IL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis

Journal of Immunology

Volumn 187, Issue 5, 2011, Pages 2130-2139

  Ke, Yan ^a   Sun, Deming ^b   Jiang, Guomin ^a   Kaplan, Henry J ^a   Shao, Hui ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD11B ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 22 RECEPTOR; INTERLEUKIN RECEPTOR; PROGRAMMED DEATH 1 LIGAND 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE UVEITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; FEMALE; IMMUNIZATION; IMMUNOREGULATION; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TREATMENT OUTCOME; UVEITIS;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD11B; AUTOIMMUNE DISEASES; CELL SEPARATION; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MICE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; UVEITIS;

EID: 80052675874     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100482     Document Type: Article

References (40)

1. Liang, S. C., X. Y. Tan, D. P. Luxenberg, R. Karim, K. Dunussi-Joannopoulos, M. Collins, and L. A. Fouser. 2006. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203: 2271-2279. (Pubitemid 44498362)
2. Zheng, Y., D. M. Danilenko, P. Valdez, I. Kasman, J. Eastham-Anderson, J. Wu, and W. Ouyang. 2007. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651. (Pubitemid 46232884)
3. Andoh, A., Z. Zhang, O. Inatomi, S. Fujino, Y. Deguchi, Y. Araki, T. Tsujikawa, K. Kitoh, S. Kim-Mitsuyama, A. Takayanagi, et al. 2005. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129: 969-984. (Pubitemid 41242688)
4. Dumoutier, L., E. Van Roost, G. Ameye, L. Michaux, and J. C. Renauld. 2000. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun. 1: 488-494.
5. Fickenscher, H., S. Hör, H. Küpers, A. Knappe, S. Wittmann, and H. Sticht. 2002. The interleukin-10 family of cytokines. Trends Immunol. 23: 89-96. (Pubitemid 34310150)
6. Geboes, L., L. Dumoutier, H. Kelchtermans, E. Schurgers, T. Mitera, J. C. Renauld, and P. Matthys. 2009. Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum. 60: 390-395.
7. Kreymborg, K., R. Etzensperger, L. Dumoutier, S. Haak, A. Rebollo, T. Buch, F. L. Heppner, J. C. Renauld, and B. Becher. 2007. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179: 8098-8104.
8. Zenewicz, L. A., G. D. Yancopoulos, D. M. Valenzuela, A. J. Murphy, S. Stevens, and R. A. Flavell. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29: 947-957.
9. Sugimoto, K., A. Ogawa, E. Mizoguchi, Y. Shimomura, A. Andoh, A. K. Bhan, R. S. Blumberg, R. J. Xavier, and A. Mizoguchi. 2008. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118: 534-544. (Pubitemid 351206544)
10. Zenewicz, L. A., G. D. Yancopoulos, D. M. Valenzuela, A. J. Murphy, M. Karow, and R. A. Flavell. 2007. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659. (Pubitemid 47615503)
11. Chang, H., H. Hanawa, H. Liu, T. Yoshida, M. Hayashi, R. Watanabe, S. Abe, K. Toba, K. Yoshida, R. Elnaggar, et al. 2006. Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. J. Immunol. 177: 3635v3643.
12. Pan, H., F. Hong, S. Radaeva, and B. Gao. 2004. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell. Mol. Immunol. 1: 43-49.
13. Radaeva, S., R. Sun, H. N. Pan, F. Hong, and B. Gao. 2004. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332-1342. (Pubitemid 38569055)
14. Aujla, S. J., Y. R. Chan, M. Zheng, M. Fei, D. J. Askew, D. A. Pociask, T. A. Reinhart, F. McAllister, J. Edeal, K. Gaus, et al. 2008. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14: 275-281. (Pubitemid 351347908)
15. Zheng, Y., P. A. Valdez, D. M. Danilenko, Y. Hu, S. M. Sa, Q. Gong, A. R. Abbas, Z. Modrusan, N. Ghilardi, F. J. De Sauvage, and W. Ouyang. 2008. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14: 282-289. (Pubitemid 351347912)
16. Wolk, K., and R. Sabat. 2006. Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev. 17: 367-380. (Pubitemid 44572879)
17. Kotenko, S. V., L. S. Izotova, O. V. Mirochnitchenko, E. Esterova, H. Dickensheets, R. P. Donnelly, and S. Pestka. 2001. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J. Biol. Chem. 276: 2725-2732.
18. Wacker, W. B., L. A. Donoso, C. M. Kalsow, J. A. Yankeelov, Jr., and D. T. Organisciak. 1977. Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina. J. Immunol. 119: 1949-1958. (Pubitemid 8232088)
19. Gery, I., B. Wiggert, T. M. Redmond, T. Kuwabara, M. A. Crawford, B. P. Vistica, and G. J. Chader. 1986. Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein. Invest. Ophthalmol. Vis. Sci. 27: 1296-1300. (Pubitemid 16033866)
20. Donoso, L. A., C. F. Merryman, T. Sery, R. Sanders, T. Vrabec, and S. L. Fong. 1989. Human interstitial retinoid binding protein. A potent uveitopathogenic agent for the induction of experimental autoimmune uveitis. J. Immunol. 143: 79-83. (Pubitemid 19174202)
21. Hu, L. H., T. M. Redmond, H. Sanui, T. Kuwabara, C. G. McAllister, B. Wiggert, G. J. Chader, and I. Gery. 1989. Rat T-cell lines specific to a non-immunodominant determinant of a retinal protein (IRBP) produce uveoretinitis and pinealitis. Cell. Immunol. 122: 251-261. (Pubitemid 19199614)
22. Agarwal, R. K., Y. Kang, E. Zambidis, D. W. Scott, C. C. Chan, and R. R. Caspi. 2000. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J. Clin. Invest. 106: 245-252. (Pubitemid 30483128)
23. Shao, H., S. Lei, S. L. Sun, H. J. Kaplan, and D. Sun. 2003. Conversion of monophasic to recurrent autoimmune disease by autoreactive T cell subsets. J. Immunol. 171: 5624-5630. (Pubitemid 37432854)
24. Luger, D., P. B. Silver, J. Tang, D. Cua, Z. Chen, Y. Iwakura, E. P. Bowman, N. M. Sgambellone, C. C. Chan, and R. R. Caspi. 2008. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 205: 799-810. (Pubitemid 351549879)
25. Amadi-Obi, A., and C. R. Yu, X. Liu, R. M., G. L. Mahdi, R. B. Clarke, I. Nussenblatt, and Gery, Y. Lee, S., and C. E. Egwuagu. 2007. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13: 711-718. (Pubitemid 46889754)
26. Cox, C. A., G. Shi, H. Yin, B. P. Vistica, E. F. Wawrousek, C. C. Chan, and I. Gery. 2008. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol. 180: 7414-7422.
27. Peng, Y., G. Han, H. Shao, Y. Wang, H. J. Kaplan, and D. Sun. 2007. Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 48: 4153-4161. (Pubitemid 351261043)
28. Ke, Y., K. Liu, G. Q. Huang, Y. Cui, H. J. Kaplan, H. Shao, and D. Sun. 2009. Anti-inflammatory role of IL-17 in experimental autoimmune uveitis. J. Immunol. 182: 3183-3190.
29. Ke, Y., G. Jiang, D. Sun, H. J. Kaplan, and H. Shao. 2009. Retinal Astrocytes respond to IL-17 differently than Retinal Pigment Epithelial cells. J. Leukoc. Biol. 86: 1377-1384.
30. Shao, H., Y. Fu, T. Liao, Y. Peng, L. Chen, H. J. Kaplan, and D. Sun. 2005. Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells. Invest. Ophthalmol. Vis. Sci. 46: 596-603. (Pubitemid 40270340)
31. Shao, H., T. Liao, Y. Ke, H. Shi, H. J. Kaplan, and D. Sun. 2006. Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells. Exp. Eye Res. 82: 323-331. (Pubitemid 43122119)
32. Trizio, D., and G. Cudkowicz. 1974. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. J. Immunol. 113: 1093-1097.
33. Liao, T., Y. Ke, W. H. Shao, B. Haribabu, H. J. Kaplan, D. Sun, and H. Shao. 2006. Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 47: 1543-1549. (Pubitemid 46780763)
34. Brand, S., F. Beigel, T. Olszak, K. Zitzmann, S. T. Eichhorst, J. M. Otte, H. Diepolder, A. Marquardt, W. Jagla, A. Popp, et al. 2006. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G827-G838.
35. Schmechel, S., A. Konrad, J. Diegelmann, J. Glas, M. Wetzke, E. Paschos, P. Lohse, B. Göke, and S. Brand. 2008. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm. Bowel Dis. 14: 204-212. (Pubitemid 351288041)
36. Wakefield, D., P. McCluskey, and P. Palladinetti. 1992. Distribution of lymphocytes and cell adhesion molecules in iris biopsy specimens from patients with uveitis. Arch. Ophthalmol. 110: 121-125.
37. Okada, T., T. Sakamoto, T. Ishibashi, and H. Inomata. 1996. Vitiligo in Vogt-Koyanagi-Harada disease: immunohistological analysis of inflammatory site. Graefes Arch. Clin. Exp. Ophthalmol. 234: 359-363.
38. Xu, H., A. Manivannan, R. Dawson, I. J. Crane, M. Mack, P. Sharp, and J. Liversidge. 2005. Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators. J. Immunol. 175: 6915-6923. (Pubitemid 41598937)
39. Wolk, K., E. Witte, K. Witte, K. Warszawska, and R. Sabat. 2010. Biology of interleukin-22. Semin. Immunopathol. 32: 17-31.
40. Wolk, K., S. Kunz, E. Witte, M. Friedrich, K. Asadullah, and R. Sabat. 2004. IL-22 increases the innate immunity of tissues. Immunity 21: 241-254. (Pubitemid 39094053)