Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): A novel analgesic with mixed muscarinic receptor agonist and antagonist activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 884-894

  Shannon, Harlan E ^a   Sheardown, Malcolm J ^b   Bymaster, Frank P ^a   Calligaro, David O ^a   Delapp, Neil W ^a   Gidda, Jaswant ^a   Mitch, Charles H ^a   Sawyer, Barry D ^a   Stengel, Peter W ^a   Ward, John S ^a   Wong, David T ^a   Olesen, Preben H ^b   Suzdak, Peter D ^b   Sauerberg, Per ^b   Swedberg, Michael D B ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 BUTYLTHIO 1,2,5 THIADIAZOL 3 YL)QUINUCLIDINE; ACETYLCHOLINE; CHARCOAL; DOPAMINE; MORPHINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR; OXOTREMORINE; PIRENZEPINE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLADDER; BRAIN HOMOGENATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; GUINEA PIG; HEART ATRIUM; HEART RATE; ILEUM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; MUSCLE CONTRACTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PAIN; PRIORITY JOURNAL; RABBITS AND HARES; RAT; SALIVATION; SUBCUTANEOUS DRUG ADMINISTRATION; TREMOR; VAS DEFERENS;

ANALGESICS; ANIMALS; ATRIAL FUNCTION; BINDING SITES; BODY TEMPERATURE REGULATION; CHARCOAL; CHOLINERGIC AGENTS; GUINEA PIGS; HEART ATRIA; HEART RATE; ILEUM; MALE; MICE; NEUROTRANSMITTER AGENTS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SALIVA; THIADIAZOLES; TREMOR; URINARY BLADDER; VAS DEFERENS;

EID: 8244240430     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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