-
1
-
-
54249124057
-
Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?
-
Becker RE, Greig NH, Giacobini E. (2008) Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices? J Alzheimers Dis 15, 303-325.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 303-325
-
-
Becker, R.E.1
Greig, N.H.2
Giacobini, E.3
-
2
-
-
84884894746
-
Development, optimization and use of pre-clinical behavioral models to maximize the productivity of drug discovery for Alzheimer's disease
-
McArthur RA, Borsini F, eds. San Diego: Academic Press
-
Lindner MD, McArthur RA, Deadwyler SA, Hampson RE, Tariot PN (2008) Development, optimization and use of pre-clinical behavioral models to maximize the productivity of drug discovery for Alzheimer's disease. In: Animal and Trans-lational Models for CNS Drug Discovery: Neurologic Disorders. McArthur RA, Borsini F, eds. San Diego: Academic Press p. 93-157.
-
(2008)
Animal and Trans-lational Models for CNS Drug Discovery: Neurologic Disorders
, pp. 93-157
-
-
Lindner, M.D.1
McArthur, R.A.2
Deadwyler, S.A.3
Hampson, R.E.4
Tariot, P.N.5
-
3
-
-
59549087712
-
Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurode-generative conditions: Exploring new territory using traditional tools and established maps
-
Bartus RT, Dean RL 3rd (2009) Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurode-generative conditions: exploring new territory using traditional tools and established maps. Psychopharmacology (Berl) 202, 15-36.
-
(2009)
Psychopharmacology (Berl)
, vol.202
, pp. 15-36
-
-
Bartus, R.T.1
Dean III, R.L.2
-
4
-
-
68349084783
-
Management of agitation and aggression associated with Alzheimer disease
-
Ballard CG, Gauthier S, Cummings JL, Brodaty H, Grossberg GT, Robert P, Lyketsos CG (2009) Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurol 5, 245-255.
-
(2009)
Nat Rev Neurol
, vol.5
, pp. 245-255
-
-
Ballard, C.G.1
Gauthier, S.2
Cummings, J.L.3
Brodaty, H.4
Grossberg, G.T.5
Robert, P.6
Lyketsos, C.G.7
-
5
-
-
34247232644
-
Effective pharmacologic management of Alzheimer's disease
-
DOI 10.1016/j.amjmed.2006.08.036, PII S0002934307001660
-
Farlow MR, Cummings JL (2007) Effective pharmacologic management of Alzheimer's disease. Am J Med 120, 388-397. (Pubitemid 46627453)
-
(2007)
American Journal of Medicine
, vol.120
, Issue.5
, pp. 388-397
-
-
Farlow, M.R.1
Cummings, J.L.2
-
6
-
-
0036370776
-
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
-
DOI 10.1385/NMM:1:1:1
-
Sambamurti K, Greig NH, Lahiri DK (2002) Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med 1, 1-31. (Pubitemid 37021521)
-
(2002)
NeuroMolecular Medicine
, vol.1
, Issue.1
, pp. 1-31
-
-
Sambamurti, K.1
Greig, N.H.2
Lahiri, D.K.3
-
7
-
-
39649101710
-
Developing preventive therapies for chronic diseases: Lessons learned from Alzheimer's disease
-
Selkoe DJ (2007) Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutr Rev 65(12 Pt 2), S239-S243.
-
(2007)
Nutr Rev
, vol.65
, Issue.12 PART 2
-
-
Selkoe, D.J.1
-
8
-
-
33645829653
-
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
-
Hardy J (2006) Has the amyloid cascade hypothesis for Alzheimer's disease been proved? Curr Alzheimer Res 3, 71-73.
-
(2006)
Curr Alzheimer Res
, vol.3
, pp. 71-73
-
-
Hardy, J.1
-
9
-
-
33645824170
-
Amyloid beta: The alternate hypothesis
-
Lee H-G, Zhu X, Nunomura A, Perry G, Smith MA (2006) Amyloid beta: the alternate hypothesis. Curr Alzheimer Res. 3, 75-80.
-
(2006)
Curr Alzheimer Res.
, vol.3
, pp. 75-80
-
-
Lee, H.-G.1
Zhu, X.2
Nunomura, A.3
Perry, G.4
Smith, M.A.5
-
10
-
-
33645846948
-
A partial failure of membrane protein turnover may cause Alzheimer's disease: A new hypothesis
-
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH (2006) A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Curr Alzheimer Res 3, 81-90.
-
(2006)
Curr Alzheimer Res
, vol.3
, pp. 81-90
-
-
Sambamurti, K.1
Suram, A.2
Venugopal, C.3
Prakasam, A.4
Zhou, Y.5
Lahiri, D.K.6
Greig, N.H.7
-
11
-
-
67649488309
-
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains
-
Welander H, Frnberg J, Graff C, Sundström E, Winblad B, Tjernberg LO (2009) Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains. J Neurochem 110, 697-706
-
(2009)
J Neurochem
, vol.110
, pp. 697-706
-
-
Welander, H.1
Frnberg, J.2
Graff, C.3
Sundström, E.4
Winblad, B.5
Tjernberg, L.O.6
-
12
-
-
67049159505
-
Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid
-
Nimmrich V, Ebert U (2009) Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid. Rev Neurosci 20, 1-12
-
(2009)
Rev Neurosci
, vol.20
, pp. 1-12
-
-
Nimmrich, V.1
Ebert, U.2
-
13
-
-
77449122733
-
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure
-
Parodi J, Sepulveda FJ, Roa J, Opazo C, Inestrosa NC, Aguayo LG (2010) Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem 285, 2506-2514.
-
(2010)
J Biol Chem
, vol.285
, pp. 2506-2514
-
-
Parodi, J.1
Sepulveda, F.J.2
Roa, J.3
Opazo, C.4
Inestrosa, N.C.5
Aguayo, L.G.6
-
14
-
-
77952519104
-
Synaptic and endosomal localization of active gamma-secretase in rat brain
-
Frykman S, Hur JY, Frnberg J, Aoki M, Winblad B, Nahalkova J, Behbahani H, Tjernberg LO (2010) Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS ONE 5, e8948.
-
(2010)
PLoS ONE
, vol.5
-
-
Frykman, S.1
Hur, J.Y.2
Frnberg, J.3
Aoki, M.4
Winblad, B.5
Nahalkova, J.6
Behbahani, H.7
Tjernberg, L.O.8
-
15
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.(2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457, 981-989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
McLaughlin, T.2
O'Leary, D.D.3
Tessier-Lavigne, M.4
-
16
-
-
40549095365
-
C-terminal cleavage of the amyloid-β protein precursor at Asp664: A switch associated with Alzheimer's disease
-
Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE (2008) C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis 13, 1-16 (Pubitemid 351365623)
-
(2008)
Journal of Alzheimer's Disease
, vol.13
, Issue.1
, pp. 1-16
-
-
Banwait, S.1
Galvan, V.2
Zhang, J.3
Gorostiza, O.F.4
Ataie, M.5
Huang, W.6
Crippen, D.7
Koo, E.H.8
Bredesen, D.E.9
-
17
-
-
56249083216
-
Neurofibrillary degeneration in Alzheimer's disease: From molecular mechanisms to identification of drug targets
-
Pei JJ, Sjögren M, Winblad B (2008) Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets. Curr Opin Psychiatry 21, 555-561.
-
(2008)
Curr Opin Psychiatry
, vol.21
, pp. 555-561
-
-
Pei, J.J.1
Sjögren, M.2
Winblad, B.3
-
18
-
-
71649108692
-
Emerging cognitive enhancing drugs
-
Buccafusco JJ (2009) Emerging cognitive enhancing drugs. Expert Opin Emerg Drugs 14, 577-589.
-
(2009)
Expert Opin Emerg Drugs
, vol.14
, pp. 577-589
-
-
Buccafusco, J.J.1
-
19
-
-
67650895354
-
The quest for small molecules as amyloid inhibiting therapies for Alzheimer's disease
-
Amijee H, Scopes DI (2009) The quest for small molecules as amyloid inhibiting therapies for Alzheimer's disease. J Alzheimers Dis 17, 33-47.
-
(2009)
J Alzheimers Dis
, vol.17
, pp. 33-47
-
-
Amijee, H.1
Scopes, D.I.2
-
20
-
-
0028894072
-
Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease
-
Greig NH, Pei XF, Soncrant TT, Ingram DK, Brossi A (1995) Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease. Med Res Rev 15, 3-31
-
(1995)
Med Res Rev
, vol.15
, pp. 3-31
-
-
Greig, N.H.1
Pei, X.F.2
Soncrant, T.T.3
Ingram, D.K.4
Brossi, A.5
-
21
-
-
22144494112
-
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
-
DOI 10.2174/1567205054367829
-
Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma GB, Lahiri DK (2005) An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res 2, 281-290. (Pubitemid 40980186)
-
(2005)
Current Alzheimer Research
, vol.2
, Issue.3
, pp. 281-290
-
-
Greig, N.H.1
Sambamurti, K.2
Yu, Q.-S.3
Brossi, A.4
Bruinsma, G.B.5
Lahiri, D.K.6
-
22
-
-
0032499879
-
Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: Phenserine
-
DOI 10.1006/bbrc.1998.8931
-
Al-Jafari AA, Kamal MA, Greig NH, Alhomida AS, Perry ER (1998) Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Biochem Biophys Res Commun 248, 180-185 (Pubitemid 28418208)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.248
, Issue.1
, pp. 180-185
-
-
Al-Jafari, A.A.1
Kamal, M.A.2
Greig, N.H.3
Alhomida, A.S.4
Perry, E.R.5
-
23
-
-
0034574284
-
The experimental alzheimer drug phenserine: Preclinical pharmacokinetics and pharmacodynamics
-
Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT (2000) The experimental Alzheimer drug phenserine: pre-clinical pharmacokinetics and pharmacodynamics. Acta Neu-rol Scand Suppl 176, 74-84. (Pubitemid 32156174)
-
(2000)
Acta Neurologica Scandinavica, Supplement
, vol.102
, Issue.176
, pp. 74-84
-
-
Greig, N.H.1
De Micheli, E.2
Holloway, H.W.3
Yu, Q.-S.4
Utsuki, T.5
Perry, T.A.6
Ingram, D.K.7
Deutsch, J.8
Lahiri, D.9
Soncrant, T.T.10
-
26
-
-
0023899578
-
Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects
-
Becker RE, Giacobini E (1988) Mechanisms of cholinesterase inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects. Drug Dev Res 12,163-195.
-
(1988)
Drug Dev Res
, vol.12
, pp. 163-195
-
-
Becker, R.E.1
Giacobini, E.2
-
27
-
-
70350517148
-
Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine
-
Rodda J, Morgan S, Walker Z (2009) Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr 21, 813-824.
-
(2009)
Int Psychogeriatr
, vol.21
, pp. 813-824
-
-
Rodda, J.1
Morgan, S.2
Walker, Z.3
-
28
-
-
73249121028
-
Disease progression meta-analysis model in Alzheimer's disease
-
Alzheimer's Disease Working Group
-
Ito K, Ahadieh S, Corrigan B, French J, Fullerton T, Tens-feldt T; Alzheimer's Disease Working Group (2010) Disease progression meta-analysis model in Alzheimer's disease. Alzheimers Dement 6, 39-53.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 39-53
-
-
Ito, K.1
Ahadieh, S.2
Corrigan, B.3
French, J.4
Fullerton, T.5
Tens-Feldt, T.6
-
29
-
-
0035912825
-
Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
-
DOI 10.1073/pnas.131152998
-
Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH (2001) Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci U S A 98, 7605-7610. (Pubitemid 32567995)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.13
, pp. 7605-7610
-
-
Shaw, K.T.Y.1
Utsuki, T.2
Rogers, J.3
Yu, Q.-S.4
Sambamurti, K.5
Brossi, A.6
Ge, Y.-W.7
Lahiri, D.K.8
Greig, N.H.9
-
30
-
-
33845905829
-
The experimental Alzheimer's Disease drug posiphen [(+)-phenserine] lowers amyloid-β peptide levels in cell culture and mice
-
DOI 10.1124/jpet.106.112102
-
Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH (2007) The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther 320, 386-396. (Pubitemid 46025753)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.1
, pp. 386-396
-
-
Lahiri, D.K.1
Chen, D.2
Maloney, B.3
Holloway, H.W.4
Yu, Q.-S.5
Utsuki, T.6
Giordano, T.7
Sambamurti, K.8
Greig, N.H.9
-
31
-
-
34447567415
-
Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer disease
-
DOI 10.1007/s12017-007-0005-4, PII NMM92157
-
Lahiri DK, Alley GM, Tweedie D, Chen D, Greig NH (2007) Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease. Neuromolecular Med 9, 157-168. (Pubitemid 47065543)
-
(2007)
NeuroMolecular Medicine
, vol.9
, Issue.2
, pp. 157-168
-
-
Lahiri, D.K.1
Alley, G.M.2
Tweedie, D.3
Chen, D.4
Greig, N.H.5
-
32
-
-
0030986003
-
Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
-
DOI 10.1016/S0169-328X(96)00297-5, PII S0169328X96002975
-
Haroutunian V, Greig N, Pei XF, Utsuki T, Gluck R, Acevedo LD, Davis KL, Wallace WC (1997) Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res Mol Brain Res 46, 161-168. (Pubitemid 27214367)
-
(1997)
Molecular Brain Research
, vol.46
, Issue.1-2
, pp. 161-168
-
-
Haroutunian, V.1
Greig, N.2
Pei, X.-F.3
Utsuki, T.4
Gluck, R.5
Acevedo, L.D.6
Davis, K.L.7
Wallace, W.C.8
-
33
-
-
24644497684
-
Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects
-
DOI 10.2174/156720505774330564
-
Greig NH, Ruckle J, Comer P, Brownell L, Holloway HW, Flanagan DR Jr, Canfield CJ, Burford RG (2005) Anti-cholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. Curr Alzheimer Res 2, 483-492. (Pubitemid 41277760)
-
(2005)
Current Alzheimer Research
, vol.2
, Issue.4
, pp. 483-492
-
-
Greig, N.H.1
Ruckle, J.2
Comer, P.3
Brownell, L.4
Holloway, H.W.5
Flanagan Jr., D.R.6
Canfield, C.J.7
Burford, R.G.8
-
34
-
-
22144492540
-
Lessons from Darwin: 21st century designs for clinical trials
-
Becker RE (2005) Lessons from Darwin: 21st century designs for clinical trials. Curr Alzheimer Res 2, 319-326.
-
(2005)
Curr Alzheimer Res
, vol.2
, pp. 319-326
-
-
Becker, R.E.1
-
35
-
-
34548667237
-
Lessons from Darwin: Evolutionary biology's implications for Alzheimer's disease research and patient care
-
Becker RE (2007) Lessons from Darwin: evolutionary biology's implications for Alzheimer's disease research and patient care. Curr Alzheimer Res 4, 458-467.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 458-467
-
-
Becker, R.E.1
-
36
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of the department of health and human services task force on Alzheimer's disease. Neurology 34, 939-944 (Pubitemid 14076461)
-
(1984)
Neurology
, vol.34
, Issue.7
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
-
37
-
-
0018887732
-
Pathological verification of ischemic score in differentiation of dementias
-
Rosen WG, Mohs RC, Davies KL (1980) Pathological Validation of Ischemia in differentiation of dementia. Ann Neurol 7, 486-488. (Pubitemid 10073130)
-
(1980)
Annals of Neurology
, vol.7
, Issue.5
, pp. 486-488
-
-
Rosen, W.G.1
Terry, R.D.2
Fuld, P.A.3
-
38
-
-
0016823810
-
Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician
-
Folstein M, Folstein S,McHugh PR(1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
-
(1975)
J Psychiatr Res
, vol.12
, pp. 189-198
-
-
Folstein, M.1
Folstein, S.2
McHugh, P.R.3
-
39
-
-
79751511985
-
-
Declaration of Helsinki, 1964 [as amended in Tokyo (1975), Venice (1983), Hong Kong (1989) South Africa ( 1996), Scotland ( 2000), with note of clarification on paragraph 29 added by the WMA General Assembly, Washington USA 2002)
-
Declaration of Helsinki, 1964 [as amended in Tokyo (1975), Venice (1983), Hong Kong (1989) South Africa ( 1996), Scotland ( 2000), with note of clarification on paragraph 29 added by the WMA General Assembly, Washington USA 2002)].
-
-
-
-
40
-
-
0021520020
-
A new rating scale for Alzheimer's disease
-
see Appendix A
-
Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141, 1356-1364 (see Appendix A).
-
(1984)
Am J Psychiatry
, vol.141
, pp. 1356-1364
-
-
Rosen, W.G.1
Mohs, R.C.2
Davis, K.L.3
-
41
-
-
0030814418
-
Development of cognitive instruments for use in clinical trials of anti-dementia drugs: Additions to the Alzheimer's disease assessment scale that broaden its scope
-
The Alzheimer's Disease Cooperative Study
-
Mohs RC, Knopman D, Petersen RC, Ferris SH, Ernesto C, Grundman M, Sano M, Bieliauskas L, Geldmacher D, Clark C, Thal LJ (1997) Development of cognitive instruments for use in clinical trials of anti-dementia drugs: additions to the Alzheimer's disease assessment scale that broaden its scope. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11 (Suppl 2), 13-21.
-
(1997)
Alzheimer Dis Assoc Disord
, vol.11
, Issue.SUPPL 2
, pp. 13-21
-
-
Mohs, R.C.1
Knopman, D.2
Petersen, R.C.3
Ferris, S.H.4
Ernesto, C.5
Grundman, M.6
Sano, M.7
Bieliauskas, L.8
Geldmacher, D.9
Clark, C.10
Thal, L.J.11
-
42
-
-
0030627145
-
Clinical global measures of dementia: Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines
-
Reisberg B, Schneider LS, Doody R, Anand R, Feldman H, Haraguchi H, Kumar R, Lucca U, Mangone CA, Mohr E, Morris JC, Rogers S, Sawada T (1997) Clinical global measures of dementia: position paper from the International Working Group on Harmonization of Dementia Drug Guidelines, Alzheimer Dis Assoc Disord 11 (Suppl 3), S8-18.
-
(1997)
Alzheimer Dis Assoc Disord
, vol.11
, Issue.SUPPL 3
-
-
Reisberg, B.1
Schneider, L.S.2
Doody, R.3
Anand, R.4
Feldman, H.5
Haraguchi, H.6
Kumar, R.7
Lucca, U.8
Mangone, C.A.9
Mohr, E.10
Morris, J.C.11
Rogers, S.12
Sawada, T.13
-
43
-
-
0030862602
-
Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change
-
The Alzheimer's Disease Cooperative Study
-
Schneider LS, Olin JT, Doody RS, Clark CM, Morris JC, Reisberg B, Schmitt FA, Grundman M, Thomas RG, Ferris SH (1997) Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11 (Suppl 2), S22-32.
-
(1997)
Alzheimer Dis Assoc Disord
, vol.11
, Issue.SUPPL 2
-
-
Schneider, L.S.1
Olin, J.T.2
Doody, R.S.3
Clark, C.M.4
Morris, J.C.5
Reisberg, B.6
Schmitt, F.A.7
Grundman, M.8
Thomas, R.G.9
Ferris, S.H.10
-
44
-
-
79751505194
-
-
Data on file (2004) Axonyx Corporation, New York, NY
-
Data on file (2004) Axonyx Corporation, New York, NY.
-
-
-
-
45
-
-
0032926540
-
The effects of donepezil in Alzheimer's disease - Results from a multinational trial
-
DOI 10.1159/000017126
-
Burns A, Rossor M, Hecker J, Gauthier S, Petit H, Möller HJ, Rogers SL, Friedhoff LT (1999) The effects of donepezil in Alzheimer's disease - results from a multinational trial. Dement Geriatr Cogn Disord 10, 237-244. (Pubitemid 29224502)
-
(1999)
Dementia and Geriatric Cognitive Disorders
, vol.10
, Issue.3
, pp. 237-244
-
-
Burns, A.1
Rossor, M.2
Hecker, J.3
Gauthier, S.4
Petit, H.5
Moller, H.-J.6
Rogers, S.L.7
Friedhoff, L.T.8
-
46
-
-
41149127264
-
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease
-
Kadir A, Andreasen N, Almkvist O, Wall A, Forsberg A, Engler H, Hagman G, Lärksäter M, Winblad B, Zetterberg H, Blennow K, Lngström B, Nordberg A (2008) Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease. Ann Neurol 63, 621-631.
-
(2008)
Ann Neurol
, vol.63
, pp. 621-631
-
-
Kadir, A.1
Andreasen, N.2
Almkvist, O.3
Wall, A.4
Forsberg, A.5
Engler, H.6
Hagman, G.7
Lärksäter, M.8
Winblad, B.9
Zetterberg, H.10
Blennow, K.11
Lngström, B.12
Nordberg, A.13
-
47
-
-
48749125741
-
Alzheimer's disease drug development in 2008 and beyond: Problems and opportunities
-
Becker RE, Greig NH (2008) Alzheimer's disease drug development in 2008 and beyond: problems and opportunities. Curr Alzheimer Res 5, 346-357.
-
(2008)
Curr Alzheimer Res
, vol.5
, pp. 346-357
-
-
Becker, R.E.1
Greig, N.H.2
-
48
-
-
34447525109
-
Rating rater improvement: A method for estimating increased effect size and reduction of clinical trial costs [17]
-
DOI 10.1097/01.jcp.0000280315.81366.f8, PII 0000471420070800000029
-
Cogger KO (2007) Rating rater improvement: a method for estimating increased effect size and reduction of clinical trial costs. J Clin Psychopharmacol 27, 418-420. (Pubitemid 47075527)
-
(2007)
Journal of Clinical Psychopharmacology
, vol.27
, Issue.4
, pp. 418-420
-
-
Cogger, K.O.1
-
49
-
-
78650203665
-
Why so few drugs for Alzheimer's disease? Are methods failing drugs?
-
Becker RE, Greig NH (2010) Why so few drugs for Alzheimer's disease? Are methods failing drugs? Curr Alzheimer Res 7(7), 642-651.
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.7
, pp. 642-651
-
-
Becker, R.E.1
Greig, N.H.2
-
50
-
-
77954116746
-
Issues in design and conductance of clinical trials for cognitive-enhancing drugs
-
Animal and Translational Models of Behavioural Disorders.McArthur RA, Borsini F, eds, New York: Elsevier
-
Schneider LS (2008) Issues in design and conductance of clinical trials for cognitive-enhancing drugs. In: Animal and Translational Models of Behavioural Disorders. McArthur RA, Borsini F, eds. Neurological disorders. Volume 2. New York: Elsevier.
-
(2008)
Neurological Disorders
, vol.2
-
-
Schneider, L.S.1
-
51
-
-
62149097584
-
The perils of Alzheimer's drug development
-
Schneider LS, Lahiri DK (2009) The perils of Alzheimer's drug development. Curr Alzheimer Res 6, 77-78.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 77-78
-
-
Schneider, L.S.1
Lahiri, D.K.2
-
52
-
-
79751522222
-
-
Axonyx press release (10/30/2001), Accessed May 4
-
Axonyx press release (10/30/2001). http://findarticles.com/ p/articles/mi-m0EIN/is-2001Oct-30/ai-79540858, Accessed May 4, 2010.
-
-
-
-
53
-
-
77449148897
-
Amyloid imaging in early detection of Alzheimer's disease
-
Nordberg A (2010) Amyloid imaging in early detection of Alzheimer's disease. Neurodegener Dis 7, 136-138.
-
(2010)
Neurodegener Dis
, vol.7
, pp. 136-138
-
-
Nordberg, A.1
-
54
-
-
84872108003
-
Oral phenserine tartrate treatment is associated with reduced plasma Aβ 1-42 in a phase i clinical study
-
Fisher A, Hanin I, Memo M, Stocchi F, Eds. Medimond, Italy, Via Maserati,5, Bologna
-
Sambamurti K, Prakasam A, Anitha S, Venugopa C, Cullen E, Zhou Y, Bruinsma G, Lahiri DK, Greig NH, Friedhoff L (2006) Oral phenserine tartrate treatment is associated with reduced plasma Aβ 1-42 in a phase I clinical study. In New Trends in Alzheimer's and Parkinson's Disorders: ADPD 2006, Fisher A, Hanin I, Memo M, Stocchi F, Eds. Medimond, Via Maserati 5, Bologna, Italy, pp. 571-575.
-
(2006)
New Trends in Alzheimer's and Parkinson's Disorders: ADPD 2006
, pp. 571-575
-
-
Sambamurti, K.1
Prakasam, A.2
Anitha, S.3
Venugopa, C.4
Cullen, E.5
Zhou, Y.6
Bruinsma, G.7
Lahiri, D.K.8
Greig, N.H.9
Friedhoff, L.10
-
55
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangaliasche F, Solomon A, Winblad B, Mecocci P and Kivipelto M (2010). Alzheimer's disease: clinical trials and drug development. Lancet Neurol 9, 702-716.
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangaliasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
|