메뉴 건너뛰기




Volumn 736, Issue , 2012, Pages 543-561

Multiscale mechanistic modeling in pharmaceutical research and development

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOINFORMATICS; CELL FUNCTION; CYTOLOGY; DATA PROCESSING; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG RESEARCH; EXEMPLARY MULTISCALE MODEL; FINITE ELEMENT ANALYSIS; HUMAN; INTEGRATION; LIPOPHILICITY; MATHEMATICAL MODEL; MEDICAL INFORMATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MULTISCALE MECHANISTIC MODELING; MULTISCALE MODELING; NONHUMAN; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STOCHASTIC MODEL; STOICHIOMETRY; TISSUE AND ORGAN SCALE;

EID: 84855923550     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7210-1_32     Document Type: Article
Times cited : (21)

References (49)
  • 1
    • 33751217466 scopus 로고    scopus 로고
    • Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    • DOI 10.1016/j.cell.2006.09.042, PII S0092867406013481
    • Anderson AR, WeaverAM, Cummings PT, Quaranta V (2006) Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127: 905-915 (Pubitemid 44792251)
    • (2006) Cell , vol.127 , Issue.5 , pp. 905-915
    • Anderson, A.R.A.1    Weaver, A.M.2    Cummings, P.T.3    Quaranta, V.4
  • 4
    • 66349123393 scopus 로고    scopus 로고
    • Tamoxifen metabolism and its effect on endocrine treatment of breast cancer
    • Briest S, Stearns V (2009) Tamoxifen metabolism and its effect on endocrine treatment of breast cancer. Clin Adv Hematol Oncol 7:185-192
    • (2009) Clin Adv Hematol Oncol , vol.7 , pp. 185-192
    • Briest, S.1    Stearns, V.2
  • 6
    • 32044442976 scopus 로고    scopus 로고
    • Using a mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development
    • DOI 10.1016/j.biosystems.2005.04.007, PII S0303264705001188
    • Chassagnole C, Jackson RC, Hussain N, Bashir L, Derow C, Savin J, Fell DA (2006) Using a mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development. Biosystems 83:91-97 (Pubitemid 43199810)
    • (2006) BioSystems , vol.83 , Issue.2-3 SPEC. ISS. , pp. 91-97
    • Chassagnole, C.1    Jackson, R.C.2    Hussain, N.3    Bashir, L.4    Derow, C.5    Savin, J.6    Fell, D.A.7
  • 7
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DOI 10.1016/S0167-6296(02)00126-1
    • DiMasi JA, Hansen RW, Grabowski HG (2003) The price of innovation: new estimates of drug development costs. J Health Econ 22:151-185 (Pubitemid 36279392)
    • (2003) Journal of Health Economics , vol.22 , Issue.2 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 9
    • 33845741225 scopus 로고    scopus 로고
    • Physiology-based versus allometric scaling of clearance in children; an eliminating process based comparison
    • DOI 10.1185/146300906778876170
    • Edginton AN, Willmann S (2006) Physiology-based versus allometric scaling of clearance in children; an eliminating process based comparison. Paediatr Perinat Drug Ther 7:146-153 (Pubitemid 46010017)
    • (2006) Paediatric and Perinatal Drug Therapy , vol.7 , Issue.3 , pp. 146-153
    • Edginton, A.N.1    Willmann, S.2
  • 10
    • 52649085416 scopus 로고    scopus 로고
    • Physiology-based simulations of a pathological condition: Prediction of pharmacokinetics in patients with liver cirrhosis
    • Edginton AN, Willmann S (2008) Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clin Pharmacokinet 47:743-752
    • (2008) Clin Pharmacokinet , vol.47 , pp. 743-752
    • Edginton, A.N.1    Willmann, S.2
  • 16
    • 68949206409 scopus 로고    scopus 로고
    • Applying mass spectrometry-based proteomics to genetics, genomics and network biology
    • Gstaiger M, Aebersold R (2009) Applying mass spectrometry-based proteomics to genetics, genomics and network biology. Nat Rev Genet 10:617-627
    • (2009) Nat Rev Genet , vol.10 , pp. 617-627
    • Gstaiger, M.1    Aebersold, R.2
  • 17
    • 68049092169 scopus 로고    scopus 로고
    • Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery
    • Henney AM (2009) Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery. EMBO Rep 10(Suppl 1):S9-13
    • (2009) EMBO Rep , vol.10 , Issue.SUPPL. 1
    • Henney, A.M.1
  • 19
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The Physiome Project
    • DOI 10.1038/nrm1054
    • Hunter PJ, Borg TK (2003) Integration from proteins to organs: the physiome project. Nat Rev Mol Cell Biol 4:237-243 (Pubitemid 36288045)
    • (2003) Nature Reviews Molecular Cell Biology , vol.4 , Issue.3 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 20
    • 33644527950 scopus 로고    scopus 로고
    • The model organism as a system: Integrating 'omics' data sets
    • Joyce AR, Palsson BO (2006) The model organism as a system: integrating 'omics' data sets. Nat Rev Mol Cell Biol 7:198-210
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 198-210
    • Joyce, A.R.1    Palsson, B.O.2
  • 21
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko BN (2006) Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol 7:165-176
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 22
    • 77956411284 scopus 로고    scopus 로고
    • Towards whole-body systems physiology
    • Kuepfer L (2010) Towards whole-body systems physiology. Mol Syst Biol 6:409
    • (2010) Mol Syst Biol , vol.6 , pp. 409
    • Kuepfer, L.1
  • 23
    • 34948840834 scopus 로고    scopus 로고
    • Ensemble modeling for analysis of cell signaling dynamics
    • DOI 10.1038/nbt1330, PII NBT1330
    • Kuepfer L, Peter M, Sauer U, Stelling J (2007) Ensemble modeling for analysis of cell signaling dynamics. Nat Biotechnol 25:1001-1006 (Pubitemid 47517639)
    • (2007) Nature Biotechnology , vol.25 , Issue.9 , pp. 1001-1006
    • Kuepfer, L.1    Peter, M.2    Sauer, U.3    Stelling, J.4
  • 24
    • 79951481957 scopus 로고    scopus 로고
    • Initial impact of the sequencing of the human genome
    • Lander ES (2011) Initial impact of the sequencing of the human genome. Nature 470:187-197
    • (2011) Nature , vol.470 , pp. 187-197
    • Lander, E.S.1
  • 26
    • 34447330544 scopus 로고    scopus 로고
    • Whole-body physiologically based pharmacokinetic models
    • DOI 10.1517/17425255.3.2.235
    • Nestorov I (2007)Whole-body physiologically based pharmacokinetic models. Exp Opin Drug Metab Toxicol 3:235-249 (Pubitemid 47321518)
    • (2007) Expert Opinion on Drug Metabolism and Toxicology , vol.3 , Issue.2 , pp. 235-249
    • Nestorov, I.1
  • 27
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart - From genes to cells to the whole organ
    • DOI 10.1126/science.1069881
    • Noble D (2002) Modeling the heart-from genes to cells to the whole organ. Science 295: 1678-1682 (Pubitemid 34202896)
    • (2002) Science , vol.295 , Issue.5560 , pp. 1678-1682
    • Noble, D.1
  • 28
    • 84855979318 scopus 로고    scopus 로고
    • Which path will you take?
    • PricewaterhouseCoopers
    • PricewaterhouseCoopers (2007) Which path will you take? Pharma 2020: The vision
    • (2007) Pharma 2020: The Vision
  • 30
    • 0037078982 scopus 로고    scopus 로고
    • Control, exploitation and tolerance of intracellular noise
    • DOI 10.1038/nature01258
    • Rao CV, Wolf DM, Arkin AP (2002) Control, exploitation and tolerance of intracellular noise. Nature 420:231-237 (Pubitemid 35340135)
    • (2002) Nature , vol.420 , Issue.6912 , pp. 231-237
    • Rao, C.V.1    Wolf, D.M.2    Arkin, A.P.3
  • 31
    • 77953811461 scopus 로고    scopus 로고
    • The systems biology approach to drug development: Application to toxicity assessment of cardiac drugs
    • Rodriguez B, Burrage K, Gavaghan D, Grau V, Kohl P, Noble D (2010) The systems biology approach to drug development: application to toxicity assessment of cardiac drugs. Clin Pharmacol Ther 88:130-134
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 130-134
    • Rodriguez, B.1    Burrage, K.2    Gavaghan, D.3    Grau, V.4    Kohl, P.5    Noble, D.6
  • 34
    • 21744457064 scopus 로고    scopus 로고
    • Physiology-based pharmacokinetic modeling: Ready to be used
    • SchmittW,Willmann S (2005) Physiology-based pharmacokinetic modeling: ready to be used. Drug Discov Today 2:125-132
    • (2005) Drug Discov Today , vol.2 , pp. 125-132
    • Schmitt, W.1    Willmann, S.2
  • 35
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    • Schuetz R, Kuepfer L, Sauer U (2007) Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli. Mol Syst Biol 3:119
    • (2007) Mol Syst Biol , vol.3 , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 37
    • 66249132328 scopus 로고    scopus 로고
    • Predicting metabolic biomarkers of human inborn errors of metabolism
    • Shlomi T, Cabili MN, Ruppin E (2009) Predicting metabolic biomarkers of human inborn errors of metabolism. Mol Syst Biol 5:263
    • (2009) Mol Syst Biol , vol.5 , pp. 263
    • Shlomi, T.1    Cabili, M.N.2    Ruppin, E.3
  • 38
    • 77955785233 scopus 로고    scopus 로고
    • Integration of in silico and in vitro platforms for pharmacokinetic- pharmacodynamic modeling
    • Sung JH, Esch MB, Shuler ML (2010) Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling. Exp Opin Drug Metab Toxicol 6:1063-1081
    • (2010) Exp Opin Drug Metab Toxicol , vol.6 , pp. 1063-1081
    • Sung, J.H.1    Esch, M.B.2    Shuler, M.L.3
  • 39
    • 79956116374 scopus 로고    scopus 로고
    • Multi-scale lung modeling
    • Tawhai MH, Bates JH (2011) Multi-scale lung modeling. J Appl Physiol 110(5):1466-1572
    • (2011) J Appl Physiol , vol.110 , Issue.5 , pp. 1466-1572
    • Tawhai, M.H.1    Bates, J.H.2
  • 41
    • 4143068042 scopus 로고    scopus 로고
    • Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations
    • DOI 10.1016/j.cmpb.2004.01.001, PII S0169260704000136
    • Tornoe CW, Agerso H, Jonsson EN, Madsen H, Nielsen HA (2004) Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations. Comput Methods Progr Biomed 76:31-40 (Pubitemid 39094638)
    • (2004) Computer Methods and Programs in Biomedicine , vol.76 , Issue.1 , pp. 31-40
    • Tornoe, C.W.1    Agerso, H.2    Jonsson, E.N.3    Madsen, H.4    Nielsen, H.A.5
  • 42
    • 79959900575 scopus 로고    scopus 로고
    • Systems pharmacology: Bridging systems biology and pharmacokinetics- pharmacodynamics (PKPD) in drug discovery and development
    • van der Graaf PH, Benson N (2011) Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development. Pharm Res 28(7):1460-1464
    • (2011) Pharm Res , vol.28 , Issue.7 , pp. 1460-1464
    • Van Der Graaf, P.H.1    Benson, N.2
  • 43
    • 0030932272 scopus 로고    scopus 로고
    • A general model for the origin of allometric scaling laws in biology
    • DOI 10.1126/science.276.5309.122
    • West GB, Brown JH, Enquist BJ (1997) A general model for the origin of allometric scaling laws in biology. Science 276:122-126 (Pubitemid 27161259)
    • (1997) Science , vol.276 , Issue.5309 , pp. 122-126
    • West, G.B.1    Brown, J.H.2    Enquist, B.J.3
  • 44
    • 70450240777 scopus 로고    scopus 로고
    • Risk to the breast-fed neonate from codeine treatment to the mother: A quantitative mechanistic modeling study
    • Willmann S, Edginton AN, Coboeken K, Ahr G, Lippert J (2009) Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study. Clin Pharmacol Ther 86:634-643
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 634-643
    • Willmann, S.1    Edginton, A.N.2    Coboeken, K.3    Ahr, G.4    Lippert, J.5
  • 45
    • 34249905607 scopus 로고    scopus 로고
    • Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
    • DOI 10.1007/s10928-007-9053-5
    • Willmann S, Hohn K, Edginton A, Sevestre M, Solodenko J, Weiss W, Lippert J, Schmitt W (2007) Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs. J Pharmacokinet Pharmacodyn 34:401-431 (Pubitemid 46873033)
    • (2007) Journal of Pharmacokinetics and Pharmacodynamics , vol.34 , Issue.3 , pp. 401-431
    • Willmann, S.1    Hohn, K.2    Edginton, A.3    Sevestre, M.4    Solodenko, J.5    Weiss, W.6    Lippert, J.7    Schmitt, W.8
  • 46
    • 33748338819 scopus 로고    scopus 로고
    • From physicochemistry to absorption and distribution: Predictive mechanistic modelling and computational tools
    • Willmann S, Lippert J, Schmitt W (2005) From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools. Exp Opin DrugMetab Toxicol 1:159-168
    • (2005) Exp Opin DrugMetab Toxicol , vol.1 , pp. 159-168
    • Willmann, S.1    Lippert, J.2    Schmitt, W.3
  • 48
    • 0344084044 scopus 로고    scopus 로고
    • A physiologic model for simulating gastrointestinal flow and drug absorption in rats
    • DOI 10.1023/B:PHAM.0000003373.72652.c0
    • Willmann S, SchmittW, Keldenich J, Dressman JB (2003) A physiologic model for simulating gastrointestinal flow and drug absorption in rats. Pharm Res 20:1766-1771 (Pubitemid 37449449)
    • (2003) Pharmaceutical Research , vol.20 , Issue.11 , pp. 1766-1771
    • Willmann, S.1    Schmitt, W.2    Keldenich, J.3    Dressman, J.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.