Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

Biochemistry

Volumn 36, Issue 48, 1997, Pages 14642-14651

  Saxena, Ashima ^a   Redman, Ann M G ^a   Jiang, Xuliang ^b   Lockridge, Oksana ^c   Doctor, B P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Columbia University ^*  (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DECAMETHONIUM; EDROPHONIUM; HUPERZINE A; PROFENAMINE; PROPIDIUM IODIDE; TACRINE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; MOLECULAR MODEL; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; BUTYRYLTHIOCHOLINE; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; COMPUTER SIMULATION; ENZYME ACTIVATION; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN CONFORMATION; SPECIES SPECIFICITY; TORPEDO;

MAMMALIA;

EID: 0030780763     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971425+     Document Type: Article

References (42)

1. Alles, G. A., and Hawes, P. C. (1940) J. Biol. Chem. 133, 375-390.
2. Augustinsson, K. B. (1948) Acta Physiol. Scand., Suppl. 52, 1-182.
3. Barnard, E. A. (1974) in The Peripheral Nervous System (Hubbard, J. I., Ed.) pp 201-224, Plenum Press, New York.
4. Chatonnet, A., and Lockridge, O. (1989) Biochem. J. 260, 625-634.
5. Gentry, M. K., and Doctor, B. P. (1991) in Cholinesterases: Structure, Function, Mechanism, Genetics and Cell Biology (Massoulié, J., Bacou, F., Barnard, E. A., Chatonnet, A., Doctor, B. P., and Quinn, D. M., Eds.) pp 394-398, American Chemical Society, Washington, DC.
6. Sussman, J. L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L., and Silman, I. (1991) Science 253, 872-879.
7. Vellom, D. C., Radić, Z., Ying, L., Pickering, N. A., Camp, S., and Taylor, P. (1993) Biochemistry 32, 12-17.
8. Radić, Z., Pickering, N., Vellom, D. C., Camp, S., and Taylor, P. (1993) Biochemistry 32, 12074-12084.
9. Massoulié, J., Sussman, J. L., Doctor, B. P., Soreq, H., Velan, B., Cygler, M., Rotundo, R., Shafferman, A., Silman, I., and Taylor, P. (1992) in Multidisciplinary Approaches to Cholinesterase Functions (Shafferman, A., and Velan, B., Eds.) pp 285-288, Plenum Press, New York.
10. Harel, M., Sussman, J. L., Krejci, E., Bon, S., Chanal, P., Massoulie, J., and Silman, I. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 10827-10831.
11. Ordentlich, A., Barak, D., Kronman, C., Flashner, Y., Leitner, M., Segall, Y., Ariel, N., Cohen, S., Velan, B., and Shafferman, A. (1993) J. Biol. Chem. 268, 17083-17095.
12. Fournier, D., Bride, J. M., Hoffman, F., and Karch, F. (1992) J. Biol. Chem. 267, 14270-14274.
13. Shafferman, A., Velan, B., Ordentlich, A., Kronman, C., Grosfeld, H., Leitner, M., Flashner, Y., Cohen, S., Barak, D., and Ariel, N. (1992) EMBO J. 11, 3561-3568.
14. Kreienkamp, H. J., Weise, C., Raba, R., Aaviksaar, A., and Hucho, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 6117-6121.
15. Weise, C., Kreienkamp, H. J., Raba, R., Pedak, A., Aaviksaar, A., and Hucho, F. (1990) EMBO J. 9, 3385-3388.
16. Sussman, J. L., Harel, M., and Silman, I. (1992) in Multidisciplinary Approaches to Cholinesterase Functions (Shafferman, A., and Velan, B., Eds.) pp 95-108, Plenum Press, New York.
17. Saxena, A., Qian, N., Kovach, I. M., Kozikowski, A. P., Pang, Y.-P., Vellom, D. C., Radić, Z., Quinn, D., Taylor, P., and Doctor, B. P. (1994) Protein Sci. 3, 1770-1778.
18. Ashani, Y., Grunwald, J., Kronman, C., Velan, B., and Shafferman, A. (1994) Mol. Pharmacol. 45, 555-560.
19. De La Hoz, D., Doctor, B. P., Ralston, J. S., Rush, R. S., and Wolfe, A. D. (1986) Life Sci. 9, 195-199.
20. Klein, C. L., Lear, J., O'Rourke, S., Williams, S., and Liang, L. (1994) J. Pharm. Sci. 83, 1253-1256.
21. McTiernan, C., Adkins, S., Chatonnet, A., Vaughan, T. A., Bartels, C. F., Kott, M., Rosenberry, T. L., La Du, B. N., and Lockridge, O. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 6682-6686.
22. Chen, B., and Przybyla, A. E. (1994) Biotechniques 17, 657-659.
23. Ellman, G. L., Courtney, D., Andres, V., and Featherstone, R. M. (1961) Biochem. Pharmacol. 1, 88-95.
24. Levy, D., and Ashani, Y. (1986) Biochem. Pharmacol. 35, 1079-1085.
25. Aldridge, W. N., and Reiner, E. (1972) in Enzyme inhibitors as substrates, North Holland, Amsterdam.
26. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjeldgaad, M. (1991) Acta Crystallogr. A47, 110-119.
27. Kleywegt, G. J., and Jones, T. A. (1994) Acta Crystallogr. D50, 178-185.
28. Brunger, A. T. (1992) X-PLOR: A system for X-ray crystallography and NMR, version 3.1, Yale University, New Haven, CT.
29. Kleywegt, G. J. (1995) in ESF/CCP4 News Lett. 31, 45-50.
30. Masson, P., Froment, M.-T., Bartels, C., and Lockridge, O. (1996) Eur. J. Biochem. 235, 36-48.
31. Ashani, Y., Peggins, J. O., III, and Doctor, B. P. (1992) Biochem. Biophys. Res. Commun. 184, 719-726.
32. Taylor, P., and Lappi, S. (1975) Biochemistry 14, 1989-1997.
33. Radić, Z., Reiner, E., and Taylor, P. (1990) Mol. Pharmacol. 39, 98-104.
34. Radić, Z., Gibney, G., Kawamoto, S., Bongiorno, C., and Taylor, P. (1992) Biochemistry 31, 9760-9767.
35. Masson, P., Legrand, P., Bartels, C. F., Froment, M.-T., Schopfer, L. M., and Lockridge, O. (1997) Biochemistry 36, 2266-2277.
36. Hosea, N. A., Berman, H. A., and Taylor, P. (1995) Biochemistry 34, 11528-11536.
37. Ashani, Y., Radić, Z., Tsigelny, I., Vellom, D. C., Pickering, N. A., Quinn, D. M., Doctor, B. P., and Taylor, P. (1995) J. Biol. Chem. 270, 6370-6380.
38. Raves, M. L., Harel, M., Pang, Y.-P., Silman, I., Kozikowski, A. P., and Sussman, J. L. (1997) Nat. Struct. Biol. 4, 57-63.
39. Dougherty, D. A. (1996) Science 271, 163-168.
40. Harel, M., Schalk, I., Ehret-Sabatier, L., Bouet, F., Goeldner, M., Hirth, C., Silman, I., and Sussman, J. L. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 9031-9035.
41. Chothia, C., and Lesk, A. M. (1986) EMBO J. 5, 823-826.
42. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296.