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Volumn 3, Issue 4, 2004, Pages 247-268

Tiotropium bromide: A review of its use as maintenance therapy in patients with COPD

Author keywords

Anticholinergic bronchodilators; COPD; Health related quality of life; Pharmacodynamics; Pharmacokinetics; Therapeutic use; Tiotropium; Tiotropium bromide; Tolerability

Indexed keywords

AMINOPHYLLINE; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CIMETIDINE; FORMOTEROL; GESTODENE; IPRATROPIUM BROMIDE; KETOCONAZOLE; OXITROPIUM BROMIDE; PLACEBO; QUINIDINE; RANITIDINE; SALBUTAMOL; SALMETEROL; TERBUTALINE; THEOPHYLLINE; TIOTROPIUM BROMIDE;

EID: 4644353712     PISSN: 11763450     EISSN: None     Source Type: Journal    
DOI: 10.2165/00151829-200403040-00005     Document Type: Review
Times cited : (50)

References (94)
  • 1
    • 0014019380 scopus 로고
    • The emphysematous and bronchial types of chronic airways obstruction: A clinicopathological study of patients in London and Chicago
    • Apr 16
    • Burrows B, Fletcher CM, Heard BE, et al. The emphysematous and bronchial types of chronic airways obstruction: a clinicopathological study of patients in London and Chicago. Lancet 1966 Apr 16; 1 (7442): 830-5
    • (1966) Lancet , vol.1 , Issue.7442 , pp. 830-835
    • Burrows, B.1    Fletcher, C.M.2    Heard, B.E.3
  • 2
    • 0003736032 scopus 로고    scopus 로고
    • Global Strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease updated 2003
    • National Institutes of Health: National Heart Lung and Blood Institute. Executive summary [online]. Available from URL: [Accessed Aug 20] Global Initiative for Chronic Obstructive Lung Disease
    • National Institutes of Health: National Heart Lung and Blood Institute. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease updated 2003. Executive summary [online]. Available from URL: http://www.goldcopd.com [Accessed 2003 Aug 20]
    • (2003)
  • 3
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Jun 24
    • Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004 Jun 24; 350 (26): 2645-53
    • (2004) N. Engl. J. Med. , vol.350 , Issue.26 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3
  • 4
    • 2942729608 scopus 로고    scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Jun 24
    • Sutherland ER, Cherniak RM. Management of chronic obstructive pulmonary disease. N Engl J Med 2004 Jun 24; 350 (26): 2689-97
    • (2004) N. Engl. J. Med. , vol.350 , Issue.26 , pp. 2689-2697
    • Sutherland, E.R.1    Cherniak, R.M.2
  • 5
    • 0027509977 scopus 로고
    • Muscarinic receptor subtypes in airways
    • Barnes PJ. Muscarinic receptor subtypes in airways. Life Sci 1993; 52 (5-6): 521-7
    • (1993) Life Sci. , vol.52 , Issue.5-6 , pp. 521-527
    • Barnes, P.J.1
  • 6
    • 0030442725 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes and smooth muscle function
    • Dec
    • Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996 Dec; 48 (4): 531-65
    • (1996) Pharmacol. Rev. , vol.48 , Issue.4 , pp. 531-565
    • Eglen, R.M.1    Hegde, S.S.2    Watson, N.3
  • 7
    • 0033994636 scopus 로고    scopus 로고
    • The pharmacological properties of tiotropium
    • Feb
    • Barnes PJ. The pharmacological properties of tiotropium. Chest 2000 Feb; 117 (2 Suppl.): 63S-6S
    • (2000) Chest , vol.117 , Issue.2 SUPPL.
    • Barnes, P.J.1
  • 8
    • 0036267316 scopus 로고    scopus 로고
    • Tiotropium bromide: A viewpoint by JA van Noord
    • Van Noord JA. Tiotropium bromide: a viewpoint by JA van Noord. Drugs 2002; 62 (8): 1204-5
    • (2002) Drugs , vol.62 , Issue.8 , pp. 1204-1205
    • Van Noord, J.A.1
  • 9
    • 0028179195 scopus 로고
    • Characterization of [3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: Radioligand binding and autoradiographic mapping
    • May
    • Haddad EB, Mak JCW, Barnes J. Characterization of [3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: radioligand binding and autoradiographic mapping. Mol Pharmacol 1994 May; 45: 899-907
    • (1994) Mol. Pharmacol. , vol.45 , pp. 899-907
    • Haddad, E.B.1    Mak, J.C.W.2    Barnes, J.3
  • 10
    • 0036271323 scopus 로고    scopus 로고
    • Tiotropium bromide
    • Hvizdos KM, Goa KL. Tiotropium bromide. Drugs 2002; 62 (8): 1195-203
    • (2002) Drugs , vol.62 , Issue.8 , pp. 1195-1203
    • Hvizdos, K.M.1    Goa, K.L.2
  • 11
    • 0027446311 scopus 로고
    • BA 679 BR, a novel long-acting anticholinergic bronchodilator
    • Disse B, Reichl R, Speck G, et al. BA 679 BR, a novel long-acting anticholinergic bronchodilator. Life Sci 1993; 52 (5-6): 537-44
    • (1993) Life Sci. , vol.52 , Issue.5-6 , pp. 537-544
    • Disse, B.1    Reichl, R.2    Speck, G.3
  • 12
    • 0028125006 scopus 로고
    • Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways
    • Dec
    • Takahashi T, Belvisi MG, Patel H, et al. Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am J Respir Crit Care Med 1994 Dec; 150 (6 Pt 1): 1640-5
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150 , Issue.6 PART 1 , pp. 1640-1645
    • Takahashi, T.1    Belvisi, M.G.2    Patel, H.3
  • 13
    • 0028886394 scopus 로고
    • Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: A pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD)
    • Dutch Study Group. Sep
    • Maesen FPV, Smeets JJ, Sledsens TJH, et al. Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). Dutch Study Group. Eur Respir J 1995 Sep; 8 (9): 1506-13
    • (1995) Eur. Respir. J. , vol.8 , Issue.9 , pp. 1506-1513
    • Maesen, F.P.V.1    Smeets, J.J.2    Sledsens, T.J.H.3
  • 14
    • 0141990930 scopus 로고    scopus 로고
    • Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease
    • Oct
    • Calverley PM, Lee A, Towse L, et al. Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease. Thorax 2003 Oct; 58 (10): 855-60
    • (2003) Thorax , vol.58 , Issue.10 , pp. 855-860
    • Calverley, P.M.1    Lee, A.2    Towse, L.3
  • 15
    • 0034099036 scopus 로고    scopus 로고
    • Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease
    • Apr
    • Littner MR, Ilowite JS, Tashkin DP, et al. Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000 Apr; 161 (4 Pt 1): 1136-42
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , Issue.4 PART 1 , pp. 1136-1142
    • Littner, M.R.1    Ilowite, J.S.2    Tashkin, D.P.3
  • 16
    • 0001001225 scopus 로고    scopus 로고
    • Spiriva (tiotropium) improves exercise tolerance in COPD
    • [abstract]. Apr
    • O'Donnell DE, Magnussen H, Aguilanni B, et al. Spiriva (tiotropium) improves exercise tolerance in COPD [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Suppl. Pt 2): A227
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • O'Donnell, D.E.1    Magnussen, H.2    Aguilanni, B.3
  • 17
    • 1642510371 scopus 로고    scopus 로고
    • Spiriva (tiotropium) reduces exertional dyspnea in COPD
    • [abstract]. Apr
    • O'Donnell DE, Magnussen H, Aguilaniu B, et al. Spiriva (tiotropium) reduces exertional dyspnea in COPD [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Suppl. Pt 2): A265
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • O'Donnell, D.E.1    Magnussen, H.2    Aguilaniu, B.3
  • 18
    • 4243204357 scopus 로고    scopus 로고
    • Spiriva® (tiotropium) reduces lung hyperinflation in COPD
    • [abstract]. Apr
    • Magnussen H, O'Donnell DE, Casaburi R, et al. Spiriva® (tiotropium) reduces lung hyperinflation in COPD [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Suppl. Pt 2): A227
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • Magnussen, H.1    O'Donnell, D.E.2    Casaburi, R.3
  • 19
    • 0036204964 scopus 로고    scopus 로고
    • Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease
    • Apr
    • van Noord JA, Smeets JJ, Custers FL, et al. Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease. Eur Respir J 2002 Apr; 19 (4): 639-44
    • (2002) Eur. Respir. J. , vol.19 , Issue.4 , pp. 639-644
    • van Noord, J.A.1    Smeets, J.J.2    Custers, F.L.3
  • 20
    • 0001712556 scopus 로고    scopus 로고
    • Effects of anticholinergic therapy (tiotropium) on REM-related desaturation (SaO2) and sleep quality in patients with COPD
    • [abstract]. Apr
    • McNicholas WT, Calverley PMA, Edwards C, et al. Effects of anticholinergic therapy (tiotropium) on REM-related desaturation (SaO2) and sleep quality in patients with COPD [abstract]. Am J Respir Crit Care Med 2001 Apr; 163 (5 Suppl. Pt 2): A280
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , Issue.5 SUPPL. and PART 2
    • McNicholas, W.T.1    Calverley, P.M.A.2    Edwards, C.3
  • 21
    • 0141543535 scopus 로고    scopus 로고
    • Mechanisms of improved exercise tolerance in COPD in response to tiotropium
    • [abstract no. P1826]. Sep
    • O'Donnell DE, Magnussen H, Gerken F, et al. Mechanisms of improved exercise tolerance in COPD in response to tiotropium [abstract no. P1826]. Eur Respir J 2002 Sep; 20 Suppl. 38: 288s
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38
    • O'Donnell, D.E.1    Magnussen, H.2    Gerken, F.3
  • 22
    • 4644367187 scopus 로고    scopus 로고
    • Heart rate and rhythm analysis from Holter monitoring in COPD patients receiving tiotropium
    • [abstract]
    • Langley S, Towse L, Kesten S, et al. Heart rate and rhythm analysis from Holter monitoring in COPD patients receiving tiotropium [abstract]. Am J Respir Crit Care Med 2002; 165 (8 Suppl. Pt 2): A592
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • Langley, S.1    Towse, L.2    Kesten, S.3
  • 23
    • 2442516033 scopus 로고    scopus 로고
    • The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD
    • May
    • Hasani A, Toms N, Agnew JE, et al. The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD. Chest 2004 May; 125 (5): 1726-34
    • (2004) Chest , vol.125 , Issue.5 , pp. 1726-1734
    • Hasani, A.1    Toms, N.2    Agnew, J.E.3
  • 24
    • 4644367188 scopus 로고    scopus 로고
    • Spiriva (tiotropium) reduces lung hyperinflation at rest and during exercise
    • [abstract plus poster]. Apr
    • O'Donnell D, Marcinuik D, Hernandez P, et al. Spiriva (tiotropium) reduces lung hyperinflation at rest and during exercise [abstract plus poster]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A772
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • O'Donnell, D.1    Marcinuik, D.2    Hernandez, P.3
  • 25
    • 4644371551 scopus 로고    scopus 로고
    • Spiriva (tiotropium) improves symptom-limited exercise tolerance in COPD patients
    • [abstract plus poster]. Apr
    • O'Donnell D, Maltais F, Sciurba F, et al. Spiriva (tiotropium) improves symptom-limited exercise tolerance in COPD patients [abstract plus poster]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A771
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • O'Donnell, D.1    Maltais, F.2    Sciurba, F.3
  • 26
    • 4644281296 scopus 로고    scopus 로고
    • Improvement in exercise endurance with the combination of tiotropium and rehabilitative exercise training in COPD patients
    • [abstract]. Apr
    • Casaburi R, Kukafka D, Cooper CB, et al. Improvement in exercise endurance with the combination of tiotropium and rehabilitative exercise training in COPD patients [abstract]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A756
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • Casaburi, R.1    Kukafka, D.2    Cooper, C.B.3
  • 27
    • 4644345182 scopus 로고    scopus 로고
    • Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD patients
    • [abstract plus poster]. Apr
    • Cooper B, Kukafka D, Casaburi R, et al. Tiotropium augments improvements in dyspnea and health-related quality of life following pulmonary rehabilitation in COPD patients [abstract plus poster]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A518
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • Cooper, B.1    Kukafka, D.2    Casaburi, R.3
  • 28
    • 4644247306 scopus 로고    scopus 로고
    • Improved daytime spirometric efficacy of tiotropium compared to salmeterol in COPD patients
    • [abstract plus poster]. Apr
    • Briggs Jr D, Covelli H, Lapidus R, et al. Improved daytime spirometric efficacy of tiotropium compared to salmeterol in COPD patients [abstract plus poster]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A518
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • Briggs Jr., D.1    Covelli, H.2    Lapidus, R.3
  • 29
    • 4644250537 scopus 로고    scopus 로고
    • Food and Drug Administration. [online]. Available from URL: [Accessed Sep 18]
    • Food and Drug Administration. Clinical pharmacology and biopharmaceutics briefing document [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/02/briefing/ 3890B1_06_Pharmacology-Biopharmaceutics.pdf [Accessed 2002 Sep 18]
    • (2002) Clinical Pharmacology and Biopharmaceutics Briefing Document
  • 30
    • 0036181956 scopus 로고    scopus 로고
    • A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
    • Feb
    • Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J 2002 Feb; 19 (2): 217-24
    • (2002) Eur. Respir. J. , vol.19 , Issue.2 , pp. 217-224
    • Casaburi, R.1    Mahler, D.A.2    Jones, P.W.3
  • 31
    • 18244368740 scopus 로고    scopus 로고
    • Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium
    • The Dutch/Belgian Tiotropium Study Group. Feb
    • Vincken W, van Noord JA, Greefhorst APM, et al. Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium. The Dutch/Belgian Tiotropium Study Group. Eur Respir J 2002 Feb; 19 (2): 209-16
    • (2002) Eur. Respir. J. , vol.19 , Issue.2 , pp. 209-216
    • Vincken, W.1    van Noord, J.A.2    Greefhorst, A.P.M.3
  • 32
    • 4644262283 scopus 로고    scopus 로고
    • College Ter Beoordeling Van Geneesmiddelen Medicines Evaluation Board. [online]. Available from URL: [Accessed Jul 23]
    • College Ter Beoordeling Van Geneesmiddelen Medicines Evaluation Board. Public assessment report: Spiriva 18μg, inhalation powder in hard capsules RVG 26191 [online]. Available from URL: http://www.cbg-meb.nl/nl/docs/gnsmiddl/par-spiriva.pdf [Accessed 2002 Jul 23]
    • (2002) Public Assessment Report: Spiriva 18μg, Inhalation Powder in Hard Capsules RVG 26191
  • 33
    • 0036305399 scopus 로고    scopus 로고
    • A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol
    • Jul
    • Donohue JF, Van Noord A, Bateman ED, et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002 Jul; 122 (1): 47-55
    • (2002) Chest , vol.122 , Issue.1 , pp. 47-55
    • Donohue, J.F.1    Van Noord, A.2    Bateman, E.D.3
  • 34
    • 4644245529 scopus 로고    scopus 로고
    • Comparison of once daily tiotropium, twice daily formoterol and the free combination, once daily, in patients with COPD
    • [abstract no. BO24]. May 16-21; Seattle, (WA)
    • Van Noord JA, Aumann J, Janssens E, et al. Comparison of once daily tiotropium, twice daily formoterol and the free combination, once daily, in patients with COPD [abstract no. BO24]. 99th International Conference of the American Thoracic Society; 2003 May 16-21; Seattle, (WA), A320
    • (2003) 99th International Conference of the American Thoracic Society
    • Van Noord, J.A.1    Aumann, J.2    Janssens, E.3
  • 35
    • 4644229563 scopus 로고    scopus 로고
    • Improvements with tiotropium on endurance measured by the shuttle walking test (SWT) and on health related quality of life (HRQoL) in COPD patients
    • [abstract no. P1825]
    • Huchon G, Verkindre C, Bart F, et al. Improvements with tiotropium on endurance measured by the shuttle walking test (SWT) and on health related quality of life (HRQoL) in COPD patients [abstract no. P1825]. Eur Respir J 2002; 20 Suppl. 38: 287s
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38
    • Huchon, G.1    Verkindre, C.2    Bart, F.3
  • 36
    • 85041543379 scopus 로고    scopus 로고
    • Cardiovascular evaluation of tiotropium during constant-work rate exercise in COPD
    • [abstract no. P430]
    • O'Donnell DE, Magnussen H, Gerken F, et al. Cardiovascular evaluation of tiotropium during constant-work rate exercise in COPD [abstract no. P430]. Eur Resp J 2003; 22 Suppl. 45: 49s
    • (2003) Eur. Resp. J. , vol.22 , Issue.SUPPL. 45
    • O'Donnell, D.E.1    Magnussen, H.2    Gerken, F.3
  • 37
    • 85041706568 scopus 로고    scopus 로고
    • Relation between acute response to salbutamol and long-term FEV1 responses to tiotropium (TIO), formoterol (FORM) and its combination (T+F) in COPS patients
    • [abstract no. 153]. Sep
    • Van Noord J, Aumann J, Jannsens E. Relation between acute response to salbutamol and long-term FEV1 responses to tiotropium (TIO), formoterol (FORM) and its combination (T+F) in COPS patients [abstract no. 153]. Eur Resp J 2003 Sep; 22 Suppl. 45: 4s
    • (2003) Eur. Resp. J. , vol.22 , Issue.SUPPL. 45
    • Van Noord, J.1    Aumann, J.2    Jannsens, E.3
  • 38
    • 0242721244 scopus 로고    scopus 로고
    • Improvements in inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes
    • Celli BR, ZuWallack RL, Wang S, et al. Improvements in inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003; 124 (5): 1743-8
    • (2003) Chest , vol.124 , Issue.5 , pp. 1743-1748
    • Celli, B.R.1    ZuWallack, R.L.2    Wang, S.3
  • 39
    • 0021256105 scopus 로고
    • The measurement of dyspnea. Contents, interobserver agreement and physiologic correlates of two new clinical indexes
    • Jun
    • Mahler DA, Weinberg DH, Wells CK, et al. The measurement of dyspnea. Contents, interobserver agreement and physiologic correlates of two new clinical indexes. Chest 1984 Jun; 85 (6): 751-8
    • (1984) Chest , vol.85 , Issue.6 , pp. 751-758
    • Mahler, D.A.1    Weinberg, D.H.2    Wells, C.K.3
  • 40
    • 0001397195 scopus 로고    scopus 로고
    • The pharmacokinetic (PK) profile of tiotropium during long-term treatment in stable COPD
    • [abstract]. Mar
    • Disse B, Rominger K, Serby CW, et al. The pharmacokinetic (PK) profile of tiotropium during long-term treatment in stable COPD [abstract]. Am J Respir Crit Care Med 1999 Mar; 159 (3 Suppl. Pt 2): A524
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , Issue.3 SUPPL. and PART 2
    • Disse, B.1    Rominger, K.2    Serby, C.W.3
  • 41
    • 4644257028 scopus 로고    scopus 로고
    • Samenvatting van de productkenmerken
    • [Accessed Jul 24] [online]. Available from URL: Ingelheim
    • Boehringer Ingelheim. Samenvatting van de productkenmerken [online]. Available from URL: http://www.cbg-meb.nl/IB-teksten/26191.PDF [Accessed 2002 Jul 24]
    • (2002)
  • 42
    • 0033534194 scopus 로고    scopus 로고
    • Tiotropium (Spiriva): Mechanistical considerations and clinical profile in obstructive lung disease
    • Disse B, Speck GA, Rominger KL, et al. Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease. Life Sci 1999; 64 (6-7): 457-64
    • (1999) Life Sci. , vol.64 , Issue.6-7 , pp. 457-464
    • Disse, B.1    Speck, G.A.2    Rominger, K.L.3
  • 43
    • 4644327662 scopus 로고    scopus 로고
    • Spiriva (tiotropium bromide inhalation powder)
    • Food and Drug Administration. [Accessed Sep 18] NDA 21-395 Boehringer Ingelheim Pharmaceuticals, Inc [online]. Available from URL:
    • Food and Drug Administration. Spiriva (tiotropium bromide inhalation powder) NDA 21-395 Boehringer Ingelheim Pharmaceuticals, Inc [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/02/ briefing/3890B1_Boehringer%20Ingelheim.pdf [Accessed 2002 Sep 18]
    • (2002)
  • 44
    • 1642453615 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous, single-dose tiotropium in subjects with different degrees of renal impairment
    • Türck D, Weber W, Sigmund R, et al. Pharmacokinetics of intravenous, single-dose tiotropium in subjects with different degrees of renal impairment. J Clin Pharmacol 2004; 44: 163-72
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 163-172
    • Türck, D.1    Weber, W.2    Sigmund, R.3
  • 45
    • 4644280177 scopus 로고    scopus 로고
    • Efficacy of once daily tiotropium (TIO) in stable COPD
    • [abstract no. P3406]. Oct 9-13; Madrid, (abstracts-on-disk)
    • Wanner A, ZuWallack R, Elias D, et al. Efficacy of once daily tiotropium (TIO) in stable COPD [abstract no. P3406]. 9th Annual Congress of the European Respiratory Society; 1999 Oct 9-13; Madrid, (abstracts-on-disk)
    • (1999) 9th Annual Congress of the European Respiratory Society
    • Wanner, A.1    ZuWallack, R.2    Elias, D.3
  • 46
    • 0000582425 scopus 로고    scopus 로고
    • Tiotropium (Spiriva): One year bronchodilator efficacy established with once daily dosing in COPD patients
    • [abstract]. Mar
    • San Pedro G, Elias DJ, Serby CW, et al. Tiotropium (Spiriva): one year bronchodilator efficacy established with once daily dosing in COPD patients [abstract]. Am J Respir Crit Care Med 2000 Mar; 161 (3 Suppl. Pt 2): A749
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , Issue.3 SUPPL. and PART 2
    • San Pedro, G.1    Elias, D.J.2    Serby, C.W.3
  • 47
    • 0000582420 scopus 로고    scopus 로고
    • Tiotropium (Spiriva) improves health status in patients with COPD
    • [abstract]. Mar
    • Zu Wallack R, Jones PW, Kotch A, et al. Tiotropium (Spiriva) improves health status in patients with COPD [abstract]. Am J Respir Crit Care Med 2000 Mar; 161 (3 Suppl. Pt 2): A892
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , Issue.3 SUPPL. and PART 2
    • Zu Wallack, R.1    Jones, P.W.2    Kotch, A.3
  • 48
    • 0000582421 scopus 로고    scopus 로고
    • Tiotropium (Spiriva), a new long-acting anticholinergic bronchodilator, improves dyspnea in patients with COPD
    • [abstract]. Mar
    • Mahler DA, Montner P, Brazinsky SA, et al. Tiotropium (Spiriva), a new long-acting anticholinergic bronchodilator, improves dyspnea in patients with COPD [abstract]. Am J Respir Crit Care Med 2000 Mar; 161 (3 Suppl. Pt 2): A892
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , Issue.3 SUPPL. and PART 2
    • Mahler, D.A.1    Montner, P.2    Brazinsky, S.A.3
  • 49
    • 0033748430 scopus 로고    scopus 로고
    • The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: A 13-week multicenter trial
    • The US Tiotropium Study Group. Nov
    • Casaburi R, Briggs Jr DD, Donohue JF, et al. The spirometric efficacy of once-daily dosing with tiotropium in stable COPD: a 13-week multicenter trial. The US Tiotropium Study Group. Chest 2000 Nov; 118 (5): 1294-302
    • (2000) Chest , vol.118 , Issue.5 , pp. 1294-1302
    • Casaburi, R.1    Briggs Jr., D.D.2    Donohue, J.F.3
  • 50
    • 0037879081 scopus 로고    scopus 로고
    • Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses
    • May
    • Tashkin D, Kesten S. Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 2003 May; 123 (5): 1441-9
    • (2003) Chest , vol.123 , Issue.5 , pp. 1441-1449
    • Tashkin, D.1    Kesten, S.2
  • 51
    • 0042882845 scopus 로고    scopus 로고
    • Tolerance to bronchodilating effects of salmeterol in COPD
    • Sep
    • Donohue JF, Menjoge S, Kesten S. Tolerance to bronchodilating effects of salmeterol in COPD. Respir Med 2003 Sep; 97 (9): 1014-20
    • (2003) Respir. Med. , vol.97 , Issue.9 , pp. 1014-1020
    • Donohue, J.F.1    Menjoge, S.2    Kesten, S.3
  • 52
    • 0242280749 scopus 로고    scopus 로고
    • Evaluating the efficacy of chronic therapy with tiotropium in COPD through discontinuation of treatment
    • [abstract no. P1589]. Sep
    • Briggs Jr DD, Witek TJ, Menjoge SS, et al. Evaluating the efficacy of chronic therapy with tiotropium in COPD through discontinuation of treatment [abstract no. P1589]. Eur Respir J 2002 Sep; 20 Suppl. 38: 245s
    • (2002) Eur. Respir. J. , vol.20 , Issue.SUPPL. 38
    • Briggs Jr., D.D.1    Witek, T.J.2    Menjoge, S.S.3
  • 53
    • 4243293100 scopus 로고    scopus 로고
    • Effectiveness of tiotropium or salmeterol in COPD patients receiving inhaled steroids
    • [abstract]. Apr
    • Hodder RV, White RJ, Menjoge SS, et al. Effectiveness of tiotropium or salmeterol in COPD patients receiving inhaled steroids [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Suppl. Pt 2): A228
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • Hodder, R.V.1    White, R.J.2    Menjoge, S.S.3
  • 54
    • 0011029819 scopus 로고    scopus 로고
    • Recovery of PEFR in COPD exacerbations in one year clinical trials
    • [abstract]. Apr
    • Friedman M, Korducki L, Kesten S. Recovery of PEFR in COPD exacerbations in one year clinical trials [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Part 2): A270
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 PART 2
    • Friedman, M.1    Korducki, L.2    Kesten, S.3
  • 55
    • 0011060008 scopus 로고    scopus 로고
    • Decline in health status over one year is eliminated by tiotropium
    • [abstract]. Apr Tiotropium study group
    • Spencer S, Jones PW. Decline in health status over one year is eliminated by tiotropium. Tiotropium study group [abstract]. Am J Respir Crit Care Med 2002 Apr; 165 (8 Suppl. Pt 2): A228
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , Issue.8 SUPPL. and PART 2
    • Spencer, S.1    Jones, P.W.2
  • 56
    • 4644360103 scopus 로고    scopus 로고
    • Efficacy of tiotropium in patients with mild to moderate COPD
    • [abstract plus poster]. Apr
    • Beeh KM, Beier J, Buhl R, et al. Efficacy of tiotropium in patients with mild to moderate COPD [abstract plus poster]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A519
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • Beeh, K.M.1    Beier, J.2    Buhl, R.3
  • 57
    • 4644289757 scopus 로고    scopus 로고
    • Reduced COPD exacerbations and associated health care utilization with once-daily tiotropium (TIO) in the VA medical system
    • [abstract]. Apr
    • Niewoehner D, Rice K, Cote C, et al. Reduced COPD exacerbations and associated health care utilization with once-daily tiotropium (TIO) in the VA medical system [abstract]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A207
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • Niewoehner, D.1    Rice, K.2    Cote, C.3
  • 58
    • 3242888951 scopus 로고    scopus 로고
    • Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD)
    • Friedman M, Menjoge SS, Anton S, et al. Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD). Pharmacoeconomics 2004; 22 (No. 11): 741-9
    • (2004) Pharmacoeconomics , vol.22 , Issue.11 , pp. 741-749
    • Friedman, M.1    Menjoge, S.S.2    Anton, S.3
  • 59
    • 0038366897 scopus 로고    scopus 로고
    • Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    • May
    • Brusasco V, Hodder R, Miravitlles M, et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003 May; 58 (5): 399-404
    • (2003) Thorax , vol.58 , Issue.5 , pp. 399-404
    • Brusasco, V.1    Hodder, R.2    Miravitlles, M.3
  • 60
    • 0034055236 scopus 로고    scopus 로고
    • A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease
    • The Dutch Tiotropium Study Group. Apr
    • Van Noord JA, Bantje TA, Eland ME, et al. A randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group. Thorax 2000 Apr; 55 (4): 289-94
    • (2000) Thorax , vol.55 , Issue.4 , pp. 289-294
    • Van Noord, J.A.1    Bantje, T.A.2    Eland, M.E.3
  • 61
    • 4644335313 scopus 로고    scopus 로고
    • Once-daily tiotropium (TIO) is more efficacious than Q.I.D. ipratropium (IB) as maintenance treatment of COPD
    • [abstract no. P3407]. Oct 9-13; Madrid, (abstracts-on-disk)
    • Vincken W, Greefhorst APM, Westbroek J, et al. Once-daily tiotropium (TIO) is more efficacious than Q.I.D. ipratropium (IB) as maintenance treatment of COPD [abstract no. P3407]. 9th Annual Congress of the European Respiratory Society; 1999 Oct 9-13; Madrid, (abstracts-on-disk)
    • (1999) 9th Annual Congress of the European Respiratory Society
    • Vincken, W.1    Greefhorst, A.P.M.2    Westbroek, J.3
  • 62
    • 4644341951 scopus 로고    scopus 로고
    • Evaluation of the response of Filipino patients to tiotropium (EVEREST Study)
    • [abstract]. Apr
    • de Guia T, Punzal P, Canizares L, et al. Evaluation of the response of Filipino patients to tiotropium (EVEREST Study) [abstract]. Am J Respir Crit Care Med 2004 Apr; 169 (7): A611
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , Issue.7
    • de Guia, T.1    Punzal, P.2    Canizares, L.3
  • 63
    • 4644269886 scopus 로고    scopus 로고
    • Clinical briefing document NDA 21-395 Spiriva (tiotropium bromide) inhalation powder for COPD
    • Food and Drug Administration. [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/02/ briefing/3890B1_05_Clinical%20Briefing_%20Part%202.pdf [Accessed Sep 18]
    • Food and Drug Administration. Clinical briefing document NDA 21-395 Spiriva (tiotropium bromide) inhalation powder for COPD [online]. Available from URL: http://www.fda.gov/ohrms/dockets/ac/02/briefing/ 3890B1_05_Clinical%20Briefing_%20Part%201.pdf; http://www.fda.gov/ohrms/dockets/ac/02/ briefing/3890B1_05_Clinical%20Briefing_%20Part%202.pdf [Accessed 2002 Sep 18]
    • (2002)
  • 64
    • 0037368520 scopus 로고    scopus 로고
    • Meaningful effect size and patterns of response of the transition dyspnea index
    • Mar
    • Witek Jr TJ, Mahler DA. Meaningful effect size and patterns of response of the transition dyspnea index. J Clin Epidemiol 2003 Mar; 56 (3): 248-55
    • (2003) J. Clin. Epidemiol. , vol.56 , Issue.3 , pp. 248-255
    • Witek Jr., T.J.1    Mahler, D.A.2
  • 65
    • 4644301810 scopus 로고    scopus 로고
    • Improvements in COPD following treatment with tiotropium in elderly patients
    • Oct
    • Kesten S, Flanders S, Menjoge SS, et al. Improvements in COPD following treatment with tiotropium in elderly patients. Chest 2001 Oct; 120 (4 Suppl.): 163S-4S
    • (2001) Chest , vol.120 , Issue.4 SUPPL.
    • Kesten, S.1    Flanders, S.2    Menjoge, S.S.3
  • 66
    • 4243706826 scopus 로고    scopus 로고
    • Influence of gender on outcomes in large COPD clinical trials
    • [abstract]. Apr
    • Weisman I, Menjoge SS, Serby CW, et al. Influence of gender on outcomes in large COPD clinical trials [abstract]. Am J Respir Crit Care Med 2001 Apr; 163 (5 Suppl. Pt 2): A281
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , Issue.5 SUPPL. and PART 2
    • Weisman, I.1    Menjoge, S.S.2    Serby, C.W.3
  • 67
    • 0029090616 scopus 로고
    • Standardisation of spirometry: 1994 update
    • American Thoracic Society. Sep
    • American Thoracic Society. Standardisation of spirometry: 1994 update. Am J Respir Crit Care Med 1995 Sep; 152 (3): 1107-36
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , Issue.3 , pp. 1107-1136
  • 68
    • 0009405672 scopus 로고    scopus 로고
    • Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one year clinical trials
    • [abstract]. Sep
    • Vincken WG, Vermiere P, Menjoge SS, et al. Maintenance of bronchodilation following tiotropium in patients with mild, moderate and severe COPD in one year clinical trials [abstract]. Eur Respir J 2001 Sep; 18 Suppl. 33: 331s
    • (2001) Eur. Respir. J. , vol.18 , Issue.SUPPL. 33
    • Vincken, W.G.1    Vermiere, P.2    Menjoge, S.S.3
  • 69
    • 0025886867 scopus 로고
    • The St. George's Respiratory Questionnaire
    • Jones PW, Quirk FH, Baveystock CM. The St. George's Respiratory Questionnaire. Respir Med 1991; 85 Suppl B: 25-31
    • (1991) Respir. Med. , vol.85 , Issue.SUPPL. B , pp. 25-31
    • Jones, P.W.1    Quirk, F.H.2    Baveystock, C.M.3
  • 70
    • 0026871146 scopus 로고
    • A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire
    • Jun
    • Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992 Jun; 145 (6): 1321-7
    • (1992) Am. Rev. Respir. Dis. , vol.145 , Issue.6 , pp. 1321-1327
    • Jones, P.W.1    Quirk, F.H.2    Baveystock, C.M.3
  • 71
    • 0034002446 scopus 로고    scopus 로고
    • How should health-related quality of life be assessed in patients with COPD?
    • Feb
    • Mahler DA. How should health-related quality of life be assessed in patients with COPD? Chest 2000 Feb; 117 (2 Suppl.): 54S-7S
    • (2000) Chest , vol.117 , Issue.2 SUPPL.
    • Mahler, D.A.1
  • 72
    • 0026877917 scopus 로고
    • The MOS 36-item short-form health survey (SF-36). 1. Conceptual framework and item selection
    • Jun
    • Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). 1. Conceptual framework and item selection. Med Care 1992 Jun; 30 (6): 473-83
    • (1992) Med. Care , vol.30 , Issue.6 , pp. 473-483
    • Ware Jr., J.E.1    Sherbourne, C.D.2
  • 73
    • 4243674913 scopus 로고    scopus 로고
    • Compliance with tiotropium, a once daily dry powder inhaled bronchodilator, in one year COPD trials
    • Oct
    • Kesten S, Flanders J, Serby CW, et al. Compliance with tiotropium, a once daily dry powder inhaled bronchodilator, in one year COPD trials. Chest 2000 Oct; 118 (4 Suppl.): 191S-2S
    • (2000) Chest , vol.118 , Issue.4 SUPPL.
    • Kesten, S.1    Flanders, J.2    Serby, C.W.3
  • 74
    • 1042292620 scopus 로고    scopus 로고
    • One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease
    • Oostenbrink JB, Rutten-van Mölken MPMH, Al J, et al. One-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease. Eur Respir J 2004; 23: 241-9
    • (2004) Eur. Respir. J. , vol.23 , pp. 241-249
    • Oostenbrink, J.B.1    Rutten-van Mölken, M.P.M.H.2    Al, J.3
  • 75
    • 4644224760 scopus 로고    scopus 로고
    • Summary of product characteristics: Spiriva
    • Boehringer Ingelheim International GmbH. Boehringer Ingelheim International GmbH
    • Boehringer Ingelheim International GmbH. Summary of product characteristics: Spiriva. Boehringer Ingelheim International GmbH, 2002
    • (2002)
  • 76
    • 4644318681 scopus 로고    scopus 로고
    • Prescribing information: Spiriva® Handihaler® (tiotropium bromide inhalation powder)
    • Boehringer Ingelheim, Pfizer Inc. [Accessed Mar 12] [online]. Available from URL
    • Boehringer Ingelheim, Pfizer Inc. Prescribing information: Spiriva® Handihaler® (tiotropium bromide inhalation powder) [online]. Available from URL: http://www.spiriva.com [Accessed 2004 Mar 12]
    • (2004)
  • 77
    • 4644265489 scopus 로고    scopus 로고
    • FDA approves Spiriva Handihaler for the treatment of COPD
    • Boehringer Ingelheim, Pfizer Inc. [media release]
    • Boehringer Ingelheim, Pfizer Inc. FDA approves Spiriva Handihaler for the treatment of COPD [media release]. 2004
    • (2004)
  • 78
    • 0031001720 scopus 로고    scopus 로고
    • Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study
    • May
    • Murray CJL, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997 May; 349 (9064): 1498-504
    • (1997) Lancet , vol.349 , Issue.9064 , pp. 1498-1504
    • Murray, C.J.L.1    Lopez, A.D.2
  • 79
    • 0004341496 scopus 로고    scopus 로고
    • National Institutes of Health: National Heart Lung and Blood Institute. [online]. Available from URL: [Accessed Aug 21]
    • National Institutes of Health: National Heart Lung and Blood Institute. Morbidity and Mortality: 2002 chart book on cardiovascular, lung, and blood diseases [online]. Available from URL: http://www.nhlbi.nih.gov/resources/docs/02_chtbk.pdf [Accessed 2002 Aug 21]
    • (2002) Morbidity and Mortality: 2002 Chart Book on Cardiovascular, Lung, and Blood Diseases
  • 80
    • 0032573819 scopus 로고    scopus 로고
    • Births, marriages, divorces, and deaths for 1997
    • National Center for Health Statistics. Jul 28
    • National Center for Health Statistics. Births, marriages, divorces, and deaths for 1997. Mon Vital Stat Rep 1998 Jul 28; 46 (12): 1-18
    • (1998) Mon. Vital Stat. Rep. , vol.46 , Issue.12 , pp. 1-18
  • 81
    • 4644316940 scopus 로고    scopus 로고
    • National Heart Lung and Blood Institute. [online]. Available from URL: [Accessed Jul 15]
    • National Heart Lung and Blood Institute. Data fact sheet: chronic obstructive pulmonary disease (COPD) [online]. Available from URL: http://www.nhlbi.nih.gov [Accessed 2002 Jul 15]
    • (2002) Data Fact Sheet: Chronic Obstructive Pulmonary Disease (COPD)
  • 83
    • 4644253835 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Management of chronic obstructive pulmonary disease in adults in primary and secondary care
    • National Institute for Clinical Excellence. [online]. Available from URL: [Accessed Mar 16]
    • National Institute for Clinical Excellence. Chronic obstructive pulmonary disease: management of chronic obstructive pulmonary disease in adults in primary and secondary care [online]. Available from URL: http://www.nice.org.uk [Accessed 2004 Mar 16]
    • (2004)
  • 84
    • 0034721232 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease
    • Jul 27
    • Barnes PJ. Chronic obstructive pulmonary disease. N Eng J Med 2000 Jul 27; 343 (4): 269-80
    • (2000) N. Eng. J. Med. , vol.343 , Issue.4 , pp. 269-280
    • Barnes, P.J.1
  • 85
    • 0033993882 scopus 로고    scopus 로고
    • National and international guidelines for COPD: The need for evidence
    • Feb
    • Pauwels RA. National and international guidelines for COPD: the need for evidence. Chest 2000 Feb; 117 (2 Suppl.): 20S-2S
    • (2000) Chest , vol.117 , Issue.2 SUPPL.
    • Pauwels, R.A.1
  • 87
    • 0034871011 scopus 로고    scopus 로고
    • A systematic review of the associations between dose regimens and medication compliance
    • Aug
    • Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001 Aug; 23 (8): 1296-310
    • (2001) Clin. Ther. , vol.23 , Issue.8 , pp. 1296-1310
    • Claxton, A.J.1    Cramer, J.2    Pierce, C.3
  • 88
    • 2342577516 scopus 로고    scopus 로고
    • Redefining treatment in COPD: New directions in bronchodilator therapy
    • Lipson DA. Redefining treatment in COPD: new directions in bronchodilator therapy. Treat Respir Med 2004; 3 (2): 89-95
    • (2004) Treat Respir. Med. , vol.3 , Issue.2 , pp. 89-95
    • Lipson, D.A.1
  • 89
    • 0029991285 scopus 로고    scopus 로고
    • Spirometry and dyspnea in patients with COPD: When small differences mean little
    • May
    • Redelmeier DA, Goldstein RS, Min ST, et al. Spirometry and dyspnea in patients with COPD: when small differences mean little. Chest 1996 May; 109 (5): 1163-8
    • (1996) Chest , vol.109 , Issue.5 , pp. 1163-1168
    • Redelmeier, D.A.1    Goldstein, R.S.2    Min, S.T.3
  • 91
    • 0030761378 scopus 로고    scopus 로고
    • Measurement of dyspnea and quality of life in advanced lung disease
    • Sep
    • Mahler DA, Jones PW. Measurement of dyspnea and quality of life in advanced lung disease. Clin Chest Med 1997 Sep; 18 (3): 457-69
    • (1997) Clin. Chest Med. , vol.18 , Issue.3 , pp. 457-469
    • Mahler, D.A.1    Jones, P.W.2
  • 92
    • 0035009873 scopus 로고    scopus 로고
    • Inhaled salmeterol: A review of its efficacy in chronic obstructive pulmonary disease
    • Jarvis B, Markham A. Inhaled salmeterol: a review of its efficacy in chronic obstructive pulmonary disease. Drugs Aging 2001; 18 (6): 441-72
    • (2001) Drugs Aging , vol.18 , Issue.6 , pp. 441-472
    • Jarvis, B.1    Markham, A.2
  • 93
    • 0042386628 scopus 로고    scopus 로고
    • Formoterol: A review of its use in chronic obstructive pulmonary disease
    • Cheer SM, Scott LJ. Formoterol: a review of its use in chronic obstructive pulmonary disease. Am J Respir Med 2002; 1 (4): 285-300
    • (2002) Am. J. Respir. Med. , vol.1 , Issue.4 , pp. 285-300
    • Cheer, S.M.1    Scott, L.J.2
  • 94
    • 4644299214 scopus 로고    scopus 로고
    • Largest COPD outcomes study completes patient recruitment
    • Boehringer Ingelheim, Pfizer Inc. [media release]
    • Boehringer Ingelheim, Pfizer Inc. Largest COPD outcomes study completes patient recruitment [media release]. 2004
    • (2004)


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