Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 39768-39778

  Spoerner, Michael ^a   Hozsa, Constantin ^a   Poetzl, Johann A ^a   Reiss, Kerstin ^a   Ganser, Petra ^a   Geyer, Matthias ^b   Kalbitzer, Hans Robert ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CONFORMATIONAL EQUILIBRIUM; CONFORMATIONAL STATE; DYNAMICAL EQUILIBRIUM; EFFECTOR BINDING; EXCHANGE RATES; GTP HYDROLYSIS; GTPASE ACTIVITY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANINE NUCLEOTIDE-BINDING PROTEINS; HIGH AFFINITY; NATURAL LIGANDS; POLARIZATION TRANSFER; REGULATORY EFFECTS; STABILIZING STATE; TRIPHOSPHATE; WILD TYPES;

EQUILIBRIUM CONSTANTS; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES;

POSITIVE IONS;

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MAGNESIUM ION; MUTANT PROTEIN; RAS PROTEIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POLARIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; STRUCTURE ANALYSIS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; GUANOSINE TRIPHOSPHATE; HUMANS; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS P21(RAS); RATS;

RATTUS;

EID: 78650054960     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.145235     Document Type: Article

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