Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract

International Journal of Pharmaceutics

Volumn 177, Issue 2, 1999, Pages 161-172

  Sakuma, Shinji ^a   Sudo, Rika ^a   Suzuki, Norio ^a   Kikuchi, Hiroshi ^a   Akashi, Mitsuru ^b   Hayashi, Masahiro ^c  

^a DAIICHI SANKYO CO   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Absorption enhancement; Bioadhesion; Gastrointestinal tract; Mucoadhesion; Nanoparticle; Peptide

Indexed keywords

CALCIUM ION; NANOPARTICLE; POLYSTYRENE; RADIOACTIVE IODINE; SALCATONIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; INTESTINE ABSORPTION; INTESTINE TRANSIT TIME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ADHESIONS; ANALGESICS; ANESTHESIA; ANIMALS; CALCITONIN; CALCIUM; DIAZOMETHANE; DIGESTIVE PHYSIOLOGY; GASTROINTESTINAL TRANSIT; INTESTINAL MUCOSA; MALE; PARTICLE SIZE; POLYMERS; POLYSTYRENES; RATS; SOLUBILITY;

EID: 0032969652     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00346-9     Document Type: Article

References (23)

1. Akashi M., Kirikihara I., Miyauchi N. Synthesis and polymerization of a styryl terminated oligovinylpyrrolidone macromonomer. Angew. Macromol. Chem. 132:1985;81-89.
2. Akashi M., Yanagi T., Yashima E., Miyauchi N. Graft copolymers having hydrophobic backbone and hydrophilic branches, IV. A copolymerization study of water-soluble oligovinylpyrrolidone macromonomers. J. Polym. Sci. Polym. Chem. 27:1989;3521-3530.
3. Akashi M., Chao D., Yashima E., Miyauchi N. Graft copolymers having hydrophobic backbone and hydrophilic branches, V. Microspheres obtained by the copolymerization of poly(ethylene glycol) macromonomer with methyl methacrylate. J. Appl. Polym. Sci. 39:1990;2027-2030.
4. Akiyama Y., Nagahara N., Kashihara T., Hirai S., Toguchi H. In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative. Pharm. Res. 12:1995;397-405.
5. Borchard G., Lußen H.L., de Boer A.G., Verhoef J.C., Lehr C.M., Junginger H.E. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control. Rel. 39:1996;131-138.
6. 125I]iodophenyl)diazirine, a carbene-generating reagent. Biochemistry. 20:1981;7174-7182.
7. Chen M.Q., Kishida A., Akashi M. Graft copolymers having hydrophobic backbone and hydrophilic branches, XI. Preparation and thermosensitive properties of polystyrene microspheres having poly(N-isopropylacrylamide) branches on their surfaces. J. Polym. Sci. Polym. Chem. 34:1996;2213-2220.
8. Couvreur P., Puisieux F. Nano- and microparticles for the delivery of polypeptides and proteins. Adv. Drug Deliv. Rev. 10:1993;141-162.
9. Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Rel. 36:1995;39-46.
10. Gu J.P., Robinson J.R., Leung S.H.S. Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. Crit. Rev. Ther. Drug Carrier Syst. 5:1988;21-67.
11. Junginger H.E. Bioadhesive polymer systems for peptide delivery. Acta Pharm. Technol. 36:1990;110-126.
12. Kreuter J. Peroral administration of nanoparticles. Adv. Drug Deliv. Rev. 7:1991;71-86.
13. Lehr C.M., Bouwstra J.A., Tukker J.J., Junginger H.E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat: a comparative study with copolymers and blends based on poly(acrylic acid). J. Control. Rel. 13:1990;51-62.
14. Lehr C.M., Bouwstra J.A., Kok W., De Boer A.G., Tukker J.J., Verhoef J.C., Breimer B.B., Junginger H.E. Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. J. Pharm. Pharmacol. 44:1992;402-407.
15. Longer M.A., Ch'ng H.S., Robinson J.R. Bioadhesive polymers as platforms for oral controlled drug delivery, III. Oral delivery of chlorothiazide using a bioadhesive polymer. J. Pharm. Sci. 74:1985;406-411.
16. Pimienta C., Lenaerts V., Cadieux C., Raymond P., Juhasz J., Simard M.A., Jolicoeur C. Mucoadhesion of hydroxypropylmethacrylate nanoparticles to rat intestinal ileal segments in vitro. Pharm. Res. 7:1990;49-53.
17. Riza M., Tokura S., Kishida A., Akashi M. Graft copolymers having a hydrophobic backbone and hydrophilic branches, part IX. Preparation of water-dispersible microspheres having polycationic branches on their surfaces. New Polym. Mater. 4:1994;189-198.
18. Riza M., Tokura S., Iwasaki M., Yashima E., Kishida A., Akashi M. Graft copolymers having hydrophobic backbone and hydrophilic branches, X. Preparation and properties of water-dispersible polyanionic microspheres having poly(methacrylic acid) branches on their surfaces. J. Polym. Sci. Polym. Chem. 33:1995;1219-1225.
19. Sakuma S., Suzuki N., Kikuchi H., Hiwatari K., Arikawa K., Kishida A., Akashi M. Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches. Int. J. Pharm. 149:1997a;93-106.
20. Sakuma S., Suzuki N., Kikuchi H., Hiwatari K., Arikawa K., Kishida A., Akashi M. Absorption enhancement of orally administered salmon calcitonin by polystyrene nanoparticles having poly(N-isopropylacrylamide) branches on their surfaces. Int. J. Pharm. 158:1997b;69-78.
21. Sakuma S., Ishida Y., Sudo R., Suzuki N., Kikuchi H., Hiwatari K., Kishida A., Akashi M., Hayashi M. Stabilization of salmon calcitonin by polystyrene nanoparticles having surface hydrophilic polymeric chains, against enzymatic degradation. Int. J. Pharm. 159:1997c;181-189.
22. Takeuchi H., Yamamoto H., Niwa T., Hino T., Kawashima H. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13:1996;896-901.
23. Yamaoka K., Tanigawara Y., Nakagawa T., Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio. Dyn. 4:1981;879-885.