Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor

Journal of Controlled Release

Volumn 147, Issue 1, 2010, Pages 62-69

  Iqbal, Javed ^a   Hombach, Juliane ^a   Matuszczak, Barbara ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

thiobutyrolactone; Efflux pumps; P glycoprotein; PEG; PEI; Thiomers

Indexed keywords

EFFLUX PUMPS; P-GLYCOPROTEIN; PEG; PEI; THIOMERS;

DRUG DELIVERY; DRUG PRODUCTS; ETHYLENE; ETHYLENE GLYCOL; GLYCOPROTEINS; HYDROGELS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYETHYLENE OXIDES; POLYMERS;

POLYETHYLENE GLYCOLS;

GLUTATHIONE; GLYCOPROTEIN P INHIBITOR; HEXAMETHYLENE DIISOCYANATE; LACTATE DEHYDROGENASE; MACROGOL; MACROGOL STEARATE; MERCAPTOPURINE; POLIDOCANOL; POLYETHYLENEIMINE; RHODAMINE 123; THIOL GROUP; TOCOFERSOLAN; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG PENETRATION; DRUG SCREENING; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL SURVIVAL; CHROMATOGRAPHY, GEL; DRUG CARRIERS; HUMANS; ILEUM; INTESTINAL MUCOSA; MALE; P-GLYCOPROTEIN; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; SULFHYDRYL COMPOUNDS;

EID: 79952983000     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.06.023     Document Type: Article

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