Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice

Brain Research

Volumn 859, Issue 1, 2000, Pages 38-44

  Honda, Kenji ^a   Harada, Akitsugu ^a   Takano, Yukio ^a   Kamiya, Hiro O ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Acetylcholine content; Formalin induced nociception; M3 muscarinic receptor; Spinal cord

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINE; ATROPINE; FORMALDEHYDE; HEMICHOLINIUM 3; MUSCARINIC M3 RECEPTOR; NALOXONE; NEOSTIGMINE; OTENZEPAD; PIRENZEPINE; RECEPTOR SUBTYPE; 4 DIPHENYLACETOXY 1,1 DIMETHYLPIPERIDINIUM; 4-DIPHENYLACETOXY-1,1-DIMETHYLPIPERIDINIUM; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NARCOTIC ANTAGONIST; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; ANIMAL; CHEMICALLY INDUCED DISORDER; CYTOLOGY; METABOLISM; MOUSE STRAIN; NOCICEPTIVE RECEPTOR; PAIN; PAIN ASSESSMENT;

ACETYLCHOLINE; ANIMALS; ATROPINE; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; FORMALDEHYDE; HEMICHOLINIUM 3; MALE; MICE; MICE, INBRED STRAINS; MUSCARINIC ANTAGONISTS; NALOXONE; NARCOTIC ANTAGONISTS; NEOSTIGMINE; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PIPERIDINES; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; SPINAL CORD;

EID: 0034677592     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02456-7     Document Type: Article

References (39)

1. R.P. Baber, P.E. Phelps, C.R. Houser, G.D. Grawford, P.M. Salvaterra, J.E. Vaughn, The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study, J. Comp. Neurol. 229 (1984) 329-346.
2. A. Bartolini, C. Ghelardini, L. Fantetti, M. Malcangio, P. Malmberg-Aiello, A. Giotti, Role of muscarinic receptor subtypes in central anti-nociception, Br. J. Pharmacol. 105 (1992) 77-82.
3. J.H. Beown, J.W. Kissel, P.M. Lish, Studies on the acute inflammatory response: I. Involvement of the central nervous system in certain models of inflammation, J. Pharmacol. Exp. Ther. 160 (1968) 231-242.
4. N.J.M. Birdsall, A.S.V. Burgen, R. Hummer, E.C. Hulme, J. Stockon, Pirenzepine a ligand with original binding properties to muscarinic receptors, Scand. J. Gastroenterol. Suppl. 15 (1980) 1-4.
5. H. Bouaziz, C. Tong, J.C. Eisenach, Post-operative analgesia from intrathecal neostigmine in sheep, Anesth. Analg. 80 (1995) 1140-1144.
6. R.L. Büyükuysal, I.H. Ulus, B.K. Kiran, Aged-related in pre-synaptic and receptor-mediated cholinergic function in rat brain, Neurochem. Res. 23 (1998) 719-726.
7. E.L. Cohen, R.J. Wurtman, Brain acetylcholine: increase after systemic choline administration, Life Sci. 16 (1975) 1095-1102.
8. H.N. Doods, M.J. Mathy, D. Davidesko, K.J. van Charldorp, A. de Jonge, P.A. van Zwieten, Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors, J. Pharmacol. Exp. Ther. 242 (1987) 257-262.
9. R. Dörje, R. Wess, G. Lambrecht, R. Tacke, E. Mutschler, M.R. Brann, Antagonist binding profiles of five cloned human muscarinic receptor subtypes, J. Pharmacol. Exp. Ther. 256 (1991) 727-733.
10. D. Dubuisson, S.G. Dennis, The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brainstem stimulation in rats and cats, Pain 4 (1977) 161-174.
11. J.C. Eisenach, G.F. Gebhart, Intrathecal amitripyline: anti-nociceptive interactions with intravenous morphine and intrathecal clonidine, neostigmine, and carbamylcholine in rats, Anesthesiology 83 (1995) 1036-1045.
12. J.L. Ellis, D. Harman, J. Gonzales, M.L. Spera, R. Liu, T.Y. Shen, D.M. Wypu, F. Zuo, Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype, J. Pharmacol. Exp. Ther. 288 (1999) 1143-1150.
13. C. Ghelardini, P. Mamberg-Aiello, A. Giotti, M. Malcangio, A. Martolini, Investigation into atropine-induced anti-nociception, Br. J. Pharmacol. 101 (1990) 49-54.
14. P. Hadhazy, J.C. Szerb, The effect of cholinergic drugs on H-acetylcholine release from slices of rat hippocampus, striatum and cortex, Brain Res. 123 (1977) 311-322.
15. 3H-hemicholinium-3 as a quantitative marker, J. Neurochem. 60 (1993) 1191-1201.
16. A.U. Höglund, H.A. Baghdoyan, M2, M3 and M4, but not M1, muscarinic receptor subtypes are present in the rat spinal cord, J. Pharmacol. Exp. Ther. 281 (1997) 470-477.
17. K. Honda, Y. Takano, H. Kamiya, Pharmacological profiles of muscarinic receptors in the longitudinal smooth muscle of guinea pig ileum, Jpn. J. Pharmacol. 62 (1993) 43-47.
18. E.C. Hulme, N.J.M. Birdsall, N.J. Buckley, Muscarinic receptor subtypes, Ann. Rev. Pharmacol. Toxicol. 30 (1990) 633-673.
19. J.L.K. Hylden, G.L. Wilcox, Intrathecal morphine in mice: a new technique, Eur. J. Pharmacol. 67 (1980) 313-316.
20. Y. Ikarashi, A. Takahashi, H. Ishimaru, T. Arai, Y. Maruyama, Relations between the extracellular concentrations of choline and acetylcholine in rat striatum, J. Neurochem. 69 (1997) 1246-1251.
21. A. Imperato, M.G. Scrocco, O. Ghirardi, M. Ramacci, L. Angelucci, In vivo probing of the brain cholinergic system in the aged rat: effects of long-term treatment with acetyl-L-carnitine, Ann. N. Y. Acad. Sci. 621 (1991) 90-97.
22. E.T. Iwamoto, L. Marion, Characterization of the anti-nociception produced by intrathecally administered muscarinic agonists in the rats, J. Pharmacol. Exp. Ther. 266 (1993) 329-338.
23. N. Kobayashi, M. Sakuma, K. Yoshioka, Y. Onishi, M. Yanagisawa, K. Kawashima, M. Otsuka, Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat, Neuroscience 45 (1991) 331-337.
24. P. Kostka, S. Ahmad, C.Y. Kwan, E.E. Daniel, R.K. Gordon, P.K. Chiang, Prejunctional muscarinic receptors in the deep muscarinic muscular plexus of canine ileum: comparison with smooth muscle receptors, J. Pharmacol. Exp. Ther. 263 (1992) 226-231.
25. G. Lambrecht, R. Feifel, M. Wagner-Röder, C. Strohmann, H. Zilch, R. Tacke, M. Waelbroek, J. Christophe, H. Boddeke, E. Mutshler, Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes, Eur. J. Pharmacol. 168 (1989) 71-80.
26. F. Mitchelson, Muscarinic receptor differentiation, Pharmacol. Ther. 37 (1988) 357-423.
27. M. Mori, H. Tsushima, T. Kamiya, T. Matsuda, Effect of muscarinic receptor modulators in the hypothalamic supraotic nucleus of the rat, Jpn. J. Pharmacol. 66 (1994) 413-419.
28. M. Naguib, T.L. Yaksh, Characterization of muscarinic receptor subtypes that mediate anti-nociception in the rat spinal cord, Anesth. Analg. 85 (1997) 847-853.
29. Ö. Nordström, T. Bartfai, Muscarinic autoreceptor regulates acetylcholine release in rat hippocampus: in vitro evidence, Acta Physiol. Scand. 108 (1980) 347-353.
30. G. Pepeu, The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms, Prog. Neurobiol. 2 (1973) 257-288.
31. V.H. Sethy, J.W. Francis, Regulation of brain acetylcholine concentration by muscarinic receptors, J. Pharmacol. Exp. Ther. 246 (1988) 243-248.
32. M. Shibata, T. Ohkubo, H. Takahashi, R. Inoki, Modified formalin test: characteristic biphasic pain response, Pain 38 (1989) 347-352.
33. M.D. Smith, X. Yang, J.-Y. Nha, J.J. Muccafusco, Anti-nociceptive effect of spinal cholinergic stimulation: interaction with substance P, Life Sci. 45 (1989) 1255-1261.
34. A.J. Todd, R.C. Spike, The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn, Prog. Neurobiol. 41 (1993) 609-645.
35. J. Wei, E.A. Walton, A. Milici, J.J. Buccafusco, m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC, J. Neurochem. 63 (1994) 815-821.
36. J. Wess, Molecular biology of muscarinic acetylcholine receptors, Crit. Rev. Neurobiol. 10 (1996) 69-99.
37. H. Wheeler-Aceto, F. Porreca, A. Cowan, The rat paw formalin test: comparison of noxious agents, Pain 40 (1990) 229-238.
38. T.L. Yaksh, R. Dirksen, G. Harty, Anti-nociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat, Eur. J. Pharmacol. 117 (1985) 81-88.
39. T. Yamamoto, T.L. Yaksh, Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: anti-nociception in the absence of motor dysfunction, Life Sci. 49 (1991) 1955-1963.