M2 muscarinic receptors inhibit cell proliferation in human glioblastoma cell lines

Life Sciences

Volumn 91, Issue 21-22, 2012, Pages 1134-1137

  Ferretti, M ^a   Fabbiano, C ^b   Di Bari, M ^a   Ponti, D ^b   Calogero, A ^b   Tata, A M ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Glioblastoma cell lines; M2 muscarinic receptors; Proliferation

Indexed keywords

ARECAIDINE; GALLAMINE; MUSCARINIC M2 RECEPTOR; THYMIDINE; TRITIUM; ARECOLINE; DRUG DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; GLIOBLASTOMA; GLIOMA CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ARECOLINE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; RECEPTOR, MUSCARINIC M2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84872808405     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.04.033     Document Type: Conference Paper

References (15)

1. R.B. Barlow, and P. Weston-Smith The relative potencies of some agonists at M2 muscarinic receptors in guinea pig ileum, atria and bronchi Br J Pharmacol 85 1985 437 440
2. A. Bordey, H. Sontheimer, and J. Thouslard Muscarinic activation of BK channels induces membrane oscillations in glioma cells and leads to inhibition of cell migration J Membr Biol 176 2000 31 40
3. R.E. Burke Gallamine binding to muscarinic M1 and M2 receptors, studied by inhibition of [3H]pirenzepine and [3H]quinuclidinylbenzilate binding to rat brain membranes Mol Pharmacol 1986 58 68
4. F. De Angelis, A. Bernardo, V. Magnaghi, L. Minghetti, and A.M. Tata Muscarinic receptors subtypes as potential target to modulate oligodendrocyte progenitor survival, proliferation and differentiation Dev Neurobiol 72 2012 713 728
5. M. Guizzetti, P. Costa, J. Peters, and L.G. Costa Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells Eur J Pharmacol 297 1996 265 273
6. S. Loreti, R. Ricordy, M.E. De Stefano, G. Augusti-Tocco, and A.M. Tata Acetylcholine inhibits cell cycle progression in rat Schwann cells by activation of the M2 receptor subtype Neuron Glia Biol 4 2007 269 279
7. U. Moser, G. Lambrecht, M. Wagner, J. Wess, and E. Mutschler Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1and M2 receptor subtypes Br J Pharmacol 96 1989 319 324
8. T. Mossman Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
9. S. Murphy, B. Pearce, and C. Morrow Astrocytes have both M1 and M2 muscarinic receptor subtypes Brain Res 364 1986 177 180
10. W. Rayford, M.J. Noble, M.A. Austenfeld, J. Weigel, W.K. Mebust, and G.V. Shah Muscarinic cholinergic receptors promote growth of human prostate cancer cell Prostate 30 1997 160 166
11. A.H. Shih, and E.C. Holland Developmental neurobiology and the origin of brain tumors J Neurooncol 70 2004 125 136
12. P. Song, Hs Sekhon, A. Lu, J. Arredondo, D. Sauer, and C. Gravett M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion Cancer Res 67 2007 3936 3944
13. P. Song, and E.R. Spindel Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy J Pharmacol Sci 106 2008 180 185
14. A.M. Tata Muscarinic acetylcholine receptors: new potential therapeutic targets in antinociception and in cancer therapy Rec Patents on CNS Drug Discov 3 2008 1 10
15. A.M. Tata, M. Ferretti, C. Fabbiano, L. Pacini, R. Ricordy, and G. Augusti Tocco M2 receptor activation affects survival and proliferation of human glioblastoma cells Glia S13 2009 171