Structural basis for conformational dynamics of GTP-bound ras protein

Journal of Biological Chemistry

Volumn 285, Issue 29, 2010, Pages 22696-22705

  Shima, Fumi ^a   Ijiri, Yuichi ^a   Muraoka, Shin ^a,d   Liao, Jingling ^a   Ye, Min ^a   Araki, Mitsugu ^b   Matsumoto, Kousuke ^a   Yamamoto, Naoki ^b   Sugimoto, Takeshi ^a   Yoshikawa, Yoko ^a   Kumasaka, Takashi ^c   Yamamoto, Masaki ^d   Tamura, Atsuo ^b   Kataoka, Tohru ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d RIKEN SPring 8 Center ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; GDP/GTP EXCHANGE; GTPASES; GUANINE NUCLEOTIDES; GUANOSINES; HIGH FLEXIBILITY; INTERMEDIATE STATE; MEDIATED INTERACTION; MOLECULAR BASIS; NMR SPECTRUM; STATE TRANSITIONS; STRUCTURAL BASIS; STRUCTURAL FEATURE; TERTIARY STRUCTURES; TRIPHOSPHATE; TWO-STATE; X-RAY CRYSTAL STRUCTURE ANALYSIS;

AMINO ACIDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES; ORGANIC ACIDS; PROTEINS;

CRYSTAL STRUCTURE;

AMINO ACID; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; H RAS PROTEIN; M RAS PROTEIN; PHOSPHORUS; RAS PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE REARRANGEMENT; GENE SWITCHING; HUMAN; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACIDS; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; GUANYLYL IMIDODIPHOSPHATE; HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MONOMERIC GTP-BINDING PROTEINS; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 77954611615     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.125161     Document Type: Article

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