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Volumn 8, Issue 2, 2013, Pages 1-19

New pharmacological approaches to the cholinergic system: An overview on muscarinic receptor ligands and cholinesterase inhibitors

Author keywords

Acetylcholinesterase; Butirylcholinesterase; Muscarinic receptors; Neurological diseases; Nociception; Tumors

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINESTERASE; ALVAMELINE; BENZATROPINE MESILATE; CEVIMELINE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DARIFENACIN; DONEPEZIL; FESOTERODINE; GALANTAMINE; GALLAMINE; IPROTROPIUM; LADOSTIGIL; MEMANTINE; METHOCTRAMINE; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OXITROPIUM BROMIDE; PHYSOSTIGMINE SALICYLATE; PIRENZEPINE; RIVASTIGMINE; SOLIFENACIN; TACRINE; TIOTROPIUM BROMIDE; TOLTERODINE; TROPICAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEDACLIDINE; XANOMELINE;

EID: 84882300659     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (30)

References (218)
  • 2
    • 0027007991 scopus 로고
    • + influx into embryonic cells after stimulation of the embryonic muscarinic receptors
    • + influx into embryonic cells after stimulation of the embryonic muscarinic receptors. J Dev Physiol 1992; 17: 147-155.
    • (1992) J Dev Physiol , vol.17 , pp. 147-155
    • Oettling, G.1    Götz, U.2    Drews, U.3
  • 3
    • 0029860131 scopus 로고    scopus 로고
    • From oocytes to neuron: Do neurotransmitters function in the same way throughout development
    • Buzanikov GA, Shumukler YB, Lauder JM. From oocytes to neuron: do neurotransmitters function in the same way throughout development. Cell Mol Neurobiol 1996; 16: 533-559
    • (1996) Cell Mol Neurobiol , vol.16 , pp. 533-559
    • Buzanikov, G.A.1    Shumukler, Y.B.2    Lauder, J.M.3
  • 4
    • 33744924761 scopus 로고    scopus 로고
    • Adrenergic and cholinergic control in the biology of epidermis: Physiological and clinical Significance
    • Grando SA, Pittelkow MR, Schellreunter KU. Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical Significance. J Invest Dermatol 2006; 126: 1948-1965.
    • (2006) J Invest Dermatol , vol.126 , pp. 1948-1965
    • Grando, S.A.1    Pittelkow, M.R.2    Schellreunter, K.U.3
  • 5
    • 23144441616 scopus 로고    scopus 로고
    • Expression of non neuronal acetylcholine in lymphocytes and its contributionof immune function
    • Kawashima K, Fuji T. Expression of non neuronal acetylcholine in lymphocytes and its contributionof immune function. Front Biosci 2004; 9 (suppl):2063-2085.
    • (2004) Front Biosci , vol.9 , Issue.SUPPL. , pp. 2063-2085
    • Kawashima, K.1    Fuji, T.2
  • 7
    • 0002687960 scopus 로고
    • Identification of acetylcholine and related esters of biological origin
    • In Eichler O, Farah a., Koelle GB Editors, B, Heidelberg, New York Springer
    • Whittacher VP. Identification of acetylcholine and related esters of biological origin. In Eichler O, Farah a., Koelle GB Editors. Handbuch der Experimentellen Pharmakologie. B, Heidelberg, New York Springer 1963; 1-39.
    • (1963) Handbuch Der Experimentellen Pharmakologie , pp. 1-39
    • Whittacher, V.P.1
  • 8
    • 0037470640 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in humans: Expression, function and pathophysiology
    • Wessler I, Kilbinger H, Bittinger F, Unger R, Kirkpatrick CJ. The non-neuronal cholinergic system in humans: Expression, function and pathophysiology. Life Sciences 2003; 72: 2055-2061
    • (2003) Life Sciences , vol.72 , pp. 2055-2061
    • Wessler, I.1    Kilbinger, H.2    Bittinger, F.3    Unger, R.4    Kirkpatrick, C.J.5
  • 9
    • 3342913105 scopus 로고    scopus 로고
    • Signalling cascades implicated in muscarinic regulation of proliferation of neural stem and progenitor cells
    • Ma W, Li BS, Zhang L, Pant H. Signalling cascades implicated in muscarinic regulation of proliferation of neural stem and progenitor cells. Drug News Perspect 2004; 17: 258-266
    • (2004) Drug News Perspect , vol.17 , pp. 258-266
    • Ma, W.1    Li, B.S.2    Zhang, L.3    Pant, H.4
  • 10
    • 0842327743 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro
    • Zhou C, Wen ZX, Shi DM, Xie ZP. Muscarinic acetylcholine receptors involved in the regulation of neural stem cell proliferation and differentiation in vitro. Cell Biol Inter 2004; 28: 63-67
    • (2004) Cell Biol Inter , vol.28 , pp. 63-67
    • Zhou, C.1    Wen, Z.X.2    Shi, D.M.3    Xie, Z.P.4
  • 11
    • 33845948153 scopus 로고    scopus 로고
    • Acetylcholine and regulation of gene expression in developing systems
    • Augusti TG, Biagioni S, Tata AM. Acetylcholine and regulation of gene expression in developing systems. J Mol Neurosci. 2006; 30: 45-47.
    • (2006) J Mol Neurosci , vol.30 , pp. 45-47
    • Augusti, T.G.1    Biagioni, S.2    Tata, A.M.3
  • 12
    • 70349787112 scopus 로고    scopus 로고
    • Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration
    • Magnaghi V, Procacci P, Tata AM. Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration. Int Rev Neurobiol. 2009; 87: 295-315.
    • (2009) Int Rev Neurobiol , vol.87 , pp. 295-315
    • Magnaghi, V.1    Procacci, P.2    Tata, A.M.3
  • 13
    • 46749115525 scopus 로고    scopus 로고
    • Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of M2 receptor subtype
    • Loreti S, Ricordy R, De Stefano ME, Augusti-Tocco G, Tata AM. Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of M2 receptor subtype. Neuron Glia Biol. 2007; 3: 269-279.
    • (2007) Neuron Glia Biol , vol.3 , pp. 269-279
    • Loreti, S.1    Ricordy, R.2    de Stefano, M.E.3    Augusti-Tocco, G.4    Tata, A.M.5
  • 14
    • 84859492260 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation
    • De Angelis F, Bernardo A, Magnaghi V, Minghetti L, Tata AM. Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation and differentiation. Dev. Neurobiol. 2012; 72: 713-728.
    • (2012) Dev. Neurobiol , vol.72 , pp. 713-728
    • de Angelis, F.1    Bernardo, A.2    Magnaghi, V.3    Minghetti, L.4    Tata, A.M.5
  • 15
    • 70349816648 scopus 로고    scopus 로고
    • The neurology of the immune system: Neural reflexes regulate immunity
    • Rosas-Ballina M, Tracey KJ. The neurology of the immune system: neural reflexes regulate immunity. Neuron 2009; 64:28-32.
    • (2009) Neuron , vol.64 , pp. 28-32
    • Rosas-Ballina, M.1    Tracey, K.J.2
  • 16
    • 0034104866 scopus 로고    scopus 로고
    • Extraneuronal cholinergic system in lymphocytes
    • Kawashima K, Fujii T, Extraneuronal cholinergic system in lymphocytes. Pharmacol and Ther 2000; 86: 29-48.
    • (2000) Pharmacol and Ther , vol.86 , pp. 29-48
    • Kawashima, K.1    Fujii, T.2
  • 18
    • 18144395496 scopus 로고    scopus 로고
    • Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures
    • De Simone R., Ajmone-Cat M, Carnevale D, Minghetti L. Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures. J Neuroinflammation 2005; 25: 1-10.
    • (2005) J Neuroinflammation , vol.25 , pp. 1-10
    • de Simone, R.1    Ajmone-Cat, M.2    Carnevale, D.3    Minghetti, L.4
  • 19
    • 0027465882 scopus 로고
    • Immunological localization of m1-m5 muscarinic receptor subtypes in peripheral tissues and brain
    • Levey AI. Immunological localization of m1-m5 muscarinic receptor subtypes in peripheral tissues and brain. Life Sci 1993; 52: 441-448.
    • (1993) Life Sci , vol.52 , pp. 441-448
    • Levey, A.I.1
  • 20
    • 0035016227 scopus 로고    scopus 로고
    • Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes
    • Ragheb F, Molina-Holgado E, Cui QL, et al. Pharmacological and functional characterization of muscarinic receptor subtypes in developing oligodendrocytes. J Neurochem 2001; 77:1396-1406.
    • (2001) J Neurochem , vol.77 , pp. 1396-1406
    • Ragheb, F.1    Molina-Holgado, E.2    Cui, Q.L.3
  • 22
    • 0031774720 scopus 로고    scopus 로고
    • International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors
    • Caufield MP, Birdsall NJM. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998; 50: 279-290.
    • (1998) Pharmacol Rev , vol.50 , pp. 279-290
    • Caufield, M.P.1    Birdsall, N.J.M.2
  • 23
    • 9044229994 scopus 로고
    • th international symposium on subtypes of muscarinic receptors
    • th international symposium on subtypes of muscarinic receptors. Trends Pharmacol Sci 1989; 10 suppl:1-119.
    • (1989) Trends Pharmacol Sci , vol.10 , Issue.SUPPL. , pp. 1-119
    • Levine, R.R.1    Birdsall, N.J.M.2
  • 25
    • 0023661365 scopus 로고
    • Distint primary structures, ligand binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors
    • Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ. Distint primary structures, ligand binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J 1987; 6: 3923-3929.
    • (1987) EMBO J , vol.6 , pp. 3923-3929
    • Peralta, E.G.1    Ashkenazi, A.2    Winslow, J.W.3    Smith, D.H.4    Ramachandran, J.5    Capon, D.J.6
  • 26
    • 0027208248 scopus 로고
    • Muscarinic receptors: Characterization, coupling and function
    • Caufield MP. Muscarinic receptors: characterization, coupling and function. Pharmacol Ther 1993; 58: 319-379.
    • (1993) Pharmacol Ther , vol.58 , pp. 319-379
    • Caufield, M.P.1
  • 27
    • 84882355642 scopus 로고
    • Acetylcholine
    • Siegel GJ, Agranoff BW, Albers RW, Molinoff PB, Raven Press
    • Taylor P, Brown JH. Acetylcholine. In Basic Neurochemistry. Siegel GJ, Agranoff BW, Albers RW, Molinoff PB. 1994. Raven Press.
    • (1994) In Basic Neurochemistry
    • Taylor, P.1    Brown, J.H.2
  • 28
    • 0028237231 scopus 로고
    • Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture
    • Tence M, Cordier J, Premont J, Glowinski J. Muscarinic cholinergic agonists stimulate arachidonic acid release from mouse striatal neurons in primary culture. J Pharmacol Exp Ther 1994; 269: 646-653.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 646-653
    • Tence, M.1    Cordier, J.2    Premont, J.3    Glowinski, J.4
  • 29
    • 3042992785 scopus 로고
    • Stimulation of arachidonic acid release and inhibitionof mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells
    • Conklin BR, Brann MR, Buckley MJM, Bonner IT, Axelrod J. Stimulation of arachidonic acid release and inhibitionof mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc Natl Acad Sci USA 1988; 85: 8698-8702.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8698-8702
    • Conklin, B.R.1    Brann, M.R.2    Buckley, M.J.M.3    Bonner, I.T.4    Axelrod, J.5
  • 30
    • 0037406701 scopus 로고    scopus 로고
    • Regulation of muscarinic acetylcholine receptor signalling
    • Van Koppen CJ, Kaiser B. Regulation of muscarinic acetylcholine receptor signalling. Pharmacol Ther 2003; 98: 197-220.
    • (2003) Pharmacol Ther , vol.98 , pp. 197-220
    • van Koppen, C.J.1    Kaiser, B.2
  • 31
    • 33644643568 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors mediate survival through Src-like tyrosine kinase and PI3K/Akt pathways
    • Cui QL, Fogle E, Almazan G. Muscarinic acetylcholine receptors mediate survival through Src-like tyrosine kinase and PI3K/Akt pathways. Neurochem Int 2006; 48:383-393
    • (2006) Neurochem Int , vol.48 , pp. 383-393
    • Cui, Q.L.1    Fogle, E.2    Almazan, G.3
  • 32
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
    • Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nature Rev Drug Discovery 2007; 6:721-733.
    • (2007) Nature Rev Drug Discovery , vol.6 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 33
    • 55649119507 scopus 로고
    • Modification of the binding properties of muscarinic receptors by gallamine
    • Stockton JM, Birdsall NJM, Burgen AS, Hulme EC. Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol 1983; 44:102-110.
    • (1983) Mol Pharmacol , vol.44 , pp. 102-110
    • Stockton, J.M.1    Birdsall, N.J.M.2    Burgen, A.S.3    Hulme, E.C.4
  • 34
    • 55649124467 scopus 로고
    • Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes
    • Ellis J, Seidenberg M, Brann MR. Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem Pharmacol 1993; 42: 199-205.
    • (1993) Biochem Pharmacol , vol.42 , pp. 199-205
    • Ellis, J.1    Seidenberg, M.2    Brann, M.R.3
  • 35
    • 0030902106 scopus 로고    scopus 로고
    • Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes
    • Birdsall NJM, Farries T, Gharagozloo P, et al. Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes. Life Science 1997; 60: 1047-1052.
    • (1997) Life Science , vol.60 , pp. 1047-1052
    • Birdsall, N.J.M.1    Farries, T.2    Gharagozloo, P.3
  • 37
    • 0026805538 scopus 로고
    • Two polypeptides from Dendroaspis angusticeps venom selectivity inhibit the binding of central muscarinic cholinergic receptor ligands
    • Jerulinsky D, Cervenansky C, Pena C, Raskovsky S, Dajas F. Two polypeptides from Dendroaspis angusticeps venom selectivity inhibit the binding of central muscarinic cholinergic receptor ligands. Neurochem Int 1992; 20: 237-246.
    • (1992) Neurochem Int , vol.20 , pp. 237-246
    • Jerulinsky, D.1    Cervenansky, C.2    Pena, C.3    Raskovsky, S.4    Dajas, F.5
  • 38
    • 0027485462 scopus 로고
    • Purification and properties of m1toxin, a specific antagonist of m1 muscarinic receptors
    • Max SI, Liang JS, Potter LT. Purification and properties of m1toxin, a specific antagonist of m1 muscarinic receptors. J Neurosci 1993; 13: 4293-4300.
    • (1993) J Neurosci , vol.13 , pp. 4293-4300
    • Max, S.I.1    Liang, J.S.2    Potter, L.T.3
  • 39
    • 8244240430 scopus 로고    scopus 로고
    • Pharmacology of butylthio [2.2.2] (LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity
    • Shannon HE, Sheardown MJ, Bymaster FP, et al. Pharmacology of butylthio [2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J Pharmacol Exp Ther 1997; 281: 884-894.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 884-894
    • Shannon, H.E.1    Sheardown, M.J.2    Bymaster, F.P.3
  • 40
    • 84857375139 scopus 로고    scopus 로고
    • Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery
    • Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CM. Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. J Med Chem. 2012; 55: 1445-1464.
    • (2012) J Med Chem , vol.55 , pp. 1445-1464
    • Melancon, B.J.1    Hopkins, C.R.2    Wood, M.R.3    Emmitte, K.A.4    Niswender, C.M.5    Christopoulos, A.6    Conn, P.J.7    Lindsley, C.M.8
  • 42
    • 0034676312 scopus 로고    scopus 로고
    • Therapeutic opportunities for muscarinic receptors in central nervous system
    • Felder CC, Bymaster FP, Ward J, Delapp N. Therapeutic opportunities for muscarinic receptors in central nervous system. J Med Chem 2000; 43: 4333-4353.
    • (2000) J Med Chem , vol.43 , pp. 4333-4353
    • Felder, C.C.1    Bymaster, F.P.2    Ward, J.3    Delapp, N.4
  • 43
    • 2342444247 scopus 로고    scopus 로고
    • Anti-muscarinic for the treatment of overactive bladder: Current options and emerging therapies
    • Hedge SS, Mammen M, Jasper JR. Anti-muscarinic for the treatment of overactive bladder: current options and emerging therapies. Curr Opin Inv Drugs 2004; 5:40-49.
    • (2004) Curr Opin Inv Drugs , vol.5 , pp. 40-49
    • Hedge, S.S.1    Mammen, M.2    Jasper, J.R.3
  • 44
    • 33745168973 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes in neuronal and non- neuronal cholinergic function
    • Eglen RM. Muscarinic receptor subtypes in neuronal and non- neuronal cholinergic function. Autonomic and Autocoid Pharmacol 2005; 26: 219-233
    • (2005) Autonomic and Autocoid Pharmacol , vol.26 , pp. 219-233
    • Eglen, R.M.1
  • 45
    • 0031918465 scopus 로고    scopus 로고
    • Tolterodine: A new muscarinic receptor antagonist, is metabolized by cytochrome P4502D6 and 3A4 in human liver microsomes
    • Postlind H, Danielson A, Lindgren A, Andersson SH. Tolterodine: a new muscarinic receptor antagonist, is metabolized by cytochrome P4502D6 and 3A4 in human liver microsomes. Drug Metab Dispos 1998; 26: 289-293.
    • (1998) Drug Metab Dispos , vol.26 , pp. 289-293
    • Postlind, H.1    Danielson, A.2    Lindgren, A.3    Andersson, S.H.4
  • 46
    • 48049117725 scopus 로고    scopus 로고
    • Fesoterodine: A novel muscarinic receptor antagonist for the treatment of overactive blabber syndrome
    • Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive blabber syndrome. Expert Opin Pharmacother 2008; 9: 1787-1796.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1787-1796
    • Michel, M.C.1
  • 48
    • 29344471478 scopus 로고    scopus 로고
    • Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice
    • Oki T, Maruyama S, Takagi Y, Yamamura HI, Yamada S. Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice. Europ J Pharmacol 2006; 529: 157-163.
    • (2006) Europ J Pharmacol , vol.529 , pp. 157-163
    • Oki, T.1    Maruyama, S.2    Takagi, Y.3    Yamamura, H.I.4    Yamada, S.5
  • 50
    • 3042525451 scopus 로고    scopus 로고
    • The airway cholinergic system: Physiology and pharmacology
    • Racke K, Matthiesen S. The airway cholinergic system: physiology and pharmacology. Pulm Pharmacol Ther 2004; 17: 181-198.
    • (2004) Pulm Pharmacol Ther , vol.17 , pp. 181-198
    • Racke, K.1    Matthiesen, S.2
  • 51
    • 4644353712 scopus 로고    scopus 로고
    • Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD
    • Keam SJ, Keating GM. Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD. Treat Resp Med 2004; 3: 247-268.
    • (2004) Treat Resp Med , vol.3 , pp. 247-268
    • Keam, S.J.1    Keating, G.M.2
  • 52
    • 0037315348 scopus 로고    scopus 로고
    • Sjogren's syndrome: Evolving therapies
    • Fox RI. Sjogren's syndrome: evolving therapies. Expert Opin Invest Drugs 2003; 12: 247-254.
    • (2003) Expert Opin Invest Drugs , vol.12 , pp. 247-254
    • Fox, R.I.1
  • 53
  • 54
  • 56
  • 68
    • 84882379509 scopus 로고    scopus 로고
    • US7,855,230 B2
    • Meese C, Sparf B.: US7,855,230 B2 (2008).
    • (2008)
    • Meese, C.1    Sparf, B.2
  • 77
    • 8244240430 scopus 로고    scopus 로고
    • Pharmacology of Butylthio [2.2.2](LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity
    • Shannon HE, Sheardown JM, Bymaster FP et al. Pharmacology of Butylthio [2.2.2](LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J Pharmacol Exp Ther 1997; 281: 884-894.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 884-894
    • Shannon, H.E.1    Sheardown, J.M.2    Bymaster, F.P.3
  • 79
    • 0030467247 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer's disease
    • Levey AI. Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer's disease. Proc Natl Acad Sci USA 1996; 93:13541-13546.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13541-13546
    • Levey, A.I.1
  • 80
    • 0030902127 scopus 로고    scopus 로고
    • Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in a Alzheimer disease
    • Bodick NC, Offen WW, Levey AI et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioural symptoms in a Alzheimer disease. Arch Neurol 1997; 54: 465-473.
    • (1997) Arch Neurol , vol.54 , pp. 465-473
    • Bodick, N.C.1    Offen, W.W.2    Levey, A.I.3
  • 81
    • 84860466906 scopus 로고    scopus 로고
    • Continued optimization of the MLPCN probe ML071 into higly potent agonist of the M1 muscarinic acetylcholine receptor
    • Melancon BJ, Gogliotti RD, Tarr JC, et al. Continued optimization of the MLPCN probe ML071 into higly potent agonist of the M1 muscarinic acetylcholine receptor. Bioorg Med Chem Lett. 2012; 22: 3467-3472.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 3467-3472
    • Melancon, B.J.1    Gogliotti, R.D.2    Tarr, J.C.3
  • 84
    • 13844257170 scopus 로고    scopus 로고
    • Selective targeting of Muscarinic receptors: Novel therapeutic approaches for psychotic disorders
    • Sur C and Kinney GG. Selective targeting of Muscarinic receptors: novel therapeutic approaches for psychotic disorders. Curr Neuropharmacol 2005; 3:63-71.
    • (2005) Curr Neuropharmacol , vol.3 , pp. 63-71
    • Sur, C.1    Kinney, G.G.2
  • 85
    • 0033985055 scopus 로고    scopus 로고
    • Induction of cellular contractions in the human melanoma cell line SK-mel 28 after muscarinic cholinergic stimulation
    • Sailer M, Oppitz M., Drews U. Induction of cellular contractions in the human melanoma cell line SK-mel 28 after muscarinic cholinergic stimulation. Anat Embryol 2000; 201: 27-37.
    • (2000) Anat Embryol , vol.201 , pp. 27-37
    • Sailer, M.1    Oppitz, M.2    Drews, U.3
  • 86
    • 0036223172 scopus 로고    scopus 로고
    • Muscarinic receptors in cell lines from ovarian carcinoma: Negative correlation with survival of patients
    • Oppitz M, Möbus V, Brock S, Drews U. Muscarinic receptors in cell lines from ovarian carcinoma: negative correlation with survival of patients. Gynecologic Oncol 2002; 85: 159-164.
    • (2002) Gynecologic Oncol , vol.85 , pp. 159-164
    • Oppitz, M.1    Möbus, V.2    Brock, S.3    Drews, U.4
  • 88
    • 0032884778 scopus 로고    scopus 로고
    • Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor
    • Frucht H, Jensen RT, Dexter D, Yang Wl, Xiao Y. Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clinical Cancer Res 1999; 5: 2532-2539.
    • (1999) Clinical Cancer Res , vol.5 , pp. 2532-2539
    • Frucht, H.1    Jensen, R.T.2    Dexter, D.3    Yang, W.4    Xiao, Y.5
  • 89
    • 34248597724 scopus 로고    scopus 로고
    • M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogenactivated protein kinase phosphorylation induced by acetylcholine secretion
    • Song P, Sekhon HS, Lu A, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogenactivated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 2007; 67: 3936-3944.
    • (2007) Cancer Res , vol.67 , pp. 3936-3944
    • Song, P.1    Sekhon, H.S.2    Lu, A.3
  • 90
    • 0030064643 scopus 로고    scopus 로고
    • Acetylcholine as a mitogen: Muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells
    • Guizzetti M, Costa P, Peters J, Costa LG. Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells. Eur J Pharmacol 1996; 297:265-273.
    • (1996) Eur J Pharmacol , vol.297 , pp. 265-273
    • Guizzetti, M.1    Costa, P.2    Peters, J.3    Costa, L.G.4
  • 91
    • 23044493073 scopus 로고    scopus 로고
    • Muscarinic cholinergic receptors in the human melanoma cell line SK-MEL28: Modulation of chemotaxis
    • Boss A, Oppitz M, Drews U. Muscarinic cholinergic receptors in the human melanoma cell line SK-MEL28: modulation of chemotaxis. Exp Dermatol 2005; 30: 557-564.
    • (2005) Exp Dermatol , vol.30 , pp. 557-564
    • Boss, A.1    Oppitz, M.2    Drews, U.3
  • 93
    • 21644452109 scopus 로고    scopus 로고
    • Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells
    • Jimenez E, Montiel M. Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 2005; 204: 678-686.
    • (2005) J Cell Physiol , vol.204 , pp. 678-686
    • Jimenez, E.1    Montiel, M.2
  • 95
    • 84872808405 scopus 로고    scopus 로고
    • M2 muscarinic receptor inhibits cell proliferation in human glioblastoma cell lines
    • Ferretti M, Fabbiano C, Di Bari M, Ponti D., Calogero A. and Tata AM. M2 muscarinic receptor inhibits cell proliferation in human glioblastoma cell lines. Life Sciences, 2012; 91: 1134-1137.
    • (2012) Life Sciences , vol.91 , pp. 1134-1137
    • Ferretti, M.1    Fabbiano, C.2    Di Bari, M.3    Ponti, D.4    Calogero, A.5    Tata, A.M.6
  • 96
    • 84877019142 scopus 로고    scopus 로고
    • M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells
    • doi 10.1111/jcmm.12038
    • Ferretti M, Fabbiano C, Ricordy R, et al. M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J Cell Mol Med. 2013; doi 10.1111/jcmm.12038.
    • (2013) J Cell Mol Med
    • Ferretti, M.1    Fabbiano, C.2    Ricordy, R.3
  • 97
    • 0037229715 scopus 로고    scopus 로고
    • Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma
    • Song P, Sekhon HS, Jia Y et al. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res 2003; 63: 214-221.
    • (2003) Cancer Res , vol.63 , pp. 214-221
    • Song, P.1    Sekhon, H.S.2    Jia, Y.3
  • 98
    • 21644452109 scopus 로고    scopus 로고
    • Activation of MAP kinase by Muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells
    • Jimenez E, Montiel M. Activation of MAP kinase by Muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. J Cell Physiol 2005; 204: 678-686.
    • (2005) J Cell Physiol , vol.204 , pp. 678-686
    • Jimenez, E.1    Montiel, M.2
  • 99
    • 0032561168 scopus 로고    scopus 로고
    • The role of protein kinase C and isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line
    • Guizzetti M, Wei M, Costa LG. The role of protein kinase C and isozymes in DNA synthesis induced by muscarinic receptors in a glial cell line. Eur J Pharmacol 1998; 359: 223-233.
    • (1998) Eur J Pharmacol , vol.359 , pp. 223-233
    • Guizzetti, M.1    Wei, M.2    Costa, L.G.3
  • 100
    • 0034235510 scopus 로고    scopus 로고
    • Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration
    • Bordey A, Sontheimer H, Thouslard J. Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration. J Membrane Biol. 2000; 176:31-40.
    • (2000) J Membrane Biol , vol.176 , pp. 31-40
    • Bordey, A.1    Sontheimer, H.2    Thouslard, J.3
  • 101
    • 84882443150 scopus 로고    scopus 로고
    • WO Patents: 04057344A1
    • WO Patents: 04057344A1 (2004).
    • (2004)
  • 103
    • 33645515459 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of darifenacin
    • Skerjanec A. The clinical pharmacokinetics of darifenacin. Clin Pharmakinet 2006; 45: 325-350.
    • (2006) Clin Pharmakinet , vol.45 , pp. 325-350
    • Skerjanec, A.1
  • 104
    • 40549083717 scopus 로고    scopus 로고
    • Basic and clinic aspect of non neuronal acetylcholine: Expression of non neuronal acetylcholine in lung cancer provides a new target for cancer therapy
    • Song P. and Spindel ER. Basic and clinic aspect of non neuronal acetylcholine: expression of non neuronal acetylcholine in lung cancer provides a new target for cancer therapy. J. Pharmacol Sci. 2008; 106: 180-185.
    • (2008) J. Pharmacol Sci , vol.106 , pp. 180-185
    • Song, P.1    Spindel, E.R.2
  • 105
    • 33846113921 scopus 로고    scopus 로고
    • Migrastatin acts as a muscarinic acetylcholine receptor antagonist
    • Nakae K, Nishimura Y, Ohba S, Akamatsu Y. Migrastatin acts as a muscarinic acetylcholine receptor antagonist. J Antibiot 2006; 59: 685-692.
    • (2006) J Antibiot , vol.59 , pp. 685-692
    • Nakae, K.1    Nishimura, Y.2    Ohba, S.3    Akamatsu, Y.4
  • 107
    • 0034693250 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes expression in rat and chick dorsal root ganglia
    • Tata AM, Vilaró MT, Mengod G. Muscarinic receptor subtypes expression in rat and chick dorsal root ganglia. Mol Brain Res 2000; 82: 1-10
    • (2000) Mol Brain Res , vol.82 , pp. 1-10
    • Tata, A.M.1    Vilaró, M.T.2    Mengod, G.3
  • 108
    • 0027359663 scopus 로고
    • Characterization of the antinociception produced by intrathecally administered muscarinic agonistsin rats
    • Iwamoto ET, Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonistsin rats. J Pharmacol Exp Ther 1993; 266: 329-338.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 329-338
    • Iwamoto, E.T.1    Marion, L.2
  • 109
    • 0021847471 scopus 로고
    • Cholinergic agents: Antinociception without morphine type dependence in rats
    • Widman M, Tucker S, Brase DA, Dewey WL. Cholinergic agents: antinociception without morphine type dependence in rats. Life Sci 1985; 36: 2007-2015.
    • (1985) Life Sci , vol.36 , pp. 2007-2015
    • Widman, M.1    Tucker, S.2    Brase, D.A.3    Dewey, W.L.4
  • 110
    • 0037470642 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: A review
    • Wess J, Duttaroy A, Gomeza J, et al. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sciences 2003; 72: 2047-2054
    • (2003) Life Sciences , vol.72 , pp. 2047-2054
    • Wess, J.1    Duttaroy, A.2    Gomeza, J.3
  • 111
    • 0034677592 scopus 로고    scopus 로고
    • Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice
    • Honda K, Harada A, Takano Y, Kamira H. Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice. Brain Res 2000. 859: 38-44.
    • (2000) Brain Res , vol.859 , pp. 38-44
    • Honda, K.1    Harada, A.2    Takano, Y.3    Kamira, H.4
  • 112
    • 0035341506 scopus 로고    scopus 로고
    • Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin
    • Bernardini N, Sauer S, Haberberger R, Fisher MJM, Reeh PW. Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin. J Neurosci 2001; 21: 3295-3302.
    • (2001) J Neurosci , vol.21 , pp. 3295-3302
    • Bernardini, N.1    Sauer, S.2    Haberberger, R.3    Fisher, M.J.M.4    Reeh, P.W.5
  • 113
    • 0037096241 scopus 로고    scopus 로고
    • Muscarinic M2 receptors on peripheral nerve endings: A molecular target of antinociception
    • Bernardini N, Roza C, Sauer S, Gomeza J, Wess J, Reeh W. Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. J Neurosci 2002; 22: 1-5.
    • (2002) J Neurosci , vol.22 , pp. 1-5
    • Bernardini, N.1    Roza, C.2    Sauer, S.3    Gomeza, J.4    Wess, J.5    Reeh, W.6
  • 114
    • 0346724925 scopus 로고    scopus 로고
    • Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron
    • Dussor GO, Helesic G, Hargreaves KM, Flores CM. Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron. Pain 2004; 107: 22-32.
    • (2004) Pain , vol.107 , pp. 22-32
    • Dussor, G.O.1    Helesic, G.2    Hargreaves, K.M.3    Flores, C.M.4
  • 115
    • 0033056473 scopus 로고    scopus 로고
    • Development of muscarinic analgesic derived from epibatidine: Role of the M4 receptor subtype
    • Ellis JL, Harman D, Gonzalez J et al. Development of muscarinic analgesic derived from epibatidine: role of the M4 receptor subtype. J Pharmacol Exper Ther 1999; 288: 1143-1150.
    • (1999) J Pharmacol Exper Ther , vol.288 , pp. 1143-1150
    • Ellis, J.L.1    Harman, D.2    Gonzalez, J.3
  • 117
    • 0028174977 scopus 로고
    • The cholinesterases: From genes to proteins
    • Taylor P, Radic Z. The cholinesterases: From genes to proteins. Annu Rev Pharmacol Toxicol 1994;34:281-320.
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 281-320
    • Taylor, P.1    Radic, Z.2
  • 118
    • 0028365611 scopus 로고
    • Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins
    • Karpel R, Ben Aziz-Aloya R, Sternfeld M, et al. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Exp Cell Res 1994;210:268-277.
    • (1994) Exp Cell Res , vol.210 , pp. 268-277
    • Karpel, R.1    Ben Aziz-Aloya, R.2    Sternfeld, M.3
  • 119
    • 0037028246 scopus 로고    scopus 로고
    • Complex regulation of acetyl- cholinesterase gene expression in human brain tumors
    • Perry C, Sklan EH, Birikh K, et al. Complex regulation of acetyl- cholinesterase gene expression in human brain tumors. Oncogene 2002;21:8428-8441.
    • (2002) Oncogene , vol.21 , pp. 8428-8441
    • Perry, C.1    Sklan, E.H.2    Birikh, K.3
  • 120
    • 0033120892 scopus 로고    scopus 로고
    • Osteoblast-derived acetylcholinesterase: A novel mediator of cell-matrix interactions in bone?
    • Genever PG, Birch MA, Brown E, Skerry TM. Osteoblast-derived acetylcholinesterase: A novel mediator of cell-matrix interactions in bone? Bone 1999;24:297-303.
    • (1999) Bone , vol.24 , pp. 297-303
    • Genever, P.G.1    Birch, M.A.2    Brown, E.3    Skerry, T.M.4
  • 121
    • 53949113314 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in the endothelium: Evidence and possible pathobiological significance
    • Kirkpatrick CJ, Bittinger F, Unger RE, et al. The non-neuronal cholinergic system in the endothelium: Evidence and possible pathobiological significance. Jpn J Pharmacol 2001;85:24-28.
    • (2001) Jpn J Pharmacol , vol.85 , pp. 24-28
    • Kirkpatrick, C.J.1    Bittinger, F.2    Unger, R.E.3
  • 122
    • 0036024019 scopus 로고    scopus 로고
    • Induction of acetylcholinesterase expression during apoptosis in various cell types
    • Zhang XJ, Yang L, Zhao Q, et al. Induction of acetylcholinesterase expression during apoptosis in various cell types. Cell Death Differ 2002;9:790-800.
    • (2002) Cell Death Differ , vol.9 , pp. 790-800
    • Zhang, X.J.1    Yang, L.2    Zhao, Q.3
  • 123
    • 0037198403 scopus 로고    scopus 로고
    • A non-cholinergic, trophic action of acetyl- cholinesterase on hippocampal neurones in vitro
    • Day T, Greenfield SA. A non-cholinergic, trophic action of acetyl- cholinesterase on hippocampal neurones in vitro: Molecular mechanisms. Neuroscience 2002;111:649-656.
    • (2002) Molecular Mechanisms. Neuroscience , vol.111 , pp. 649-656
    • Day, T.1    Greenfield, S.A.2
  • 124
    • 2642554616 scopus 로고    scopus 로고
    • Identification of a structural site on acetyl- cholinesterase that promotes neurite outgrowth and binds laminin-1 and collagen IV
    • Johnson G, Moore SW. Identification of a structural site on acetyl- cholinesterase that promotes neurite outgrowth and binds laminin-1 and collagen IV. Biochem Biophys Res Commun 2004;319:448-455
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 448-455
    • Johnson, G.1    Moore, S.W.2
  • 125
    • 0028027279 scopus 로고
    • Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo
    • Soreq H, Patinkin D, Lev-Lehman E, et al. Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo. Proc Natl Acad Sci 1994;91:7907-7911.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 7907-7911
    • Soreq, H.1    Patinkin, D.2    Lev-Lehman, E.3
  • 126
    • 0029863697 scopus 로고    scopus 로고
    • Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
    • Inestrosa NC, Alvarez A, Perez CA, et al. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme. Neuron 1996; 16: 881-891.
    • (1996) Neuron , vol.16 , pp. 881-891
    • Inestrosa, N.C.1    Alvarez, A.2    Perez, C.A.3
  • 127
    • 84873488356 scopus 로고    scopus 로고
    • Butyrylcholinesterase and the cholinergic system
    • Reid GA, Chilukuri N, Darvesh S. Butyrylcholinesterase and the cholinergic system. Neuroscience. 2013; doi: 10.1016/j.neuroscience.2012.12.054.
    • (2013) Neuroscience
    • Reid, G.A.1    Chilukuri, N.2    Darvesh, S.3
  • 129
    • 0037375876 scopus 로고    scopus 로고
    • Cholinesterases: New roles in brain function and in Alzheimer's disease
    • Giacobini E. Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem Res. 2003; 28:515-522.
    • (2003) Neurochem Res , vol.28 , pp. 515-522
    • Giacobini, E.1
  • 130
    • 33947659446 scopus 로고    scopus 로고
    • Butyrylcholinesterase activity in the rat forebrain and upper brainstem: Postnatal development and adult distribution
    • Geula C, Nagykery N. Butyrylcholinesterase activity in the rat forebrain and upper brainstem: postnatal development and adult distribution. Exp Neurol. 2007 204:640-57.
    • (2007) Exp Neurol , vol.204 , pp. 640-657
    • Geula, C.1    Nagykery, N.2
  • 131
    • 0027066990 scopus 로고
    • A computer model of glycosylated human butyrylcholinesterase
    • Millard, C. B. & Broomfield, C. A. A computer model of glycosylated human butyrylcholinesterase. Biochem. Biophys. Res. Commun.; 1992; 189, 1280-1286.
    • (1992) Biochem. Biophys. Res. Commun , vol.189 , pp. 1280-1286
    • Millard, C.B.1    Broomfield, C.A.2
  • 132
    • 0023118832 scopus 로고
    • Complete amino acid sequence of human serum cholinesterase
    • R Lockridge, O. et al. Complete amino acid sequence of human serum cholinesterase. J. Biol. Chem. 1987; 262, 549-557.
    • (1987) J. Biol. Chem , vol.262 , pp. 549-557
    • Lockridge, R.O.1
  • 134
    • 77957313578 scopus 로고    scopus 로고
    • Effects of donepezil on activities of daily living: Integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease
    • Gauthier S, Lopez OL, Waldemar G, Jones RW, Cummings J, Zhang R, et al. Effects of donepezil on activities of daily living: integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease. Int Psychogeriatr. 2010; 22:973-83.
    • (2010) Int Psychogeriatr , vol.22 , pp. 973-983
    • Gauthier, S.1    Lopez, O.L.2    Waldemar, G.3    Jones, R.W.4    Cummings, J.5    Zhang, R.6
  • 136
    • 16344378591 scopus 로고    scopus 로고
    • Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years
    • Small GW, Kaufer D, Mendiondo MS, Quarg P, Spiegel R. Cognitive performance in Alzheimer's disease patients receiving rivastigmine for up to 5 years. Int J Clin Pract. 2005; 59:473-7.
    • (2005) Int J Clin Pract , vol.59 , pp. 473-477
    • Small, G.W.1    Kaufer, D.2    Mendiondo, M.S.3    Quarg, P.4    Spiegel, R.5
  • 139
    • 0035320772 scopus 로고    scopus 로고
    • Acetylcholinesterase - New roles for an old actor
    • Soreq H, Seidman S. Acetylcholinesterase - New roles for an old actor. Nat Rev Neurosci 2001; 2: 294-302.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 294-302
    • Soreq, H.1    Seidman, S.2
  • 142
    • 0027337833 scopus 로고
    • Neurological cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability
    • Wright CI, Geula C, Mesulam MM. Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Ann Neurol 1993; 34: 373-84.
    • (1993) Ann Neurol , vol.34 , pp. 373-384
    • Wright, C.I.1    Geula, C.2    Mesulam, M.M.3
  • 143
    • 84655161993 scopus 로고    scopus 로고
    • Butirylcholinestarase in associated with -amyloid plaques in the transgenic APPSW/PSEN1dE9 mouse model of Amlzheimer disease
    • Jan
    • Darvesh S, Cash MK, Reid GA, Martin E, Mitnitski A, Geula C. Butirylcholinestarase in associated with -amyloid plaques in the transgenic APPSW/PSEN1dE9 mouse model of Amlzheimer disease. J Neuropathol Exp Neurol. 2012 Jan;71:2-14
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 2-14
    • Darvesh, S.1    Cash, M.K.2    Reid, G.A.3    Martin, E.4    Mitnitski, A.5    Geula, C.6
  • 144
    • 0032513557 scopus 로고    scopus 로고
    • Distribution of butyrylcholinesterase in human amygdala and hippocampal formation
    • Darvesh S, Grantham DL, Hopkins DA. Distribution of butyrylcholinesterase in human amygdala and hippocampal formation. J Comp Neurol 1998; 393: 374-390.
    • (1998) J Comp Neurol , vol.393 , pp. 374-390
    • Darvesh, S.1    Grantham, D.L.2    Hopkins, D.A.3
  • 145
    • 78549293899 scopus 로고    scopus 로고
    • Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues
    • Darvesh S, Reid GA, Martin E. Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues. Curr Alzheimer Res. 2010; 7:386-400.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 386-400
    • Darvesh, S.1    Reid, G.A.2    Martin, E.3
  • 146
    • 0016351232 scopus 로고
    • Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurons
    • Eng LF, Uyeda CT, Chao LP, Wolfgram F. Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurons. Nature 1974; 250: 243-245.
    • (1974) Nature , vol.250 , pp. 243-245
    • Eng, L.F.1    Uyeda, C.T.2    Chao, L.P.3    Wolfgram, F.4
  • 148
    • 0002783379 scopus 로고    scopus 로고
    • A new therapeutic target in AD treatment: Attention to butyrylcholinesterase: Cur Med
    • Greig N, Utsuki T, Yu Q, Zhu X, Holloway HW, Perry T, et al. A new therapeutic target in AD treatment: Attention to butyrylcholinesterase: Cur Med. Res Opinions 2001; 17: 1-7.
    • (2001) Res Opinions , vol.17 , pp. 1-7
    • Greig, N.1    Utsuki, T.2    Yu, Q.3    Zhu, X.4    Holloway, H.W.5    Perry, T.6
  • 149
    • 0036993145 scopus 로고    scopus 로고
    • Butyrylcholinesterase: An important new target in Alzheimer's disease therapy
    • Greig NH, Lahiri DK, Sambamurti K. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International Psychogeriatrics 2002; 14: 77-91.
    • (2002) International Psychogeriatrics , vol.14 , pp. 77-91
    • Greig, N.H.1    Lahiri, D.K.2    Sambamurti, K.3
  • 150
    • 67650537353 scopus 로고    scopus 로고
    • Structure, activities and biomedical applications of human butyrylcholinesterase
    • Masson P, Carletti E, Nachon F. Structure, activities and biomedical applications of human butyrylcholinesterase. Protein Pept Lett. 2009; 16: 1215-24.
    • (2009) Protein Pept Lett , vol.16 , pp. 1215-1224
    • Masson, P.1    Carletti, E.2    Nachon, F.3
  • 151
    • 50649087289 scopus 로고    scopus 로고
    • Acetylcholinesterase: How is structure related to function?
    • Silman I, Sussman JL. Acetylcholinesterase: how is structure related to function? Chem Biol Interact. 2008; 175: 3-10.
    • (2008) Chem Biol Interact , vol.175 , pp. 3-10
    • Silman, I.1    Sussman, J.L.2
  • 152
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
    • Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science. 1991; 253: 872-879.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3    Oefner, C.4    Goldman, A.5    Toker, L.6    Silman, I.7
  • 153
    • 61449122720 scopus 로고    scopus 로고
    • Butyrylcholinesterase, the Cinderella cholinesterase, as a drug target for Alzheimer's diseases and related dementias
    • In: Martinez A, Eds., Kerala, India, Transworld Research Network, Research Signpost
    • Greig NH, Yu QS, Brossi A, Matin E, Lahiri DK, Darvesh S. Butyrylcholinesterase, the Cinderella cholinesterase, as a drug target for Alzheimer's diseases and related dementias. In: Martinez A, Eds. Medicinal Chemistry of Alzheimer's Disease. Kerala, India, Transworld Research Network, Research Signpost, 2008: 79-109.
    • (2008) Medicinal Chemistry of Alzheimer's Disease , pp. 79-109
    • Greig, N.H.1    Yu, Q.S.2    Brossi, A.3    Matin, E.4    Lahiri, D.K.5    Darvesh, S.6
  • 154
    • 0028894072 scopus 로고
    • Phenserine and ring-C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease
    • Greig NH, Pei XF, Soncrant TT, Ingram, DK, Brossi A. Phenserine and ring-C hetero-analogues: drug candidates for the treatment of Alzheimer's disease. Med. Chem. Rev. 1995; 15: 3-31.
    • (1995) Med. Chem. Rev , vol.15 , pp. 3-31
    • Greig, N.H.1    Pei, X.F.2    Soncrant, T.T.3    Ingram, D.K.4    Brossi, A.5
  • 155
    • 0030780763 scopus 로고    scopus 로고
    • Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase
    • Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP. Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase. Biochemistry. 1997; 36: 14642-51
    • (1997) Biochemistry , vol.36 , pp. 14642-14651
    • Saxena, A.1    Redman, A.M.2    Jiang, X.3    Lockridge, O.4    Doctor, B.P.5
  • 156
    • 78751685186 scopus 로고    scopus 로고
    • Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method
    • Kitisripanya N, Saparpakorn P, Wolschann P, Hannongbua S. Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method. Nanomedicine. 2011; 7: 60-68.
    • (2011) Nanomedicine , vol.7 , pp. 60-68
    • Kitisripanya, N.1    Saparpakorn, P.2    Wolschann, P.3    Hannongbua, S.4
  • 157
    • 0033103478 scopus 로고    scopus 로고
    • Structure of acetylcholinesterase complexed with E2020 (Aricept): Implications for the design of new anti-Alzheimer drugs
    • Kryger G, Silman I, Sussman JL. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure. 1999; 7: 297-307.
    • (1999) Structure , vol.7 , pp. 297-307
    • Kryger, G.1    Silman, I.2    Sussman, J.L.3
  • 159
    • 0033587026 scopus 로고    scopus 로고
    • The synthesis of novel phenserine-based-selective inhibitors of butyrylcho- linesterase for Alzheimer's Disease
    • Yu Q, Holloway HW, Utsuki T, Brossi A, Greig NH. The synthesis of novel phenserine-based-selective inhibitors of butyrylcho- linesterase for Alzheimer's Disease. J Med Chem 1999; 42: 1855-1861.
    • (1999) J Med Chem , vol.42 , pp. 1855-1861
    • Yu, Q.1    Holloway, H.W.2    Utsuki, T.3    Brossi, A.4    Greig, N.H.5
  • 160
    • 9644259049 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives
    • Darvesh S, McDonald RS, Penwell A, Conrad S, Darvesh KV, Mataija D, et al. Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives. Bioorg. Med. Chem. 2005; 13: 211-22
    • (2005) Bioorg. Med. Chem , vol.13 , pp. 211-222
    • Darvesh, S.1    McDonald, R.S.2    Penwell, A.3    Conrad, S.4    Darvesh, K.V.5    Mataija, D.6
  • 161
    • 0035935699 scopus 로고    scopus 로고
    • Methyl analogues of the experimental Alzheimer drug, phenserine: Synthesis and structure/activity relationships for acetyl- and butyryl-cholinesterase inhibitory action
    • Yu QS., Holloway HW, Flippen-Anderson F, Hoffman B, Brossi A, Greig NH. Methyl analogues of the experimental Alzheimer drug, phenserine: synthesis and structure/activity relationships for acetyl- and butyryl-cholinesterase inhibitory action. J Med Chem. 2001; 44: 4062-4072
    • (2001) J Med Chem , vol.44 , pp. 4062-4072
    • Yu, Q.S.1    Holloway, H.W.2    Flippen-Anderson, F.3    Hoffman, B.4    Brossi, A.5    Greig, N.H.6
  • 162
    • 47749102491 scopus 로고    scopus 로고
    • Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase
    • Darvesh S, Darvesh KV, McDonald RS, et al. Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008; 51: 4200-1422.
    • (2008) J Med Chem , vol.51 , pp. 1422-4200
    • Darvesh, S.1    Darvesh, K.V.2    McDonald, R.S.3
  • 163
    • 0034574284 scopus 로고    scopus 로고
    • The experimental Alzheimer drug phenserine: Preclinical pharmacodynamics and kinetics in the rat
    • Greig NH, De Micheli E, Utsuki T, Holloway HW, Yu QS, Perry T, et al. The experimental Alzheimer drug phenserine: preclinical pharmacodynamics and kinetics in the rat Acta Neurol Scand 2000; 102: 74-84.
    • (2000) Acta Neurol Scand , vol.102 , pp. 74-84
    • Greig, N.H.1    de Micheli, E.2    Utsuki, T.3    Holloway, H.W.4    Yu, Q.S.5    Perry, T.6
  • 165
    • 22144494112 scopus 로고    scopus 로고
    • An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma G, Lahiri DK. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr. Alzheimer Res. 2005; 2: 281-91.
    • (2005) Curr. Alzheimer Res , vol.2 , pp. 281-291
    • Greig, N.H.1    Sambamurti, K.2    Yu, Q.S.3    Brossi, A.4    Bruinsma, G.5    Lahiri, D.K.6
  • 168
    • 33748751561 scopus 로고    scopus 로고
    • Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnor-cymserine
    • Kamal MA, Klein P, Yu QS, Tweedie D, Li Y, Holloway HW, Greig NH. Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnor-cymserine. J Alzheimer Dis. 2006; 10:43-51.
    • (2006) J Alzheimer Dis , vol.10 , pp. 43-51
    • Kamal, M.A.1    Klein, P.2    Yu, Q.S.3    Tweedie, D.4    Li, Y.5    Holloway, H.W.6    Greig, N.H.7
  • 169
    • 28044437122 scopus 로고    scopus 로고
    • Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer -amyloid peptide in rodent
    • Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, et al. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer -amyloid peptide in rodent. Proc. Natl. Acad. Sci. USA, 2005; 102: 17213-8.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17213-17218
    • Greig, N.H.1    Utsuki, T.2    Ingram, D.K.3    Wang, Y.4    Pepeu, G.5    Scali, C.6
  • 170
    • 33846981174 scopus 로고    scopus 로고
    • Excessive levels of hippocampal acetylcholine in acetyl- cholinesterase-knockout mice are moderated by butyrylcho- linesterase activity
    • Hartmann J, Kiewert C, Duysen EG, Lockridge O, Greig NH, Klein J. Excessive levels of hippocampal acetylcholine in acetyl- cholinesterase-knockout mice are moderated by butyrylcho- linesterase activity. J. Neurochem. 2007; 100: 1421-8.
    • (2007) J. Neurochem , vol.100 , pp. 1421-1428
    • Hartmann, J.1    Kiewert, C.2    Duysen, E.G.3    Lockridge, O.4    Greig, N.H.5    Klein, J.6
  • 171
    • 70349319533 scopus 로고    scopus 로고
    • Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice
    • Naik RS, Hartmann J, Kiewert C, Duysen EG, Lockridge O, Klein J. Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. J Pharm Pharm Sci. 2009; 12: 79-85.
    • (2009) J Pharm Pharm Sci , vol.12 , pp. 79-85
    • Naik, R.S.1    Hartmann, J.2    Kiewert, C.3    Duysen, E.G.4    Lockridge, O.5    Klein, J.6
  • 172
    • 34548779802 scopus 로고    scopus 로고
    • N1-phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: A comparison with donepezil and rivastigmine
    • Cerbai F, Giovannini MG, Melani C, Enz A, Pepeu G. N1-phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. Eur J Pharmacol. 2007; 572: 142-150.
    • (2007) Eur J Pharmacol , vol.572 , pp. 142-150
    • Cerbai, F.1    Giovannini, M.G.2    Melani, C.3    Enz, A.4    Pepeu, G.5
  • 173
    • 0031443044 scopus 로고    scopus 로고
    • Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats
    • Scali C, Giovannini MG, Prosperi C, Bartolini L, Pepeu G. Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats. Pharmacol Res. 1997; 36: 463-469.
    • (1997) Pharmacol Res , vol.36 , pp. 463-469
    • Scali, C.1    Giovannini, M.G.2    Prosperi, C.3    Bartolini, L.4    Pepeu, G.5
  • 174
    • 0030917597 scopus 로고    scopus 로고
    • Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats
    • Scali C, Giovannini MG, Bartolini L, Prosperi C, Hinz V, Schmidt B, et al. Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats. Eur J Pharmacol. 1997; 325: 173-180.
    • (1997) Eur J Pharmacol , vol.325 , pp. 173-180
    • Scali, C.1    Giovannini, M.G.2    Bartolini, L.3    Prosperi, C.4    Hinz, V.5    Schmidt, B.6
  • 175
    • 0028341720 scopus 로고
    • Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo
    • Cuadra G, Summers K, Giacobini E. Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. J Pharmacol Exp Ther. 1994; 270: 277-84.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 277-284
    • Cuadra, G.1    Summers, K.2    Giacobini, E.3
  • 176
    • 84864628610 scopus 로고    scopus 로고
    • The impact of acetyl- cholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: A meta-analysis
    • Noori HR, Fliegel S, Brand I, Spanagel R. The impact of acetyl- cholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse. 2012; 66: 893-901.
    • (2012) Synapse , vol.66 , pp. 893-901
    • Noori, H.R.1    Fliegel, S.2    Brand, I.3    Spanagel, R.4
  • 177
    • 85027938555 scopus 로고    scopus 로고
    • Role of acetylcholinesterase on the structure and function of cholinergic synapses: Insights gained from studies on knockout mice
    • Adler M, Sweeney RE, Hamilton TA, Lockridge O, Duysen EG, Purcell AL, et al. Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. Cell Mol Neurobiol. 2011; 31: 909-20.
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 909-920
    • Adler, M.1    Sweeney, R.E.2    Hamilton, T.A.3    Lockridge, O.4    Duysen, E.G.5    Purcell, A.L.6
  • 178
    • 77955511755 scopus 로고    scopus 로고
    • Contributions of selective knockout studies to understanding cholinesterase disposition and function
    • Camp S, Zhang L, Krejci E, Dobbertin A, Bernard V, Girard E, et al. Contributions of selective knockout studies to understanding cholinesterase disposition and function. Chem Biol Interact. 2010; 187: 72-77.
    • (2010) Chem Biol Interact , vol.187 , pp. 72-77
    • Camp, S.1    Zhang, L.2    Krejci, E.3    Dobbertin, A.4    Bernard, V.5    Girard, E.6
  • 179
    • 30344485665 scopus 로고    scopus 로고
    • Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    • Lane RM, Potkin SG, Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int J Neuropsychopharmacol. 2006; 9: 101-24.
    • (2006) Int J Neuropsychopharmacol , vol.9 , pp. 101-124
    • Lane, R.M.1    Potkin, S.G.2    Enz, A.3
  • 180
    • 67349247652 scopus 로고    scopus 로고
    • Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and sup- presses NMDA currents in hippocampus slices
    • Wang Y, Greig NH, Yu QS, Mattson MP. Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and sup- presses NMDA currents in hippocampus slices. Neurobiol Aging. 2009; 30: 1061-8.
    • (2009) Neurobiol Aging , vol.30 , pp. 1061-1068
    • Wang, Y.1    Greig, N.H.2    Yu, Q.S.3    Mattson, M.P.4
  • 181
    • 84864676984 scopus 로고    scopus 로고
    • Donepezil in a narrow concentration range augments control and impaired by beta-amyloid peptide hippocampal LTP in NMDAR-independent manner
    • Kapai NA, Bukanova JV, Solntseva EI, Skrebitsky VG. Donepezil in a narrow concentration range augments control and impaired by beta-amyloid peptide hippocampal LTP in NMDAR-independent manner. Cell Mol Neurobiol. 2012; 32: 219-226.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 219-226
    • Kapai, N.A.1    Bukanova, J.V.2    Solntseva, E.I.3    Skrebitsky, V.G.4
  • 182
    • 0032742810 scopus 로고    scopus 로고
    • Toward a Molecular Explanation for Long-Term Potentiation
    • Sweatt JD. Toward a Molecular Explanation for Long-Term Potentiation. Learn. Mem. 1999; 6: 399-416.
    • (1999) Learn. Mem , vol.6 , pp. 399-416
    • Sweatt, J.D.1
  • 183
    • 0028300482 scopus 로고
    • New pharmacological strategies for cognitive enhancement using a rat model of age-related memory impairment
    • Ingram DK, Spangler EL, Iijima S, Kuo H, Bresnahan EL, Greig NH, et al. New pharmacological strategies for cognitive enhancement using a rat model of age-related memory impairment. Ann N Y Acad Sci. 1994; 717: 16-32
    • (1994) Ann N Y Acad Sci , vol.717 , pp. 16-32
    • Ingram, D.K.1    Spangler, E.L.2    Iijima, S.3    Kuo, H.4    Bresnahan, E.L.5    Greig, N.H.6
  • 185
  • 187
    • 84882439202 scopus 로고    scopus 로고
    • US5602176
    • Enz A. US5602176 (1997).
    • (1997)
    • Enz, A.1
  • 192
    • 29844444718 scopus 로고    scopus 로고
    • Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease
    • Martinez A, Castro A. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease. Expert Opin Investig Drugs. 2006; 15: 1-12.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 1-12
    • Martinez, A.1    Castro, A.2
  • 193
    • 79955671904 scopus 로고    scopus 로고
    • Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases
    • Kawamata J, Shimohama S. Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases. J Alzheimers Dis. 2011; 24 Suppl 2: 95-109.
    • (2011) J Alzheimers Dis , vol.24 , Issue.SUPPL. 2 , pp. 95-109
    • Kawamata, J.1    Shimohama, S.2
  • 194
    • 33748094425 scopus 로고    scopus 로고
    • Preclinical evidence of neuroprotection by cholinesterase inhibitors
    • Akaike A. Preclinical evidence of neuroprotection by cholinesterase
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , Issue.2 SUPPL. 1 , pp. 8-11
    • Akaike, A.1
  • 196
    • 77954471982 scopus 로고    scopus 로고
    • Early stages of pathogenesis in memory impairment during normal senescence and Alzheimer's disease
    • Daulatzai MA. Early stages of pathogenesis in memory impairment during normal senescence and Alzheimer's disease. J Alzheimers Dis. 2010; 20: 355-67.
    • (2010) J Alzheimers Dis , vol.20 , pp. 355-367
    • Daulatzai, M.A.1
  • 198
    • 0036370776 scopus 로고    scopus 로고
    • Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
    • Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med. 2002; 1: 1-31.
    • (2002) Neuromolecular Med , vol.1 , pp. 1-31
    • Sambamurti, K.1    Greig, N.H.2    Lahiri, D.K.3
  • 200
    • 84655176404 scopus 로고    scopus 로고
    • Functions of A, sAPP and sAPP: Similarities and differences
    • Chasseigneaux S, Allinquant B. Functions of A, sAPP and sAPP: similarities and differences. J Neurochem. 2012; 120 S1:99-108.
    • (2012) J Neurochem , vol.120 , Issue.S1 , pp. 99-108
    • Chasseigneaux, S.1    Allinquant, B.2
  • 201
    • 33846076665 scopus 로고    scopus 로고
    • The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30
    • Youdim MB. The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30. Curr Alzheimer Res. 2006; 3: 541-50.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 541-550
    • Youdim, M.B.1
  • 202
    • 84857709982 scopus 로고    scopus 로고
    • Ladostigil: A novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment
    • Weinreb O, Amit T, Bar-Am O, Youdim MB. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012; 13: 483-94.
    • (2012) Curr Drug Targets , vol.13 , pp. 483-494
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 203
    • 57749094960 scopus 로고    scopus 로고
    • Novel anti-Alzheimer's dimer Bis(7)-cognitin: Cellular and molecular mechanisms of neuroprotection through multiple targets
    • Li W, Mak M, Jiang H, Wang Q, Pang Y, Chen K, et al. Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. Neurotherapeutics. 2009; 6: 187-201.
    • (2009) Neurotherapeutics , vol.6 , pp. 187-201
    • Li, W.1    Mak, M.2    Jiang, H.3    Wang, Q.4    Pang, Y.5    Chen, K.6
  • 204
    • 84863144997 scopus 로고    scopus 로고
    • Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid- - mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo
    • Pi R, Mao X, Chao X, Cheng Z, Liu M, Duan X, et al. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid- - mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS One. 2012; 7(2):e31921.
    • (2012) PLoS One , vol.7 , Issue.2
    • Pi, R.1    Mao, X.2    Chao, X.3    Cheng, Z.4    Liu, M.5    Duan, X.6
  • 205
    • 33845905829 scopus 로고    scopus 로고
    • The experimental Alzheimer's disease drug posiphen [(+)- phenserine] lowers amyloid-beta peptide levels in cell culture and mice
    • Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, et al. The experimental Alzheimer's disease drug posiphen [(+)- phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther. 2007; 320: 386-396.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 386-396
    • Lahiri, D.K.1    Chen, D.2    Maloney, B.3    Holloway, H.W.4    Yu, Q.S.5    Utsuki, T.6
  • 206
    • 0030986003 scopus 로고    scopus 로고
    • Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
    • Haroutunian V, Greig NH, Pei XF, Utsuki T, Gluck R, Acevedo LD, et al. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res Mol Brain Res. 1997; 46: 161-168.
    • (1997) Brain Res Mol Brain Res , vol.46 , pp. 161-168
    • Haroutunian, V.1    Greig, N.H.2    Pei, X.F.3    Utsuki, T.4    Gluck, R.5    Acevedo, L.D.6
  • 207
    • 34547615593 scopus 로고    scopus 로고
    • Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine
    • Marutle A, Ohmitsu M, Nilbratt M, Greig NH, Nordberg A, Sugaya K. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine. Proc Natl Acad Sci U S A. 2007; 104: 12506-12511.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12506-12511
    • Marutle, A.1    Ohmitsu, M.2    Nilbratt, M.3    Greig, N.H.4    Nordberg, A.5    Sugaya, K.6
  • 208
    • 84864803418 scopus 로고    scopus 로고
    • Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-peptide and levels: Target engagement, tolerability and pharmacokinetics in humans
    • Maccecchini ML, Chang MY, Pan C, John V, Zetterberg H, Greig NH. Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-peptide and levels: target engagement, tolerability and pharmacokinetics in humans. J Neurol Neurosurg Psychiatry. 2012; 83: 894-902.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 894-902
    • Maccecchini, M.L.1    Chang, M.Y.2    Pan, C.3    John, V.4    Zetterberg, H.5    Greig, N.H.6
  • 209
    • 0035912825 scopus 로고    scopus 로고
    • Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
    • Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, et al. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci 2001; 98: 7605-7610.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 7605-7610
    • Shaw, K.T.1    Utsuki, T.2    Rogers, J.3    Yu, Q.S.4    Sambamurti, K.5    Brossi, A.6
  • 210
    • 84862290233 scopus 로고    scopus 로고
    • The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression
    • Mikkilineni S, Cantuti-Castelvetri I, Cahill CM, Balliedier A, Greig NH, Rogers JT. The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. Parkinsons Dis. 2012; 2012: 142372.
    • Parkinsons Dis , vol.2012 , pp. 2012
    • Mikkilineni, S.1    Cantuti-Castelvetri, I.2    Cahill, C.M.3    Balliedier, A.4    Greig, N.H.5    Rogers, J.T.6
  • 215
    • 1342302338 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptor knockout mice: Novel phenotypes and clinical implications
    • Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Ann Rev Pharmacol Toxicol 2004; 44:423-450.
    • (2004) Ann Rev Pharmacol Toxicol , vol.44 , pp. 423-450
    • Wess, J.1
  • 218
    • 84875226386 scopus 로고    scopus 로고
    • Design of new drugs for the treatment of Alzheimer's disease based on tacrine structure
    • De Aquino RAN, Modolo LV, alves RB, de Fatima A. Design of new drugs for the treatment of Alzheimer's disease based on tacrine structure. Curr Drug Targets 2013; 14: 1-20.
    • (2013) Curr Drug Targets , vol.14 , pp. 1-20
    • de Aquino, R.A.N.1    Modolo, L.V.2    Alves, R.B.3    de Fatima, A.4


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