Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine

Clinical and Diagnostic Laboratory Immunology

Volumn 6, Issue 3, 1999, Pages 437-439

  Gendron, Renée ^a   Grenier, Daniel ^a   Sorsa, Timo ^b   Mayrand, Denis ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; GELATINASE A; GELATINASE B; NEUTROPHIL COLLAGENASE;

ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL INFECTION; CHELATION; DRUG EFFECT; INFLAMMATION; NONHUMAN; PERIODONTAL DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION;

EID: 0032911382     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.6.3.437-439.1999     Document Type: Article

References (34)

1. Beckett, R. P., A. H. Davidson, A. H. Drummond, P. Huxley, and M. Whittaker. 1996. Recent advances in matrix metalloproteinase inhibitor research. Drug Discov. Today 1:16-26.
2. Beighton, D., J. Decker, and K. A. Homer. 1991. Effects of chlorhexidine on enzyme activities of dental plaque bacteria. J. Clin. Periodontol. 18:85-89.
3. Birkedal-Hansen, H. 1993. Role of matrix metalloproteinases in human periodontal diseases. J. Periodontol. 64:474-484.
4. Charon, J., T. Thomas, F. Joachim, G. Lempereur, and A. Capron. 1985. Métabolisme oxydatif et chlorhexidine. J. Parodontol. 4:377-382.
5. Crout, R. J., H. M. Lee, K. Schroeder, H. Crout, N. S. Ramamurthy, M. Wiener, and L. M. Golub. 1996. The cyclic regimen of low-dose doxycycline for adult periodontitis: a preliminary study. J. Periodontol. 67:506-514.
6. Golub, L., H. M. Lee, G. Lehrer, A. Nemiroff, T. F. McNamara, R. Kaplan, and N. Ramamurthy. 1983. Minocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of action. J. Periodontal Res. 18:516-526.
7. Golub, L. M., T. Sorsa, H. M. Lee, S. Ciancio, D. Sorbi, N. S. Ramamurthy, B. Gruber, T. Salo, and Y. T. Konttinen. 1995. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J. Clin. Periodontol. 22:100-109.
8. Greenwald, R. A., L. M. Golub, B. Lavietes, N. S. Ramamurthy, B. Gruber, R. S. Laskin, and T. F. McNamara. 1987. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J. Rheumatol. 14:28-32.
9. Grenier, D. 1996. Effect of chlorhexidine on the adherence properties of Porphyromonas gingivalis. J. Clin. Periodontol. 23:140-142.
10. Grenier, D. 1993. Reduction of proteolytic degradation by chlorhexidine, J. Dent. Res. 72:630-633.
11. Haffajee, A. D., and S. S. Socransky. 1994. Microbial etiological agents of destructive periodontal diseases. Periodontol. 2000 5:78-111.
12. Hanemaaijer, R., T. Sorsa, Y. T. Konttinen, Y. Ding, M. Sutinen, H. Visser, V. W. M. van Hinsbergh, T. Helaakoski, T. Kainulainen, H. Ronka, H. Tschesche, and T. Salo. 1997. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J. Biol. Chem. 272:31504-31509.
13. Hjeljord, L. G., G. Rolla, and P. Bonesvoll. 1973. Chlorhexidine-protein interactions. J. Periodontal Res. 8:11-16.
14. Ingman, T., T. Sorsa, O. Lindy, H. Koski, and Y. T. Konttinen. 1994. Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J. Clin. Periodontol. 21:26-31.
15. Ingman, T., T. Tervahartiala, Y. Ding, H. Tschesche, A. Haerian, D. F. Kinane, and Y. T. Konttinen. 1996. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J. Clin. Periodontol. 23:1127-1132.
16. Jolkovsky, D. L., M. Y. Waki, M. G. Newman, J. Otomo-Corgel, M. Madison, T. F. Flemming, S. Nachnani, and H. Nowzari. 1990. Clinical and microbiological effects of subgingival and gingival marginal irrigation with chlorhexidine gluconate. J. Periodontol. 61:663-669.
17. Konttinen, Y. T., O. Lindy, P. Kemppinen, H. Saari, K. Suomalainen, M. Vauhkonen, S. Lindy, and T. Sorsa. 1991. Collagenase reserves in polymorphonuclear neutrophil leukocytes from synovial fluid and peripheral blood of patients with rheumatoid arthritis. Matrix 11:296-301.
18. Kornman, K. S., R. C. Page, and M. S. Tonetti. 1997. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol. 2000 14:33-53.
19. Lee, W., S. Aitken, J. Sodek, and C. A. G. McCulloch. 1995. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: a role of active enzyme in human periodontitis. J. Periodontal Res. 30:23-33.
20. Löe, H., and C. R. Schiott. 1970. The effect of mouthrinses and topical applications of chlorhexidine on the development of dental plaque and gingivitis in man. J. Periodontal Res. 5:79-83.
21. Mäkela, M., T. Salo, V.-J. Uitto, and H. Larjava. 1994. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J. Dent. Res. 73:1387-1406.
22. McCulloch, C. A. G. 1994. Collagenolytic enzymes in gingival crevicular fluid as diagnostic indicators of periodontitis. Ann. N. Y. Acad. Sci. 732:152-164.
23. Rifkin, B. R., A. T. Vernillo, and L. M. Golub. 1993. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J. Periodontol. 64:819-827.
24. Sorsa, T., Y.-L. Ding, T. Ingman, T. Salo, U. Westerlund, M. Haapasalo, H. Tschesche, and Y. T. Konttinen. 1995. Cellular source, activation and inhibition of dental plaque collagenase. J. Clin. Periodontol. 22:709-717.
25. Sorsa, T., P. L. Lukinmaa, U. Westerlund, T. Ingman, Y. Ding, H. Tschesche, Y. T. Konttinen, T. Helaakoski, and T. Salo. 1996. The expression, activation and chemotherapeutic inhibition of matrix metalloproteinase-8 (neutrophil collagenase/collagenase-2) in inflammation, p. 317-323. In Z. Davidovitch and L., A. Norton (ed.), Biological mechanisms of tooth movement and craniofacial adaptation. Harvard Society for the Advancement of Orthodontics, Boston, Mass.
26. Southard, G. L., and K. C. Godowski. 1998. Subgingival controlled release of antimicrobial agents in the treatment of periodontal disease. Int. J. Antimicrob. Agents 9:239-253.
27. Stanley, A., M. Wilson, and H. N. Newman. 1989. The in vitro effects of chlorhexidine on subgingival plaque bacteria. J. Clin. Periodontol. 16:259-264.
28. Teronen, O., Y. T. Konttinen, C. Lindqvist, T. Salo, T. Ingman, A. Lauhio, Y. Ding, S. Santavirta, H. Valleala, and T. Sorsa. 1997. Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate). Calcif. Tissue Int. 61:59-61.
29. Teronen, O., Y. T. Konttinen, T. Salo, T. Ingman, A. Lauhio, Y. Ding, S. Santavirta, and T. Sorsa. 1997. Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate. J. Dent. Res. 76: 1529-1537.
30. Uitto, V.-J., H. Turio, A. Huttunen, S. Lindy, and J. Uitto. 1980. Activation of human leukocyte collagenase by compounds reacting with sulfhydryl groups. Biochim. Biophys. Acta 613:168-177.
31. Uitto, V.-J., K. Suomalainen, and T. Sorsa. 1990. Salivary collagenase: origin, characteristics and relationship to periodontal health. J. Periodontal Res. 25:135-142.
32. Van Wart, H. E., and H. Birkedal-Hansen. 1990. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc. Natl. Acad. Sci. USA 87:5578-5582.
33. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320: 365-376.
34. Wieder, S. G., H. N. Newman, and J. D. Strahan. 1983. Stannous fluoride and subgingival chlorhexidine irrigation in the control of plaque and chronic periodontitis. J. Clin. Periodontol. 10:172-181.