메뉴 건너뛰기




Volumn 4, Issue 3, 2012, Pages 221-235

The virtual liver: A multidisciplinary, multilevel challenge for systems biology

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEPCIDIN; INTERLEUKIN 10;

EID: 84859840179     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.1158     Document Type: Article
Times cited : (97)

References (74)
  • 1
    • 0025923478 scopus 로고
    • Mathematical analysis of enzymic reaction systems using optimization principles.
    • Heinrich R, Schuster S, Holzhutter HG. Mathematical analysis of enzymic reaction systems using optimization principles. Eur J Biochem 1991, 201:1-21.
    • (1991) Eur J Biochem , vol.201 , pp. 1-21
    • Heinrich, R.1    Schuster, S.2    Holzhutter, H.G.3
  • 2
    • 78651449005 scopus 로고    scopus 로고
    • Evolutionary design principles and functional characteristics based on kingdom-specific network motifs.
    • Kim TH, Kim J, Heslop-Harrison P, Cho KH. Evolutionary design principles and functional characteristics based on kingdom-specific network motifs. Bioinformatics 2010, 27:245-251.
    • (2010) Bioinformatics , vol.27 , pp. 245-251
    • Kim, T.H.1    Kim, J.2    Heslop-Harrison, P.3    Cho, K.H.4
  • 5
    • 48049099736 scopus 로고    scopus 로고
    • On the use of PIPSA to guide target-selective drug design.
    • Henrich S, Richter S, Wade RC. On the use of PIPSA to guide target-selective drug design. ChemMedChem 2008, 3:413-417.
    • (2008) ChemMedChem , vol.3 , pp. 413-417
    • Henrich, S.1    Richter, S.2    Wade, R.C.3
  • 6
  • 7
    • 34147108307 scopus 로고    scopus 로고
    • Pathway analysis for design of promiscuous drugs and selective drug mixtures.
    • Sivachenko A, Kalinin A, Yuryev A. Pathway analysis for design of promiscuous drugs and selective drug mixtures. Curr Drug Discov Technol 2006, 3:269-277.
    • (2006) Curr Drug Discov Technol , vol.3 , pp. 269-277
    • Sivachenko, A.1    Kalinin, A.2    Yuryev, A.3
  • 9
    • 79957949050 scopus 로고    scopus 로고
    • In silico models of bone remodeling from macro to nano-from organ to cell.
    • Webster D, Muller R. In silico models of bone remodeling from macro to nano-from organ to cell. Wiley Interdiscip Rev Syst Biol Med 2010, 3:241-251.
    • (2010) Wiley Interdiscip Rev Syst Biol Med , vol.3 , pp. 241-251
    • Webster, D.1    Muller, R.2
  • 10
    • 64749110869 scopus 로고    scopus 로고
    • The cardiac physiome: perspectives for the future.
    • Bassingthwaighte J, Hunter P, Noble D. The cardiac physiome: perspectives for the future. Exp Physiol 2009, 94:597-605.
    • (2009) Exp Physiol , vol.94 , pp. 597-605
    • Bassingthwaighte, J.1    Hunter, P.2    Noble, D.3
  • 12
    • 45949089554 scopus 로고    scopus 로고
    • Bioinformatics, multiscale modeling and the IUPS physiome project.
    • Hunter PJ, Crampin EJ, Nielsen PM. Bioinformatics, multiscale modeling and the IUPS physiome project. Brief Bioinform 2008, 9:333-343.
    • (2008) Brief Bioinform , vol.9 , pp. 333-343
    • Hunter, P.J.1    Crampin, E.J.2    Nielsen, P.M.3
  • 13
    • 51749094610 scopus 로고    scopus 로고
    • Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise.
    • Walser B, Stebbins CL. Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise. Eur J Appl Physiol 2008, 104:455-461.
    • (2008) Eur J Appl Physiol , vol.104 , pp. 455-461
    • Walser, B.1    Stebbins, C.L.2
  • 14
    • 0036204119 scopus 로고    scopus 로고
    • Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example.
    • Montgomery H, Brull D, Humphries SE. Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example. Ital Heart J 2002, 3:10-14.
    • (2002) Ital Heart J , vol.3 , pp. 10-14
    • Montgomery, H.1    Brull, D.2    Humphries, S.E.3
  • 16
    • 73949091032 scopus 로고    scopus 로고
    • Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas.
    • Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010, 176:2-13.
    • (2010) Am J Pathol , vol.176 , pp. 2-13
    • Michalopoulos, G.K.1
  • 18
    • 37349053742 scopus 로고    scopus 로고
    • Impact of fatty liver disease on health care utilization and costs in a general population: a 5-year observation.
    • Baumeister SE, Volzke H, Marschall P, John U, Schmidt CO, Flessa S, Alte D. Impact of fatty liver disease on health care utilization and costs in a general population: a 5-year observation. Gastroenterology 2008, 134:85-94.
    • (2008) Gastroenterology , vol.134 , pp. 85-94
    • Baumeister, S.E.1    Volzke, H.2    Marschall, P.3    John, U.4    Schmidt, C.O.5    Flessa, S.6    Alte, D.7
  • 19
    • 0024226701 scopus 로고
    • Metabolic zonation of liver parenchyma.
    • Jungerman K. Metabolic zonation of liver parenchyma. Semin Liver Dis 1988, 8:329-341.
    • (1988) Semin Liver Dis , vol.8 , pp. 329-341
    • Jungerman, K.1
  • 20
    • 0033960898 scopus 로고    scopus 로고
    • Oxygen: modulator of metabolic zonation and disease of the liver.
    • Jungermann K, Kietzmann T. Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 2000, 31:255-260.
    • (2000) Hepatology , vol.31 , pp. 255-260
    • Jungermann, K.1    Kietzmann, T.2
  • 22
    • 77957332990 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
    • Ahmed MH, Abu EO, Byrne CD. Non-alcoholic fatty liver disease (NAFLD): new challenge for general practitioners and important burden for health authorities? Prim Care Diabetes 2010, 4:129-137.
    • (2010) Prim Care Diabetes , vol.4 , pp. 129-137
    • Ahmed, M.H.1    Abu, E.O.2    Byrne, C.D.3
  • 23
    • 77951539837 scopus 로고    scopus 로고
    • The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD).
    • Liu Q, Bengmark S, Qu S. The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Lipids Health Dis 2010, 9:42.
    • (2010) Lipids Health Dis , vol.9 , pp. 42
    • Liu, Q.1    Bengmark, S.2    Qu, S.3
  • 24
    • 34247098754 scopus 로고    scopus 로고
    • Multiscale modeling of biomolecular systems: in serial and in parallel.
    • Ayton GS, Noid WG, Voth GA. Multiscale modeling of biomolecular systems: in serial and in parallel. Curr Opin Struct Biol 2007, 17:192-198.
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 192-198
    • Ayton, G.S.1    Noid, W.G.2    Voth, G.A.3
  • 25
    • 65549129171 scopus 로고    scopus 로고
    • Multiscale, multiorgan and multivariate complexity analyses of cardiovascular regulation.
    • Cerutti S, Hoyer D, Voss A. Multiscale, multiorgan and multivariate complexity analyses of cardiovascular regulation. Philos Transact A Math Phys Eng Sci 2009, 367:1337-1358.
    • (2009) Philos Transact A Math Phys Eng Sci , vol.367 , pp. 1337-1358
    • Cerutti, S.1    Hoyer, D.2    Voss, A.3
  • 26
    • 36048931366 scopus 로고    scopus 로고
    • Multiscale modeling of biological pattern formation.
    • Grima R. Multiscale modeling of biological pattern formation. Curr Top Dev Biol 2008, 81:435-460.
    • (2008) Curr Top Dev Biol , vol.81 , pp. 435-460
    • Grima, R.1
  • 29
    • 35948964347 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis.
    • Moreira RK. Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 2007, 131:1728-1734.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1728-1734
    • Moreira, R.K.1
  • 30
    • 0025080104 scopus 로고
    • Mathematical modelling of the purine metabolism of the rat liver.
    • Bartel T, Holzhutter HG. Mathematical modelling of the purine metabolism of the rat liver. Biochim Biophys Acta 1990, 1035:331-339.
    • (1990) Biochim Biophys Acta , vol.1035 , pp. 331-339
    • Bartel, T.1    Holzhutter, H.G.2
  • 31
    • 13844289127 scopus 로고    scopus 로고
    • Thermodynamic-based computational profiling of cellular regulatory control in hepatocyte metabolism.
    • Beard DA, Qian H. Thermodynamic-based computational profiling of cellular regulatory control in hepatocyte metabolism. Am J Physiol Endocrinol Metab 2005, 288:E633-E644.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Beard, D.A.1    Qian, H.2
  • 32
    • 37149002215 scopus 로고    scopus 로고
    • A computer model of gluconeogenesis and lipid metabolism in the perfused liver.
    • Chalhoub E, Hanson RW, Belovich JM. A computer model of gluconeogenesis and lipid metabolism in the perfused liver. Am J Physiol Endocrinol Metab 2007, 293:E1676-E1686.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Chalhoub, E.1    Hanson, R.W.2    Belovich, J.M.3
  • 33
    • 38049159766 scopus 로고    scopus 로고
    • Construction of a biological tissue model based on a single-cell model: a computer simulation of metabolic heterogeneity in the liver lobule.
    • Ohno H, Naito Y, Nakajima H, Tomita M. Construction of a biological tissue model based on a single-cell model: a computer simulation of metabolic heterogeneity in the liver lobule. Artif Life 2008, 14:3-28.
    • (2008) Artif Life , vol.14 , pp. 3-28
    • Ohno, H.1    Naito, Y.2    Nakajima, H.3    Tomita, M.4
  • 34
    • 29144533195 scopus 로고    scopus 로고
    • Pyruvate metabolism in rat liver mitochondria. What is optimized at steady state?
    • Stucki JW, Urbanczik R. Pyruvate metabolism in rat liver mitochondria. What is optimized at steady state? Febs J 2005, 272:6244-6253.
    • (2005) Febs J , vol.272 , pp. 6244-6253
    • Stucki, J.W.1    Urbanczik, R.2
  • 39
    • 34249905607 scopus 로고    scopus 로고
    • Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.
    • Willmann S, Hohn K, Edginton A, Sevestre M, Solodenko J, Weiss W, Lippert J, Schmitt W. Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs. J Pharmacokinet Pharmacodyn 2007, 34:401-431.
    • (2007) J Pharmacokinet Pharmacodyn , vol.34 , pp. 401-431
    • Willmann, S.1    Hohn, K.2    Edginton, A.3    Sevestre, M.4    Solodenko, J.5    Weiss, W.6    Lippert, J.7    Schmitt, W.8
  • 40
    • 3242778534 scopus 로고    scopus 로고
    • A physiological model for the estimation of the fraction dose absorbed in humans.
    • Willmann S, Schmitt W, Keldenich J, Lippert J, Dressman JB. A physiological model for the estimation of the fraction dose absorbed in humans. J Med Chem 2004, 47:4022-4031.
    • (2004) J Med Chem , vol.47 , pp. 4022-4031
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3    Lippert, J.4    Dressman, J.B.5
  • 42
    • 80054718671 scopus 로고    scopus 로고
    • A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
    • Eissing T, Kuepfer L, Becker C, Block M, Coboeken K, Gaub T, Goerlitz L, Jaeger J, Loosen R, Ludewig B, et al. A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks. Front Physiol 2011, 2:4.
    • (2011) Front Physiol , vol.2 , pp. 4
    • Eissing, T.1    Kuepfer, L.2    Becker, C.3    Block, M.4    Coboeken, K.5    Gaub, T.6    Goerlitz, L.7    Jaeger, J.8    Loosen, R.9    Ludewig, B.10
  • 45
    • 77956393435 scopus 로고    scopus 로고
    • A biphasic model for sinusoidal liver perfusion remodeling after outflow obstruction.
    • Ricken T, Dahmen U, Dirsch O. A biphasic model for sinusoidal liver perfusion remodeling after outflow obstruction. Biomech Model Mechanobiol 9:435-450.
    • Biomech Model Mechanobiol , vol.9 , pp. 435-450
    • Ricken, T.1    Dahmen, U.2    Dirsch, O.3
  • 47
    • 0027499061 scopus 로고
    • Computer generation of complex arterial tree models.
    • Schreiner W. Computer generation of complex arterial tree models. J Biomed Eng 1993, 15:148-150.
    • (1993) J Biomed Eng , vol.15 , pp. 148-150
    • Schreiner, W.1
  • 49
    • 67649160515 scopus 로고    scopus 로고
    • Architectural changes during regenerative and ontogenic liver growth in the rat.
    • Papp V, Dezso K, Laszlo V, Nagy P, Paku S. Architectural changes during regenerative and ontogenic liver growth in the rat. Liver Transpl 2009, 15:177-183.
    • (2009) Liver Transpl , vol.15 , pp. 177-183
    • Papp, V.1    Dezso, K.2    Laszlo, V.3    Nagy, P.4    Paku, S.5
  • 50
    • 34249873259 scopus 로고    scopus 로고
    • On the role of physics in the growth and pattern formation of multi-cellular systems:what can we learn from individual-cell based models?
    • Drasdo D, Hoehme S, Block M. On the role of physics in the growth and pattern formation of multi-cellular systems:what can we learn from individual-cell based models? J Stat Phys 2007, 128:287-345.
    • (2007) J Stat Phys , vol.128 , pp. 287-345
    • Drasdo, D.1    Hoehme, S.2    Block, M.3
  • 51
    • 33750234189 scopus 로고    scopus 로고
    • Modeling multicellular systems using subcellular elements.
    • Newman TJ. Modeling multicellular systems using subcellular elements. Math Biosci Eng 2005, 2:613-624.
    • (2005) Math Biosci Eng , vol.2 , pp. 613-624
    • Newman, T.J.1
  • 52
    • 77957769697 scopus 로고    scopus 로고
    • A sub-cellular viscoelastic model for cell population mechanics.
    • 5:e12097. doi:10.1371/journal.pone. 0012097.
    • Jamali Y, Azimi M, Mofrad MR. A sub-cellular viscoelastic model for cell population mechanics. PLoS ONE 2010, 5:e12097. doi:10.1371/journal.pone. 0012097.
    • (2010) PLoS ONE
    • Jamali, Y.1    Azimi, M.2    Mofrad, M.R.3
  • 53
    • 34248201490 scopus 로고    scopus 로고
    • A parallel implementation of the cellular potts model for simulation of cell-based morphogenesis.
    • Chen N, Glazier JA, Izaguirre JA, Alber MS. A parallel implementation of the cellular potts model for simulation of cell-based morphogenesis. Comput Phys Commun 2007, 176:670-681.
    • (2007) Comput Phys Commun , vol.176 , pp. 670-681
    • Chen, N.1    Glazier, J.A.2    Izaguirre, J.A.3    Alber, M.S.4
  • 55
    • 46749151795 scopus 로고    scopus 로고
    • Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach.
    • Ramis-Conde I, Drasdo D, Anderson AR, Chaplain MA. Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J 2008, 95:155-165.
    • (2008) Biophys J , vol.95 , pp. 155-165
    • Ramis-Conde, I.1    Drasdo, D.2    Anderson, A.R.3    Chaplain, M.A.4
  • 57
    • 0021245189 scopus 로고
    • Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis.
    • Rotstein J, Macdonald PD, Rabes HM, Farber E. Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res 1984, 44:2913-2917.
    • (1984) Cancer Res , vol.44 , pp. 2913-2917
    • Rotstein, J.1    Macdonald, P.D.2    Rabes, H.M.3    Farber, E.4
  • 58
    • 0027457896 scopus 로고
    • A rapid method to study heterogeneous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates.
    • Saarinen J, Saarelainen R, Lindros KO. A rapid method to study heterogeneous gene expression in liver by direct assay of messenger RNA from periportal and perivenous cell lysates. Hepatology 1993, 17:466-469.
    • (1993) Hepatology , vol.17 , pp. 466-469
    • Saarinen, J.1    Saarelainen, R.2    Lindros, K.O.3
  • 61
    • 80053140672 scopus 로고    scopus 로고
    • Performance of Hybrid Programming Models for Multiscale, Cardiac Simulations: Preparing for Petascale Computation, IEEE Trans Biomed Eng
    • Pope B, Fitch B, Pitman M, Rice J, Reumann M. Performance of Hybrid Programming Models for Multiscale, Cardiac Simulations: Preparing for Petascale Computation, IEEE Trans Biomed Eng, 2011.
    • (2011)
    • Pope, B.1    Fitch, B.2    Pitman, M.3    Rice, J.4    Reumann, M.5
  • 62
    • 79956200825 scopus 로고    scopus 로고
    • Model decomposition and reduction tools for large-scale networks in systems biology.
    • Anderson J, Chang YC, Papachristodoulou A. Model decomposition and reduction tools for large-scale networks in systems biology. Automatica. 2011, 47:1165-1174.
    • (2011) Automatica. , vol.47 , pp. 1165-1174
    • Anderson, J.1    Chang, Y.C.2    Papachristodoulou, A.3
  • 63
    • 75849137232 scopus 로고    scopus 로고
    • Model aggregation: a building-block approach to creating large macromolecular regulatory networks.
    • Randhawa R, Shaffer CA, Tyson JJ. Model aggregation: a building-block approach to creating large macromolecular regulatory networks. Bioinformatics 2009, 25:3289-3295.
    • (2009) Bioinformatics , vol.25 , pp. 3289-3295
    • Randhawa, R.1    Shaffer, C.A.2    Tyson, J.J.3
  • 64
    • 0021026827 scopus 로고
    • Rapid changes in chick liver acetyl-CoA carboxylase indicative of phosphorylation control.
    • Clarke SD. Rapid changes in chick liver acetyl-CoA carboxylase indicative of phosphorylation control. Biochem Biophys Res Commun 1983, 116:633-638.
    • (1983) Biochem Biophys Res Commun , vol.116 , pp. 633-638
    • Clarke, S.D.1
  • 65
    • 0028343389 scopus 로고
    • Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.
    • Gronowski AM, Rotwein P. Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91. J Biol Chem 1994, 269:7874-7878.
    • (1994) J Biol Chem , vol.269 , pp. 7874-7878
    • Gronowski, A.M.1    Rotwein, P.2
  • 66
    • 33750040836 scopus 로고    scopus 로고
    • Reduction of a biochemical model with preservation of its basic dynamic properties.
    • Dano S, Madsen MF, Schmidt H, Cedersund G. Reduction of a biochemical model with preservation of its basic dynamic properties. Febs J 2006, 273:4862-4877.
    • (2006) Febs J , vol.273 , pp. 4862-4877
    • Dano, S.1    Madsen, M.F.2    Schmidt, H.3    Cedersund, G.4
  • 67
    • 0001799628 scopus 로고
    • Essai éxperimental et analytique: sur les lois de la dilatabilité de fluides élastique et sur celles de la force expansive de la vapeur de l'alkool, à différentes températures.
    • de Prony GR. Essai éxperimental et analytique: sur les lois de la dilatabilité de fluides élastique et sur celles de la force expansive de la vapeur de l'alkool, à différentes températures. Jl de l'école Polytechnique 1795, 1:24-76.
    • (1795) Jl de l'école Polytechnique , vol.1 , pp. 24-76
    • de Prony, G.R.1
  • 68
    • 78449275457 scopus 로고    scopus 로고
    • Model reduction using piecewise-linear approximations preserves dynamic properties of the carbon starvation response in Escherichia coli.
    • Ropers D, Baldazzi V, de Jong H. Model reduction using piecewise-linear approximations preserves dynamic properties of the carbon starvation response in Escherichia coli. IEEE/ACM Trans Comput Biol Bioinform 8:166-181.
    • IEEE/ACM Trans Comput Biol Bioinform , vol.8 , pp. 166-181
    • Ropers, D.1    Baldazzi, V.2    de Jong, H.3
  • 69
    • 0020617293 scopus 로고
    • Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver
    • Häussinger D. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem 1983, 133:269-275.
    • (1983) Eur J Biochem , vol.133 , pp. 269-275
    • Häussinger, D.1
  • 70
    • 33947139689 scopus 로고    scopus 로고
    • Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver.
    • Gebhardt R, Baldysiak-Figiel A, Krugel V, Ueberham E, Gaunitz F. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog Histochem Cytochem 2007, 41:201-266.
    • (2007) Prog Histochem Cytochem , vol.41 , pp. 201-266
    • Gebhardt, R.1    Baldysiak-Figiel, A.2    Krugel, V.3    Ueberham, E.4    Gaunitz, F.5
  • 71
    • 77957786145 scopus 로고    scopus 로고
    • A cell-based simulation software for multi-cellular systems
    • Hoehme S, Drasdo D. A cell-based simulation software for multi-cellular systems. Bioinformatics 2010, 26:2641-2642.
    • (2010) Bioinformatics , vol.26 , pp. 2641-2642
    • Hoehme, S.1    Drasdo, D.2
  • 72
    • 5044229321 scopus 로고    scopus 로고
    • The impact of systems approaches on biological problems in drug discovery.
    • Hood L, Perlmutter RM. The impact of systems approaches on biological problems in drug discovery. Nature Biotechnol 2004, 22:1215-1217.
    • (2004) Nature Biotechnol , vol.22 , pp. 1215-1217
    • Hood, L.1    Perlmutter, R.M.2
  • 73
    • 53649095010 scopus 로고    scopus 로고
    • A network solution.
    • Henney A, Superti-Furga G. A network solution. Nature 2008, 455:730-731.
    • (2008) Nature , vol.455 , pp. 730-731
    • Henney, A.1    Superti-Furga, G.2
  • 74
    • 68049092169 scopus 로고    scopus 로고
    • Who will take up the gauntlet? Challenges and opportunites for systems biollogy and drug discovery.
    • Henney AM. Who will take up the gauntlet? Challenges and opportunites for systems biollogy and drug discovery. EMBO Rep 2009, 10:S9-S13.
    • (2009) EMBO Rep , vol.10
    • Henney, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.