The allosteric switch and conformational states in ras gtpase affected by small molecules

Enzymes

Volumn 33, Issue , 2013, Pages 41-67

  Johnson, Christian W ^a   Mattos, Carla ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Allosteric modulation; Allosteric networks; Binding site hot spots; FTMap; G domain; GTPase; MSCS; Oncogenic mutants; Protein conformation; Raf; Ras; Ras inhibitor; Ras intrinsic hydrolysis; Ras Raf MEK ERK pathway

Indexed keywords

DRUG; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN;

ALLOSTERIC MODULATION; ALLOSTERIC NETWORKS; ANIMAL; ARTICLE; BINDING SITE; BINDING SITE HOT SPOTS; CHEMISTRY; FTMAP; G DOMAIN; HUMAN; METABOLISM; MOLECULAR LIBRARY; MSCS; ONCOGENIC MUTANTS; PROTEIN CONFORMATION; RAF; RAS; RAS INHIBITOR; RAS INTRINSIC HYDROLYSIS; RAS/RAF/MEK/ERK PATHWAY;

ALLOSTERIC MODULATION; ALLOSTERIC NETWORKS; BINDING SITE HOT SPOTS; FTMAP; G DOMAIN; GTPASE; MSCS; ONCOGENIC MUTANTS; PROTEIN CONFORMATION; RAF; RAS; RAS INHIBITOR; RAS INTRINSIC HYDROLYSIS; RAS/RAF/MEK/ERK PATHWAY;

ALLOSTERIC SITE; ANIMALS; HUMANS; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; RAS GTPASE-ACTIVATING PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84881535434     PISSN: 18746047     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-416749-0.00003-8     Document Type: Chapter

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