Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Qu, Ning ^a   Xu, Mingli ^b   Mizoguchi, Izuru ^a   Furusawa, Jun Ichi ^a   Kaneko, Kotaro ^a   Watanabe, Kazunori ^a   Mizuguchi, Junichiro ^a   Itoh, Masahiro ^a   Kawakami, Yutaka ^b   Yoshimoto, Takayuki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 23P19; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; STAT3 PROTEIN; USTEKINUMAB; CYTOKINE; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22;

ALLERGIC AIRWAY INFLAMMATION; APOPTOSIS; ASTHMA; ATOPIC DERMATITIS; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DENDRITIC CELL; DERMATITIS; ENCEPHALOMYELITIS; ENTERITIS; GRAFT REJECTION; HEPATITIS; HUMAN; HUMORAL IMMUNITY; INFLAMMATORY DISEASE; KERATINOCYTE; KERATITIS; MACROPHAGE; MALE INFERTILITY; MULTIPLE SCLEROSIS; NEPHRITIS; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SKIN ALLERGY; SKIN BIOPSY; SPERMATOGENESIS; STAPHYLOCOCCUS AUREUS; TH17 CELL; ANIMAL; IMMUNOLOGY; INFLAMMATION; METABOLISM;

ANIMALS; CYTOKINES; HUMANS; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-23; INTERLEUKINS; TH17 CELLS;

EID: 84881502993     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/968549     Document Type: Review

References (149)

1. Abbas A. K., Murphy K. M., Sher A., Functional diversity of helper T lymphocytes. Nature 1996 383 6603 787 793 2-s2.0-0029847368 10.1038/383787a0 (Pubitemid 26372655)
2. Glimcher L. H., Murphy K. M., Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes and Development 2000 14 14 1693 1711 2-s2.0-0034661356 (Pubitemid 30602989)
3. Vignali D. A. A., Collison L. W., Workman C. J., How regulatory T cells work. Nature Reviews Immunology 2008 8 7 523 532 2-s2.0-46249101518 10.1038/nri2343
4. + T-regulatory cells: toward therapy for human diseases. Immunological Reviews 2008 223 1 391 421 2-s2.0-47249102067 10.1111/j.1600-065X.2008.00634.x (Pubitemid 351986179)
5. Cua D. J., Sherlock J., Chen Y., Murphy C. A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S. A., Gorman D., Kastelein R. A., Sedgwick J. D., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003 421 6924 744 748 2-s2.0-0037434789 10.1038/nature01355 (Pubitemid 36227625)
6. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunology 2005 6 11 1123 1132 2-s2.0-27544490377 10.1038/ni1254 (Pubitemid 41541790)
7. Langrish C. L., Chen Y., Blumenschein W. M., Mattson J., Basham B., Sedgwick J. D., McClanahan T., Kastelein R. A., Cua D. J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. Journal of Experimental Medicine 2005 201 2 233 240 2-s2.0-13244283212 10.1084/jem.20041257 (Pubitemid 40189432)
8. Park H., Li Z., Yang X. O., Chang S. H., Nurieva R., Wang Y., Wang Y., Hood L., Zhu Z., Tian Q., Dong C., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nature Immunology 2005 6 11 1133 1141 2-s2.0-27544465354 10.1038/ni1261 (Pubitemid 41541791)
9. Veldhoen M., Hocking R. J., Flavell R. A., Stockinger B., Signals mediated by transforming growth factor- β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nature Immunology 2006 7 11 1151 1156 2-s2.0-33750142276 10.1038/ni1391 (Pubitemid 44594310)
10. Liang S. C., Tan X., Luxenberg D. P., Karim R., Dunussi-Joannopoulos K., Collins M., Fouser L. A., Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. Journal of Experimental Medicine 2006 203 10 2271 2279 2-s2.0-33749318470 10.1084/jem.20061308 (Pubitemid 44498362)
11. Korn T., Bettelli E., Gao W., Awasthi A., Jäger A., Strom T. B., Oukka M., Kuchroo V. K., IL-21 initiates an alternative pathway to induce proinflammatory T H17 cells. Nature 2007 448 7152 484 487 2-s2.0-34547232503 10.1038/nature05970 (Pubitemid 47123515)
12. Zheng Y., Danilenko D. M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., Ouyang W., Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007 445 7128 648 651 2-s2.0-33846906224 10.1038/nature05505 (Pubitemid 46232884)
13. Wilson N. J., Boniface K., Chan J. R., McKenzie B. S., Blumenschein W. M., Mattson J. D., Basham B., Smith K., Chen T., Morel F., Lecron J., Kastelein R. A., Cua D. J., McClanahan T. K., Bowman E. P., Malefyt R. D. W., Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nature Immunology 2007 8 9 950 957 2-s2.0-34548133583 10.1038/ni1497 (Pubitemid 47300009)
14. Dong C., TH17 cells in development: an updated view of their molecular identity and genetic programming. Nature Reviews Immunology 2008 8 5 337 348 2-s2.0-42649115767 10.1038/nri2295 (Pubitemid 351595217)
15. Korn T., Bettelli E., Oukka M., Kuchroo V. K., IL-17 and Th17 cells. Annual Review of Immunology 2009 27 485 517 2-s2.0-61949463911 10.1146/annurev.immunol.021908.132710
16. Littman D. R., Rudensky A. Y., Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010 140 6 845 858 2-s2.0-77950349016 10.1016/j.cell.2010.02.021
17. Gutcher I., Becher B., APC-derived cytokines and T cell polarization in autoimmune inflammation. Journal of Clinical Investigation 2007 117 5 1119 1127 2-s2.0-34248137873 10.1172/JCI31720 (Pubitemid 46718396)
18. Saijo S., Ikeda S., Yamabe K., Kakuta S., Ishigame H., Akitsu A., Fujikado N., Kusaka T., Kubo S., Chung S., Komatsu R., Miura N., Adachi Y., Ohno N., Shibuya K., Yamamoto N., Kawakami K., Yamasaki S., Saito T., Akira S., Iwakura Y., Dectin-2 recognition of α -mannans and induction of Th17 cell differentiation is essential for host defense against candida albicans. Immunity 2010 32 5 681 691 2-s2.0-77953289487 10.1016/j.immuni.2010.05.001
19. Yoshimoto T., Xu M., Mizoguchi I., Morishima N., Chiba Y., Mizuguchi J., Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clinical and Developmental Immunology 2010 2010 9 2-s2.0-77957866376 10.1155/2010/832454 832454
20. Fischer A., Human immunodeficiency: connecting STAT3, Th17 and human mucosal immunity. Immunology and Cell Biology 2008 86 7 549 551 2-s2.0-53249153474 10.1038/icb.2008.52
21. Tesmer L. A., Lundy S. K., Sarkar S., Fox D. A., Th17 cells in human disease. Immunological Reviews 2008 223 1 87 113 2-s2.0-47249128991 10.1111/j.1600-065X.2008.00628.x (Pubitemid 351986173)
22. Nestle F. O., Turka L. A., Nickoloff B. J., Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. Journal of Clinical Investigation 1994 94 1 202 209 2-s2.0-0028245467
23. Lowes M. A., Chamian F., Abello M. V., Fuentes-Duculan J., Lin S., Nussbaum R., Novitskaya I., Carbonaro H., Cardinale I., Kikuchi T., Gilleaudeau P., Sullivan-Whalen M., Wittkowski K. M., Papp K., Garovoy M., Dummer W., Steinman R. M., Krueger J. G., Increase in TNF- α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proceedings of the National Academy of Sciences of the United States of America 2005 102 52 19057 19062 2-s2.0-30044435436 10.1073/pnas.0509736102 (Pubitemid 43049565)
24. Teunissen M. B. M., Koomen C. W., De Waal Malefyt R., Wierenga E. A., Bos J. D., Interleukin-17 and interferon- γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. Journal of Investigative Dermatology 1998 111 4 645 649 2-s2.0-0031691282 10.1046/j.1523-1747.1998.00347.x (Pubitemid 28452327)
25. Nakajima K., Kanda T., Takaishi M., Shiga T., Miyoshi K., Nakajima H., Kamijima R., Tarutani M., Benson J. M., Elloso M. M., Gutshall L. L., Naso M. F., Iwakura Y., DiGiovanni J., Sano S., Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. Journal of Immunology 2011 186 7 4481 4489 2-s2.0-79955045064 10.4049/jimmunol.1000148
26. Nakajima K., Critical role of the interleukin-23//T-helper 17 cell axis in the pathogenesis of psoriasis. Journal of Dermatology 2012 39 3 219 224 2-s2.0-84857616727 10.1111/j.1346-8138.2011.01458.x
27. Elder J. T., Bruce A. T., Gudjonsson J. E., Johnston A., Stuart P. E., Tejasvi T., Voorhees J. J., Abecasis G. R., Nair R. P., Molecular dissection of psoriasis: integrating genetics and biology. Journal of Investigative Dermatology 2010 130 5 1213 1226 2-s2.0-77951094127 10.1038/jid.2009.319
28. Toichi E., Torres G., McCormick T. S., Chang T., Mascelli M. A., Kauffman C. L., Aria N., Gottlieb A. B., Everitt D. E., Frederick B., Pendley C. E., Cooper K. D., An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. Journal of Immunology 2006 177 7 4917 4926 2-s2.0-33749151636 (Pubitemid 44469828)
29. Wiekowski M. T., Leach M. W., Evans E. W., Sullivan L., Chen S.-C., Vassileva G., Bazan J. F., Gorman D. M., Kastelein R. A., Narula S., Lira S. A., Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. Journal of Immunology 2001 166 12 7563 7570 2-s2.0-0035877257 (Pubitemid 32525637)
30. Chan J. R., Blumenschein W., Murphy E., Diveu C., Wiekowski M., Abbondanzo S., Lucian L., Geissler R., Brodie S., Kimball A. B., Gorman D. M., Smith K., Malefyt R. D. W., Kastelein R. A., McClanahan T. K., Bowman E. P., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. Journal of Experimental Medicine 2006 203 12 2577 2587 2-s2.0-33751546237 10.1084/jem.20060244 (Pubitemid 44833335)
31. Wolk K., Witte E., Wallace E., Döcke W., Kunz S., Asadullah K., Volk H., Sterry W., Sabat R., IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. European Journal of Immunology 2006 36 5 1309 1323 2-s2.0-33646552450 10.1002/eji.200535503
32. Boniface K., Bernard F., Garcia M., Gurney A. L., Lecron J., Morel F., IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. Journal of Immunology 2005 174 6 3695 3702 2-s2.0-14844342604 (Pubitemid 40354080)
33. Zaba L. C., Cardinale I., Gilleaudeau P., Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. The Journal of Experimental Medicine 2007 204 13 3183 3194
34. Arican O., Aral M., Sasmaz S., Ciragil P., Serum levels of TNF- α IFN- γ IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators of Inflammation 2005 2005 5 273 279 2-s2.0-27644565806 10.1155/MI.2005.273 (Pubitemid 41577417)
35. Xavier R. J., Podolsky D. K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007 448 7152 427 434 2-s2.0-34547176642 10.1038/nature06005 (Pubitemid 47123518)
36. + T cells. Immunity 1994 1 7 553 562 2-s2.0-0028519015
37. Hue S., Ahern P., Buonocore S., Kullberg M. C., Cua D. J., McKenzie B. S., Powrie F., Maloy K. J., Interleukin-23 drives innate and T cell-mediated intestinal inflammation. Journal of Experimental Medicine 2006 203 11 2473 2483 2-s2.0-33750505009 10.1084/jem.20061099 (Pubitemid 44664617)
38. Kullberg M. C., Jankovic D., Feng C. G., Hue S., Gorelick P. L., McKenzie B. S., Cua D. J., Powrie F., Cheever A. W., Maloy K. J., Sher A., IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. Journal of Experimental Medicine 2006 203 11 2485 2494 2-s2.0-33750530394 10.1084/jem.20061082 (Pubitemid 44664618)
39. Duerr R. H., Taylor K. D., Brant S. R., Rioux J. D., Silverberg M. S., Daly M. J., Steinhart A. H., Abraham C., Regueiro M., Griffiths A., Dassopoulos T., Bitton A., Yang H., Targan S., Datta L. W., Kistner E. O., Schumm L. P., Lee A. T., Gregersen P. K., Barmada M. M., Rotter J. I., Nicolae D. L., Cho J. H., A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006 314 5804 1461 1463 2-s2.0-33845340501 10.1126/science.1135245 (Pubitemid 44871953)
40. Zenewicz L. A., Yancopoulos G. D., Valenzuela D. M., Murphy A. J., Stevens S., Flavell R. A., Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008 29 6 947 957 2-s2.0-57449090428 10.1016/j.immuni.2008.11.003
41. Andoh A., Zhang Z., Inatomi O., Fujino S., Deguchi Y., Araki Y., Tsujikawa T., Kitoh K., Kim-Mitsuyama S., Takayanagi A., Shimizu N., Fujiyama Y., Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 2005 129 3 969 984 2-s2.0-24144477540 10.1053/j.gastro.2005.06.071 (Pubitemid 41242688)
42. Veldhoen M., Hirota K., Westendorf A. M., Buer J., Dumoutier L., Renauld J., Stockinger B., The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 2008 453 7191 106 109 2-s2.0-42649106556 10.1038/nature06881 (Pubitemid 351630329)
43. Trifari S., Kaplan C. D., Tran E. H., Crellin N. K., Spits H., Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nature Immunology 2009 10 8 864 871 2-s2.0-67651171182 10.1038/ni.1770
44. Monteleone I., Rizzo A., Sarra M., Sica G., Sileri P., Biancone L., MacDonald T. T., Pallone F., Monteleone G., Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology 2011 141 1 237.e1 248.e1 2-s2.0-79959918506 10.1053/j.gastro.2011.04.007
45. Yang X. O., Chang S. H., Park H., Regulation of inflammatory responses by IL-17F. The Journal of Experimental Medicine 2008 205 5 1063 1075 (Pubitemid 351679682)
46. Ogawa A., Andoh A., Araki Y., Bamba T., Fujiyama Y., Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clinical Immunology 2004 110 1 55 62 2-s2.0-0842324613 10.1016/j.clim.2003.09. 013 (Pubitemid 38177420)
47. Yen D., Cheung J., Scheerens H., Poulet F., McClanahan T., Mckenzie B., Kleinschek M. A., Owyang A., Mattson J., Blumenschein W., Murphy E., Sathe M., Cua D. J., Kastelein R. A., Rennick D., IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. Journal of Clinical Investigation 2006 116 5 1310 1316 2-s2.0-33646397611 10.1172/JCI21404
48. O'Connor W. Jr., Kamanaka M., Booth C. J., Town T., Nakae S., Iwakura Y., Kolls J. K., Flavell R. A., A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunology 2009 10 6 603 609 2-s2.0-65749091607 10.1038/ni.1736
49. McGeachy M. J., Chen Y., Tato C. M., Laurence A., Joyce-Shaikh B., Blumenschein W. M., McClanahan T. K., O'Shea J. J., Cua D. J., The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nature Immunology 2009 10 3 314 324 2-s2.0-60749107176 10.1038/ni.1698
50. Awasthi A., Riol-Blanco L., Jäger A., Korn T., Pot C., Galileos G., Bettelli E., Kuchroo V. K., Oukka M., Cutting Edge: IL-23 receptor GFP reporter mice reveal distinct populations of IL-17-producing cells. Journal of Immunology 2009 182 10 5904 5908 2-s2.0-68649090645 10.4049/jimmunol.0900732
51. Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., Sudo K., Iwakura Y., IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. Journal of Immunology 2006 177 1 566 573 2-s2.0-33745321276 (Pubitemid 43939170)
52. Hofstetter H. H., Ibrahim S. M., Koczan D., Kruse N., Weishaupt A., Toyka K. V., Gold R., Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cellular Immunology 2005 237 2 123 130 2-s2.0-30944452780 10.1016/j.cellimm.2005.11.002 (Pubitemid 43117208)
53. Kreymborg K., Etzensperger R., Dumoutier L., Haak S., Rebollo A., Buch T., Heppner F. L., Renauld J., Becher B., IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. Journal of Immunology 2007 179 12 8098 8104 2-s2.0-40049103352
54. Matusevicius D., Kivisäkk P., He B., Kostulas N., Özenci V., Fredrikson S., Link H., Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Multiple Sclerosis 1999 5 2 101 104 2-s2.0-0344389016 (Pubitemid 29186827)
55. Lock C., Hermans G., Pedotti R., Brendolan A., Schadt E., Garren H., Langer-Gould A., Strober S., Cannella B., Allard J., Klonowski P., Austin A., Lad N., Kaminski N., Galli S. J., Oksenberg J. R., Raine C. S., Heller R., Steinman L., Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Medicine 2002 8 5 500 508 2-s2.0-0036105484 10.1038/nm0502-500 (Pubitemid 34546753)
56. Chen Y., Langrish C. L., Mckenzie B., Joyce-Shaikh B., Stumhofer J. S., McClanahan T., Blumenschein W., Churakovsa T., Low J., Presta L., Hunter C. A., Kastelein R. A., Cua D. J., Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. Journal of Clinical Investigation 2006 116 5 1317 1326 2-s2.0-33646433989 10.1172/JCI25308
57. Koenders M. I., Van Den Berg W. B., Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity? Clinical and Experimental Immunology 2010 159 2 131 136 2-s2.0-72949086194 10.1111/j.1365-2249.2009.04039.x
58. Hwang S., Kim H., Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. Molecules and Cells 2005 19 2 180 184 2-s2.0-26044455144
59. Chabaud M., Durand J. M., Buchs N., Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999 42 5 963 970 (Pubitemid 29215007)
60. Ziolkowska M., Koc A., Luszczykiewicz G., Ksiezopolska-Pietrzak K., Klimczak E., Chwalinska-Sadowska H., Maslinski W., High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. Journal of Immunology 2000 164 5 2832 2838 2-s2.0-0034161692 (Pubitemid 30115519)
61. Lubberts E., Joosten L. A. B., Van de Loo F. A. J., Schwarzenberger P., Kolls J., Van den Berg W. B., Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflammation Research 2002 51 2 102 104 2-s2.0-0036192064 (Pubitemid 34183634)
62. Ikeuchi H., Kuroiwa T., Hiramatsu N., Kaneko Y., Hiromura K., Ueki K., Nojima Y., Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis and Rheumatism 2005 52 4 1037 1046 2-s2.0-17244381180 10.1002/art.20965 (Pubitemid 40530109)
63. Kim H.-R., Kim H.-S., Park M.-K., Cho M.-L., Lee S.-H., Kim H.-Y., The clinical role of IL-23p19 in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology 2007 36 4 259 264 2-s2.0-34548331593 10.1080/03009740701286813 (Pubitemid 47346915)
64. Kim H.-R., Cho M.-L., Kim K.-W., Juhn J.-Y., Hwang S.-Y., Yoon C.-H., Park S.-H., Lee S.-H., Kim H., Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF- B- and p38 MAPK-dependent signalling pathways. Rheumatology 2007 46 1 57 64 2-s2.0-33845576001 10.1093/rheumatology/kel159 (Pubitemid 44932784)
65. Honorati M. C., Meliconi R., Pulsatelli L., Canè S., Frizziero L., Facchini A., High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. Rheumatology 2001 40 5 522 527 2-s2.0-0034986385
66. Lubberts E., Koenders M. I., Oppers-Walgreen B., Van Den Bersselaar L., Coenen-De Roo C. J. J., Joosten L. A. B., Van Den Berg W. B., Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis and Rheumatism 2004 50 2 650 659 2-s2.0-1042267236 10.1002/art.20001 (Pubitemid 38198849)
67. Zhang C., Zhang J., Yang B., Wu C., Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine 2008 42 3 345 352 2-s2.0-44549083419 10.1016/j.cyto.2008.03.006
68. Koenders M. I., Kolls J. K., Oppers-Walgreen B., Van Den Bersselaar L., Joosten L. A. B., Schurr J. R., Schwarzenberger P., Van Den Berg W. B., Lubberts E., Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis and Rheumatism 2005 52 10 3239 3247 2-s2.0-26844554064 10.1002/art.21342 (Pubitemid 41447107)
69. Koenders M. I., Lubberts E., Van De Loo F. A. J., Oppers-Walgreen B., Van Den Bersselaar L., Helsen M. M., Kolls J. K., Di Padova F. E., Joosten L. A. B., Van Den Berg W. B., Interleukin-17 acts independently of TNF- α under arthritic conditions. Journal of Immunology 2006 176 10 6262 6269 2-s2.0-33646490259
70. Paust H., Turner J., Steinmetz O. M., Peters A., Heymann F., Hölscher C., Wolf G., Kurts C., Mittrücker H., Stahl R. A. K., Panzer U., The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. Journal of the American Society of Nephrology 2009 20 5 969 979 2-s2.0-65649133662 10.1681/ASN.2008050556
71. Turner J., Paust H., Steinmetz O. M., Panzer U., The Th17 immune response in renal inflammation. Kidney international 2010 77 12 1070 1075 2-s2.0-77955172196 10.1038/ki.2010.102
72. Dong X., Bachman L. A., Miller M. N., Nath K. A., Griffin M. D., Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. Kidney International 2008 74 10 1294 1309 2-s2.0-55249118612 10.1038/ki.2008.394
73. Kitching A. R., Turner A. L., Semple T., Li M., Edgtton K. L., Wilson G. R., Timoshanko J. R., Hudson B. G., Holdsworth S. R., Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN- γ Journal of the American Society of Nephrology 2004 15 7 1764 1774 2-s2.0-3042572721 10.1097/01.ASN.0000128968.27705.5E (Pubitemid 38822055)
74. Ooi J. D., Phoon R. K. S., Holdsworth S. R., Kitching A. R., IL-23, not IL-12, directs autoimmunity to the goodpasture antigen. Journal of the American Society of Nephrology 2009 20 5 980 989 2-s2.0-65649109428 10.1681/ASN. 2008080891
75. Li L., Huang L., Vergis A. L., Ye H., Bajwa A., Narayan V., Strieter R. M., Rosin D. L., Okusa M. D., IL-17 produced by neutrophils regulates IFN- γ -mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. Journal of Clinical Investigation 2010 120 1 331 342 2-s2.0-74949108768 10.1172/JCI38702
76. Van Kooten C., Boonstra J. G., Paape M. E., Fossiez F., Banchereau J., Lebecque S., Bruijn J. A., De Fijter J. W., Van Es L. A., Daha M. R., Interleukin-17 activates human renal epithelial cells in vitro and is expressed during renal allograft rejection. Journal of the American Society of Nephrology 1998 9 8 1526 1534 2-s2.0-0031903820 (Pubitemid 28354565)
77. Kwan B. C., Tam L., Lai K., Lai F. M., Li E. K., Wang G., Chow K., Li P. K., Szeto C., The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology 2009 48 12 1491 1497 2-s2.0-75649142843 10.1093/rheumatology/kep255
78. Yang J., Chu Y., Yang X., Gao D., Zhu L., Yang X., Wan L., Li M., Th17 and natural treg cell population dynamics in systemic lupus erythematosus. Arthritis and Rheumatism 2009 60 5 1472 1483 2-s2.0-66049151440 10.1002/art.24499
79. Zhao X. F., Pan H. F., Yuan H., Increased serum interleukin 17 in patients with systemic lupus erythematosus. Mol Biol Rep 2010 37 1 81 85
80. Yang X. Y., Wang H. Y., Zhao X. Y., Wang L. J., Lv Q. H., Wang Q. Q., Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus. Journal of Clinical Immunology 33 4 767 774 10.1007/s10875-013-9878-1 2013
81. Duhen T., Geiger R., Jarrossay D., Lanzavecchia A., Sallusto F., Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nature Immunology 2009 10 8 857 863 2-s2.0-67651154105 10.1038/ni.1767
82. Tiegs G., Hentschel J., Wendel A., A T cell-dependent experimental liver injury in mice inducible by concanavalin A. Journal of Clinical Investigation 1992 90 1 196 203 2-s2.0-0026643743
83. Radaeva S., Sun R., Pan H., Hong F., Gao B., Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004 39 5 1332 1342 2-s2.0-2342462460 10.1002/hep.20184 (Pubitemid 38569055)
84. Zenewicz L. A., Yancopoulos G. D., Valenzuela D. M., Murphy A. J., Karow M., Flavell R. A., Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 2007 27 4 647 659 2-s2.0-35348983341 10.1016/j.immuni.2007.07.023 (Pubitemid 47615503)
85. Nagata T., McKinley L., Peschon J. J., Alcorn J. F., Aujla S. J., Kolls J. K., Requirement of IL-17RA in con a induced hepatitis and negative regulation of IL-17 production in mouse T cells. Journal of Immunology 2008 181 11 7473 7479 2-s2.0-58149306041
86. Xu M., Morishima N., Mizoguchi I., Chiba Y., Fujita K., Kuroda M., Iwakura Y., Cua D. J., Yasutomo K., Mizuguchi J., Yoshimoto T., Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production. European Journal of Immunology 2011 41 10 2828 2839 2-s2.0-80053162706 10.1002/eji.201141291
87. Yan S., Wang L., Liu N., Wang Y., Chu Y., Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis. Immunology and Cell Biology 2012 90 4 421 428 2-s2.0-84859948273 10.1038/icb.2011.59
88. Smith E., Stark M. A., Zarbock A., Burcin T. L., Bruce A. C., Vaswani D., Foley P., Ley K., IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. Journal of Immunology 2008 181 2 1357 1364 2-s2.0-49049115394
89. Crispe I. N., IL-17 in liver injury: an inflammatory issue? Immunology & Cell Biology 2012 90 4 369 370
90. Lafdil F., Wang H., Park O., Zhang W., Moritoki Y., Yin S., Fu X. Y., Gershwin M. E., Lian Z., Gao B., Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology 2009 137 6 2125.e2 2135.e2 2-s2.0-70749102261 10.1053/j.gastro.2009.08.004
91. Radtke F., Raj K., The role of Notch in tumorigenesis: oncogene or tumour suppressor. Nature Reviews Cancer 2003 3 10 756 767 2-s2.0-0142259346 (Pubitemid 37328814)
92. Osborne B. A., Minter L. M., Notch signalling during peripheral T-cell activation and differentiation. Nature Reviews Immunology 2007 7 1 64 75 2-s2.0-33845894709 10.1038/nri1998 (Pubitemid 46020828)
93. + T cells by stimulating the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America 2010 107 13 5943 5948 2-s2.0-77950534839 10.1073/pnas.0911755107
94. Tagawa Y., Matthys P., Heremans H., Dillen C., Zaman Z., Iwakura Y., Billiau A., Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice. Journal of Leukocyte Biology 2000 67 1 90 96 2-s2.0-0033979047 (Pubitemid 30046822)
95. Aggarwal S., Ghilardi N., Xie M., De Sauvage F. J., Gurney A. L., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. Journal of Biological Chemistry 2003 278 3 1910 1914 2-s2.0-0037449737 10.1074/jbc.M207577200 (Pubitemid 36801431)
96. Eyerich S., Eyerich K., Pennino D., Carbone T., Nasorri F., Pallotta S., Cianfarani F., Odorisio T., Traidl-Hoffmann C., Behrendt H., Durham S. R., Schmidt-Weber C. B., Cavani A., Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. Journal of Clinical Investigation 2009 119 12 3573 3585 2-s2.0-72849131815 10.1172/JCI40202
97. Zhang Y., Cobleigh M. A., Lian J., Huang C., Booth C. J., Bai X., Robek M. D., A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology 2011 141 5 1897 1906 2-s2.0-80054847781 10.1053/j.gastro.2011.06.051
98. Jiang R., Tan Z., Deng L., Chen Y., Xia Y., Gao Y., Wang X., Sun B., Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology 2011 54 3 900 909 2-s2.0-80052023399 10.1002/hep.24486
99. + T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology 2010 51 1 81 91 2-s2.0-73449125874 10.1002/hep.23273
100. Gritz D. C., Wong I. G., Incidence and prevalence of uveitis in Northern California: the Northern California Epidemiology of Uveitis Study. Ophthalmology 2004 111 3 491 500 2-s2.0-1442275270 10.1016/j.ophtha.2003.06.014 (Pubitemid 38293104)
101. Yoshimura T., Sonoda K., Miyazaki Y., Iwakura Y., Ishibashi T., Yoshimura A., Yoshida H., Differential roles for IFN- γ and IL-17 in experimental autoimmune uveoretinitis. International Immunology 2008 20 2 209 214 2-s2.0-39049129395 10.1093/intimm/dxm135 (Pubitemid 351234388)
102. Nussenblatt R. B., Bench to bedside: new approaches to the immunotherapy of uveitic disease. International Reviews of Immunology 2002 21 2-3 273 289 2-s2.0-0035997394 10.1080/08830180212067 (Pubitemid 34791944)
103. Luger D., Caspi R. R., New perspectives on effector mechanisms in uveitis. Seminars in Immunopathology 2008 30 2 135 143 2-s2.0-42449154999 10.1007/s00281-008-0108-5
104. Caspi R. R., A look at autoimmunity and inflammation in the eye. Journal of Clinical Investigation 2010 120 9 3073 3083 2-s2.0-77956389310 10.1172/JCI42440
105. Amadi-Obi A., Yu C., Liu X., Mahdi R. M., Clarke G. L., Nussenblatt R. B., Gery I., Lee Y. S., Egwuagu C. E., TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nature Medicine 2007 13 6 711 718 2-s2.0-34250005444 10.1038/nm1585 (Pubitemid 46889754)
106. Luger D., Silver P. B., Tang J., Cua D., Chen Z., Iwakura Y., Bowman E. P., Sgambellone N. M., Chan C., Caspi R. R., Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. Journal of Experimental Medicine 2008 205 4 799 810 2-s2.0-42249084849 10.1084/jem.20071258 (Pubitemid 351549879)
107. + interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Investigative Ophthalmology and Visual Science 2007 48 9 4153 4161 2-s2.0-35148837549 10.1167/iovs.07-0251 (Pubitemid 351261043)
108. Ke Y., Liu K., Huang G., Cui Y., Kaplan H. J., Shao H., Sun D., Anti-inflammatory role of IL-17 in experimental autoimmune uveitis. Journal of Immunology 2009 182 5 3183 3190 2-s2.0-64849085126 10.4049/jimmunol.0802487
109. + APCs suppress experimental autoimmune uveitis. Journal of Immunology 2011 187 5 2130 2139 2-s2.0-80052675874 10.4049/jimmunol.1100482
110. Caspi R. R., Kuwabara T., Nussenblatt R. B., Characterization of a suppressor cell line which downgrades experimental autoimmune uveoretinitis in the rat. Journal of Immunology 1988 140 8 2579 2584 2-s2.0-0023951063
111. Peng Y., Shao H., Ke Y., Zhang P., Han G., Kaplan H. J., Sun D., Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive. Investigative Ophthalmology and Visual Science 2007 48 5 2178 2184 2-s2.0-34250157039 10.1167/iovs.06-1189 (Pubitemid 351261292)
112. Jenkins M. K., The ups and downs of T cell costimulation. Immunity 1994 1 6 443 446 2-s2.0-0028501442
113. Janeway C. A. Jr., Bottomly K., Signals and signs for lymphocyte responses. Cell 1994 76 2 275 285 2-s2.0-0028178873 10.1016/0092-8674(94)90335-2
114. Bagenstose L. M., Agarwal R. K., Silver P. B., Harlan D. M., Hoffmann S. C., Kampen R. L., Chan C., Caspi R. R., Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. Journal of Immunology 2005 175 1 124 130 2-s2.0-21244503823 (Pubitemid 40884308)
115. Fukai T., Okada A. A., Sakai J., Kezuka T., Keino H., Usui M., Yagita H., Okumura K., Mizuguchi J., The role of costimulatory molecules B7-1 and B7-2 in mice with experimental antoimmune uveoretinitis. Graefe's Archive for Clinical and Experimental Ophthalmology 1999 237 11 928 933 2-s2.0-0032872655 (Pubitemid 29484168)
116. Namba K., Ogasawara K., Kitaichi N., Morohashi T., Sasamoto Y., Kotake S., Matsuda H., Iwabuchi K., Iwabuchi C., Ohno S., Onoe K., Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody. Journal of Immunology 2000 165 6 2962 2969 2-s2.0-0034665320
117. Maertzdorf J., Osterhaus A. D. M. E., Verjans G. M. G. M., IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. Journal of Immunology 2002 169 10 5897 5903 2-s2.0-0037111404 (Pubitemid 35291695)
118. De Paiva C. S., Chotikavanich S., Pangelinan S. B., Pitcher J. D., Fang B., Zheng X., Ma P., Farley W. J., Siemasko K. F., Niederkorn J. Y., Stern M. E., Li D.-Q., Pflugfelder S. C., IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunology 2009 2 3 243 253 2-s2.0-65449187119 10.1038/mi.2009.5
119. Zheng X., Bian F., Ma P., De Paiva C. S., Stern M., Pflugfelder S. C., Li D., Induction of Th17 differentiation by corneal epithelial-derived cytokines. Journal of Cellular Physiology 2010 222 1 95 102 2-s2.0-73949125666 10.1002/jcp.21926
120. Suryawanshi A., Veiga-Parga T., Rajasagi N. K., Reddy P. B. J., Sehrawat S., Sharma S., Rouse B. T., Role of il-17 and th17 cells in herpes simplex virus-induced corneal immunopathology. Journal of Immunology 2011 187 4 1919 1930 2-s2.0-80051935234 10.4049/jimmunol.1100736
121. Veiga-Parga T., Suryawanshi A., Rouse B. T., Controlling viral immuno-inflammatory lesions by modulating aryl hydrocarbon receptor signaling. PLoS Pathogens 2011 7 12 2-s2.0-84855274941 10.1371/journal.ppat.1002427 e1002427
122. Fleiszig S. M. J., Zaidi T. S., Fletcher E. L., Preston M. J., Pier G. B., Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infection and Immunity 1994 62 8 3485 3493 2-s2.0-0027954004 (Pubitemid 24232137)
123. Hohki S., Ohguro N., Haruta H., Nakai K., Terabe F., Serada S., Fujimoto M., Nomura S., Kawahata H., Kishimoto T., Naka T., Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses. Experimental Eye Research 2010 91 2 162 170 2-s2.0-77954952358 10.1016/j.exer.2010.04.009
124. Arranz-Valsero I., Schulze U., Contreras-Ruiz L., Involvement of corneal epithelial cells in the Th17 response in an in vitro bacterial inflammation model. Molecular Vision 2013 19 85 99
125. Barker C. F., Billingham R. E., Immunologically privileged sites. Advances in Immunology 1978 25 C 1 54 2-s2.0-0017734968 10.1016/S0065-2776(08) 60930-X
126. Itoh M., Terayama H., Naito M., Ogawa Y., Tainosho S., Tissue microcircumstances for leukocytic infiltration into the testis and epididymis in mice. Journal of Reproductive Immunology 2005 67 1-2 57 67 2-s2.0-26244442091 10.1016/j.jri.2005.06.007 (Pubitemid 41415556)
127. Fijak M., Meinhardt A., The testis in immune privilege. Immunological Reviews 2006 213 1 66 81 2-s2.0-33748748036 10.1111/j.1600-065X.2006.00438.x (Pubitemid 44401494)
128. Hedger M. P., Hales D. B., Neill J. D., Immunophysiology of the male reproductive tract. Knobil's and Neill's Physiology of Reproduction 2006 Amsterdam, The Netherlands Elsevier 1195 1286
129. Tompkins A. B., Hutchinson P., De Kretser D. M., Hedger M. P., Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor β on lymphocyte subsets in vitro. Biology of Reproduction 1998 58 4 943 951 2-s2.0-0031943966 10.1095/biolreprod58.4.943 (Pubitemid 28144982)
130. Mukasa A., Hiromatsu K., Matsuzaki G., O'Brien R., Born W., Nomoto K., Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of α β and γ δ T cells. Journal of Immunology 1995 155 4 2047 2056 2-s2.0-0029084946
131. Hedger M. P., Testicular leukocytes: what are they doing? Reviews of Reproduction 1997 2 1 38 47 2-s2.0-0030970892 10.1530/ror.0.0020038 (Pubitemid 27165965)
132. Schuppe H., Meinhardt A., Immune privilege and inflammation of the testis. Chemical immunology and allergy 2005 88 1 14 2-s2.0-32944465442
133. Weidner W., Krause W., Ludwig M., Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Human Reproduction Update 1999 5 5 421 432 2-s2.0-0032714099 10.1093/humupd/5.5.421 (Pubitemid 29512130)
134. Haidl G., Allam J. P., Schuppe H.-C., Chronic epididymitis: impact on semen parameters and therapeutic options. Andrologia 2008 40 2 92 96 2-s2.0-40749085627 10.1111/j.1439-0272.2007.00819.x (Pubitemid 351379664)
135. Schuppe H.-C., Meinhardt A., Allam J. P., Bergmann M., Weidner W., Haidl G., Chronic orchitis: a neglected cause of male infertility? Andrologia 2008 40 2 84 91 2-s2.0-40749097276 10.1111/j.1439-0272.2008.00837.x (Pubitemid 351379679)
136. + effector and regulatory T lymphocyte subsets in the testis of rats undergoing autoimmune orchitis. Journal of Reproductive Immunology 2009 81 1 44 54 2-s2.0-67649743418 10.1016/j.jri.2009.04.005
137. Duan Y.-G., Yu C.-F., Novak N., Bieber T., Zhu C.-H., Schuppe H.-C., Haidl G., Allam J.-P., Immunodeviation towards a Th17 immune response associated with testicular damage in azoospermic men. International Journal of Andrology 2011 34 6 e536 e545 2-s2.0-80052620304 10.1111/j.1365-2605.2010.01137.x
138. Terayama H., Naito M., Qu N., Hirai S., Kitaoka M., Ogawa Y., Itoh M., Intratesticular expression of mRNAs of both interferon γ and tumor necrosis factor α is significantly increased in experimental autoimmune orchitis in mice. Journal of Reproduction and Development 2011 57 2 296 302 2-s2.0-79957569543 10.1262/jrd.10-121N
139. Stephan J. P., Syed V., Jegou B., Regulation of sertoli cell IL-1 and IL-6 production in vitro. Molecular and Cellular Endocrinology 1997 134 2 109 118 (Pubitemid 27510877)
140. Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., Sekikawa K., Asano M., Iwakura Y., Antigen-specific T cell sensitization is impaired in Il-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002 17 3 375 387 2-s2.0-0036754255 10.1016/S1074-7613(02) 00391-6 (Pubitemid 35279557)
141. Sundrud M. S., Koralov S. B., Feuerer M., Calado D. P., Kozhaya A. E., Rhule-Smith A., Lefebvre R. E., Unutmaz D., Mazitschek R., Waldner H., Whitman M., Keller T., Rao A., Halofuginone inhibits th17 cell differentiation by activating the amino acid starvation response. Science 2009 324 5932 1334 1338 2-s2.0-66749107425 10.1126/science.1172638
142. Schnyder-Candrian S., Togbe D., Couillin I., Mercier I., Brombacher F., Quesniaux V., Fossiez F., Ryffel B., Schnyder B., Interleukin-17 is a negative regulator of established allergic asthma. Journal of Experimental Medicine 2006 203 12 2715 2725 2-s2.0-33751506710 10.1084/jem.20061401 (Pubitemid 44833347)
143. Song C., Luo L., Lei Z., Li B., Liang Z., Liu G., Li D., Zhang G., Huang B., Feng Z., IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. Journal of Immunology 2008 181 9 6117 6124 2-s2.0-58749093940
144. Schnyder B., Lima C., Schnyder-Candrian S., Interleukin-22 is a negative regulator of the allergic response. Cytokine 2010 50 2 220 227 2-s2.0-77950860148 10.1016/j.cyto.2010.02.003
145. Peng J., Yang X. O., Chang S. H., Yang J., Dong C., IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Cell Research 2010 20 1 62 71 2-s2.0-73849098292 10.1038/cr.2009.128
146. Wakashin H., Hirose K., Maezawa Y., Kagami S., Suto A., Watanabe N., Saito Y., Hatano M., Tokuhisa T., Iwakura Y., Puccetti P., Iwamoto I., Nakajima H., IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. American Journal of Respiratory and Critical Care Medicine 2008 178 10 1023 1032 2-s2.0-57349084248 10.1164/rccm.200801-086OC
147. Aujla S. J., Alcorn J. F., TH17 cells in asthma and inflammation. Biochimica et Biophysica Acta 2011 1810 11 1066 1079 2-s2.0-80054906310 10.1016/j.bbagen.2011.02.002
148. Lajoie S., Lewkowich I. P., Suzuki Y., Clark J. R., Sproles A. A., Dienger K., Budelsky A. L., Wills-Karp M., Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nature Immunology 2010 11 10 928 935 2-s2.0-77956955243 10.1038/ni.1926
149. Wang J. Y., Shyur S. D., Wang W. H., Liou Y. H., Lin C. G. J., Wu Y. J., Wu L. S. H., The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population. Allergy: European Journal of Allergy and Clinical Immunology 2009 64 7 1056 1060 2-s2.0-66749096632 10.1111/j.1398-9995.2009.01950.x