Using an In Silico Liver to evaluate a hepatic enzyme induction mechanism

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Volumn , Issue , 2008, Pages 2415-2418

  Hunt, C Anthony ^b   Ropella, Glen E P ^a  

^a TEMPUS DICTUM INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MULTI AGENT SYSTEMS;

ENZYME INDUCTION; FINE GRAINED; HEPATIC ENZYMES; IN-SILICO; MULTI AGENT; MULTILEVELS; UNIFORM DISTRIBUTION;

ENZYMES;

ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPUTER; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG INTERACTION; ENZYMOLOGY; HISTOLOGY; HUMAN; LIVER; LIVER CIRCULATION; MONTE CARLO METHOD; PHENOTYPE; PHYSICAL CHEMISTRY; STATISTICAL MODEL; THEORETICAL MODEL; TIME;

CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; COMPUTERS; DRUG INTERACTIONS; HUMANS; LIVER; LIVER CIRCULATION; MODELS, STATISTICAL; MODELS, THEORETICAL; MONTE CARLO METHOD; NEURAL NETWORKS (COMPUTER); PHENOTYPE; SOFTWARE; TIME FACTORS;

EID: 61849159972     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/iembs.2008.4649686     Document Type: Conference Paper

References (7)

1. Fisher J and Henzinger TA (2007) Executable cell biology. Nat Biotech 25: 1239-49.
2. Hunt CA, Ropella GEP, Park S., and Engelberg J (2008) "Dichotomies Between Computational and Mathematical Models." Nat Biotech 26: 737-8.
3. Hunt CA, Ropella GEP, Yan, L, Hung DY, and Roberts MS (2006) "Physiologically based synthetic models of hepatic disposition." J Pharmacokinet Pharmacodyn 33: 737-72.
4. Yan L., Ropella GEP, Park S., Roberts MS, and Hunt CA (2008) Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver. Pharm Res 25: 1023-36.
5. Yan L., Sheihk-Bahaei S, Park S., Ropella GEP, and Hunt CA (2008) Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model. Drug Metab Dispos 36: 759-68.
6. Ropella GEP, Hunt CA, and Nag DA (2005) "Using Heuristic Models to Bridge the Gap between Analytic and Experimental Models in Biology." In L. Yilmaz (ed), Agent-Directed Simulation Symposium, Vol. Simulation Series 37(2), (ADS'05), SCS Press, San Diego, CA,; pp. 182-90.
7. Bankes S and Gillogly J (1994) "Exploratory Modeling: Search Through Spaces of Computational Experiments." Proceedings of the Third Annual Conference on Evolutionary Programming, Sebald AV, Fogel LJ (eds.), River Edge, New Jersey: World Scientific Publishing Co., pp. 353-60.