메뉴 건너뛰기




Volumn 46, Issue 1-2, 1997, Pages 161-168

Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions

Author keywords

Acetylcholine; Acetylcholinesterase; Acetylcholinesterase inhibitor; Alzheimer's disease; Amyloid protein; Amyloid protein, precursor; Basal nucleus of Meynert; Butyrylcholinesterase; Cerebral cortex; Cerebrospinal fluid; DFP; In vivo; Phenserine; Rat; Receptor, muscarinic

Indexed keywords

AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; DYFLOS; PROTEIN PRECURSOR; SCOPOLAMINE;

EID: 0030986003     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00297-5     Document Type: Article
Times cited : (80)

References (59)
  • 2
    • 0026545684 scopus 로고
    • An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence
    • Anderson, J.P., Chen, Y., Kim, K.S. and Robakis, N.K., An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence, J. Neurochem., 59 (1992) 2328-2331.
    • (1992) J. Neurochem. , vol.59 , pp. 2328-2331
    • Anderson, J.P.1    Chen, Y.2    Kim, K.S.3    Robakis, N.K.4
  • 3
    • 0028345162 scopus 로고
    • Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain
    • Beeson, J., Shelton, E., Chan, H. and Gage, F., Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain, Comp. Neurol., 342 (1994) 69-77.
    • (1994) Comp. Neurol. , vol.342 , pp. 69-77
    • Beeson, J.1    Shelton, E.2    Chan, H.3    Gage, F.4
  • 4
    • 0023701581 scopus 로고
    • Long-term outpatient treatment of senile dementia with oral physostigmine
    • Beller, S.A., Overall, J.E., Rhoades, H.M. and Swann, A.C., Long-term outpatient treatment of senile dementia with oral physostigmine, J. Clin. Psychiatry, 49 (1988) 400-404.
    • (1988) J. Clin. Psychiatry , vol.49 , pp. 400-404
    • Beller, S.A.1    Overall, J.E.2    Rhoades, H.M.3    Swann, A.C.4
  • 6
    • 0019957211 scopus 로고
    • Effects of antimuscarinic cholinergic drugs injected systemically or into the hippocampo-entorhinal area upon passive avoidance learning in young rats
    • Blozovski, D. and Hennocq, N., Effects of antimuscarinic cholinergic drugs injected systemically or into the hippocampo-entorhinal area upon passive avoidance learning in young rats, Psychopharmacology, 76 (1982) 351-358.
    • (1982) Psychopharmacology , vol.76 , pp. 351-358
    • Blozovski, D.1    Hennocq, N.2
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72 (1976) 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0000549714 scopus 로고
    • Selective inhibition of acetyl- And butyrylcholinesterases by phenylcarbamates of (-)-eseroline, (-)-(N1)-noreseroline and physovenol
    • Brzostowska, M., He, X.S., Greig, N.H., Rapaport, S. and Brossi, A., Selective inhibition of acetyl- and butyrylcholinesterases by phenylcarbamates of (-)-eseroline, (-)-(N1)-noreseroline and physovenol, Med. Chem. Res., 2 (1992) 238-246.
    • (1992) Med. Chem. Res. , vol.2 , pp. 238-246
    • Brzostowska, M.1    He, X.S.2    Greig, N.H.3    Rapaport, S.4    Brossi, A.5
  • 9
    • 0026448114 scopus 로고
    • Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer B/A4 amyloid protein precursor
    • Buxbaum, J., Oishi, M., Chen, H., Pinkas-Kramarski, R., Jaffe, E., Gandy, S. and Greengard, P., Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer B/A4 amyloid protein precursor, Proc. Natl. Acad. Sci. USA, 89 (1992) 10075-10078.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10075-10078
    • Buxbaum, J.1    Oishi, M.2    Chen, H.3    Pinkas-Kramarski, R.4    Jaffe, E.5    Gandy, S.6    Greengard, P.7
  • 11
    • 0015338776 scopus 로고
    • Effect of central stimulants and depressants on mouse brain acetylcholine and choline levels
    • Consolo, S., Ladinsky, H., Peri, G. and Garattini, S., Effect of central stimulants and depressants on mouse brain acetylcholine and choline levels, Eur. J. Pharmacol., 18 (1972) 251-255.
    • (1972) Eur. J. Pharmacol. , vol.18 , pp. 251-255
    • Consolo, S.1    Ladinsky, H.2    Peri, G.3    Garattini, S.4
  • 12
    • 0028947791 scopus 로고
    • Alzheimer's disease: Tacrine and tacrine metabolite concentrations in plasma and cognitive change
    • Davis, K., Yang, R., Davidson, M., Mohs, R., Ryan, T., Schmeidler, J., Knott, P., Thal, L. and Gamzu, E., Tacrine Collaborative Study Group, Alzheimer's disease: tacrine and tacrine metabolite concentrations in plasma and cognitive change, Drug Dev. Res., 34 (1995) 55-65.
    • (1995) Drug Dev. Res. , vol.34 , pp. 55-65
    • Davis, K.1    Yang, R.2    Davidson, M.3    Mohs, R.4    Ryan, T.5    Schmeidler, J.6    Knott, P.7    Thal, L.8    Gamzu, E.9
  • 13
    • 0343322335 scopus 로고
    • Strategies for the treatment of multi-neurotransmitter deficits in Alzheimer's disease
    • In Z.S. Khachaturian and J.P. Blass (Eds.), Marcel Dekker, New York, NY
    • Davis, K.L. and Haroutunian, V., Strategies for the treatment of multi-neurotransmitter deficits in Alzheimer's disease. In Z.S. Khachaturian and J.P. Blass (Eds.), Alzheimer's Disease: New Treatment Strategies, Marcel Dekker, New York, NY, 1992, pp. 23-36.
    • (1992) Alzheimer's Disease: New Treatment Strategies , pp. 23-36
    • Davis, K.L.1    Haroutunian, V.2
  • 15
    • 0025825073 scopus 로고
    • The role of cholinergic projections from the nucleus basalis in memory
    • Dekker, A.J., Connor, D.J. and Thal, L.J., The role of cholinergic projections from the nucleus basalis in memory, Neurosci. Biobehav. Rev. 15 (1991) 299-317.
    • (1991) Neurosci. Biobehav. Rev. , vol.15 , pp. 299-317
    • Dekker, A.J.1    Connor, D.J.2    Thal, L.J.3
  • 16
    • 0026440987 scopus 로고
    • Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group
    • DeKosky, S.T., Harbaugh, R.E., Schmitt, F.A., Bakay, R.A., Chui, H.C., Knopman, D.S., Reeder, T.M., Shetter, A.G., Senter, H.J. and Markesbery, W.R., Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group, Ann. Neurol., 32 (1992) 625-632.
    • (1992) Ann. Neurol. , vol.32 , pp. 625-632
    • DeKosky, S.T.1    Harbaugh, R.E.2    Schmitt, F.A.3    Bakay, R.A.4    Chui, H.C.5    Knopman, D.S.6    Reeder, T.M.7    Shetter, A.G.8    Senter, H.J.9    Markesbery, W.R.10
  • 18
    • 0028971033 scopus 로고
    • Regulated secretion of β-amyloid precursor protein in rat brain
    • Farber, S., Nitsch, R., Schulz, J. and Wurtman, R., Regulated secretion of β-amyloid precursor protein in rat brain, J. Neurosci., 15 (1995) 7442-7451.
    • (1995) J. Neurosci. , vol.15 , pp. 7442-7451
    • Farber, S.1    Nitsch, R.2    Schulz, J.3    Wurtman, R.4
  • 19
    • 0028491536 scopus 로고
    • Therapy for Alzheimer's disease. Symptomatic or neuroprotective?
    • Giacobini, E., Therapy for Alzheimer's disease. Symptomatic or neuroprotective?, Mol. Neurobiol., 9 (1994) 115-118.
    • (1994) Mol. Neurobiol. , vol.9 , pp. 115-118
    • Giacobini, E.1
  • 20
    • 0016138658 scopus 로고
    • Effects of dIIsopropyl phosphorofluoridate on acetylcholine, cholinesterase and catecholamines of several parts of rabbit brain
    • Glisson, S., Karczmar, A. and Barnes, L., Effects of dIIsopropyl phosphorofluoridate on acetylcholine, cholinesterase and catecholamines of several parts of rabbit brain, Neuropharmacology, 13 (1974) 623-631.
    • (1974) Neuropharmacology , vol.13 , pp. 623-631
    • Glisson, S.1    Karczmar, A.2    Barnes, L.3
  • 22
    • 0029078203 scopus 로고
    • Nicotinic and muscarinic receptors in the rat prefrontal cortex: Differential roles in working memory, response selection and effortful processing
    • Granon, S., Poucet, B., Thinus-Blanc, C., Changeux, J. and Vidal, C., Nicotinic and muscarinic receptors in the rat prefrontal cortex: differential roles in working memory, response selection and effortful processing, Psychopharmacology, 119 (1995) 139-144.
    • (1995) Psychopharmacology , vol.119 , pp. 139-144
    • Granon, S.1    Poucet, B.2    Thinus-Blanc, C.3    Changeux, J.4    Vidal, C.5
  • 23
    • 0024472078 scopus 로고
    • Muscarinic agonists for senile dementia: Past experience and future trends
    • Gray, J., Enz, A. and Spiegel, R., Muscarinic agonists for senile dementia: past experience and future trends, TiPS, (1989) 85-88.
    • (1989) TiPS , pp. 85-88
    • Gray, J.1    Enz, A.2    Spiegel, R.3
  • 24
    • 0028894072 scopus 로고
    • Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease
    • Greig, N.H., Pei, X.-F., Soncrant, T.T., Ingram, D.K. and Brossi, A., Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease, Med. Res. Rev., 15 (1995) 3-31.
    • (1995) Med. Res. Rev. , vol.15 , pp. 3-31
    • Greig, N.H.1    Pei, X.-F.2    Soncrant, T.T.3    Ingram, D.K.4    Brossi, A.5
  • 25
    • 84961027135 scopus 로고
    • Effects in man of the anticholinesterase compound sarin (isopropyl methyl phosphonofluoridate)
    • Grob, D. and Harvey, J.C., Effects in man of the anticholinesterase compound sarin (isopropyl methyl phosphonofluoridate), J. Clin. Invest., 37 (1958) 350-368.
    • (1958) J. Clin. Invest. , vol.37 , pp. 350-368
    • Grob, D.1    Harvey, J.C.2
  • 26
    • 0027725881 scopus 로고
    • Mechanism of action of cholinesterase inhibitors in Alzheimer's disease
    • Hakansson, L., Mechanism of action of cholinesterase inhibitors in Alzheimer's disease, Acta Neurol. Scand. Suppl., 149 (1993) 7-9.
    • (1993) Acta Neurol. Scand. Suppl. , vol.149 , pp. 7-9
    • Hakansson, L.1
  • 27
    • 0021815426 scopus 로고
    • Pharmacological alleviation of cholinergic lesions induced memory deficits in rats
    • Haroutunian, V., Kanof, P. and Davis, K.L., Pharmacological alleviation of cholinergic lesions induced memory deficits in rats, Life Sci., 37 (1985) 945-952.
    • (1985) Life Sci. , vol.37 , pp. 945-952
    • Haroutunian, V.1    Kanof, P.2    Davis, K.L.3
  • 28
    • 0023121160 scopus 로고
    • Cysteamine-induced depletion of central somatostatin-like immunoactivity: Effects on behavior, learning, memory and brain neurochemistry
    • Haroutunian, V., Mantin, R., Campbell, G.A., Tsuboyama, D.K. and Davis, K.L., Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry, Brain Res., 403 (1987) 234-242.
    • (1987) Brain Res. , vol.403 , pp. 234-242
    • Haroutunian, V.1    Mantin, R.2    Campbell, G.A.3    Tsuboyama, D.K.4    Davis, K.L.5
  • 30
    • 0020071497 scopus 로고
    • A review of atropinic drug effects on exploratory choice behavior in laboratory rodents
    • Hughes, R., A review of atropinic drug effects on exploratory choice behavior in laboratory rodents, Behav. Neural Biol., 34 (1982) 5-41.
    • (1982) Behav. Neural Biol. , vol.34 , pp. 5-41
    • Hughes, R.1
  • 31
    • 0026774392 scopus 로고
    • The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze
    • Iijima, S., Greig, N.H., Garofalo, P., Spangler, E.L., Heller, B., Brossi, A. and Ingram, D.K., The long-acting cholinesterase inhibitor heptyl-physostigmine attenuates the scopolamine-induced learning impairment of rats in a 14-unit T-maze, Neurosci. Lett., 144 (1992) 79-83.
    • (1992) Neurosci. Lett. , vol.144 , pp. 79-83
    • Iijima, S.1    Greig, N.H.2    Garofalo, P.3    Spangler, E.L.4    Heller, B.5    Brossi, A.6    Ingram, D.K.7
  • 32
    • 0027367122 scopus 로고
    • Phenserine: A physostigmine derivative that is a long-acting inhibitor of acetylcholinesterase and demonstrates a wide dose-range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze
    • Iijima, S., Greig, N.H., Garofalo, P., Spangler, E.L., Heller, B., Brossi, A. and Ingram, D.K., Phenserine: a physostigmine derivative that is a long-acting inhibitor of acetylcholinesterase and demonstrates a wide dose-range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze, Psychopharmacology, 112 (1993) 415-420.
    • (1993) Psychopharmacology , vol.112 , pp. 415-420
    • Iijima, S.1    Greig, N.H.2    Garofalo, P.3    Spangler, E.L.4    Heller, B.5    Brossi, A.6    Ingram, D.K.7
  • 33
    • 0028894038 scopus 로고
    • Performance of aged rats in a 14-unit T-maze is improved following chronic treatment with phenserine, a novel long-acting anticholinesterase
    • Ikari, H., Spangler, E.L., Greig, N.H., Pei, X.-F., Brossi, A., Speer, D., Patel, N. and Ingram, D.K., Performance of aged rats in a 14-unit T-maze is improved following chronic treatment with phenserine, a novel long-acting anticholinesterase, NeuroReport, 6 (1995) 481-484.
    • (1995) NeuroReport , vol.6 , pp. 481-484
    • Ikari, H.1    Spangler, E.L.2    Greig, N.H.3    Pei, X.-F.4    Brossi, A.5    Speer, D.6    Patel, N.7    Ingram, D.K.8
  • 34
    • 0016654358 scopus 로고
    • A rapid, simple radiometric assay for acetylcholinesterase, suitable for multiple determinations
    • Johnson, C.D. and Russell, R.L., A rapid, simple radiometric assay for acetylcholinesterase, suitable for multiple determinations, Anal. Biochem., 64 (1975) 229-232.
    • (1975) Anal. Biochem. , vol.64 , pp. 229-232
    • Johnson, C.D.1    Russell, R.L.2
  • 35
    • 0027984447 scopus 로고
    • Reversibility of the effect of tacrine on the secretion of the β-amyloid precursor protein in cultured cells
    • Lahiri, D., Reversibility of the effect of tacrine on the secretion of the β-amyloid precursor protein in cultured cells, Neurosci. Lett., 181 (1994) 149-142.
    • (1994) Neurosci. Lett. , vol.181 , pp. 149-1142
    • Lahiri, D.1
  • 36
    • 0028197477 scopus 로고
    • Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines
    • Lahiri, D., Lewis, S. and Farlow, M., Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines, J. Neurosci. Res., 37 (1994) 777-787.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 777-787
    • Lahiri, D.1    Lewis, S.2    Farlow, M.3
  • 37
    • 0027059023 scopus 로고
    • The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells
    • Lahiri, D.K., Nall, C. and Farlow, M.R., The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells, Biochem. Int., 28 (1992) 853-860.
    • (1992) Biochem. Int. , vol.28 , pp. 853-860
    • Lahiri, D.K.1    Nall, C.2    Farlow, M.R.3
  • 38
    • 0027281533 scopus 로고
    • Organophosphate poisoning
    • Marrs, T., Organophosphate poisoning, Pharmacol. Ther., 58 (1993) 51-66.
    • (1993) Pharmacol. Ther. , vol.58 , pp. 51-66
    • Marrs, T.1
  • 42
    • 0021956441 scopus 로고
    • Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine
    • Murray, C.L. and Fibiger, H.C., Learning and memory deficits after lesions of the nucleus basalis magnocellularis: reversal by physostigmine, Neuroscience, 19 (1985) 1025-1032.
    • (1985) Neuroscience , vol.19 , pp. 1025-1032
    • Murray, C.L.1    Fibiger, H.C.2
  • 43
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • Nitsch, R.M., Slack, B.E., Wurtman, R.J. and Growdon, J.H., Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors, Science, 258 (1992) 304-307.
    • (1992) Science , vol.258 , pp. 304-307
    • Nitsch, R.M.1    Slack, B.E.2    Wurtman, R.J.3    Growdon, J.H.4
  • 44
    • 0025027376 scopus 로고
    • Dementia: Animal models of the cognitive impairments following damage to the basal forebrain cholinergic system
    • Olton, D.S., Dementia: animal models of the cognitive impairments following damage to the basal forebrain cholinergic system, Brain Res. Bull., 25 (1990) 499-502.
    • (1990) Brain Res. Bull. , vol.25 , pp. 499-502
    • Olton, D.S.1
  • 46
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H. and Perry, R.H., Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Br. Med. J., 2 (1978) 1457-1459.
    • (1978) Br. Med. J. , vol.2 , pp. 1457-1459
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3    Bergmann, K.4    Gibson, P.H.5    Perry, R.H.6
  • 47
    • 0022473115 scopus 로고
    • Learning impairment following lesions of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs
    • Ridley, R.M., Murray, T.K., Johnson, J.A. and Baker, H.F., Learning impairment following lesions of the basal nucleus of Meynert in the marmoset: modification by cholinergic drugs, Brain Res., 376 (1986) 108-116.
    • (1986) Brain Res. , vol.376 , pp. 108-116
    • Ridley, R.M.1    Murray, T.K.2    Johnson, J.A.3    Baker, H.F.4
  • 48
    • 0024793416 scopus 로고
    • Therapeutics of Alzheimer's disease for clinical and pre-clinical issues
    • K. Iqbal, H.M. Wisniewski and B. Winblad (Eds.), Alan R. Liss, New York, NY
    • Santucci, A.C., Haroutunian, V., Tsuboyama, G.K., Kanof, P.D. and Davis, K.L., Therapeutics of Alzheimer's disease for clinical and pre-clinical issues. In K. Iqbal, H.M. Wisniewski and B. Winblad (Eds.), Progress in Clinical and Biological Research, Alan R. Liss, New York, NY, 1989, pp. 1111-1120.
    • (1989) Progress in Clinical and Biological Research , pp. 1111-1120
    • Santucci, A.C.1    Haroutunian, V.2    Tsuboyama, G.K.3    Kanof, P.D.4    Davis, K.L.5
  • 49
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the β-amyloid precursor protein
    • Selkoe, D.J., Normal and abnormal biology of the β-amyloid precursor protein, Annu. Rev. Neurosci., 17 (1994) 489-517.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 50
    • 0022654027 scopus 로고
    • Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease
    • Selkoe, D.J., Abraham, C.R., Podlisny, M.B. and Duffy, L.K., Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease, J. Neurochem., 146 (1986) 1820-1834.
    • (1986) J. Neurochem. , vol.146 , pp. 1820-1834
    • Selkoe, D.J.1    Abraham, C.R.2    Podlisny, M.B.3    Duffy, L.K.4
  • 51
    • 0343758322 scopus 로고
    • Does chronic oral physostigmine alter the course of Alzheimer's disease?
    • B. Corain, K. Iqbal, M. Nicolini, B. Winblad, H. Wisnieski and P. Zatta (Eds.), John Wiley & Sons, New York, NY
    • Storey, P.L., Harrell, L.E., Duke, L.W., Callaway, R. and Marson, D.C., Does chronic oral physostigmine alter the course of Alzheimer's disease? In B. Corain, K. Iqbal, M. Nicolini, B. Winblad, H. Wisnieski and P. Zatta (Eds.), Alzheimer's Disease: Advances in Clinical and Brain Research, John Wiley & Sons, New York, NY, 1993, pp. 563-568.
    • (1993) Alzheimer's Disease: Advances in Clinical and Brain Research , pp. 563-568
    • Storey, P.L.1    Harrell, L.E.2    Duke, L.W.3    Callaway, R.4    Marson, D.C.5
  • 52
    • 0024561304 scopus 로고
    • Chronic oral physostigmine without lecethin improves memory in Alzheimer's disease
    • Thal, L.J., Masur, D.M., Blau, A.D., Fuld, P.A. and Klaiber, M.R., Chronic oral physostigmine without lecethin improves memory in Alzheimer's disease, J. Am. Geriatr. Soc., 37 (1989) 42-48.
    • (1989) J. Am. Geriatr. Soc. , vol.37 , pp. 42-48
    • Thal, L.J.1    Masur, D.M.2    Blau, A.D.3    Fuld, P.A.4    Klaiber, M.R.5
  • 53
    • 0024402763 scopus 로고
    • Muscarinic receptor plasticity in rats lesioned in the nucleus basalis of Meynert
    • Vige, X. and Briley, M., Muscarinic receptor plasticity in rats lesioned in the nucleus basalis of Meynert, Neuropharmacology, 28 (1989) 727-732.
    • (1989) Neuropharmacology , vol.28 , pp. 727-732
    • Vige, X.1    Briley, M.2
  • 56
    • 0029013955 scopus 로고
    • Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats
    • Wallace, W., Lieberburg, I., Schenk, D., Vigo-Pelfrey, C., Davis, K. and Haroutunian, V., Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats, J. Neurosci., 15 (1995) 4896-4905.
    • (1995) J. Neurosci. , vol.15 , pp. 4896-4905
    • Wallace, W.1    Lieberburg, I.2    Schenk, D.3    Vigo-Pelfrey, C.4    Davis, K.5    Haroutunian, V.6
  • 58
    • 0002893850 scopus 로고
    • Atropine, scopolamine, and related antimuscarinic drugs
    • A. Goodman Gilman, L.S. Goodman, T.W. Rall and F. Murad (Eds.), Macmillan, New York, NY
    • Weiner, N., Atropine, scopolamine, and related antimuscarinic drugs. In A. Goodman Gilman, L.S. Goodman, T.W. Rall and F. Murad (Eds.), The Pharmacological Basis of Therapeutics, Macmillan, New York, NY, 1985, pp. 130-144.
    • (1985) The Pharmacological Basis of Therapeutics , pp. 130-144
    • Weiner, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.