메뉴 건너뛰기




Volumn 48, Issue 5, 2007, Pages 2178-2184

Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; TRANSCRIPTION FACTOR FOXP3; CD8 ANTIGEN; EYE PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GAMMA INTERFERON; INTERLEUKIN 2; RETINOL BINDING PROTEIN; RETINOL-BINDING GLYCOPROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 34250157039     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1189     Document Type: Article
Times cited : (25)

References (44)
  • 1
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz JD, Wang B, Haskins K, et al. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 1993;74:1089-1100.
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.D.1    Wang, B.2    Haskins, K.3
  • 2
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • Goverman J, Woods A, Larson L, et al. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993;72:551-560.
    • (1993) Cell , vol.72 , pp. 551-560
    • Goverman, J.1    Woods, A.2    Larson, L.3
  • 3
    • 0034084162 scopus 로고    scopus 로고
    • Shevach EM. Regulatory T cells in autoimmunity. Annu Rev Immunol. 2000;18:423-449.
    • Shevach EM. Regulatory T cells in autoimmunity. Annu Rev Immunol. 2000;18:423-449.
  • 4
    • 0031939403 scopus 로고    scopus 로고
    • CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
    • Suripayer E, Amar AZ, Thornton AM, Shevach EM. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol. 1998;160:1212-1218.
    • (1998) J Immunol , vol.160 , pp. 1212-1218
    • Suripayer, E.1    Amar, A.Z.2    Thornton, A.M.3    Shevach, E.M.4
  • 5
    • 0023904339 scopus 로고
    • Suppression of experimentally-induced autoimmune encephalomyelitis by cytolytic T-T cell interactions
    • Sun D, Qin Y, Chluba J, et al. Suppression of experimentally-induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature. 1988;332:843-846.
    • (1988) Nature , vol.332 , pp. 843-846
    • Sun, D.1    Qin, Y.2    Chluba, J.3
  • 6
    • 0032990188 scopus 로고    scopus 로고
    • Regulatory T cells in experimental allergic encephalomyelitis. I. Frequency and specificity analysis in normal and immune rats of a T cell subset that inhibits disease
    • Sun D, Whitaker JN, Wilson DB. Regulatory T cells in experimental allergic encephalomyelitis. I. Frequency and specificity analysis in normal and immune rats of a T cell subset that inhibits disease. Int Immunol. 1999;11:307-315.
    • (1999) Int Immunol , vol.11 , pp. 307-315
    • Sun, D.1    Whitaker, J.N.2    Wilson, D.B.3
  • 7
    • 0026647293 scopus 로고
    • + T cells in murine experimental allergic encephalomyelitis
    • + T cells in murine experimental allergic encephalomyelitis. Science. 1992;256:1213-1215.
    • (1992) Science , vol.256 , pp. 1213-1215
    • Jiang, H.1    Zhang, S.-I.2    Pernis, B.3
  • 8
    • 28244441236 scopus 로고    scopus 로고
    • Endharti AT, Rifa'I M 1st, Shi Z, et al. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-γ production and proliferation of CD8+ T Cells. J Immunol. 2005;175:7093-7097.
    • Endharti AT, Rifa'I M 1st, Shi Z, et al. Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-γ production and proliferation of CD8+ T Cells. J Immunol. 2005;175:7093-7097.
  • 9
    • 85047690427 scopus 로고    scopus 로고
    • Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    • Najanan N, Chitnis T, Salama AD, et al. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest. 2003;112:1037-1048.
    • (2003) J Clin Invest , vol.112 , pp. 1037-1048
    • Najanan, N.1    Chitnis, T.2    Salama, A.D.3
  • 10
    • 31044434001 scopus 로고    scopus 로고
    • Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells
    • Shao H, Liao T, Ke Y, et al. Severe chronic experimental autoimmune uveitis (EAU) of the C57BL/6 mouse induced by adoptive transfer of IRBP1-20-specific T cells. Exp Eye Res. 2006;82:323-331.
    • (2006) Exp Eye Res , vol.82 , pp. 323-331
    • Shao, H.1    Liao, T.2    Ke, Y.3
  • 11
    • 33645788014 scopus 로고    scopus 로고
    • In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors
    • Peng Y, Shao H, Ke Y, et al. In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors. J Immunol. 2006;176:5006-5014.
    • (2006) J Immunol , vol.176 , pp. 5006-5014
    • Peng, Y.1    Shao, H.2    Ke, Y.3
  • 12
    • 22544441855 scopus 로고    scopus 로고
    • + and CD8+ autoreactive T cells
    • + and CD8+ autoreactive T cells. J Immunol. 2005;175:1851-1857.
    • (2005) J Immunol , vol.175 , pp. 1851-1857
    • Shao, H.1    Peng, Y.2    Liao, T.3
  • 13
    • 4043160580 scopus 로고    scopus 로고
    • Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191
    • Shao H, Sun SL, Kaplan HJ, Sun D. Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191. J Immunol. 2004;173:2849-2854.
    • (2004) J Immunol , vol.173 , pp. 2849-2854
    • Shao, H.1    Sun, S.L.2    Kaplan, H.J.3    Sun, D.4
  • 14
    • 0027365523 scopus 로고
    • Staphylococcal enterotoxin enhances the activation of rat encephalitogenic T cells by myelin basic protein
    • Sun D. Staphylococcal enterotoxin enhances the activation of rat encephalitogenic T cells by myelin basic protein. J Neuroimmunol. 1993;46:5-10.
    • (1993) J Neuroimmunol , vol.46 , pp. 5-10
    • Sun, D.1
  • 15
    • 0027273025 scopus 로고
    • Major role of antigen-presenting cells in the response of rat encephalitogenic T cells to myelin basic proteins
    • Sun D, Le J, Yang S, et al. Major role of antigen-presenting cells in the response of rat encephalitogenic T cells to myelin basic proteins. J Immunol. 1993;151:111-118.
    • (1993) J Immunol , vol.151 , pp. 111-118
    • Sun, D.1    Le, J.2    Yang, S.3
  • 16
    • 8644240281 scopus 로고    scopus 로고
    • Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation
    • Xystrakis E, Dejean AS, Bernard I, et al. Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood. 2004;104:3294-3301.
    • (2004) Blood , vol.104 , pp. 3294-3301
    • Xystrakis, E.1    Dejean, A.S.2    Bernard, I.3
  • 17
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 18
    • 0025180318 scopus 로고
    • Multiple suppressive effects of transforming growth factor β1 on the immune response in chickens
    • Quere P, Thorbecke GJ. Multiple suppressive effects of transforming growth factor β1 on the immune response in chickens. Cell Immunol. 1990;129:468-477.
    • (1990) Cell Immunol , vol.129 , pp. 468-477
    • Quere, P.1    Thorbecke, G.J.2
  • 19
    • 0032519412 scopus 로고    scopus 로고
    • TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells
    • Takeuchi M, Alard P. TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J Immunol. 1998; 160:1589-1597.
    • (1998) J Immunol , vol.160 , pp. 1589-1597
    • Takeuchi, M.1    Alard, P.2
  • 20
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol. 2003;3:253-257.
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 21
    • 0142179310 scopus 로고    scopus 로고
    • CpG-ODN1826 converts the weak uveitogenic rat IRBP1181-91 peptide into a strong uveitogen
    • Shao H, Lei S, Sun S, et al. CpG-ODN1826 converts the weak uveitogenic rat IRBP1181-91 peptide into a strong uveitogen. J Immunol. 2003;171:4780-4785.
    • (2003) J Immunol , vol.171 , pp. 4780-4785
    • Shao, H.1    Lei, S.2    Sun, S.3
  • 22
    • 0242410774 scopus 로고    scopus 로고
    • Conversion of monophasic to recurrent autoimmune disease by autoreactive T cell subsets
    • Shao H, Song L, Sun SL, et al. Conversion of monophasic to recurrent autoimmune disease by autoreactive T cell subsets. J Immunol. 2003;171:5624-5630.
    • (2003) J Immunol , vol.171 , pp. 5624-5630
    • Shao, H.1    Song, L.2    Sun, S.L.3
  • 23
    • 0037544148 scopus 로고    scopus 로고
    • Signal 3 determines tolerance versus full activation of naive CD8 T cells: Dissociating proliferation and development of effector function
    • Curtsinger JM, Lins DC, Mescher MF. Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med. 2003;197: 1141-1151.
    • (2003) J Exp Med , vol.197 , pp. 1141-1151
    • Curtsinger, J.M.1    Lins, D.C.2    Mescher, M.F.3
  • 24
    • 0036604252 scopus 로고    scopus 로고
    • Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12
    • Schmidt CS, Mescher MF. Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12. J Immunol. 2002;168:5521-5529.
    • (2002) J Immunol , vol.168 , pp. 5521-5529
    • Schmidt, C.S.1    Mescher, M.F.2
  • 25
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert LA, Jeffery E, Zhang Y, et al. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem. 2001;276:37672-37679.
    • (2001) J Biol Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3
  • 26
    • 0041931076 scopus 로고    scopus 로고
    • Foxp3 and natural regulatory T cells: Key to a cell lineage?
    • Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity. 2003;19:165-168.
    • (2003) Immunity , vol.19 , pp. 165-168
    • Ramsdell, F.1
  • 27
    • 2442425262 scopus 로고    scopus 로고
    • Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    • Cobbold SP, Castejon R, Adams E, et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol. 2004;172:6003-6010.
    • (2004) J Immunol , vol.172 , pp. 6003-6010
    • Cobbold, S.P.1    Castejon, R.2    Adams, E.3
  • 28
    • 0141796312 scopus 로고    scopus 로고
    • TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith M, Bluestone JA, Barriot S, et al. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med. 2003;9: 1202-1208.
    • (2003) Nat Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3
  • 29
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med. 2003; 198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 30
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994;265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3
  • 32
    • 4744356110 scopus 로고    scopus 로고
    • TGF-β induces Foxp3+ T-regulatory cells from CD4+ CD25- precursors
    • Fu S, Zhang N, Yopp AC, et al. TGF-β induces Foxp3+ T-regulatory cells from CD4+ CD25- precursors. Am J Transplant. 2004;4: 1614-1627.
    • (2004) Am J Transplant , vol.4 , pp. 1614-1627
    • Fu, S.1    Zhang, N.2    Yopp, A.C.3
  • 33
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-310.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 34
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou I, Sarukhan A, Klein L, von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol. 2002;3:756-763.
    • (2002) Nat Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 35
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki S, Iyoda T, Tarbell K, et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med. 2003;198:235-247.
    • (2003) J Exp Med , vol.198 , pp. 235-247
    • Yamazaki, S.1    Iyoda, T.2    Tarbell, K.3
  • 36
    • 0025131038 scopus 로고
    • Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8 and αβ T cell receptor molecules
    • Nanda NK, Thomson E, Mason I. Murine suppressor T cell clones specific for minor histocompatibility antigens express CD4, CD8 and αβ T cell receptor molecules. Int Immunol. 1990;2:1063-1071.
    • (1990) Int Immunol , vol.2 , pp. 1063-1071
    • Nanda, N.K.1    Thomson, E.2    Mason, I.3
  • 37
    • 0026748869 scopus 로고
    • Stigma variations: Observations on suppressor T cells and leprosy
    • Bloom BR, Modlin RL, Salgame P. Stigma variations: observations on suppressor T cells and leprosy. Ann Rev Immunol. 1992;10: 453-488.
    • (1992) Ann Rev Immunol , vol.10 , pp. 453-488
    • Bloom, B.R.1    Modlin, R.L.2    Salgame, P.3
  • 38
    • 0033231445 scopus 로고    scopus 로고
    • Regulatory T cells in experimental allergic encephalomyelitis. II. CD8+ T cells functionally antagonistic to CD4+ encephalitogenic MBP-specific T cells show persistent expression of FasL
    • Sun D, Whitaker JN, Wilson DB. Regulatory T cells in experimental allergic encephalomyelitis. II. CD8+ T cells functionally antagonistic to CD4+ encephalitogenic MBP-specific T cells show persistent expression of FasL. J Neurosci Res. 1999;58:357-366.
    • (1999) J Neurosci Res , vol.58 , pp. 357-366
    • Sun, D.1    Whitaker, J.N.2    Wilson, D.B.3
  • 39
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering
    • Miller A, Lider O, Roberts AB, et al. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc Natl Acad Sci USA. 1992;89:421-425.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3
  • 40
    • 0035932949 scopus 로고    scopus 로고
    • CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice
    • Jiang H, Braunstein NS, Yu B, et al. CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Natl Acad Sci USA. 2001;98:6301-6306.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6301-6306
    • Jiang, H.1    Braunstein, N.S.2    Yu, B.3
  • 41
    • 0034176744 scopus 로고    scopus 로고
    • Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
    • Graser RT, DiLorenzo TP, Wang FM, et al. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol. 2000;164:3913-3918.
    • (2000) J Immunol , vol.164 , pp. 3913-3918
    • Graser, R.T.1    DiLorenzo, T.P.2    Wang, F.M.3
  • 42
    • 0028143869 scopus 로고
    • Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides
    • Tsuchida T, Parker KC, Turner RV, et al. Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides. Proc Natl Acad Sci USA. 1994;91:10859-10863.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10859-10863
    • Tsuchida, T.1    Parker, K.C.2    Turner, R.V.3
  • 43
    • 0032795784 scopus 로고    scopus 로고
    • Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: Insight from transgenic mouse models
    • Vizler C, Bercovici N, Cornet A, et al. Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models. Immunol Rev. 1999;169:81-92.
    • (1999) Immunol Rev , vol.169 , pp. 81-92
    • Vizler, C.1    Bercovici, N.2    Cornet, A.3
  • 44
    • 10744226674 scopus 로고    scopus 로고
    • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    • Cosmi L, Liotta F, Lazzeri E, et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood. 2003;102:4107-4114.
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1    Liotta, F.2    Lazzeri, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.