Does vitamin C reduce blood pressure? Results of a large study of people aged 65 or older

Journal of Hypertension

Volumn 16, Issue 7, 1998, Pages 925-932

  Bates, Christopher J ^a   Walmsley, Catherine M ^a   Prentice, Ann ^a   Finch, Steven ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Social and Comm Planning Research   (United Kingdom)

Author keywords

British; Diastolic blood pressure; Elderly; Pulse rate; Systolic blood pressure; Vitamin C

Indexed keywords

ASCORBIC ACID; CREATININE; FIBRINOGEN; GAMMA TOCOPHEROL; RETINOL;

AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD SAMPLING; CORRELATION FUNCTION; CREATININE URINE LEVEL; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; ERYTHROCYTE COUNT; FEMALE; FIBRINOGEN BLOOD LEVEL; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; INTERVIEW; LIFESTYLE; MALE; NORMAL HUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; PROTHROMBIN TIME; PULSE RATE; RISK FACTOR; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; UNITED KINGDOM; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

EID: 0031849887     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816070-00005     Document Type: Article

References (34)

1. Department of Health: Nutritional aspects of cardiovascular disease. Report of the cardiovascular review group committee on medical aspects of food policy. London: HMSO; 1994.
2. Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 1993; 57 (suppl):787S-797S.
3. Gey KF. Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk. J Nutr Biochem 1994; 6:206-236.
4. Todd S, Woodward M, Bolton-Smith C, Tunstall-Pedoe H. An investigation of the relationship between antioxidant vitamin intake and coronary heart disease in men and women, using discriminant analysis. J Clin Epidemiol 1995; 48:297-305.
5. Wilson PWF, Hoeg JM, D'Agostino RB, Silberhatz H, Belanger AM, Poehlmann H, et al. Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis. N Engl J Med 1997; 337:516-522.
6. Simon JA, Vitamin C and cardiovascular disease [review]. J Am Coll Nutr 1992; 11:107-125.
7. Fehily AM, Yarnell JWG, Sweetnam PM, Elwood PC. Diet and incident ischaemic heart disease: the Caerphilly Study. Br J Nutr 1993; 69:303-314.
8. Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in a cohort of elderly people. BMJ 1995; 310:1563-1566.
9. Trout DL. Vitamin C and cardiovascular risk factors. Am J Clin Nutr 1991; 53 (suppl):322S-325S.
10. Koh ET, Chi MS. Relationship of serum vitamin C and globulin fractions with anthropometric measurements in adults. Nutr Rep Int 1980; 21:537-549.
11. Yoshioka M, Matsushita T, Chuman Y. Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-30 years. Int J Vit Nutr Res 1984; 54:343-347.
12. McCarron DA, Morris CD, Henry HJ, Stanton JL. Blood pressure and nutrient intake in the United States. Science 1984; 224:1392-1398.
13. Joffres MR, Reed DM, Yano K. Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu Heart Study. Am J Clin Nutr 1987; 45:469-475.
14. Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppanen R, Kantola M, et al. Blood pressure, dietary fats and antioxidants. Am J Clin Nutr 1988; 48:1225-1232.
15. Jacques PF. Relationship of vitamin C status to cholesterol and blood pressure. Ann NY Acad Sci 1992; 669:205-214.
16. Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993; 57:213-217.
17. Ness AR, Khaw K-T, Bingham S, Day NE. Vitamin C status and blood pressure. J Hypertens 1996; 14:503-508.
18. Bulpitt CJ. Vitamin C and blood pressure. J Hypertens 1990; 8:1071-1075.
19. Stamler J, Ruth KJ, Liu K, Shekelle RB. Dietary antioxidants and blood pressure change in the Western Electric study [abstract]. Circulation 1994; 89:932.
20. Koh ET. Effect of vitamin C on blood parameters of hypertensive subjects. J Oklahoma Med Assoc 1984; 77:177-182.
21. Osilesi O, Trout DL, Ogunwolu JO, Glover EE. Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutr Res 1991; 11:405-412.
22. Feldman EB, Gold S, Greene J, Moran J, Xu G, Shultz GG, et al. Ascorbic acid supplements and blood pressure. A four-week pilot study. Ann NY Acad Sci 1992; 669:342-344.
23. Salonen R, Korpela H, Nyyssonen K, Porkkala E, Salonen JT, Reduction of blood pressure by antioxidant supplementation: a randomised double-blind clinical trial. Life Chem Rep 1994; 12:65-68.
24. Lovat LB, Lu Y, Palmer AJ, Edwards R, Fletcher AE, Bulpitt CJ. Double blind trial of vitamin C in elderly hypertensives. J Hum Hypertens 1993; 7:403-405.
25. Mostafa S el D, Garner DD, Garrett L, Whaley RF, el Sekate M, Kiker M. Beneficial effects of vitamin C on risk factors of cardiovascular diseases. J Egypt Publ Health Assoc 1989; 64:123-133.
26. Ghosh SK, Ekpo EB, Shah IU, Girling AJ, Jenkins C, Sinclair AJ. A double blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994; 40:268-272.
27. Finch S, Doyle W, Lowe C, Bates CJ, Prentice A, Smithers G, et al. National diet and nutrition survey: people aged 65 years or over. Volume 1. Report of the diet and nutrition survey. London: The Stationary Office; 1998, in press.
28. Bolling K. The Dinamap 8100 calibration study. London: HMSO; 1994.
29. Vuilleumier JP, Keck E. Fluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment. J Micronutrient Anal 1989; 5:25-34.
30. Davis JE, McDonald JM, Jarrett L. A high performance liquid chromatography method for haemoglobin A1c. Diabetes 1978; 27:102-107.
31. Kannel WB, Gordon T, Schwartz MJ. Systolic versus diastolic blood pressure and the risk of coronary heart disease. The Framingham study. Am J Cardiol 1971; 27:335-345.
32. Mark SD, Wang W, Fraumeni JF. Li J-Y, Taylor PR, Wang G-Q, et al. Do nutritional supplements lower the risk of stroke or hypertension? Epidemiology 1998; 9:9-15.
33. Yoshioka M, Aoyama K, Matsushita T. Effects of ascorbic acid on blood pressure and ascorbic acid metabolism in spontaneously hypertensive rats (SH rats). Int J Vit Nutr Res 1985; 55:301-307.
34. Ziemlanski S, Wartanowicz M, Potrebnicka K, Burgos de Moor A, Iwanow K, Ignatowska-Switalska M, et al. Effect of exogenous ascorbic acid on experimental hypertension and mineral balance in rats fed low- and high-fat diets. Nutrition 1991; 7:131-135.