Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Molecular Biology of the Cell

Volumn 23, Issue 20, 2012, Pages 4079-4096

  Lirussi, Lisa ^a   Antoniali, Giulia ^a   Vascotto, Carlo ^a   D'Ambrosio, Chiara ^b   Poletto, Mattia ^a   Romanello, Milena ^a   Marasco, Daniela ^b,c   Leone, Marilisa ^b   Quadrifoglio, Franco ^a   Bhakat, Kishor K ^d   Scaloni, Andrea ^b   Tell, Gianluca ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APURINIC APYRIMIDINIC ENDONUCLEASE 1; ENDONUCLEASE; LYSINE; UNCLASSIFIED DRUG;

ACETYLATION; AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; EXCISION REPAIR; GENOTOXICITY; MOLECULAR INTERACTION; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

ACETYLATION; CELL NUCLEOLUS; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENZYME STABILITY; HELA CELLS; HUMANS; LYSINE; MUTANT PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RNA, RIBOSOMAL; SIRTUIN 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867479746     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-04-0299     Document Type: Article

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