Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Cesaratto, Laura ^a,b   Codarin, Erika ^a   Vascotto, Carlo ^a   Leonardi, Antonio ^c   Kelley, Mark R ^d   Tiribelli, Claudio ^b,e   Tell, Gianluca ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b Fondazione Italiana Fegato   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (5,6 DIMETHOXY 3 METHYL 1,4 BENZOQUINONYL)] 2 NONYL PROPENOIC ACID; APE1 PROTEIN; E 3330; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; PLASMID VECTOR; PROTEIN INHIBITOR; REDOX EFFECTOR FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; LIPID STORAGE; LIVER CANCER; OXIDATION REDUCTION REACTION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION;

BENZOQUINONES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; FATTY ACIDS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; INTERLEUKIN-8; LIVER NEOPLASMS; NF-KAPPA B; OXIDATION-REDUCTION; PROMOTER REGIONS, GENETIC; PROPIONATES; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84881604178     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070909     Document Type: Article

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