The effects of vitamin C supplementation on serum concentrations of uric acid: Results of a randomized controlled trial

Arthritis and Rheumatism

Volumn 52, Issue 6, 2005, Pages 1843-1847

  Huang, Han Yao ^a,c   Appel, Lawrence J ^a   Choi, Michael J ^a   Gelber, Allan C ^a   Charleston, Jeanne ^a   Norkus, Edward P ^b   Miller III, Edgar R ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b OUR LADY OF MERCY MEDICAL CENTER   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; PLACEBO; URIC ACID;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION RATE; GOUT; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; URIC ACID BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; AGED; ASCORBIC ACID; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; URIC ACID;

EID: 20744456897     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21105     Document Type: Article

References (15)

1. Stein HB, Hasan A, Fox IH. Ascorbic acid-induced uricosuria: a consequency of megavitamin therapy. Ann Intern Med 1976;84: 385-8.
2. Sutton JL, Basu TK, Dickerson JW. Effect of large doses of ascorbic acid in man on some nitrogenous components of urine. Hum Nutr Appl Nutr 1983;37:136-40.
3. Berger L, Gerson CD, Yu TF. The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Am J Med 1977;62:71-6.
4. Mitch WE, Johnson MW, Kirshenbaum JM, Lopez RE. Effect of large oral doses of ascorbic acid on uric acid excretion by normal subjects. Clin Pharmacol Ther 1981;29:318-21.
5. Huang HY, Appel LJ, Croft KD, Miller ER III, Mori TA, Puddey IB. Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am J Clin Nutr 2002;76:549-55.
6. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D, and the Modification of Diet in Renal Disease Study Group. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 1999;130: 461-70.
7. Gochman N, Schmitz JM. Automated determination of uric acid, with use of a uricase-peroxidase system. Clin Chem 1971;17: 1154-9.
8. McGown EL, Rusnak MG, Lewis CM, Tillotson JA. Tissue ascorbic acid analysis using ferrozine compared with the dinitrophenylhydrazine method. Anal Biochem 1982;119:55-61.
9. Campion EW, Glynn RJ, deLabry LO. Asymptomatic hyperuricemia: risks and consequences in the Normative Aging Study. Am J Med 1987;82:421-6.
10. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002;13:2888-97.
11. Sanchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaria J, et al. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol 2002;283: F1105-10.
12. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, et al. Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol 2003;23:2-7.
13. Iseki K, Oshiro S, Tozawa M, Iseki C, Ikemiya Y, Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res 2001;24: 691-7.
14. Syrjanen J, Mustonen J, Pasternack A. Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy. Nephrol Dial Transplant 2000;15:34-42.
15. Ohno I, Hosoya T, Gomi H, Ichida K, Okabe H, Hikita M. Serum uric acid and renal prognosis in patients with IgA nephropathy. Nephron 2001;87:333-9.