Dentin adhesion and MMPs: A comprehensive review

Journal of Esthetic and Restorative Dentistry

Volumn 25, Issue 4, 2013, Pages 219-241

  Perdigão, Jorge ^a   Reis, Alessandra ^b   Loguercio, Alessandro D ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DENTIN BONDING AGENT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR;

ABSORPTION; ADSORPTION; CHEMICAL PHENOMENA; CHEMISTRY; DENTAL BONDING; DENTIN; HUMAN; MECHANICAL STRESS; PH; PHYSIOLOGY; POLYMERIZATION; ULTRASTRUCTURE;

ABSORPTION, PHYSICOCHEMICAL; ADSORPTION; DENTAL BONDING; DENTIN; DENTIN-BONDING AGENTS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; POLYMERIZATION; STRESS, MECHANICAL;

EID: 84881427775     PISSN: 14964155     EISSN: 17088240     Source Type: Journal    
DOI: 10.1111/jerd.12016     Document Type: Review

References (202)

1. Buonocore MG,. A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. J Dent Res 1955; 34: 849-853.
2. Gwinnett AJ, Matsui A,. A study of enamel adhesives: the physical relationship between enamel and adhesive. Arch Oral Biol 1967; 12: 1615-1620.
3. Buonocore MG, Matsui A, Gwinnett AJ,. Penetration of resin into enamel surfaces with reference to bonding. Arch Oral Biol 1968; 13: 61-70.
4. Asmussen E, Uno S,. Adhesion of restorative resin to dentin: chemical and physicochemical aspects. Oper Dent 1992;(Suppl. 5): 68-74.
5. Van Meerbeek B, De Munck J, Yoshida Y, et al. Buonocore memorial lecture. Adhesion to enamel and dentin: current status and future challenges. Oper Dent 2003; 28: 215-235.
6. Pashley DH,. Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 1996; 7: 104-133.
7. Pashley DH,. The effects of acid etching on the pulpodentin complex. Oper Dent 1992; 17: 229-242.
8. Nakabayashi N, Kojima K, Masuhara E,. The promotion of adhesion by the infiltration of monomers into tooth substrates. J Biomed Mater Res 1982; 16: 265-273.
9. Van Meerbeek B, Inokoshi S, Braem M, et al. Morphological aspects of the resin-dentin interdiffusion zone with different dentin adhesive systems. J Dent Res 1992; 71: 1530-1540.
10. Hashimoto M, Ohno H, Sano H, et al. In vitro degradation of resin-dentin bonds analyzed by microtensile bond test, scanning and transmission electron microscopy. Biomaterials 2003; 24: 3795-3803.
11. Breschi L, Mazzoni A, Ruggeri A, et al. Dental adhesion review: aging and stability of the bonded interface. Dent Mater 2008; 24: 90-101.
12. Salz U, Zimmermann J, Zeuner F, Moszner N,. Hydrolytic stability of self-etching adhesive systems. J Adhes Dent 2005; 7: 107-116.
13. Kanca J,. Resin bonding to wet substrate: I. Bonding to dentin. Quintessence Int 1992; 23: 39-41.
14. Gwinnett AJ,. Dentin bond strengths after air-drying and re-wetting. Am J Dent 1994; 7: 144-148.
15. Ito S, Hashimoto M, Wadgaonkar B, et al. Effects of resin hydrophilicity on water sorption and changes in modulus of elasticity. Biomaterials 2005; 26: 6449-6459.
16. Chiaraputt S, Mai S, Huffman BP, et al. Changes in resin-infiltrated dentin stiffness after water storage. J Dent Res 2008; 87: 655-660.
17. Hashimoto M, Ohno H, Kaga M, et al. In vivo degradation of resin-dentin bonds in humans over 1 to 3 years. J Dent Res 2000; 79: 1385-1391.
18. Paul SJ, Leach M, Rueggeberg FA, Pashley DH,. Effect of water content on the physical properties of model dentine primer and bonding resins. J Dent 1999; 27: 209-214.
19. Spencer P, Wang Y,. Adhesive phase separation at dentin interface under wet bonding conditions. J Biomed Mater Res 2002; 62: 447-456.
20. Pashley DH, Tay FR, Yiu C, et al. Collagen degradation by host-derived enzymes during aging. J Dent Res 2004; 83: 216-221.
21. Wang Y, Spencer P,. Hybridization efficiency of the adhesive/dentin interface with wet bonding. J Dent Res 2003; 82: 141-145.
22. Hashimoto M, Ohno H, Kaga M, et al. Over-etching effects on micro-tensile bond strength and failure patterns for two dentin bonding systems. J Dent 2002; 30: 99-105.
23. Bourd-Boittin K, Fridman R, Fanchon S, et al. Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Exp Cell Res 2005; 304: 493-505.
24. Mazzoni A, Mannello F, Tay FR, et al. Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin. J Dent Res 2007; 86: 436-440.
25. Sulkala M, Tervahartiala T, Sorsa T, et al. Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin. Arch Oral Biol 2007; 52: 121-127.
26. Kinney JH, Balooch M, Marshall GW, Marshall SJ,. Atomic-force microscopic study of dimensional changes in human dentine during drying. Arch Oral Biol 1993; 38: 1003-1007.
27. Van der Graaf ER, ten Bosch JJ,. Changes in dimension and weight of human dentine after different drying procedures and during subsequent rehydration. Arch Oral Biol 1993; 38: 97-99.
28. Maciel KT, Carvalho RM, Ringle RD, et al. The effect of acetone, ethanol, HEMA, and air on the stiffness of human decalcified dentin matrix. J Dent Res 1996; 75: 1851-1858.
29. Perdigão J,. Dentin bonding as function of dentin structure. Dent Clin North Am 2002; 46: 1-25.
30. Sano H, Takatsu T, Ciucchi B, et al. Nanoleakage: leakage within the hybrid layer. Oper Dent 1995; 20: 18-25.
31. Nakajima M, Okuda M, Pereira PNR, et al. Dimensional changes and ultimate tensile strengths of dentin applied with one-bottle adhesives. Dent Mater 2002; 18: 603-608.
32. Liu Y, Tjäderhane L, Breschi L, et al. Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res 2011; 90: 953-968.
33. Kostoryz EL, Dharmala K, Ye Q, et al. Enzymatic biodegradation of HEMA/bisGMA adhesives formulated with different water content. J Biomed Mater Res B Appl Biomater 2009; 88: 394-401.
34. Wang Y, Spencer P,. Quantifying adhesive penetration in adhesive/dentin interface using confocal Raman microspectroscopy. J Biomed Mater Res 2002; 59: 46-55.
35. Wang Y, Spencer P, Walker MP,. Chemical profile of adhesive/caries- affected dentin interfaces using Raman microspectroscopy. J Biomed Mater Res A 2007; 81: 279-286.
36. Pashley DH, Agee KA, Wataha JC, et al. Viscoelastic properties of demineralized dentin matrix. Dent Mater 2003; 19: 700-706.
37. Fung DT, Wang VM, Laudier DM, et al. Subrupture tendon fatigue damage. J Orthop Res 2009; 27: 264-273.
38. Hashimoto M, Ohno H, Sano H, et al. Micromorphological changes in resin-dentin bonds after 1 year of water storage. J Biomed Mater Res 2002; 63: 306-311.
39. Gwinnett AJ, Yu S,. Effect of long-term water storage on dentin bonding. Am J Dent 1995; 8: 109-111.
40. De Munck J, Van Meerbeek B, Yoshida Y, et al. Four-year water degradation of total-etch adhesives bonded to dentin. J Dent Res 2003; 82: 136-140.
41. Armstrong SR, Vargas MA, Chung I, et al. Resin-dentin interfacial ultrastructure and microtensile dentin bond strength after five-year water storage. Oper Dent 2004; 29: 705-712.
42. De Munck J, Van den Steen PE, Mine A, et al. Inhibition of enzymatic degradation of adhesive-dentin interfaces. J Dent Res 2009; 88: 1101-1106.
43. Hashimoto M, Tay FR, Ohno H, et al. SEM and TEM analysis of water degradation of human dentinal collagen. J Biomed Mater Res B Appl Biomater 2003; 66: 287-298.
44. Hashimoto M,. A review-micromorphological evidence of degradation in resin-dentin bonds and potential preventional solutions. J Biomed Mater Res B Appl Biomater 2010; 92: 268-280.
45. Sano H, Yoshikawa T, Pereira PN, et al. Long-term durability of dentin bonds made with a self-etching primer in vivo. J Dent Res 1999; 78: 906-911.
46. Takahashi A, Inoue S, Kawamoto C, et al. In vivo long-term durability of the bond to dentin using two adhesive systems. J Adhes Dent 2002; 4: 151-159.
47. Tay FR, King NM, Chan KM, Pashley DH,. How can nanoleakage occur in self-etching adhesive systems that demineralize and infiltrate simultaneously? J Adhes Dent 2002; 4: 255-269.
48. Perdigão J, Lopes MM, Gomes G,. In vitro bonding performance of self-etch adhesives: II-ultramorphological evaluation. Oper Dent 2008; 33: 534-549.
49. Carvalho RM, Chersoni S, Frankenberger R, et al. A challenge to the conventional wisdom that simultaneous etching and resin infiltration always occurs in self-etch adhesives. Biomaterials 2005; 26: 1035-1042.
50. Nishitani Y, Yoshiyama M, Donnelly AM, et al. Effects of resin hydrophilicity on dentin bond strength. J Dent Res 2006; 85: 1016-1021.
51. Malacarne J, Carvalho RM, de, Goes MF, et al. Water sorption/solubility of dental adhesive resins. Dent Mater 2006; 22: 973-980.
52. Hosaka K, Nakajima M, Takahashi M, et al. Relationship between mechanical properties of one-step self-etch adhesives and water sorption. Dent Mater 2010; 26: 360-367.
53. Ito S, Hoshino T, Iijima M, et al. Water sorption/solubility of self-etching dentin bonding agents. Dent Mater 2010; 26: 617-626.
54. Reis A, Albuquerque M, Pegoraro M, et al. Can the durability of one-step self-etch adhesives be improved by double application or by an extra layer of hydrophobic resin? J Dent 2008; 36: 309-315.
55. Reis A, Leite TM, Matte K, et al. Improving clinical retention of one-step self-etching adhesive systems with an additional hydrophobic adhesive layer. J Am Dent Assoc 2009; 140: 877-885.
56. Tay FR, Pashley DH, Suh BI, et al. Single-step adhesives are permeable membranes. J Dent 2002; 30: 371-382.
57. Tay FR, Pashley DH, Suh BI, et al. Buonocore memorial lecture: water treeing in simplified dentin adhesives-déjà vu? Oper Dent 2005; 30: 561-579.
58. Tay FR, Pashley DH, Yiu CKY, et al. Factors contributing to the incompatibility between simplified-step adhesives and chemically-cured or dual-cured composites. Part I. Single-step self-etching adhesive. J Adhes Dent 2003; 5: 27-40.
59. Tay FR, King NM, Suh BI, Pashley DH,. Effect of delayed activation light-cured resin composites on bonding of all-in-one adhesives. J Adhes Dent 2001; 3: 207-225.
60. Zhou J, Tan J, Chen L, et al. The incorporation of chlorhexidine in a two-step self-etching adhesive preserves dentin bond in vitro. J Dent 2009; 37: 807-812.
61. Nishiyama N, Tay FR, Fujita K, et al. Hydrolysis of functional monomers in a single-bottle self-etching primer-correlation of 13C NMR and TEM findings. J Dent Res 2006; 85: 422-426.
62. Gross J, Lapiere CM,. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci USA 1962; 48: 1014-1022.
63. Nagase H, Woessner JF Jr,. Matrix metalloproteinases. J Biol Chem 1999; 274: 21491-21494.
64. Jeffrey JJ, Gross J,. Collagenase from rat uterus. Isolation and partial characterization. Biochemistry 1970; 9: 268-273.
65. Osorio R, Yamauti M, Osorio E, et al. Effect of dentin etching and chlorhexidine application on metalloproteinase-mediated collagen degradation. Eur J Oral Sci 2011; 119: 79-85.
66. Brinckerhoff CE, Matrisian LM,. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002; 3: 207-214.
67. Sternlicht MD, Werb Z,. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17: 463-516.
68. Nishitani Y, Yoshiyama M, Wadgaonkar B, et al. Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives. Eur J Oral Sci 2006; 114: 160-166.
69. Visse R, Nagase H,. Matrix metalloproteinases and tissue inhibitors of metalloproteinases-structure, function, and biochemistry. Circ Res 2003; 92: 827-839.
70. Nagase H, Visse R, Murphy G,. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006; 69: 562-573.
71. Tjaderhane L, Larjava H, Sorsa T, et al. The activation and function of host matrix metalloproteinase in dentin matrix during breakdown in carious lesions. J Dent Res 1998; 77: 1622-1629.
72. Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S,. The role of matrix metalloproteinases (MMPs) in human caries. J Dent Res 2006; 85: 22-32.
73. Mazzoni A, Pashley DH, Nishitani Y, et al. Reactivation of quenched endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives. Biomaterials 2006; 27: 4470-4476.
74. Mazzoni A, Pashley DH, Tay FR, et al. Immunohistochemical identification of MMP-2 and MMP-9 in human dentin: correlative FEI-SEM/TEM analysis. J Biomed Mater Res A 2009; 88: 697-703.
75. Sulkala M, Larmas M, Sorsa T, et al. The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth. J Dent Res 2002; 81: 603-607.
76. Aimes RT, Quigley JP,. Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem 1995; 270: 5872-5876.
77. Garnero P, Ferraras M, Karsdal MA, et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003; 18: 859-867.
78. Carrilho MRO, Geraldeli S, Tay F, et al. In vivo preservation of the hybrid layer by chlorhexidine. J Dent Res 2007; 86: 529-533.
79. Carrilho MR, Tay FR, Donnelly AM, et al. Host-derived loss of dentin matrix stiffness associated with solubilization of collagen. J Biomed Mater Res B Appl Biomater 2009; 90: 373-380.
80. Breschi L, Martin P, Mazzoni A, et al. Use of a specific MMP-inhibitor (Galardin) for preservation of hybrid layer. Dent Mater 2010; 26: 571-578.
81. Loguercio AD, Stanislawczuk R, Polli LG, et al. Influence of chlorhexidine digluconate concentration and application time on resin-dentin bond strength durability. Eur J Oral Sci 2009; 117: 587-596.
82. Demeule M, Brossard M, Pagé M, et al. Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta 2000; 1478: 51-60.
83. Garbisa S, Sartor L, Biggin S, et al. Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 2001; 91: 822-832.
84. Lecaille F, Kaleta J, Bromme D,. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev 2002; 102: 4459-4488.
85. Drake FH, Dodds RA, James IE, et al. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 1996; 271: 12511-12516.
86. 2 in Spodoptera frugiperda and characterization of the enzyme. J Biol Chem 1996; 271: 2126-2132.
87. Paloosari H,. Matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) in mature human odontoblasts and pulp tissue. The regulation of expressions of fibrillar collagens, MMPs and TIMPs by growth factors, transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2). Doctoral Thesis, University of Oulu 2003, ISBN 951-42-7078-9. Available at: http://herkules.oulu.fi/isbn9514270789/isbn9514270789.pdf (accessed January 9, 2013).
88. Marshall GW Jr, Marshall SJ, Kinney JH, Balooch M,. The dentine substrate: structure and properties related to bonding. J Dent 1997; 25: 441-458.
89. Breschi L, Lopes M, Gobbi P, et al. Dentin proteoglycans: an immunocytochemical FEISEM study. J Biomed Mater Res 2002; 61: 40-46.
90. Okazaki J, Embery G, Hall RC, et al. Adsorption of glycosaminoglycans onto hydroxyapatite using chromatography. Biomaterials 1999; 20: 309-314.
91. Tersariol IL, Pimenta DC, Chagas JR, Almeida PC,. Proteinase activity regulation by glycosaminoglycans. Braz J Med Biol Res 2002; 35: 135-144.
92. Tersariol IL, Geraldeli S, Minciotti CL, et al. Cysteine cathepsins in human dentin-pulp complex. J Endod 2010; 36: 475-481.
93. Nascimento FD, Minciotti CL, Geraldeli S, et al. Cysteine cathepsins in human carious dentin. J Dent Res 2011; 90: 506-511.
94. Garnero P, Borel O, Byrjalsen I, et al. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem 1998; 273: 32347-32352.
95. Kafienah W, Bromme D, Buttle DJ, et al. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J 1998; 331: 727-732.
96. Mallya SK, Mookhtiar KA, Van Wart HE,. Kinetics of hydrolysis of type I, II, and III collagens by the class I and II Clostridium histolyticum collagenases. J Protein Chem 1992; 11: 99-107.
97. Stanley A, Wilson M, Newman HN,. The in vitro effects of chlorhexidine on subgingival plaque bacteria. J Clin Periodontol 1989; 16: 259-264.
98. Carrilho MR, Carvalho RM, Sousa EN, et al. Substantivity of chlorhexidine to human dentin. Dent Mater 2010; 26: 779-785.
99. Cosyn J, Wyn I, De Rouck T, Sabzevar MM,. Long-term clinical effects of a chlorhexidine varnish implemented treatment strategy for chronic periodontitis. J Periodontol 2006; 77: 406-415.
100. Gendron R, Grenier D, Sorsa T, Mayrand D,. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine. Clin Diagn Lab Immunol 1999; 6: 437-443.
101. Perdigao J, Denehy GE, Swift EJ Jr,. Effects of chlorhexidine on dentin surfaces and shear bond strengths. Am J Dent 1994; 7: 81-84.
102. Scaffa PM, Vidal CM, Barros N, et al. Chlorhexidine inhibits the activity of dental cysteine cathepsins. J Dent Res 2012; 91: 420-425.
103. Ricci HA, Sanabe ME, De Souza Costa CA, et al. Chlorhexidine increases the longevity of in vivo resin-dentin bonds. Eur J Oral Sci 2010; 118: 411-416.
104. Hebling J, Pashley DH, Tjäderhane L, Tay FR,. Chlorhexidine arrests subclinical breakdown of dentin hybrid layers in vivo. J Dent Res 2005; 84: 741-746.
105. Carrilho MRO, Carvalho RM, de, Goes MF, et al. Chlorhexidine preserves dentin bond in vitro. J Dent Res 2007; 86: 90-94.
106. Stanislawczuk R, Amaral RC, Zander-Grande C, et al. Chlorhexidine- containing acid conditioner preserves the longevity of resin-dentin bonds. Oper Dent 2009; 34: 481-490.
107. Stanislawczuk R, Reis A, Loguercio AD,. A 2-year in vitro evaluation of a chlorhexidine-containing acid on the durability of resin-dentin interfaces. J Dent 2011; 39: 40-47.
108. Zhou J, Tan J, Yang X, et al. MMP-inhibitory effect of chlorhexidine applied in a self-etching adhesive. J Adhes Dent 2011; 13: 111-115.
109. Kim J, Uchiyama T, Carrilho M, et al. Chlorhexidine binding to mineralized versus demineralized dentin powder. Dent Mater 2010; 26: 771-778.
110. Almahdy A, Koller G, Sauro S, et al. Effects of MMP inhibitors incorporated within dental adhesives. J Dent Res 2012; 91: 605-611.
111. Magalhães AC, Wiegand A, Rios D, et al. Chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ. J Dent 2009; 37: 994-998.
112. Taniguchi S, Fujiki H, Kobayashi H, et al. Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. Cancer Lett 1992; 65: 51-54.
113. Katiyar SK, Mukhtar H,. Inhibition of phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate-caused inflammatory responses in SENCAR mouse skin by black tea polyphenols. Carcinogenesis 1997; 18: 1911-1916.
114. Chiang WC, Wong YK, Lin SC, et al. Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression. Oral Dis 2006; 12: 27-33.
115. Curran S, Murray GI,. Matrix metalloproteinases in tumour invasion and metastasis. J Pathol 1999; 189: 300-308.
116. Sen T, Moulik S, Dutta A, et al. Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. Life Sci 2009; 84: 194-204.
117. Yun JH, Pang EK, Kim CS, et al. Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts. J Periodontal Res 2004; 39: 300-307.
118. Du X, Huang X, Huang C, et al. Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive. J Dent 2012; 40: 485-492.
119. Grobelny D, Poncz L, Galardy RE,. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 1992; 31: 7152-7154.
120. Hao JL, Nagano T, Nakamura M, et al. Galardin inhibits collagen degradation by rabbit keratocytes by inhibiting the activation of pro-matrix metalloproteinases. Exp Eye Res 1999; 68: 565-572.
121. Lund LR, Rømer J, Bugge TH, et al. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J 1999; 18: 4645-4656.
122. Lund LR, Green KA, Stoop AA, et al. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J 2006; 25: 2686-2697.
123. Wiseman BS, Sternlicht MD, Lund LR, et al. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol 2003; 162: 1123-1133.
124. Almholt K, Juncker-Jensen A, Laerum OD, et al. Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model. Mol Cancer Ther 2008; 7: 2758-2767.
125. Golub LM, Lee HM, Ryan ME, et al. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 1998; 12: 12-26.
126. Golub LM, Ramamurthy NS, McNamara TF, et al. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991; 2: 297-321.
127. Acharya MR, Venitz J, Figg WD, Sparreboom A,. Chemically modified tetracyclines as inhibitors of matrix Metalloproteinases. Drug Resist Updat 2004; 7: 195-208.
128. Sapadin AN, Fleischmajer R,. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006; 54: 258-265.
129. Fife R, Sledge G,. Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J Lab Clin Med 1995; 125: 407-411.
130. Fife RS, Rougraff B, Proctor C, Sledge G,. Induction of apoptosis by doxycycline in cultured human osteosarcoma cells. J Lab Clin Med 1997; 130: 530-534.
131. Gilbertson-Beadling S, Powers EA, Stamp-Cole M, et al. The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism. Cancer Chemother Pharmacol 1995; 36: 418-424.
132. Caton J, Ryan ME,. Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD). Pharmacol Res 2011; 63: 114-120.
133. Golub LM, Ciancio S, Ramamurthy NS, et al. Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. J Periodontal Res 1990; 25: 321-330.
134. Stanislawczuk R, Costa JA, Polli LG, et al. Effect of tetracycline on the bond performance of etch-and-rinse adhesives to dentin. Braz Oral Res 2011; 25: 459-465.
135. Imazato S,. Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry. Dent Mater J 2009; 28: 11-19.
136. Imazato S, Kinomoto Y, Tarumi H, et al. Incorporation of antibacterial monomer MDPB into dentin primer. J Dent Res 1997; 76: 768-772.
137. Namba N, Yoshida Y, Nagaoka N, et al. Antibacterial effect of bactericide immobilized in resin matrix. Dent Mater 2009; 25: 424-430.
138. Imazato S, Tay FR, Kaneshiro AV, et al. An in vivo evaluation of bonding ability of comprehensive antibacterial adhesive system incorporating MDPB. Dent Mater 2007; 23: 170-176.
139. Tezvergil-Mutluay A, Agee KA, Uchiyama T, et al. The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs. J Dent Res 2011; 90: 535-540.
140. Donmez N, Belli S, Pashley DH, Tay FR,. Ultrastructural correlates of in vivo/in vitro bond degradation in self-etch adhesives. J Dent Res 2005; 84: 355-359.
141. Kanca J,. One Step bond strength to enamel and dentin. Am J Dent 1997; 9: 5-8.
142. Tezvergil-Mutluay A, Mutluay MM, Gu LS, et al. The anti-MMP activity of benzalkonium chloride. J Dent 2011; 39: 57-64.
143. Hülsmann M, Heckendorff M, Lennon A,. Chelating agents in root canal treatment: mode of action and indications for their use. Int Endod J 2003; 36: 810-830.
144. Srirangarajan S, Ravindra S, Aparna S, Thakur S,. EDTA-S: a novel root conditioning agent. J Indian Soc Periodontol 2012; 16: 70-73.
145. 2+ in pronuclear formation induction by Ca-EDTA. Reproduction 2002; 124: 235-240.
146. Osorio R, Yamauti M, Osorio E, et al. Zinc-doped dentin adhesive for collagen protection at the hybrid layer. Eur J Oral Sci 2011; 119: 401-410.
147. Thompson JM, Agee K, Sidow SJ, et al. Inhibition of endogenous dentin matrix metalloproteinases by ethylene-diaminetetraacetic acid. J Endod 2012; 38: 62-65.
148. Jacques P, Hebling J,. Effect of dentin conditioners on the microtensile bond strength of a conventional and a self-etching primer adhesive system. Dent Mater 2005; 21: 103-109.
149. Torii Y, Hikasa R, Iwate S, et al. Effect of EDTA conditioning on bond strength to bovine dentin promoted by four current adhesives. Am J Dent 2003; 16: 395-400.
150. 4/NaOCl dentine treatments may increase hybrid layers' resistance to degradation: a microtensile bond strength and confocal-micropermeability study. J Dent 2009; 37: 279-288.
151. Bedran-Russo AK, Pashley DH, Agee K, et al. Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res B Appl Biomater 2008; 86: 330-334.
152. Xu C, Wang Y,. Cross-linked demineralized dentin maintains its mechanical stability when challenged by bacterial collagenase. J Biomed Mater Res B Appl Biomater 2010; 96: 242-248.
153. Tezvergil-Mutluay A, Mutluay MM, Agee KA, et al. Carbodiimide cross-linking inactivates soluble and matrix-bound MMPs, in vitro. J Dent Res 2012; 91: 192-196.
154. Munksgaard EC, Asmussen E,. Bond strength between dentin and restorative resins mediated by mixtures of HEMA and glutaraldehyde. J Dent Res 1984; 63: 1087-1089.
155. Castellan CS, Pereira PN, Grande RH, Bedran-Russo AK,. Mechanical characterization of proanthocyanidin- dentin matrix interaction. Dent Mater 2010; 26: 968-973.
156. Han B, Jaurequi J, Tang BW, Nimni ME,. Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A 2003; 65: 118-124.
157. Bedran-Russo AK, Pereira PN, Duarte WR, et al. Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. J Biomed Mater Res B Appl Biomater 2007; 80: 268-272.
158. Nimni ME, Cheung D, Strates B, et al. Chemically modified collagen: a natural biomaterial for tissue replacement. J Biomed Mater Res 1987; 21: 741-771.
159. Cova A, Breschi L, Nato F, et al. Effect of UVA-activated riboflavin on dentin bonding. J Dent Res 2011; 90: 1439-1445.
160. Fawzy A, Nitisusanta L, Iqbal K, et al. Characterization of riboflavin-modified dentin collagen matrix. J Dent Res 2012; 91: 1049-1054.
161. Jung GB, Lee HJ, Kim JH, et al. Effect of cross-linking with riboflavin and ultraviolet A on the chemical bonds and ultrastructure of human sclera. J Biomed Opt 2011; 16: 125004.
162. Joshi SS, Kuszynski CA, Bagchi D,. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr Pharm Biotechnol 2001; 2: 187-200.
163. Fine AM,. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 2000; 5: 144-151.
164. Castellan CS, Bedran-Russo AK, Karol S, Pereira PN,. Long-term stability of dentin matrix following treatment with various natural collagen cross-linkers. J Mech Behav Biomed Mater 2011; 4: 1343-1450.
165. Song SE, Choi BK, Kim SN, et al. Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens. J Periodontal Res 2003; 38: 282-289.
166. Epasinghe DJ, Yiu CK, Burrow MF, et al. Effect of proanthocyanidin incorporation into dental adhesive resin on resin-dentine bond strength. J Dent 2012; 40: 173-180.
167. Bedran-Russo AK, Vidal CM, Dos Santos PH, Castellan CS,. Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds. J Biomed Mater Res B Appl Biomater 2010; 94: 250-255.
168. Fusayama T, Terachima S,. Differentiation of two layers of carious dentin by staining. J Dent Res 1972; 51: 866.
169. Ohgushi K, Fusayama T,. Electron microscopic structure of the two layers of carious dentin. J Dent Res 1975; 54: 1019-1026.
170. Kuboki Y, Ohgushi K, Fusayama T,. Collagen biochemistry of the two layers of carious dentin. J Dent Res 1977; 56: 1233-1237.
171. Tay FR, Pashley DH,. Guided tissue remineralisation of partially demineralised human dentine. Biomaterials 2008; 29: 1127-1137.
172. Tay FR, Pashley DH,. Biomimetic remineralization of resin-bonded acid-etched dentin. J Dent Res 2009; 88: 719-724.
173. Kim J, Vaughn RM, Gu L, et al. Imperfect hybrid layers created by an aggressive one-step self-etch adhesive in primary dentin are amendable to biomimetic remineralization in vitro. J Biomed Mater Res A 2010; 93: 1225-1234.
174. Brackett MG, Li N, Brackett WW, et al. The critical barrier to progress in dentine bonding with the etch-and-rinse technique. J Dent 2011; 39: 238-248.
175. Mai S, Kim YK, Toledano M, et al. Phosphoric acid esters cannot replace polyvinylphosphonic acid as phosphoprotein analogs in biomimetic remineralization of resin-bonded dentin. Dent Mater 2009; 25: 1230-1239.
176. Mai S, Kim YK, Kim J, et al. In vitro remineralization of severely compromised bonded dentin. J Dent Res 2010; 89: 405-410.
177. Breschi L, Mazzoni A, Nato F, et al. Chlorhexidine stabilizes the adhesive interface over time: a 2-year in vitro study. Dent Mater 2010; 26: 320-325.
178. Vaidyanathan TK, Vaidyanathan J,. Recent advances in the theory and mechanism of adhesive resin bonding to dentin: a critical review. J Biomed Mater Res B Appl Biomater 2009; 88: 558-578.
179. Pashley DH, Tay FR, Carvalho RM, et al. From dry bonding to water-wet bonding to ethanol-wet bonding. A review of the interactions between dentin matrix and solvated resins using a macromodel of the hybrid layer. Am J Dent 2007; 20: 7-20.
180. Tay FR, Pashley DH, Kapur RR, et al. Bonding BisGMA to dentin-a proof of concept for hydrophobic dentin bonding. J Dent Res 2007; 86: 1034-1039.
181. Hosaka K, Nishitani Y, Tagami J, et al. Durability of resin-dentin bonds to water- vs. ethanol saturated dentin. J Dent Res 2009; 88: 146-151.
182. Sadek FT, Mazzoni A, Breschi L, et al. Six-month evaluation of adhesives interface created by a hydrophobic adhesive to acid-etched ethanol-wet bonded dentine with simplified dehydration protocols. J Dent 2010; 38: 276-283.
183. Kim J, Gu L, Breschi L, et al. Implication of ethanol wet-bonding in hybrid layer remineralization. J Dent Res 2010; 89: 575-580.
184. Tezvergil-Mutluay A, Agee KA, Hoshika T, et al. Inhibition of MMPs by alcohols. Dent Mater 2011; 27: 926-933.
185. de Souza LB, de Aquino SG, de Souza PP, et al. Cytotoxic effects of different concentrations of chlorhexidine. Am J Dent 2007; 20: 400-404.
186. Calt S, Serper A,. Smear layer removal by EGTA. J Endod 2000; 26: 459-461.
187. Torabinejad M, Shabahang S, Aprecio RM, Kettering JD,. The antimicrobial effect of MTAD: an in vitro investigation. J Endod 2003; 29: 400-403.
188. Egeblad M, Werb Z,. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-174.
189. Martin MD, Matrisian LM,. The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev 2007; 26: 717-724.
190. Solberg H, Rinkenberger J, Danø K, et al. A functional overlap of plasminogen and MMPs regulates vascularization during placental development. Development 2003; 130: 4439-4450.
191. Stickens D, Behonick DJ, Ortega N, et al. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development 2004; 131: 5883-5895.
192. Boushell LW, Kaku M, Mochida Y, et al. Immunohistochemical localization of matrix metalloproteinase-2 in human coronal dentin. Arch Oral Biol 2008; 53: 109-116.
193. De Munck J, Mine A, Van den Steen PE, et al. Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives. Eur J Oral Sci 2010; 118: 494-501.
194. Sadek FT, Castellan CS, Braga RR, et al. One-year stability of resin-dentin bonds created with a hydrophobic ethanol-wet bonding technique. Dent Mater 2010; 26: 380-386.
195. García-Caballero L, Carmona IT, Gonzalez MCC, et al. Evaluation of the substantivity in saliva of different forms of application of chlorhexidine. Quintessence Int 2009; 40: 141-144.
196. Verraedt E, Braem A, Chaudhari A, et al. Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface. Int J Pharm 2011; 419: 28-32.
197. Yue IC, Poff J, Cortés ME, et al. A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials 2004; 25: 3743-3750.
198. Lee DY, Spångberg LS, Bok YB, et al. The sustaining effect of three polymers on the release of chlorhexidine from a controlled release drug device
199. Thompson RW, Baxter BT,. MMP inhibition in abdominal aortic aneurysms: rationale for a prospective randomized clinical trial. Ann N Y Acad Sci 1999; 878: 159-178.
200. Kato MT, Leite AL, Hannas AR, et al. Effect of iron on matrix metalloproteinase inhibition and on the prevention of dentine erosion. Caries Res 2010; 44: 309-316.
201. Tezvergil-Mutluay A, Agee KA, Hoshika T, et al. The requirement of zinc and calcium ions for functional MMP activity in demineralized dentin matrices. Dent Mater 2010; 26: 1059-1067.
202. Osorio R, Yamauti M, Osorio E, et al. Zinc reduces collagen degradation in demineralized human dentin explants. J Dent 2011; 39: 148-153.