396
-
Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): Preparation and evaluation of their bioadhesive properties
-
K. Yoncheva, E. Lizarraga and J.M. Irache (2005) Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): Preparation and evaluation of their bioadhesive properties. Eur. J. Pharm. Sci. 24 411-419.
-
(2005)
Eur. J. Pharm. Sci.
, vol.24
, pp. 411-419
-
-
Yoncheva, K.1
Lizarraga, E.2
Irache, J.M.3
-
111
-
-
33846841057
-
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
-
S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.Y. Wang, R. Cone and J. Hanes (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc. Natl. Acad. Sci. U.S.A. 104 1482-1487.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 1482-1487
-
-
Lai, S.K.1
O'Hanlon, D.E.2
Harrold, S.3
Man, S.T.4
Wang, Y.Y.5
Cone, R.6
Hanes, J.7
-
112
-
-
77952312245
-
Recent advances in research on P-glycoprotein inhibitors
-
K. Yang, J. Wu and X. Li (2008) Recent advances in research on P-glycoprotein inhibitors. BioScience Trends 2 137-146.
-
(2008)
BioScience Trends
, vol.2
, pp. 137-146
-
-
Yang, K.1
Wu, J.2
Li, X.3
-
113
-
-
79952983000
-
Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor
-
J. Iqbal, J. Hombach, B. Matuszczak and A. Bernkop-Schnürch (2010) Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor. J. Control. Release 147 62-69.
-
(2010)
J. Control. Release
, vol.147
, pp. 62-69
-
-
Iqbal, J.1
Hombach, J.2
Matuszczak, B.3
Bernkop-Schnürch, A.4
-
114
-
-
33846940490
-
A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin
-
K.B. Chalasani, G.-J. Russell-Jones, S.K. Yandrapu, P.V. Diwan and S.K. Jain (2007) A novel vitamin B12-nanosphere conjugate carrier system for peroral delivery of insulin. J. Control. Release 117 421-429.
-
(2007)
J. Control. Release
, vol.117
, pp. 421-429
-
-
Chalasani, K.B.1
Russell-Jones, G.-J.2
Yandrapu, S.K.3
Diwan, P.V.4
Jain, S.K.5
-
115
-
-
34447577190
-
Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles
-
K.B. Chalasani, G.-J. Russell-Jones, A.K. Jain, P.V. Diwan and S.K. Jain (2007) Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J. Control. Release 122 141-150.
-
(2007)
J. Control. Release
, vol.122
, pp. 141-150
-
-
Chalasani, K.B.1
Russell-Jones, G.-J.2
Jain, A.K.3
Diwan, P.V.4
Jain, S.K.5
-
116
-
-
33747884001
-
Biodegradable nanoparticles loaded with insulin–phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation
-
F. Cui, K. Shi, L. Zhang and Y. Kawashima (2006) Biodegradable nanoparticles loaded with insulin–phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J. Control. Release 114 242-250.
-
(2006)
J. Control. Release
, vol.114
, pp. 242-250
-
-
Cui, F.1
Shi, K.2
Zhang, L.3
Kawashima, Y.4
-
117
-
-
60849130683
-
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
-
K. Sonaje, Y.-H. Lin and J.-H. Juang (2009) In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 30 2329-2339.
-
(2009)
Biomaterials
, vol.30
, pp. 2329-2339
-
-
Sonaje, K.1
Lin, Y.-H.2
Juang, J.-H.3
-
118
-
-
33846543799
-
Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
-
C. Damge, P. Maincent and N. Ubrich (2007) Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Release 117 271-280.
-
(2007)
J. Control. Release
, vol.117
, pp. 271-280
-
-
Damge, C.1
Maincent, P.2
Ubrich, N.3
-
119
-
-
33847666114
-
Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery
-
F. Cui, A.-J. Tao, D.-M. Cun, L.Q. Zhang and K. Shi (2006) Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J. Pharm. Sci. 96 421-427.
-
(2006)
J. Pharm. Sci.
, vol.96
, pp. 421-427
-
-
Cui, F.1
Tao, A.-J.2
Cun, D.-M.3
Zhang, L.Q.4
Shi, K.5
-
120
-
-
23944494896
-
Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts
-
K.-H. Song, S.-J. Chung and C.-K. Shim (2005) Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. J. Control. Release 106 298-308.
-
(2005)
J. Control. Release
, vol.106
, pp. 298-308
-
-
Song, K.-H.1
Chung, S.-J.2
Shim, C.-K.3
-
121
-
-
0027730863
-
Colloidal carriers for intravenous targeting: Plasma protein adsorption patterns on surface modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis
-
T. Blunk, D.F. Hochstrasser, J.-C. Sanchez, B.W. Müller and R.H. Müller (1993) Colloidal carriers for intravenous targeting: Plasma protein adsorption patterns on surface modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 14 1382-1387.
-
(1993)
Electrophoresis
, vol.14
, pp. 1382-1387
-
-
Blunk, T.1
Hochstrasser, D.F.2
Sanchez, J.-C.3
Müller, B.W.4
Müller, R.H.5
-
122
-
-
0032485414
-
Analysis of plasma protein adsorption on polymeric nanoparticles with different surface chacteristics
-
M. Luck, B.R. Paulke, W. Schröder, T. Blunk and R.H. Müller (1998) Analysis of plasma protein adsorption on polymeric nanoparticles with different surface chacteristics. J. Biomed. Mater. Res. 39 478-485.
-
(1998)
J. Biomed. Mater. Res.
, vol.39
, pp. 478-485
-
-
Luck, M.1
Paulke, B.R.2
Schröder, W.3
Blunk, T.4
Müller, R.H.5
-
123
-
-
28844488494
-
Opsonisation, biodistribution and pharmacokinetics of polymeric nanoparticles
-
D.E. Ovens III and N.A. Peppas (2006) Opsonisation, biodistribution and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 307 93-102.
-
(2006)
Int. J. Pharm.
, vol.307
, pp. 93-102
-
-
Ovens, D.E.1
Peppas, N.A.2
-
124
-
-
38049103405
-
Characterisation of nanoparticles for therapeutics
-
J.B. Hall, M.A. Dobrovolskaia and A.K. Patri (2007) Characterisation of nanoparticles for therapeutics. Nanomedicine 2 789-803.
-
(2007)
Nanomedicine
, vol.2
, pp. 789-803
-
-
Hall, J.B.1
Dobrovolskaia, M.A.2
Patri, A.K.3
-
125
-
-
33846833901
-
Toxicological overview of impurities in pharmaceutical products
-
D. Jacobson-Kram and T. McGovern (2007) Toxicological overview of impurities in pharmaceutical products. Adv. Drug Deliv. Rev. 59 38-42.
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 38-42
-
-
Jacobson-Kram, D.1
McGovern, T.2
-
126
-
-
57349099275
-
Toxicological assessment of orally delivered nanoparticulate insulin
-
C.P. Reis, I.V. Figueiredo and R.A. Carvalho (2008) Toxicological assessment of orally delivered nanoparticulate insulin. Nanotoxicology 2 205-217.
-
(2008)
Nanotoxicology
, vol.2
, pp. 205-217
-
-
Reis, C.P.1
Figueiredo, I.V.2
Carvalho, R.A.3
-
127
-
-
0035206137
-
Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
-
J.F. Hillyer and R.M. Albrecht (2001) Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90 1927-1936.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 1927-1936
-
-
Hillyer, J.F.1
Albrecht, R.M.2
-
128
-
-
0035940059
-
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
-
N. Hussain, V. Jaitley and A.T. Florence (2001) Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50 107-142.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.50
, pp. 107-142
-
-
Hussain, N.1
Jaitley, V.2
Florence, A.T.3
-
129
-
-
0024953407
-
The uptake and translocation of latex nanospheres and microspheres after oral administration to rats
-
P. Jani, G.W. Halbert, J. Langridge and A.T. Florence (1989) The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J. Pharm. Pharmacol. 41 809-812.
-
(1989)
J. Pharm. Pharmacol.
, vol.41
, pp. 809-812
-
-
Jani, P.1
Halbert, G.W.2
Langridge, J.3
Florence, A.T.4
-
130
-
-
0025674686
-
Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
-
P. Jani, G.W. Halbert, J. Langridge and A.T. Florence (1990) Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J. Pharm. Pharmacol. 42 821-826.
-
(1990)
J. Pharm. Pharmacol.
, vol.42
, pp. 821-826
-
-
Jani, P.1
Halbert, G.W.2
Langridge, J.3
Florence, A.T.4
|