Vitamin C - ascorbic acid

Vitamins in the Prevention of Human Diseases

Volumn , Issue , 2011, Pages 323-362

  Frikke Schmidt, Henriette ^a   Tveden Nyborg, Pernille ^a   Lykkesfeldt, Jens ^a   Drake, Victoria J ^b   Frei, Balz ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84881757399     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1515/9783110214499     Document Type: Chapter

References (296)

1. Ali MS, Phillippo ET, Simultaneous determination of ascorbic, dehydroascorbic, isoascorbic, and dehydroisoascorbic acids in meat-based food products by liquid chromatography with postcolumn fluorescence detection: a method extension. J AOAC Int 1996;79: 803-8.
2. Ault RG, Baird DK, Carrington HC, Haworth WN, Herbert RW, Hirst EL, Percival EGV, Smith F, Stacey M, Synthesis of D- and L-ascorbic acid and of analogous substances. J Chem Soc 1933; 1419-23.
3. Aycicek A, Erel O, Kocyigit A, Increased oxidative stress in infants exposed to passive smoking. Eur J Pediatr 2005;164: 775-8.
4. Bennett M, Coninx R, The mystery of the wooden leg: vitamin C deficiency in East African prisons. Trop Doct 2005;35: 81-4.
5. Berman SB, Zigmond MJ, Hastings TG, Modification of dopamine transporter function: effect of reactive oxygen species and dopamine. J Neurochem 1996;67: 593-600.
6. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C, Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and metaanalysis. J AmMed Assoc 2007;297: 842-57.
7. Block G, Epidemiologic evidence regarding vitamin C and cancer. Am J Clin Nutr 1991;54: 1310S-4S.
8. Block G, Dietrich M, Norkus EP, Morrow JD, Hudes M, Caan B, Packer L, Factors associated with oxidative stress in human populations. Am J Epidemiol 2002;156: 274-85.
9. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY, Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85: 1483-92.
10. Bode AM, Cunningham L, Rose RC, Spontaneous decay of oxidized ascorbic acid (dehydro-Lascorbic acid) evaluated by high-pressure liquid chromatography. Clin Chem 1990;36: 1807-9.
11. Bornstein SR, Yoshida-Hiroi M, Sotiriou S, Levine M, Hartwig HG, Nussbaum RL, Eisenhofer G, Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2). FASEB J 2003;17: 1928-30.
12. Buettner GR, The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 1993;300: 535-43.
13. Buettner GR, Schafer FQ, Ascorbate as an antioxidant. In: Asard H, May JM, Smirnoff N, editors. Vitamin C: its functions and biochemistry in animals and plants. Oxford: BIOS Scientific Publishers Limited; 2004. pp. 173-88.
14. Carr A, Frei B, Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 1999;13: 1007-24.
15. Chambers JC, McGregor A, Jean-Marie J, Obeid OA,Kooner JS, Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999;99: 1156-60.
16. Cook NR, Albert CM, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, Manson JE, A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med 2007;167: 1610-8.
17. Cooke JR, Moxon RED, The detection and measurement of vitamin C. In: Counsell JN, Hornig DH, editors. Vitamin C. London: Applied Science Publishers; 1981. pp. 167-89.
18. Cordero ME, D'Acuna E, Benveniste S, Prado R, Nunez JA, Colombo M, Dendritic development in neocortex of infants with early postnatal life undernutrition. Pediatr Neurol 1993;9: 457-64.
19. Delanghe JR, Langlois MR, De Buyzere ML, Torck MA, Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism. Clin Chem 2007;53: 1397-400.
20. Deutsch JC, Kolhouse JF, Ascorbate and dehydroascorbate measurements in aqueous solutions and plasma determined by gas chromatography-mass spectrometry. Anal Chem 1993;65: 321-6.
21. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids: a report of the Panel on Dietary Antioxidants and Related Compounds, Subcommitties on Upper Reference Levels of Nutrients and of the Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine, National Academy of Sciences. Washington DC: National Academy Press; 2000.
22. Dragsted LO, Pedersen A, Hermetter A, Basu S, Hansen M, Haren GR, Kall M, Breinholt V, Castenmiller JJ, Stagsted J, Jakobsen J, Skibsted L, Rasmussen SE, Loft S, Sandstrom B, The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. Am J Clin Nutr 2004;79: 1060-72.
23. Erdman JW, Klein BP, Harvesting, processing, and cooking influences on vitamin-C in foods. Adv Chem Series 1982; 499-532.
24. Fediuk K, Hidiroglou N, Madere R, Kuhnlein HV, Vitamin C in Inuit traditional food and women's diets. J Food Compos Anal 2002;15: 221-35.
25. Frei B, Stocker R, Ames BN, Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci U S A 1988;85: 9748-52.
26. Frei B, England L, Ames BN, Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989;86: 6377-81.
27. Frei B, Stocker R, England L, Ames BN, Ascorbate: the most effective antioxidant in human blood plasma. Adv Exp Med Biol 1990;264: 155-63.
28. Frei B, Forte TM, Ames BN, Cross CE, Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J 1991;277: 133-8.
29. Frikke-Schmidt H, Lykkesfeldt J, Role of marginal vitamin C deficiency in atherogenesis: in vivo models and clinical studies. Basic Clin Pharmacol Toxicol 2009;104: 419-33.
30. Fujita Y, Mori I, Yamaguchi T, Hoshino M, Shigemura Y, Shimano M, Spectrophotometric determination of ascorbic acid with iron(III) and p-carboxyphenylfluorone in a cationic surfactant micellar medium. Anal Sci 2001;17: 853-7.
31. Gale CR, Martyn CN, Winter PD, Cooper C, Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. B Med J 1995;310: 1563-6.
32. Gey KF, Brubacher GB, Stahelin HB, Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. Am J Clin Nutr 1987a;45: 1368-77.
33. Gey KF, Stahelin HB, Puska P, Evans A, Relationship of plasma level of vitamin C to mortality from ischemic heart disease. Ann NY Acad Sci 1987b;498: 110-23.
34. Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E, Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 1993a;57: 787S-97S.
35. Gey KF, Stahelin HB, Eichholzer M, Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study. Clin Invest 1993b;71: 3-6.
36. Gil MI, Aguayo E, Kader AA, Quality changes and nutrient retention in fresh-cut versus whole fruits during storage. J Agric Food Chem 2006;54: 4284-96.
37. Gokce N, Frei B, Basic research in antioxidant inhibition of steps in atherogenesis. J Cardiovasc Risk 1996;3: 352-7.
38. Gokce N, Keaney JF Jr, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA, Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1999;99: 3234-40.
39. Ha YM, Park MK, Kim HJ, Seo HG, Lee JH, Chang KC, High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor. Cancer Lett 2009;277: 48-54.
40. Hack M, Survival and neurodevelopmental outcomes of preterm infants. J Pediatr Gastroenterol Nutr 2007;45(Suppl 3): S141-2.
41. Hampl JS, Taylor CA, Johnston CS,VitaminCdeficiency and depletion in the United States: theThird National Health and Nutrition Examination Survey, 1988 to 1994. Am J Public Health 2004;94: 870-5.
42. Harrison FE, May JM,Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med 2009;46: 719-30.
43. Haworth WN, Hirst EL, Synthesis of ascorbic acid. J Soc Chem Indust (Lond) 1933;52: 645-7.
44. Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360: 23-33.
45. Heitzer T, Just H, Munzel T, Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996;94: 6-9.
46. Heitzer T, Brockhoff C, Mayer B, Warnholtz A, Mollnau H, Henne S, Meinertz T, Munzel T, Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase. Circ Res 2000;86: E36-41.
47. Heller R, Munscher-Paulig F, Grabner R, Till U, L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. J Biol Chem 1999;274: 8254-60.
48. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briancon S, The SUVIMAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004;164: 2335-42.
49. Hewitson KS, McNeill LA, Elkins JM, Schofield CJ, The role of iron and 2-oxoglutarate oxygenases in signalling. Biochem Soc Trans 2003;31: 510-5.
50. Hodges RE, Hood J, Canham JE, Sauberlich HE, Baker EM, Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr 1971;24: 432-43.
51. Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L, Miller WH Jr, Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol 2008;19: 1969-74.
52. Hornig B, Arakawa N, Kohler C, Drexler H, Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998;97: 363-8.
53. Huang A,Vita JA,Venema RC, Keaney JF Jr,Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 2000;275: 17399-406.
54. Ignarro LJ, Napoli C, Loscalzo J, Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circ Res 2002;90: 21-8.
55. Ito K, Akita H, Kanazawa K, Yamada S, Terashima M, Matsuda Y, Yokoyama M, Comparison of effects of ascorbic acid on endothelium-dependent vasodilation in patients with chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy versus patients with effort angina pectoris secondary to coronary artery disease. Am J Cardiol 1998;82: 762-7.
56. Jackson TS, Xu A, Vita JA, Keaney JF Jr, Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res 1998;83: 916-22.
57. Jacob RA, Sotoudeh G, Vitamin C function and status in chronic disease. Nutr Clin Care 2002;5: 66-74.
58. Johnston CS, Biomarkers for establishing a tolerable upper intake level for vitamin C. Nutr Rev 1999;57: 71-7.
59. Johnston CS, Thompson LL, Vitamin C status of an outpatient population. J Am Coll Nutr 1998;17: 366-70.
60. Kabasakalis V, Siopidou D, Moshatou E, Ascorbic acid content of commercial fruit juices and its rate of loss upon storage. Food Chem 2000;70: 325-8.
61. Kall MA, Andersen C, Improved method for simultaneous determination of ascorbic acid and dehydroascorbic acid, isoascorbic acid and dehydroisoascorbic acid in food and biological samples. J Chromatogr B Biomed Sci Appl 1999;730: 101-11.
62. Kallner AB, Hartmann D, Hornig DH, On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers. Am J Clin Nutr 1981;34: 1347-55.
63. Katsuki H, Vitamin C and nervous tissue. In vivo and in vitro aspects. Sub-Cellular Biochem 1996;25: 293-311.
64. Katusic ZS, Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? Am J Physiol Heart Circ Physiol 2001;281: H981-6.
65. Kratzing CC, Kelly JD, Kratzing JE, Ascorbic acid in fetal rat brain. J Neurochem 1985;44: 1623-4.
66. Kritchevsky SB, ShimakawaT, Tell GS, Dennis B, Carpenter M, Eckfeldt JH, Peacher-Ryan H, Heiss G, Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995;92: 2142-50.
67. Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, Misumi K, Kawano H, Miyao Y, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S, Yasue H, Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 1998;32: 103-9.
68. Lee JY, Chang MY, Park CH, Kim HY, Kim JH, Son H, Lee YS, Lee SH, Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes. J Neurosci Res 2003;73: 156-65.
69. Leung PY, Miyashita K, Young M, Tsao CS, Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines. Anticancer Res 1993;13: 475-80.
70. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF Jr, Vita JA, Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996;93: 1107-13.
71. Levine M, Morita K, Ascorbic acid in endocrine systems. Vitamin Horm 1985;42: 1-64.
72. Levine M, Asher A, Pollard H, Zinder O, Ascorbic acid and catecholamine secretion from cultured chromaffin cells. J Biol Chem 1983;258: 13111-5.
73. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR, Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996;93: 3704-9.
74. Levine M, Wang Y, Rumsey SC, Analysis of ascorbic acid and dehydroascorbic acid in biological samples. Methods Enzymol 1999;299: 65-76.
75. Lin SY, Lai WW, Chou CC, Kuo HM, Li TM, Chung JG, Yang JH, Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells. Melanoma Res 2006;16: 509-19.
76. Lind J, A treatise on the scurvy in three parts containing an enquiry into the nature, causes and cure of that disease, together with a critical and chronological view of what has been published on the subject. Edinburgh: Sands, Murray and Cochran; 1753.
77. Litt J, Taylor HG, Klein N, Hack M, Learning disabilities in children with very low birthweight: prevalence, neuropsychological correlates, and educational interventions. J Learn Disabil 2005;38: 130-41.
78. Loria CM, Klag MJ, Caulfield LE, Whelton PK, Vitamin C status and mortality in US adults. Am J Clin Nutr 2000;72: 139-45.
79. Low JA, Handley-Derry MH, Burke SO, Peters RD, Pater EA, Killen HL, Derrick EJ, Association of intrauterine fetal growth retardation and learning deficits at age 9 to 11 years. Am J Obstet Gynecol 1992;167: 1499-505.
80. Lykkesfeldt J, Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal Biochem 2000;282: 89-93.
81. Lykkesfeldt J, Measurement of ascorbic acid and dehydroascorbic acid in biological samples. In: Maines M, Costa LG, Hodson E, Reed JC, editors. Current protocols in toxicology. New York: John Wiley & Sons; 2002. pp. 7.6.1-15.
82. Lykkesfeldt J, Smoking depletes vitamin C: Should smokers be recommended to take supplements? In: Halliwell B, Poulsen HE, editors. Cigarette smoke and oxidative stress. Berlin: Springer Verlag; 2006. pp. 237-60.
83. Lykkesfeldt J, Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer Epidemiol Biomarkers Prev 2007;16: 2513-6.
84. Lykkesfeldt J, Ames BN, Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: decline with age. Methods Enzymol 1999;299: 83-8.
85. Lykkesfeldt J, Poulsen HE, Is vitamin C supplementation beneficial? Lessons learned from randomized controlled trials. Br J Nutr 2010;103:1251-9.
86. Lykkesfeldt J, Loft S, Poulsen HE, Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection - are they reliable biomarkers of oxidative stress? Anal Biochem 1995;229: 329-35.
87. Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE, Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 1997;65: 959-63.
88. Lykkesfeldt J, Christen S, Wallock LM, Chang HH, Jacob RA, Ames BN, Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr 2000;71: 530-6.
89. Lykkesfeldt J, Viscovich M, Poulsen HE, Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. Free Radic Biol Med 2003;35: 1439-47.
90. Lykkesfeldt J, Trueba GP, Poulsen HE, Christen S, Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. Br J Nutr 2007;98: 1116-9.
91. Lynch SM, Morrow JD, Roberts LJ, Frei B, Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest 1994;93: 998-1004.
92. Madruga de Oliveira A, de Carvalho Rondo PH, Barros SB, Concentrations of ascorbic acid in the plasma of pregnant smokers and nonsmokers and their newborns. Int J Vitam Nutr Res 2004;74: 193-8.
93. Malo C, Wilson JX, Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesicles. J Nutr 2000;130: 63-9.
94. Mandl J, Szarka A, Banhegyi G, Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009;157: 1097-110.
95. Martino F, Loffredo L, Carnevale R, Sanguigni V, Martino E, Catasca E, Zanoni C, Pignatelli P, Violi F, Oxidative stress is associated with arterial dysfunction and enhanced intima-media thickness in children with hypercholesterolemia: the potential role of nicotinamide-adenine dinucleotide phosphate oxidase. Pediatrics 2008;122: e648-55.
96. May JM, Qu ZC, Ascorbic acid efflux and re-uptake in endothelial cells: maintenance of intracellular ascorbate. Mol Cell Biochem 2009;325: 79-88.
97. May JM, Qu ZC, Whitesell RR, Ascorbic acid recycling enhances the antioxidant reserve of human erythrocytes. Biochemistry 1995;34: 12721-8.
98. May JM, Qu ZC, Whitesell RR, Cobb CE, Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate. Free Radic Biol Med 1996;20: 543-51.
99. May JM, Mendiratta S, Hill KE, Burk RF, Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase. J Biol Chem 1997;272: 22607-10.
100. May JM, Qu ZC, Mendiratta S, Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. Arch Biochem Biophys 1998;349: 281-9.
101. May JM, Qu Z, Cobb CE, Extracellular reduction of the ascorbate free radical by human erythrocytes. Biochem Biophys Res Commun 2000a;267: 118-23.
102. May JM, Qu Z, Morrow JD, Cobb CE, Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. Biochem Pharmacol 2000b;60: 47-53.
103. May JM, Qu Z, Cobb CE, Recycling of the ascorbate free radical by human erythrocyte membranes. Free Radic Biol Med 2001a;31: 117-24.
104. May JM, Qu Z, Morrow JD, Mechanisms of ascorbic acid recycling in human erythrocytes. Biochim Biophys Acta 2001b;1528: 159-66.
105. McCall MR, Frei B, Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic Biol Med 1999;26: 1034-53.
106. McFadden E, Luben R, Wareham N, Bingham S, Khaw KT, Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort. Eur J Epidemiol 2008;23: 449-58.
107. Mendiratta S, Qu ZC, May JM, Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase. Free Radic Biol Med 1998a;25: 221-8.
108. Mendiratta S, Qu ZC, May JM, Erythrocyte ascorbate recycling: antioxidant effects in blood. Free Radic Biol Med 1998b;24: 789-97.
109. Metzen E, Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps. Biochem J 2007;408: e5-6.
110. Miele M, Boutelle MG, Fillenz M, The physiologically induced release of ascorbate in rat brain is dependent on impulse traffic, calcium influx and glutamate uptake. Neuroscience 1994;62: 87-91.
111. Miglio C, Chiavaro E, Visconti A, Fogliano V, Pellegrini N, Effects of different cooking methods on nutritional and physicochemical characteristics of selected vegetables. J Agric Food Chem 2008;56: 139-47.
112. Morgane PJ, ustin-LaFrance R, Bronzino J, Tonkiss J, az-Cintra S, Cintra L, Kemper T, Galler JR, Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev 1993;17: 91-128.
113. MotoyamaT, Kawano H, Kugiyama K, Hirashima O, Ohgushi M,Yoshimura M, Ogawa H, Yasue H, Endothelium-dependent vasodilation in the brachial artery is impaired in smokers: effect of vitamin C. Am J Physiol 1997;273: H1644-50.
114. Murad S, Grove D, Lindberg KA, Reynolds G, Sivarajah A, Pinnell SR, Regulation of collagen synthesis by ascorbic acid. Proc Natl Acad Sci U S A 1981a;78: 2879-82.
115. Murad S, Sivarajah A, Pinnell SR, Regulation of prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts by ascorbic acid. Biochem Biophys Res Commun 1981b;101: 868-75.
116. Myatt L, Cui X, Oxidative stress in the placenta. Histochem Cell Biol 2004;122: 369-82.
117. Myllyharju J, Kivirikko KI, Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet 2004;20: 33-43.
118. Nyyssonen K, Porkkala-Sarataho E, Kaikkonen J, Salonen JT, Ascorbate and urate are the strongest determinants of plasma antioxidative capacity and serum lipid resistance to oxidation in Finnish men. Atherosclerosis 1997;130: 223-33.
119. O'Neill RD, Fillenz M, Albery WJ, Goddard NJ, The monitoring of ascorbate and monoamine transmitter metabolites in the striatum of unanaesthetised rats using microprocessor-based voltammetry. Neuroscience 1983;9: 87-93. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M, Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004;140: 533-7.
120. Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M, Intravenously administered vitamin C as cancer therapy: three cases. Can Med Assoc J 2006;174: 937-42.
121. Padayatty SJ, Doppman JL, Chang R, Wang Y, Gill J, Papanicolaou DA, Levine M, Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone. Am J Clin Nutr 2007;86: 145-9.
122. Padhy PK, Padhi BK, Effects of biomass combustion smoke on hematological and antioxidant profile among children (8-13 years) in India. Inhal Toxicol 2009;21: 705-11.
123. Poulsen HE, Møller P, Lykkesfeldt J,Weimann A, Loft S, Ascorbic acid andDNAdamage. In: Asard H, May JM, Smirnoff N, editors. Vitamin C: its functions and biochemistry in animals and plants. Oxford: BIOS Scientific Publishers Limited; 2003. pp. 189-202.
124. Ranade SC, Rose A, Rao M, Gallego J, Gressens P, Mani S, Different types of nutritional deficiencies affect different domains of spatial memory function checked in a radial arm maze. Neuroscience 2008;152: 859-66.
125. Rice ME, Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000;23: 209-16.
126. Rice ME, Russo-Menna I, Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience 1998;82: 1213-23.
127. Riviere S, Birlouez-Aragon I, Nourhashemi F, Vellas B, Low plasma vitamin C inAlzheimer patients despite an adequate diet. Int J Geriatr Psychiatry 1998;13: 749-54.
128. Rumsey SC, Levine M, Vitamin C. In: SongWO, Beecher GR, Eitenmiller RR, editors. Modern analytical methodologies in fat- and water-soluble vitamins. New York: John Wiley & Sons; 2000. pp. 411-45.
129. Salonen JT, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE, Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000;248: 377-86.
130. Salonen RM, Nyyssonen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE, Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation 2003;107: 947-53.
131. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV, SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 2008;34: 347-55.
132. Schectman G, Estimating ascorbic acid requirements for cigarette smokers. Ann N Y Acad Sci 1993;686: 335-45.
133. Schectman G, Byrd JC, Gruchow HW, The influence of smoking on vitamin C status in adults. Am J Public Health 1989;79: 158-62.
134. Schectman G, Byrd JC, Hoffmann R, Ascorbic acid requirements for smokers: analysis of a population survey. Am J Clin Nutr 1991;53: 1466-70.
135. Schofield CJ, Ratcliffe PJ, Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004;5: 343-54.
136. Schofield CJ, Zhang Z, Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol 1999;9: 722-31.
137. Simon JA, Hudes ES, Browner WS, Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults. Epidemiology 1998;9: 316-21.
138. Simon JA, Hudes ES, Tice JA, Relation of serum ascorbic acid to mortality among US adults. J Am Coll Nutr 2001;20: 255-63.
139. Sinha R, Block G, Taylor PR, Problems with estimating vitamin C intakes. Am J Clin Nutr 1993;57: 547-50.
140. Smith JL, Hodges RE, Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and nonsmokers. Ann NY Acad Sci 1987;498: 144-52.
141. Solzbach U, Hornig B, JeserichM, Just H, Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96: 1513-9.
142. Steinberg D, Antioxidants and atherosclerosis. A current assessment. Circulation 1991;84: 1420-5.
143. Steinberg D, Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997;272: 20963-6.
144. Steinberg FM, Chait A, Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am J Clin Nutr 1998;68: 319-27.
145. Subar AF, Krebs-Smith SM, Cook A, Kahle LL, Dietary sources of nutrients among US adults, 1989 to 1991. J Am Diet Assoc 1998;98: 537-47.
146. Szent-Györgyi A, Observations on the function of the peroxidase systems. Biochem J 1928;22: 1387-09.
147. Szeto YT, Tomlinson B, Benzie IF, Total antioxidant and ascorbic acid content of fresh fruits and vegetables: implications for dietary planning and food preservation. Br J Nutr 2002;87: 55-9.
148. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A, Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97: 2222-9.
149. Timimi FK, Ting HH, Haley EA, Roddy MA, Ganz P, Creager MA, Vitamin C improves endothelium- dependent vasodilation in patients with insulin-dependent diabetes mellitus. J Am Coll Cardiol 1998;31: 552-7.
150. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA, Vitamin C improves endotheliumdependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996;97: 22-8.
151. Ting HH, Timimi FK, Haley EA, RoddyMA, Ganz P, Creager MA,Vitamin C improves endotheliumdependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997;95: 2617-22.
152. Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y, Histone demethylation by a family of JmjC domain-containing proteins Nature 2006;439: 811-6.
153. Tveden-Nyborg P, Lykkesfeldt J, Does vitamin C deficiency result in impaired brain development in infants? Redox Rep 2009;14: 2-6.
154. Tveden-Nyborg P, Johansen LK, Raida Z, Villumsen CK, Larsen JO, Lykkesfeldt J, Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. Am J Clin Nutr 2009;90: 540-6.
155. Villalpando S, Montalvo-Velarde I, Zambrano N, Garcia-GuerraA, Ramirez-SilvaCI, Shamah-LevyT, Rivera JA, Vitamins A, and C and folate status in Mexican children under 12 years and women 12-49 years: a probabilistic national survey. Salud Publica Mex 2003;45(Suppl 4): S508-19.
156. Vincent HK, Innes KE, Vincent KR, Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007;9: 813-39.
157. Washko PW, Wang Y, Levine M, Ascorbic acid recycling in human neutrophils. J Biol Chem 1993;268: 15531-5.
158. Willcox JK, Ash SL, Catignani GL, Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004;44: 275-95.
159. Wrieden WL, Hannah MK, Bolton-Smith C, Tavendale R, Morrison C, Tunstall-Pedoe H, Plasma vitamin C and food choice in the third Glasgow MONICA population survey. J Epidemiol Community Health 2000;54: 355-60.
160. Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H, Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community: The Shibata Study. Stroke 2000;31: 2287-94.
161. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001a;119: 1417-36.
162. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 2001b;119: 1439-52.
163. Adhikari D, Baxi J, Risal S, Singh PP, Oxidative stress and antioxidant status in cancer patients and healthy subjects, a case-control study. Nepal Med Coll J 2005;7: 112-5.
164. American Heart Association. Statistical fact sheet - populations. 2007 Update. International cardiovascular disease statistics . Accessed 1/13/10.
165. Ascherio A, Rimm EB, Hernan MA, et al., Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999;130: 963-70.
166. Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KE, Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. Gut 1994;35: 317-22.
167. Bates CJ, Walmsley CM, Prentice A, Finch S, Does vitamin C reduce blood pressure? Results of a large study of people aged 65 or older. J Hypertens 1998;16: 925-32.
168. Berndt SI, Carter HB, Landis PK, et al., Prediagnostic plasma vitamin C levels and the subsequent risk of prostate cancer. Nutrition 2005;21: 686-90.
169. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C, Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements. Aliment Pharmacol Ther 2008;28: 689-703.
170. Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB,Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women. Nutr J 2008;7: 35.
171. Blot WJ, Li JY, Taylor PR, et al., Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85: 1483-92.
172. Carr A, Frei B, The role of natural antioxidants in preserving the biological activity of endotheliumderived nitric oxide. Free Radic Biol Med 2000;28: 1806-14.
173. Carr AC, Frei B, Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69: 1086-107.
174. Chainani-Wu N, Diet and oral, pharyngeal, and esophageal cancer. Nutr Cancer 2002;44: 104-26.
175. Cho E, Hunter DJ, Spiegelman D, et al., Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int J Cancer 2006;118: 970-8.
176. Choi ESK, Jacques PF, Dallal GE, Jacob RA, Correlation of blood pressure with plasma ascorbic acid. Nutr Res 1991;11: 1377-82.
177. Choi HK, Curhan G, Gout: epidemiology and lifestyle choices. Curr Opin Rheumatol 2005;17: 341-5.
178. Choi HK, Gao X, Curhan G, Vitamin C intake and the risk of gout in men: a prospective study. Arch Intern Med 2009;169: 502-7.
179. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH, Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. Br Med J 2007;335: 755.
180. Congdon NG, Friedman DS, Lietman T, Important causes of visual impairment in the world today. J AmMed Assoc 2003;290: 2057-60.
181. Cook NR, Albert CM, Gaziano JM, et al., A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med 2007;167: 1610-8.
182. Cumming RG, Mitchell P, Smith W, Diet and cataract: the Blue Mountains Eye Study. Ophthalmology 2000;107: 450-6.
183. Daviglus ML, Orencia AJ, Dyer AR, et al., Dietary vitamin C, beta-carotene and 30-year risk of stroke: results from the Western Electric Study. Neuroepidemiology 1997;16: 69-77.
184. Dehghan M, Akhtar-Danesh N, McMillan CR, Thabane L, Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis. Nutr J 2007;6: 41. del Arbol JL, Ascorbic acid and uricosuria. Ann Intern Med 1976;85: 829.
185. Dherani M, Murthy GV, Gupta SK, et al. Blood levels of vitamin C, carotenoids and retinol are inversely associated with cataract in a North Indian population. Invest Ophthalmol Vis Sci 2008;49: 3328-35.
186. Douglas RM, Chalker EB, Treacy B, Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2000;2: CD000980.
187. Douglas RM, Hemila H, D'Souza R, Chalker EB, Treacy B, Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2004;4: CD000980.
188. Douglas RM, Hemila H, Chalker E, Treacy B, Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007;3: CD000980.
189. Drake IM, Davies MJ, Mapstone NP, et al., Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis 1996;17: 559-62.
190. Duffy SJ, Gokce N, Holbrook M, et al., Treatment of hypertension with ascorbic acid. Lancet 1999;354: 2048-9.
191. Edwards NL, The role of hyperuricemia and gout in kidney and cardiovascular disease. Cleve Clin J Med 2008;75(Suppl 5): S13-6.
192. Eichholzer M, Stahelin HB, Gey KF, Ludin E, Bernasconi F, Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study. Int J Cancer 1996;66: 145-50.
193. Erhola M, Nieminen MM, Kellokumpu-Lehtinen P, Metsa-Ketela T, Poussa T, Alho H, Plasma peroxyl radical trapping capacity in lung cancer patients: a case-control study. Free Radic Res 1997;26: 439-47.
194. Evans J, Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis. Eye (Lond) 2008;22: 751-60.
195. Fehily AM, Yarnell JW, Sweetnam PM, Elwood PC, Diet and incident ischaemic heart disease: the Caerphilly Study. Br J Nutr 1993;69: 303-14.
196. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V, Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 2009;8: 355-69.
197. Food and Nutrition Board, Institute of Medicine. Vitamin C, dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington DC: National Academy Press; 2000. pp. 95-185.
198. Frei B, Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease. J Nutr 2004;134: 3196S-8S.
199. Frei B, England L, Ames BN, Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1989;86: 6377-81.
200. Gale CR, Martyn CN, Winter PD, Cooper C, Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. Br Med J 1995;310: 1563-6.
201. Gao X, Curhan G, Forman JP, Ascherio A, Choi HK, Vitamin C intake and serum uric acid concentration in men. J Rheumatol 2008;35: 1853-8.
202. Gaziano JM, Glynn RJ, Christen WG, et al., Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. J AmMed Assoc 2009;301: 52-62.
203. Genkinger JM, Platz EA, Hoffman SC, Comstock GW, Helzlsouer KJ, Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. Am J Epidemiol 2004;160: 1223-33.
204. Hankinson SE, Stampfer MJ, Seddon JM, et al., Nutrient intake and cataract extraction in women: a prospective study. Br Med J 1992;305: 335-9.
205. Heaney RP, Nutrients, endpoints, and the problem of proof. J Nutr 2008;138: 1591-5.
206. Heistad DD, Wakisaka Y, Miller J, Chu Y, Pena-Silva R, Novel aspects of oxidative stress in cardiovascular diseases. Circ J 2009;73: 201-7.
207. Hercberg S, Galan P, Preziosi P, et al., The SUVIMAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004;164: 2335-42.
208. Higdon J, Vitamin C, An evidence-based approach to vitamins and minerals: health benefits and intake recommendations. New York: Thieme; 2003. pp. 65-72.
209. Hirvonen T, Virtamo J, Korhonen P, Albanes D, Pietinen P, Intake of flavonoids, carotenoids, vitamins C and E, and risk of stroke in male smokers. Stroke 2000;31: 2301-6.
210. Huang HY, Appel LJ, Choi MJ, et al., The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial. Arthritis Rheum 2005;52: 1843-7.
211. Hunter DJ, Manson JE, Colditz GA, et al., A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med 1993;329: 234-40.
212. Jacques PF, A cross-sectional study of vitamin C intake and blood pressure in the elderly. Int JVitam Nutr Res 1992a;62: 252-5.
213. Jacques PF, Effects of vitamin C on high-density lipoprotein cholesterol and blood pressure. J Am Coll Nutr 1992b;11: 139-44.
214. Jacques PF, Relationship of vitamin C status to cholesterol and blood pressure. Ann NY Acad Sci 1992c;669: 205-13; discussion 213-4.
215. Jacques PF, Taylor A, Hankinson SE, et al., Long-term vitamin C supplement use and prevalence of early age-related lens opacities. Am J Clin Nutr 1997;66: 911-6.
216. Jenab M, Riboli E, Ferrari P, et al., Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Carcinogenesis 2006;27: 2250-7.
217. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J, Global burden of hypertension: analysis of worldwide data. Lancet 2005;365: 217-23.
218. Keli SO, Hertog MG, Feskens EJ, Kromhout D, Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 1996;156: 637-42.
219. Kelley DS, Bendich A, Essential nutrients and immunologic functions. Am J Clin Nutr 1996;63: 994S-6S.
220. Kirsh VA, Hayes RB, Mayne ST, et al., Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk. J Natl Cancer Inst 2006;98: 245-54.
221. Knekt P, Reunanen A, Jarvinen R, Seppanen R, Heliovaara M, Aromaa A, Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994;139: 1180-9.
222. Kurl S, Tuomainen TP, Laukkanen JA, et al., Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke 2002;33: 1568-73.
223. Kushi LH, Fee RM, Sellers TA, Zheng W, Folsom AR, Intake of vitamins A, C, and E and postmenopausal breast cancer. The Iowa Women's Health Study. Am J Epidemiol 1996;144: 165-74.
224. Levine M, Conry-Cantilena C, Wang Y, et al., Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996;93: 3704-9.
225. Levine M, Wang Y, Padayatty SJ, Morrow J, A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 2001;98: 9842-6.
226. Libby P, Ridker PM, Hansson GK, Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009;54: 2129-38.
227. Lin J, Cook NR, Albert C, et al., Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009;101: 14-23.
228. Lloyd-Jones D, Adams RJ, Brown TM, et al., Heart disease and stroke statistics - 2010 update. A report from the American Heart Association. Circulation 2010;121: e46-215.
229. Losonczy KG, Harris TB, Havlik RJ, Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr 1996;64: 190-6.
230. Luben R, Khaw KT, Welch A, et al., Plasma vitamin C, cancer mortality and incidence in men and women: a prospective study. IARC Sci Publ 2002;156: 117-8.
231. Lykkesfeldt J, Poulsen HE, Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr 2010;103:1251-9.
232. Lyle BJ, Mares-Perlman JA, Klein BE, Klein R, Greger JL, Antioxidant intake and risk of incident agerelated nuclear cataracts in the Beaver Dam Eye Study. Am J Epidemiol 1999;149: 801-9.
233. Mark SD, Wang W, Fraumeni JF Jr, et al., Do nutritional supplements lower the risk of stroke or hypertension? Epidemiology 1998;9: 9-15.
234. McCarty CA, Taylor HR, A review of the epidemiologic evidence linking ultraviolet radiation and cataracts. Dev Ophthalmol 2002;35: 21-31.
235. Mirvish SS, Effects of vitamins C and E on N-nitroso compound formation, carcinogenesis, and cancer. Cancer 1986;58(8 Suppl): 1842-50.
236. Moor de Burgos A, Wartanowicz M, Ziemlanski S, Blood vitamin and lipid levels in overweight and obese women. Eur J Clin Nutr 1992;46: 803-8.
237. Moran JP, Cohen L, Greene JM, et al., Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993;57: 213-7.
238. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360: 23-33.
239. Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT, Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr 2008;87: 64-9.
240. Ness AR, Khaw KT, Bingham S, Day NE, Vitamin C status and blood pressure. J Hypertens 1996;14: 503-8.
241. Osganian SK, Stampfer MJ, Rimm E, et al., Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol 2003;42: 246-52.
242. Pandey DK, Shekelle R, Selwyn BJ, Tangney C, Stamler J, Dietary vitamin C and beta-carotene and risk of death in middle-aged men. The Western Electric Study. Am J Epidemiol 1995;142: 1269-78.
243. Pauling LC, Vitamin C and the common cold. San Francisco: W.H. Freeman; 1970.
244. Pauling L, Ascorbic acid and the common cold. Am J Clin Nutr 1971;24: 1294-99.
245. Pauling L, The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad Sci USA 1971;68: 2678-81.
246. Pocobelli G, Peters U, Kristal AR, White E, Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol 2009;170: 472-83.
247. Ramaswamy G, Krishnamoorthy L, Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix. Nutr Cancer 1996;25: 173-7.
248. Rautiainen S, Lindblad BE, Morgenstern R,WolkA,VitaminCsupplements and the risk of age-related cataract: a population-based prospective cohort study in women. Am J Clin Nutr 2010;91: 487-93.
249. Retsky KL, Freeman MW, Frei B, Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti-rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem 1993;268: 1304-9.
250. Rice ME, Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000;23: 209-16.
251. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC, Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328: 1450-6.
252. Rokkas T, Papatheodorou G, Karameris A, Mavrogeorgis A, Kalogeropoulos N, Giannikos N, Helicobacter pylori infection and gastric juice vitamin C levels. Impact of eradication. Dig Dis Sci 1995;40: 615-21.
253. Romney SL, Duttagupta C, Basu J, et al., Plasma vitamin C and uterine cervical dysplasia. Am J Obstet Gynecol 1985;151: 976-80.
254. Ross RK, Yuan JM, Henderson BE, Park J, Gao YT, Yu MC, Prospective evaluation of dietary and other predictors of fatal stroke in Shanghai, China. Circulation.1997;96: 50-5.
255. Saag KG, Choi H, Epidemiology, risk factors, and lifestyle modifications for gout. Arthritis Res Ther 2006;8(Suppl 1): S2.
256. Sahyoun NR, Jacques PF, Russell RM, Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol 1996;144: 501-11.
257. Salonen JT, Salonen R, Ihanainen M, et al., Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 1988;48: 1226-32.
258. Schroeder AP, Falk E,Vulnerable and dangerous coronary plaques. Atherosclerosis 1995;118(Suppl): S141-9.
259. Seddon JM, Christen WG, Manson JE, et al., The use of vitamin supplements and the risk of cataract among US male physicians. Am J Public Health 1994;84: 788-92.
260. Sesso HD, Buring JE, Christen WG, et al., Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. J Am Med Assoc 2008;300: 2123-33.
261. Sharma A, Tripathi M, Satyam A, Kumar L, Study of antioxidant levels in patients with multiple myeloma. Leuk Lymphoma 2009;50: 809-15.
262. Shibata A, Paganini-Hill A, Ross RK, Henderson BE, Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer 1992;66: 673-9.
263. Simon JA, Hudes ES, Browner WS, Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults. Epidemiology 1998;9: 316-21.
264. Simon JA, Hudes ES, Serum ascorbic acid and other correlates of self-reported cataract among older Americans. J Clin Epidemiol 1999;52: 1207-11.
265. Slatore CG, Littman AJ, Au DH, Satia JA, White E, Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. Am J Respir Crit Care Med 2008;177: 524-30.
266. Stahelin HB, Gey KF, Eichholzer M, et al., Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the prospective Basel Study. Am J Epidemiol 1991;133: 766-75.
267. Stahelin HB, Rosel F, Buess E, Brubacher G, Cancer, vitamins, and plasma lipids: prospective Basel study. J Natl Cancer Inst 1984;73: 1463-8.
268. Stein HB, Hasan A, Fox IH, Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy. Ann Intern Med 1976;84: 385-8.
269. Suzuki H, Iwasaki E, Hibi T, Helicobacter pylori and gastric cancer. Gastric Cancer 2009;12: 79-87.
270. Tannenbaum SR, Wishnok JS, Leaf CD, Inhibition of nitrosamine formation by ascorbic acid. Am J Clin Nutr 1991;53(1 Suppl): 247S-50S.
271. Terkeltaub RA, Clinical practice. Gout. N Engl J Med 2003;349: 1647-55.
272. Tessier F, Moreaux V, Birlouez-Aragon I, Junes P, Mondon H, Decrease in vitamin C concentration in human lenses during cataract progression. Int J Vitam Nutr Res 1998;68: 309-15.
273. Thomas SR, Witting PK, Drummond GR, Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2008;10: 1713-65.
274. Toohey L, Harris MA, Allen KG, Melby CL, Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African-Americans. J Nutr 1996;126: 121-8.
275. Tsugane S, Sasazuki S, Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007;10: 75-83.
276. Varma SD, Ascorbic acid and the eye with special reference to the lens. Ann N Y Acad Sci 1987;498: 280-306.
277. Verhoeven DT, Assen N, Goldbohm RA, et al., Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. Br J Cancer 1997;75: 149-55.
278. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ, Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003;361: 2017-23.
279. Voko Z, Hollander M, Hofman A, Koudstaal PJ, Breteler MM, Dietary antioxidants and the risk of ischemic stroke: the Rotterdam Study. Neurology 2003;61: 1273-5.
280. Waring AJ, Drake IM, Schorah CJ, et al., Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut 1996;38: 171-6.
281. Waters DD, Alderman EL, Hsia J, et al., Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. J AmMed Assoc 2002;288: 2432-40.
282. West S, Ocular ultraviolet B exposure and lens opacities: a review. J Epidemiol 1999;9(6 Suppl): S97-101.
283. Whelton PK, Epidemiology of hypertension. Lancet 1994;344: 101-6.
284. Willis MS, Wians FH, The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin Chim Acta 2003;330: 57-83.
285. Wong TY, Hyman L, Population-based studies in ophthalmology. Am J Ophthalmol 2008;146: 656-63.
286. World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington, DC: AICR; 2007.
287. World Health Organization, Visual impairment and blindness >http://www.who.int/mediacentre/factsheets/fs282/en/>. Accessed 1/8/10, May 2009.
288. Ye Z, Song H, Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Eur J Cardiovasc Prev Rehabil 2008;15: 26-34.
289. Yochum LA, Folsom AR, Kushi LH, Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women. Am J Clin Nutr 2000;72: 476-83.
290. Yokoyama T, Date C, Kokubo Y, Yoshiike N, Matsumura Y, Tanaka H, Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community. The Shibata study. Stroke 2000;31: 2287-94.
291. Yoshida M, Takashima Y, Inoue M, et al., Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population. Eur J Nutr 2007;46: 118-24.
292. Yoshioka M, Matsushita T, Chuman Y, Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years. Int J Vitam Nutr Res 1984;54: 343-7.
293. You WC, Zhang L, Gail MH, et al., Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J Natl Cancer Inst 2000;92: 1607-12.
294. Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC, Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2004;13: 1772-80.
295. Zhang SM, Role of vitamins in the risk, prevention, and treatment of breast cancer. Curr Opin Obstet Gynecol 2004;16: 19-25.
296. Zureik M, Galan P, Bertrais S, et al., Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler Thromb Vasc Biol 2004;24: 1485-91.