A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk

Frontiers in Pharmacology

Volumn 4 JAN, Issue , 2014, Pages

  Diaz Ochoa, Juan G ^a   Bucher, Joachim ^a   Péry, Alexandre R R ^b   Zaldivar Comenges, José M ^a,c   Niklas, Jens ^a   Mauch, Klaus ^a  

^a INSILICO Biotechnology GmbH   (Germany)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^c JOINT RESEARCH CENTRE   (Italy)

Author keywords

Acetaminophen; Drug metabolism; Hepatotoxicity; Pharmacokinetics; Toxicity testing

Indexed keywords

CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DRUG METABOLITE; PARACETAMOL;

ARTICLE; CASE STUDY; CELL MODEL; COMPUTER MODEL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG OVERDOSE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; MODEL; MULTISCALE MODELING; PHARMACOKINETICS; PREDICTION; SIMULATION; SINGLE DRUG DOSE; TOXIC HEPATITIS; TWO DIMENSIONAL LIVER MODEL; WHOLE BODY MODEL;

EID: 84881524953     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00204     Document Type: Article

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