Identification of a gene-pathway associated with non-alcoholic steatohepatitis

Journal of Hepatology

Volumn 46, Issue 4, 2007, Pages 708-718

  Rubio, Angel ^a   Guruceaga, Elizabeth ^b   Vázquez Chantada, Mercedes ^c   Sandoval, Juan ^d   Martínez Cruz, L Alfonso ^c   Segura, Victor ^a   Sevilla, José L ^b   Podhorski, Adam ^b   Corrales, Fernando J ^e   Torres, Luis ^d   Rodríguez, Manuel ^c   Aillet, Fabienne ^c   Ariz, Usue ^c   Arrieta, Felix Martínez ^h   Caballería, Juan ⁱ   Martín Duce, Antonio ^f   Lu, Shelly C ^g   Martínez Chantar, M Luz ^c   Mato, José M ^c  

^a UNIVERSITY OF NAVARRA   (Spain)

^b CEIT   (Spain)

^c Centro de Investigación Biomédica en Red de Cáncer CIBERONC University of Barcelona   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e UNIVERSITY OF NAVARRA   (Spain)

^f INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^g UNIVERSITY OF ALCALÁ   (Spain)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

Gene pathway; Non alcoholic steatohepatitis; S adenosylmethionine; Sp1

Indexed keywords

TRANSCRIPTION FACTOR SP1;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FATTY LIVER; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; KNOCKOUT MOUSE; LIVER BIOPSY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE;

ADULT; ANIMALS; FATTY LIVER; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; MICE; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MIDDLE AGED; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR;

EID: 33947266548     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.10.021     Document Type: Article

References (37)

1. Reid A.E. Nonalcoholic steatohepatitis. Gastroenterology 121 (2001) 710-723
2. Brunt E.M. Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 21 (2001) 3-16
3. Teli M., James O.F., Burt A.D., Bennett M.K., and Day C.P. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology 22 (1995) 1714-1717
4. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 346 (2002) 1221-1231
5. Wanless I.R., and Lentz J.S. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12 (1990) 1106-1110
6. Marchesini G., Brizi M., Morselli-Labate A.M., Bianchi G., Bugianesi E., McCullough A.J., Forlani G., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107 (1999) 450-455
7. Flegal K.M., Carroll M.D., Kuczmarski R.J., and Johnson C.L. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord 22 (1998) 39-47
8. McCullough A.J. Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 34 (2002) 255-262
9. Farrell G.C. Non-alcoholic steatohepatitis: what is it, and why is it important in the Aisa-Pacific region?. J Gastroenterol Hepatol 18 (2003) 124-138
10. Yang S., Zhu H., Li Y., Lin H., Gabrielson K., Trush M.A., and Diehl A.M. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophys 378 (2000) 259-268
11. Perez-Carreras M., Del Hoyo P., Martin M.A., Rubio J.C., Martin A., Castellano G., et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38 (2003) 999-1007
12. Santamari{dotless}́a E., Avila M.A., Latasa M.U., Rubio A., Marti{dotless}́n-Duce A., Lu S.C., et al. Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci USA 100 (2002) 3065-3070
13. Li Z., Lin H., Yang S., and Diehl A.M. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology 123 (2002) 1304-1310
14. Lu S.C., Alvarez L., Huang Z.-Z., Chen L., Corrales F.J., Avila M.A., et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 98 (2001) 5560-5565
15. Martínez-Chantar M.L., Corrales F.J., Martínez-Cruz A.L., García-Trevijano E.R., Huang Z.-Z., Chen L., et al. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J (2002). http://WWW.fasebj.org/cgi/doi/10.1096/fj.02-0078fje
16. Mato J.M., Corrales F.J., Lu S.C., and Avila M.A. S-Adenosylmethionine: a control switch that regulates liver function. FASEB J 16 (2002) 15-26
17. Duce A.M., Cabrero C., Ortiz P., and Mato J.M. S-Adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 8 (1988) 65-68
18. Lee T.D., Sadda M.R., Mendler M.H., Bottiglieri T., Kanel G., Mato J.M., et al. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 28 (2004) 173-181
19. Mato J.M., Cámara J., Fernández de Paz J., Caballeri{dotless}́a L., Coll S., Caballero A., et al. S-Adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 30 (1999) 1081-1089
20. Brunt E.M., Janney C.G., Di Bisceglie A.M., Neuschwander-Tetri B.A., and Bacon B.R. Nonalcoholic steatohepatitis: a proposal for grading and staging the. Am J Gastroenterol 94 (1999) 2467-2474
21. Martínez-Cruz L.A., Rubio A., Martínez-Chantar M.L., Labarga A., Barrio I., Podhorski A., et al. GARBAN: genomic analysis and rapid biological annotation of cDNA microarray and proteomic data. Bioinformatics 19 (2003) 2158-2160
22. The Gene Ontology Consortium. Gene Ontology: tool for the unification of biology. Nat Genet 2000;25:25-9.
23. Quackenbush J. Microarray data normalization and transformation. Nat Genet 32 (2002) 496-501
24. Sandoval J., Rodri{dotless}́guez J.L., Tur G., Serviddio G., Pereda J., Boukaba A., et al. RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription. Nucleic Acids Res 32 (2004) e88
25. Phornphutkul C., Frick G.P., Goodman H.M., Berry S.A., and Gruppuso P.A. Hepatic growth hormone signaling in the late gestation fetal rat. Endocrinology 141 (2000) 3527-3533
26. Dela Pena A., Leclercq I., Field J., George J., Jones B., and Farrell G. NF-kappaB activation, rathet than TNF, mediates hepatic inflammation in a murine dietary model steatohepatitis. Gastroenterology 129 (2005) 1663-1674
27. Hewrzig S., Hedrick S., Morantte I., Koo S.H., Galimi F., and Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 426 (2003) 190-193
28. Lu S.C., and Mato J.M. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol 35 (2005) 227-234
29. Niemela O., Parkkila S., Juvonem R.O., Viitala K., Gelboin H.V., and Pasanen M. Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. J Hepatol 33 (2000) 893-901
30. Everett L., Galli A., and Crabb D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 20 (2000) 191-199
31. Schwahn B.C., Chen Z., Laryea M.D., Wendel U., Lussier-Cacan S., Genest Jr. J., et al. Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency. FASEB J 17 (2003) 512-514
32. Bataller R., Paik Y.H., Lindquist J.N., Lemasters J.J., and Brenner D.A. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 126 (2004) 529-540
33. Adinolfi L.E., Ingrosso D., Cesaro G., Cimmino A., D'Antò, Capasso R., et al. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 41 (2005) 995-1003
34. Mato J.M., and Lu S.C. Homocysteine, the bad thiol. Hepatology 41 (2005) 976-979
35. Chu S., and Ferro T.J. Sp1: regulation of gene expression by phosphorylation. Gene 348 (2005) 1-11
36. s. Hepatology 40 (2004) 221-231
37. Martínez-Chantar M.L., Vázquez M., Garnacho M., Latasa M.U., Varela-Rey M., Dotor J., et al. S-Adenosylmethionine regulates cytoplasmic HuR via AMP-activated Kinase. Gastroenterology 131 (2006) 223-232