Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients

Molecules and Cells

Volumn 19, Issue 2, 2005, Pages 180-184

  Hwang, Sue Yun ^a   Kim, Ho Youn ^b  

^a Hankyong National University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Fibroblast Like Synoviocytes (FLS); Interleukin 17; Rheumatoid Arthritis; Synovial Fluid Mononuclear Cell (SFMC)

Indexed keywords

CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 25; INTERLEUKIN 27; CYTOKINE; IL17D PROTEIN, HUMAN; IL17R PROTEIN, HUMAN; IL17RB PROTEIN, HUMAN; IL17RD PROTEIN, HUMAN; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN RECEPTOR; MESSENGER RNA;

ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; IMMUNOMODULATION; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; T LYMPHOCYTE ACTIVATION; BLOOD; COMPARATIVE STUDY; FEMALE; FIBROBLAST; GENETICS; MALE; METABOLISM; MIDDLE AGED; SYNOVIAL FLUID;

ARTHRITIS, RHEUMATOID; CYTOKINES; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-15; INTERLEUKIN-17; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-17; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNOVIAL FLUID;

EID: 26044455144     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Aggarwal, S. and Gurney, A. (2002) IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71, 1-8.
2. Bush, K., Walker, J., Lee, C., and Kirham, B. (2001) Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease. Clin. Exp. Immunol. 123, 487-495.
3. Cai, L., Yin, J., Starovasnik, M., Hogue, D., Hillan, K., et al. (2001) Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 16, 10-21.
4. Chabaud, M., Durand, J., Buchs, N., Fossiez, F., Page, G., et al. (1999) Human interleukin 17; a T cell-derived proinflammatory cytokine produced by the rheumatoid arthritis synovium. Arth. Rheum. 42, 963-970.
5. Chabaud, M., Lubberts, E., Joosten, L., van den Berg, W., and Miossec, P. (2001) IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arth. Res. Ther. 3, 168-177.
6. Cho, M.-L., Yoon, J.-H., Hwang, S.-Y., Park, M.-K., Min, S.-Y., et al. (2004) Effector function of type II collagen stimulated T-cells of rheumatoid arthritis patients: cross-talk between antigen stimulated T-cells and synovial fibroblasts. Arth. Rheum. 50, 776-784.
7. Gonzales-Alvaro, I., Ortiz, A. M., Garcia-Vicuna, R., Balsa, A., Pascual-Salcedo, D., et al. (2003) Increased serum levels of interleukin-15 in rheumatoid arthritis with long-term disease. Clin. Exp. Rheumatol. 21, 639-642.
8. Hwang, S.-Y, Kim, J.-Y, Kim, K.-W., Park, M.-K., Moon, Y., et al. (2004) IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB and PI3-kinase/Akt-dependent pathways. Arth. Res. Ther. 6, 120-128.
9. Katz, Y., Nadiv, O., and Beer, Y (2001) Interleukin-17 enhances tumor necrosis factor α-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts. Arth. Rheum. 44, 2176-2184.
10. Lee, J., Ho, W.-H., Maruoka, M., Corpuz, R., Baldwin, D., et al. (2001) IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rhl. J. Biol. Chem. 276, 1660-1664.
11. Li, H., Chen, J., Huang, A., Stinson, J., Heldens, S., et al. (2000) Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proc. Natl. Acad. Sci. USA 97, 773-778.
12. Lubberts, E., Joosten, L., Oppers, B., van den Bersselaar, L., Coenen-de Roo, C., et al. (2001) IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J. Immunol. 167, 1004-1013.
13. Miossec, P. (2003) Interleukin-17 in rheumatoid arthritis. Arth. Rheum. 48, 594-601.
14. Min, S.-Y., Hwang, S.-Y., Jung, Y.-O., Min, D.-J., Park, S.-H., et al. (2004) Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes. J. Rheumatol. 31, 875-883.
15. Moseley, T., Haudenschild, D., Rose, L., and Reddi, A. (2003) Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14, 155-174.
16. Park, S.-H., Min, D.-J., Cho, M.-L., Kim, W.-U., Youn, J., et al. (2001) Shift toward T helper 1 cytokines by type II collagen-reactive T-cells in patients with rheumatoid arthritis. Arth. Rheum. 44, 561-569.
17. Rho, J., Takami, M., and Choi, Y. (2004) Osteoimmunology: interactions of the immune and skeletal systems. Mol. Cells 17, 1-9.
18. Shi, Y., Ullrich, S., Zhang, J., Connolly, K., Grzegorzewski, K., et al. (2000) A novel cytokine receptor-ligand pair. J. Biol. Chem. 275, 19167-19176.
19. F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J. Immunol. 167, 4137-4140.
20. Starnes, T., Broxmeyer, H. E., Robertson, M. J., and Hromas, R. (2002) IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. J. Immunol. 169, 642-646.
21. Ziolkowska, M., Koe, A., Luszczykiewicz, G., Ksiezopolska-Pietrzak, K., Klimczak, E., et al. (2000) High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporine A-sensitive mechanism. J. Immunol. 164, 2832-2838.