Cysteine cathepsins in human carious dentin

Journal of Dental Research

Volumn 90, Issue 4, 2011, Pages 506-511

  Nascimento, F D ^a   Minciotti, C L ^b   Geraldeli, S ^c   Carrilho, M R ^a   Pashley, D H ^d   Tay, F R ^d   Nader, H B ^e   Salo, T ^f,g   Tjaderhane L ^f,g   Tersariol, I L S ^b,e  

^a Universidade Bandeirante de Sao Paulo   (Brazil)

^b UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

^c UNIVERSITY OF IOWA   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF OULU   (Finland)

^g OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

cathepsin; dentin; enzyme; human; MMP; tooth

Indexed keywords

ABZ GGFLRKHGQ EDDNP; ABZ-GGFLRKHGQ-EDDNP; CATHEPSIN; CATHEPSIN B; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORESCENT DYE; GLYCOPEPTIDE; LEUCINE; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; OLIGOPEPTIDE; PEPSTATIN; PHOSPHORAMIDON; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

ADOLESCENT; ADULT; AGE; CHILD; CONFERENCE PAPER; DENTAL CARIES; DENTIN; DRUG ANTAGONISM; ENDODONTICS; ENZYMOLOGY; HUMAN; MIDDLE AGED; ODONTOBLAST; PATHOLOGY; SALIVA; SPECTROFLUOROMETRY;

ADOLESCENT; ADULT; AGE FACTORS; CATHEPSIN B; CATHEPSINS; CHILD; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; DENTAL CARIES; DENTAL PULP EXPOSURE; DENTIN; FLUORESCENT DYES; GLYCOPEPTIDES; HUMANS; LEUCINE; MATRIX METALLOPROTEINASES; METALLOENDOPEPTIDASES; MIDDLE AGED; ODONTOBLASTS; OLIGOPEPTIDES; PEPSTATINS; PROTEASE INHIBITORS; SALIVA; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, FLUORESCENCE; YOUNG ADULT;

EID: 79954575378     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510391906     Document Type: Conference Paper

References (42)

1. Benjamin IJ (2001). Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease. J Investig Med 49: 381-397. (Pubitemid 32777002)
2. Boushell LW, Kaku M., Mochida Y., Bagnell R., Yamauchi M. (2008). Immunohistochemical localization of matrixmetalloproteinase-2 in human coronal dentin. Arch Oral Biol 53: 109-116. (Pubitemid 350296044)
3. Brömme D., Okamoto K., Wang BB, Biroc S. (1996). Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J Biol Chem 271: 2126-2132.
4. Brown LR, Lefkowitz W. (1966). Influences of dentinal fluids on experimental caries. J Dent Res 45: 1493-1498.
5. Buck MR, Karustis DG, Day NA, Honn KV, Sloane BF (1992). Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues. Biochem J 282 (Pt 1). 273-278.
6. Burleigh MC, Barrett AJ, Lazarus GS (1974). Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J 137: 387-398.
7. Buttle DJ (1994). Immunopharmacology of joints and connective tissue. Davies EM, Dingle JT, editors. San Diego, CA: Academic Press Inc., pp. 225-243.
8. Byers MR, Lin KJ (2003). Patterns of fluoro-gold entry into rat molar enamel, dentin, and pulp. J Dent Res 82: 312-317. (Pubitemid 41766031)
9. Chaussain-Miller C., Fioretti F., Goldberg M., Menashi S. (2006). The role of matrix metalloproteinases (MMPs) in human caries. J Dent Res 85: 22-32. (Pubitemid 43827758)
10. Dickinson DP (2002). Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease. Crit Rev Oral Biol Med 13: 238-275. (Pubitemid 34791209)
11. Fejerskov O., Nyvad B., Kidd EAM (2008). Clinical appearance of caries lesions. In: Dental caries. The disease and its clinical management. 2 nd ed. Oxford, UK: Blackwell Munksgaard Ltd., pp. 7-18.
12. Hashimoto Y., Kakegawa H., Narita Y., Hachiya Y., Hayakawa T., Kos J., et al. (2001). Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis. Biochem Biophys Res Commun 283: 334-339. (Pubitemid 32924693)
13. Hojo S., Komatsu M., Okuda R., Takahashi N., Yamada T. (1994). Acid profiles and pH of carious dentin in active and arrested lesions. J Dent Res 73: 1853-1857.
14. Kafienah W., Buttle DJ, Burnett D., Hollander AP (1998). Cleavage of native type I collagen by human neutrophil elastase. Biochem J 330 (Pt 2). 897-902. (Pubitemid 28111994)
15. Katz S., Park KK, Palenik CJ (1987). In-vitro root surface caries studies. J Oral Med 42: 40-48.
16. Kennett CN, Cox SW, Eley BM (1997). Ultrastructural localization of cathepsin B in gingival tissue from chronic periodontitis patients. Histochem J 29: 727-734. (Pubitemid 28005117)
17. Kirschke H., Kembhavi AA, Bohley P., Barrett AJ (1982). Action of rat liver cathepsin L on collagen and other substrates. Biochem J 201: 367-372. (Pubitemid 12160167)
18. Kirschke H., Barrett AJ, Rawlings ND (1995). Proteinases 1: lysosomal cysteine proteinases. Protein Profile 2: 1581-1643.
19. Lauer-Fields JL, Juska D., Fields GB (2002). Matrix metalloproteinases and collagen catabolism. Biopolymers 66: 19-32.
20. Lecaille F., Kaleta J., Bromme D. (2002). Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev 102: 4459-4488.
21. Ljusberg J., Wang Y., Lang P., Norgard M., Dodds R., Hultenby K., et al. (2005). Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclasts. J Biol Chem 280: 28370-28381. (Pubitemid 41105735)
22. Mohamed MM, Sloane BF (2006). Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6: 764-775. (Pubitemid 44450465)
23. Mort JS, Buttle DJ (1997). Cathepsin B Int J Biochem Cell Biol 29: 715-720. (Pubitemid 27323159)
24. Nagase H. (1997). Activation mechanisms of matrix metalloproteinases. Biol Chem 378: 151-160. (Pubitemid 27230597)
25. Nguyen Q., Mort JS, Roughley PJ (1990). Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B. Biochem J 266: 569-573. (Pubitemid 20090162)
26. Okamura T., Shimokawa H., Takagi Y., Ono H., Sasaki S. (1993). Detection of collagenase mRNA in odontoclasts of bovine root-resorbing tissue by in situ hybridization. Calcif Tissue Int 52: 325-330. (Pubitemid 23097166)
27. Ortega N., Behonick D., Stickens D., Werb Z. (2003). How proteases regulate bone morphogenesis. Ann NY Acad Sci 995: 109-116. (Pubitemid 36706618)
28. Pashley DH (1996). Dynamics of the pulpo-dentin complex. Crit Rev Oral Biol Med 7: 104-133. (Pubitemid 26296117)
29. Pozgan U., Caglic D., Rozman B., Nagase H., Turk V., Turk B. (2010). Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis Biol Chem 391: 571-579.
30. Seiki M. (2003). Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer Lett 194: 1-11. (Pubitemid 36428879)
31. Smith AJ (2003). Vitality of the dentin-pulp complex in health and disease: growth factors as key mediators. J Dent Educ 67: 678-689.
32. Steinman RR (1985). Physiologic activity of the pulp-dentin complex. Quintessence Int 16: 723-726.
33. Steinman RR, Leonora J., Singh RJ (1980). The effect of desalivation upon pulpal function and dental caries in rats. J Dent Res 59: 176-185. (Pubitemid 10097125)
34. Sulkala M., Wahlgren J., Larmas M., Sorsa T., Teronen O., Salo T., et al. (2001). The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats. J Dent Res 80: 1545-1549.
35. Sulkala M., Larmas M., Sorsa T., Salo T., Tjäderhane L. (2002). The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth. J Dent Res 81: 603-607.
36. Tersariol IL, Geraldeli S., Minciotti CL, Nascimento FD, Paakkonen V., Martins MT, et al. (2010). Cysteine cathepsins in human dentin-pulp complex. J Endod 36: 475-481.
37. Tjäderhane L., Larjava H., Sorsa T., Uitto VJ, Larmas M., Salo T. (1998). The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 77: 1622-1629. (Pubitemid 32770513)
38. Tjäderhane L., Sulkala M., Sorsa T., Teronen O., Larmas M., Salo T. (1999). The effect of MMP inhibitor metastat on fissure caries progression in rats. Ann NY Acad Sci 878: 686-688. (Pubitemid 29353648)
39. Tjäderhane L., Ahonen M., Salo T. (2006). Local matrix metalloproteinase (MMP) inhibition reduces dentinal caries in vivo [abstract]. J Dent Res 85 (Spec Iss B): 2536, URL http://iadr.confex.com/iadr/2006Brisb/ techprogram/abstract-79764.htm (accessed 11/16/2010).
40. Turk B., Turk D., Turk V. (2000). Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 1477: 98-111. (Pubitemid 30119895)
41. van Strijp AJ, Jansen DC, DeGroot J., ten Cate JM, Everts V. (2003). Host-derived proteinases and degradation of dentine collagen in situ. Caries Res 37: 58-65. (Pubitemid 37026232)
42. Yamashita DS, Dodds RA (2000). Cathepsin K and the design of inhibitors of cathepsin K. Curr Pharm Des 6: 1-24. (Pubitemid 30395459)