Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1

Molecular Carcinogenesis

Volumn 46, Issue 2, 2007, Pages 91-99

  McNeill, Daniel R ^a   Wong, Heng Kuan ^a   Narayana, Avinash ^a   Wilson III, David M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Abasic site; Ape1; DNA base excision repair; Environmental metal lead; Mutagenesis

Indexed keywords

8 HYDROXYGUANINE; ALKYLATING AGENT; CARCINOGEN; CELL EXTRACT; ENDONUCLEASE; ENVIRONMENTAL MUTAGEN; GENOMIC DNA; HEAVY METAL; HYDROGEN PEROXIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEAD; MESYLIC ACID METHYL ESTER; MITOMYCIN C; OXIDIZING AGENT; PAINT; PROTEIN APE1; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TOXIN; UNCLASSIFIED DRUG;

ABASIC SITE; ANIMAL CELL; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; CANCER RESEARCH; CHEMICAL MUTAGENESIS; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE; GENE MUTATION; GENE OVEREXPRESSION; HPRT GENE; IN VITRO STUDY; INTERNATIONAL COOPERATION; MAMMAL CELL; MUTATION RATE; NONHUMAN; OCCUPATIONAL TOXICOLOGY; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; WATER CONTAMINATION;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LEAD; MUTAGENESIS; MUTAGENS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

CRICETULUS GRISEUS; MAMMALIA;

EID: 33847117649     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20196     Document Type: Article

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