Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3323-3331

  Buhrman, Greg ^a   Kumar, V S Senthil ^a   Cirit, Murat ^b   Haugh, Jason M ^b   Mattos, Carla ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b North Carolina State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC MODULATION; GTPASE ACTIVITY; GTPASE-ACTIVATING PROTEIN; HYDROLYSIS RATE; IN-CELL; INDEPENDENT MODEL; PHOSPHOINOSITIDE 3-KINASE; WILD TYPES;

BACTERIOPHAGES; BIOCHEMISTRY; CHEMICAL ACTIVATION; CONFORMATIONS; ENZYMES; HYDROLASES; STRUCTURAL ANALYSIS;

SIGNAL TRANSDUCTION;

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; GUANOSINE TRIPHOSPHATE;

ALLOSTERISM; ARTICLE; CATALYSIS; CELL STRAIN 3T3; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; GENETIC TRANSFECTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WILD TYPE; ANIMAL; BINDING SITE; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; MOUSE; PROTEIN STABILITY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; GUANOSINE TRIPHOSPHATE; KINETICS; MICE; MUTATION, MISSENSE; NIH 3T3 CELLS; PROTEIN CONFORMATION; PROTEIN STABILITY; RAF KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 79952811451     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.193854     Document Type: Article

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