The role of matrix metalloproteinases (MMPs) in human caries

Journal of Dental Research

Volumn 85, Issue 1, 2006, Pages 22-32

  Chaussain Miller, C ^a,b   Fioretti, F ^b   Goldberg, M ^a   Menashi, S ^c  

^a France   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Université Paris Est Créteil   (France)

Author keywords

Caries; Dentin; Matrix metalloproteinases; MMP inhibitors; Saliva

Indexed keywords

GLYCOPROTEIN; LIGAND; MATRIX METALLOPROTEINASE; PROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE;

DENTAL CARIES; DENTIN; DISEASE COURSE; ENZYMOLOGY; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; PH; PHYSIOLOGY; REVIEW; SALIVA; TOOTH DISEASE;

DENTAL CARIES; DENTIN; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; GLYCOPROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; SALIVA; TISSUE INHIBITOR OF METALLOPROTEINASES; TOOTH DEMINERALIZATION;

EID: 33644989938     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910608500104     Document Type: Review

References (118)

1. Acharya MR, Venitz J, Figg WD, Sparreboom A (2004). Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist Updat 7:195-208.
2. Ahonen M, Ala-Aho R, Baker AH, George SJ, Grenman R, Saarialho-Kere U, et al. (2002). Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3. Mol Ther 5:705-715.
3. Anderson RS, Schwartz ER (1984). Phosphorylation of proteoglycans from human articular cartilage. Arthritis Rheum 27:58-71.
4. Armstrong WG (1958). Further studies on the action of collagenase on sound and carious human dentin. J Dent Res 37:1001-1015.
5. Baba O, Qin C, Brunn JC, Jones JE, Wygant JN, McIntyre BW, et al. (2004). Detection of dentin sialoprotein in rat periodontium. Eur J Oral Sci 112:163-170.
6. Baker AH, George SJ, Zaltsman AB, Murphy G, Newby AC (1999). Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. Br J Cancer 79:1347-1355.
7. Baker AH, Edwards DR, Murphy G (2002). Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115:3719-3727.
8. Bellahcene A, Merville MP, Castronovo V (1994). Expression of bone sialoprotein, a bone matrix protein, in human breast cancer. Cancer Res 54:2823-2826.
9. Bellahcene A, Antoine N, Clausse N, Tagliabue E, Fisher LW, Kerr JM, et al. (1996). Detection of bone sialoprotein in human breast cancer tissue and cell lines at both protein and messenger ribonucleic acid levels. Lab Invest 75:203-210.
10. Berton A, Rigot V, Huet E, Decarme M, Eeckhout Y, Patthy L, et al. (2001). Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids. J Biol Chem 276:20458-20465.
11. Birkedal-Hansen H (1993). Role of matrix metalloproteinases in human periodontal diseases. J Periodontol 64:474-484.
12. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, et al. (1993). Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4:197-250.
13. Bode W, Fernandez-Catalan C, Tschesche H, Grams F, Nagase H, Maskos K (1999). Structural properties of matrix metalloproteinases. Cell Mol Life Sci 55:639-652.
14. Boissier S, Ferreras M, Peyruchaud O, Magnetic S, Ebetino FH, Colombel M, et al (2000). Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res 60:2949-2954.
15. Bourd-Boittin K, Septier D, Hall R, Goldberg M, Menashi S (2004). Immunolocalization of enamelysin (matrix metalloproteinase-20) in the forming rat incisor. J Histochem Cytochem 52:437-445.
16. Bourd-Boittin K, Fridman R, Fanchon S, Septier D, Goldberg M, Menashi S (2005). Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development. Exp Cell Res 304:493-505.
17. Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA (2002). A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 87:161-167.
18. Brinckerhoff CE, Matrisian LM (2002). Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3:207-214.
19. Butler WT, Ritchie H (1995). The nature and functional significance of dentin extracellular matrix proteins. Int J Dev Biol 39:169-179.
20. Caron C, Xue J, Bartlett JD (1998). Expression and localization of membrane type 1 matrix metalloproteinase in tooth tissues. Matrix Biol 17:501-511.
21. Caron C, Xue J, Sun X, Simmer JP, Bartlett JD (2001). Gelatinase A (MMP-2) in developing tooth tissues and amelogenin hydrolysis. J Dent Res 80:1660-1664.
22. Caufield PW, Griffen AL (2000). Dental caries. An infectious and transmissible disease. Pediatr Clin North Am 47:1001-1019.
23. Davis GE (1991). Identification of an abundant latent 94-kDa gelatin-degrading metalloprotease in human saliva which is activated by acid exposure: implications for a role in digestion of collagenous proteins. Arch Biochem Biophys 286:551-554.
24. Dayan D, Binderman I, Mechanic GL (1983). A preliminary study of activation of collagenase in carious human dentine matrix. Arch Oral Biol 28:185-187.
25. Demeule M, Brossard M, Page M, Gingras D, Beliveau R (2000). Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta 1478:51-60.
26. Drouin L, Overall CM, Sodek J (1988). Identification of matrix metalloendo-proteinase inhibitor (TIMP) in human parotid and submandibular saliva: partial purification and characterization. J Periodontal Res 23:370-377.
27. Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, et al. (1996). Increased bone formation in osteocalcin-deficient mice. Nature 382:448-452.
28. Dumas J, Hurion N, Weill R, Keil B (1985). Collagenase in mineralized tissues of human teeth. FEBS Lett 187:51-55.
29. Dung SZ, Gregory RL, Li Y, Stookey GK (1995). Effect of lactic acid and proteolytic enzymes on the release of organic matrix components from human root dentin. Caries Res 29:483-489.
30. Ekstrand KR, Ricketts DN, Kidd EA (2001). Occlusal caries: pathology, diagnosis and logical management. Dent Update 28:380-387.
31. Eley BM, Cox SW (1992). Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: correlation with clinical parameters in untreated chronic periodontitis patients. J Periodontal Res 27:62-69.
32. Embery G, Hall R, Waddington R, Septier D, Goldberg M (2001). Proteoglycans in dentinogenesis. Crit Rev Oral Biol Med 12:331-349.
33. Evans JD, Stark A, Johnson CD, Daniel F, Carmichael J, Buckels J, et al. (2001). A phase II trial of marimastat in advanced pancreatic cancer. Br J Cancer 85:1865-1870.
34. Fanchon S, Bourd K, Septier D, Everts V, Beertsen W, Menashi S, et al. (2004). Involvement of matrix metalloproteinases in the onset of dentin mineralization. Eur J Oral Sci 112:171-176.
35. Farges JC, Romeas A, Melin M, Pin JJ, Lebecque S, Lucchini M, et al. (2003). TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. J Dent Res 82:652-656.
36. Featherstone JD (2004). The continuum of dental caries-evidence for a dynamic disease process. J Dent Res 83(Spec Iss C):C39-C42.
37. Fedarko NS, Jain A, Karadag A, Van Eman MR, Fisher LW (2001). Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clin Cancer Res 7:4060-4066.
38. Fedarko NS, Jain A, Karadag A, Fisher LW (2004). Three small integrin binding ligand N-linked glycoproteins (SIBLINGS) bind and activate specific matrix metalloproteinases. FASEB J 18:734-736.
39. Fincham AG, Moradian-Oldak J, Simmer JP (1999). The structural biology of the developing dental enamel matrix. J Struct Biol 126:270-299.
40. Finkelman RD, Mohan S, Jennings JC, Taylor AK, Jepsen S, Baylink DJ (1990). Quantitation of growth factors IGF-I, SGF/IGF-II, and TGF-beta in human dentin. J Bone Miner Res 5:717-723.
41. Fisher LW, Fedarko NS (2003). Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res 44(Suppl 1):33-40.
42. Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R, Albini A (2001). Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91:822-832.
43. Gaultier F, Foucault-Bertaud A, Lamy E, Ejeil AL, Dridi SM, Piccardi N, et al. (2003). Effects of a vegetable extract from Lupinus albus (LU105) on the production of matrix metalloproteinases (MMP1, MMP2, MMP9) and tissue inhibitor of metalloproteinases (TIMP1, TIMP2) by human gingival fibroblasts in culture. Clin Oral Investig 7:198-205.
44. George SJ (2000). Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis. Expert Opin Investig Drugs 9:993-1007.
45. Goldberg M, Boskey AL (1996). Lipids and biomineralizations. Prog Histochem Cytochem 31:1-187.
46. Goldberg M, Keil B (1989). Action of a bacterial Achromobacter collagenase on the soft carious dentine: an in vitro study with the scanning electron microscope. J Biol Buccale 17:269-274.
47. Goldberg M, Septier D, Bourd K, Hall R, George A, Goldberg H, et al. (2003a). Immunohistochemical localization of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the forming rat incisor. Connect Tissue Res 44:143-153.
48. Goldberg M, Rapoport O, Septier D, Palmier K, Hall R, Embery G, et al. (2003b). Proteoglycans in predentin: the last 15 micrometers before mineralization. Connect Tissue Res 44(Suppl 1):184-188.
49. Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T (1998). Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 12:12-26.
50. Gunja-Smith Z, Woessner JF Jr (1993). Activation of cartilage stromelysin-1 at acid pH and its relation to enzyme pH optimum and osteoarthritis. Agents Actions 40:228-231.
51. Gupta SP, Maheswaran V, Pande V, Kumar D (2003). A comparative QSAR study on carbonic anhydrase and matrix metalloproteinase inhibition by sulfonylated amino acid hydroxamates. J Enzyme Inhib Med Chem 18:7-13.
52. Hall R, Septier D, Embery G, Goldberg M (1999). Stromelysin-1 (MMP-3) in forming enamel and predentine in rat incisor-coordinated distribution with proteoglycans suggests a functional role. Histochem J 31:761-770.
53. Heikinheimo K, SaIo T (1995). Expression of basement membrane type IV collagen and type IV collagenases (MMP-2 and MMP-9) in human fetal teeth. J Dent Res 74:1226-1234.
54. Henrotin YE, Sanchez C, Deberg MA, Piccardi N, Guillou GB, Msika P, et al. (2003). Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 30:1825-1834.
55. Huet E, Cauchard JH, Berton A, Robinet A, Decarme M, Hornebeck W, et al. (2004). Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5. Biochem Pharmacol 67:643-654.
56. Iijima K, Ando K, Kishi M, Nakashizuka T, Hayakawa T (1983). Collagenase activity in human saliva. J Dent Res 62:709-712.
57. Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT (1994). Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J Clin Periodontol 21:26-31.
58. Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane DF, et al. (1996). Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 23:1127-1132.
59. Karsdal MA, Larsen L, Engsig MT, Lou H, Ferreras M, Lochter A, et al. (2002). Matrix metalloproteinase-dependent activation of latent trans-forming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem 277:44061-44067.
60. Katz S, Park KK, Palenik CJ (1987). In-vitro root surface caries studies. J Oral Med 42:40-48.
61. Kawasaki K, Featherstone JD (1997). Effects of collagenase on root demineralization. J Dent Res 76:588-595.
62. Kinoshita Y (1979). Incorporation of serum albumin into the developing dentine and enamel matrix in the rabbit incisor. Calcif Tissue Int 29:41-46.
63. Kivela-Rajamaki M, Maisi P, Srinivas R, Tervahartiala T, Teronen O, Husa V, et al. (2003). Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid. J Periodontal Res 38:583-590.
64. Knott L, Bailey A (2000). Collagen cross-links in mineralized tissues: a role for the pyrrole cross-link. In: Chemistry and biology of mineralized tissues. Goldberg M, Boskey A, Robinson C, eds. Rosemont, IL: American Academy of Orthopaedic Surgeons, pp. 125-128.
65. Kut C, Assoumou A, Dridi M, Bonnefoix M, Gogly B, Pellat B, et al. (1998). Morphometric analysis of human gingival elastic fibres degradation by human leukocyte elastase protective effect of avocado and soybean unsaponifiables (ASU). Pathol Biol 46:571-576.
66. Lauhio A, Salo T, Tjäderhane L, Lahdevirta J, Golub LM, Sorsa T (1995). Tetracyclines in treatment of rheumatoid arthritis. Lancet 346:645-646.
67. Loesche WJ (1986). Role of Streptococcus mutans in human dental decay. Microbiol Rev 50:353-380.
68. Lynch CC, Matrisian LM (2002). Matrix metalloproteinases in tumor-host cell communication. Differentiation 70:561-573.
69. MacDougall M (1998). Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci. Eur J Oral Sci 106(Suppl 1):227-233.
70. MacDougall M, Gu TT, Simmons D (1996). Dentin matrix protein-1, a candidate gene for dentinogenesis imperfecta. Connect Tissue Res 35:267-272.
71. Makela M, Salo T, Uitto VJ, Larjava H (1994). Matrix metalloproteinases (MMP-2 and MMP-9) of die oral cavity: cellular origin and relationship to periodontal status. J Dent Res 73:1397-1406.
72. Marsh PD (1999). Microbiologic aspects of dental plaque and dental caries. Dent Clin North Am 43:599-614.
73. McCawley LJ, Matrisian LM (2001). Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol 13:534-540.
74. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, et al. (2002). The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-betal. J Cell Biol 157:493-507.
75. Mukhtar H, Ahmad N (1999). Green tea in chemoprevention of cancer. Toxicol Sci 52:111-117.
76. Munksgaard EC, Rhodes M, Mayne R, Butler WT (1978). Collagen synthesis and secretion by rat incisor odontoblasts in organ culture. Eur J Biochem 82:609-617.
77. Nagase H, Woessner JF Jr (1999). Matrix metalloproteinases. J Biol Chem 274:21491-21494.
78. NIH Consensus Statement on diagnosis and management of dental caries throughout life. Consensus Development Conference, 2001. http://consensus.nih. gOV/cons/115/115_statement.pdf
79. Nyvad B, Fejerskov O (1990). An ultrastructural study of bacterial invasion and tissue breakdown in human experimental root-surface caries. J Dent Res 69:1118-1125.
80. Ogbureke KU, Fisher LW (2004). Expression of SIBLINGS and their partner MMPs in salivary glands. J Dent Res 83:664-670.
81. Overall CM, Lopez-Otin C (2002). Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2:657-672.
82. Overall CM, McQuibban GA, Clark-Lewis I (2002). Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics. Biol Chem 383:1059-1066.
83. Palosaari H, Pennington CJ, Larmas M, Edwards DR, Tjäderhane L, Salo T (2003). Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue. Eur J Oral Sci 111:117-127.
84. Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, et al. (2002). The expression of dentin sialophosphoprotein gene in bone. J Dent Res 81:392-394.
85. Ramamurthy NS, Rifkin BR, Greenwald RA, Xu JW, Liu Y, Turner G, et al. (2002). Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. J Periodontal 73:726-734.
86. Randall LE, Hall RC (2002). Temperospatial expression of matrix metalloproteinases 1, 2, 3, and 9 during early tooth development. Connect Tissue Res 43:205-211.
87. Rasmussen HS, McCann PP (1997). Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Ther 75:69-75.
88. Rostand KS, Esko JD (1997). Microbial adherence to and invasion through proteoglycans. Infect Immun 65:1-8.
89. Ryan ME, Ramamurthy S, Golub LM (1996). Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontol 3:85-96.
90. Sadowski T, Dietrich S, Koschinsky F, Sedlacek R (2003). Matrix metalloproteinase 19 regulates insulin-like growth actor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth fector binding protein-3. Mol Biol Cell 14:4569-4580.
91. Sahlberg C, Reponen P, Tryggvason K, Thesleff I (1992). Association between the expression of murine 72 kDa type IV collagenase by odontoblasts and basement membrane degradation during mouse tooth development. Arch Oral Biol 37:1021-1030.
92. Sahlberg C, Reponen P, Tryggvason K, Thesleff I (1999). Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis. Eur J Oral Sci 107:121-130.
93. Sartor L, Pezzato E, Dell'Aica I, Caniato R, Biggin S, Garbisa S (2002). Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design. Biochem Pharmacol 64:229-237.
94. Schmidtchen A, Frick IM, Bjorck L (2001). Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial alpha-defensin. Mol Microbiol 39:708-713.
95. Schüpbach P, Guggenheim B, Lutz F (1989). Human root caries: histopathology of initial lesions in cementum and dentin. J Oral Pathol Med 18:146-156.
96. Smith AJ, Wade W, Addy M, Embery G (1997). The relationship between microbial factors and gingival crevicular fluid glycosaminoglycans in human adult periodontitis. Arch Oral Biol 42:89-92.
97. Sognnaes RF (1965). Introduction to the problem of caries. Ann NY Acad Sci 131:687-689.
98. Song SE, Choi BK, Kim SN, Yoo YJ, Kim MM, Park SK, et al. (2003). Inhibitory effect of procyanidin oligomer from elm cortex on the matrix metalloproteinases and proteases of periodontopathogens. J Periodontal Res 38:282-289.
99. Sorsa T, Suomalainen K, Uitto VJ (1990). The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal diseases. Arch Oral Biol 35(Suppl):193S-196S.
100. Strand S, Vollmer P, van den Abeelen L, Gottfried D, Alla V, Heid H, et al. (2004). Cleavage of CD95 by matrix metalloproteinase-7 induces apoptosis resistance in tumour cells. Oncogens 23:3732-3736.
101. Sulkala M, Wahlgren J, Larmas M, Sorsa T, Teronen O, Salo T, et al. (2001). The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats. J Dent Res 80:1545-1549.
102. Sulkala M, Larmas M, Sorsa T, Salo T, Tjäderhane L (2002). The localization of matrix metalloproteinase-20 (MMP-20, enamelysin) in mature human teeth. J Dent Res 81:603-607.
103. Takagi Y, Shimokawa H, Suzuki M, Nagai H, Sasaki S (1990). Immunohistochemical localization of alpha 2HS glycoprotein in dentin. Calcif Tissue Int 47:40-45.
104. Tanzer JM, Livingston J, Thompson AM (2001). The microbiology of primary dental caries in humans. J Dent Educ 65:1028-1037.
105. Teng YT, Sodek J, McCulloch CA (1992). Gingival crevicular fluid gelatinase and its relationship to periodontal disease in human subjects. J Periodontal Res 27:544-552.
106. Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T (1998). The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 77:1622-1629.
107. Tjäderhane L, Sulkala M, Sorsa T, Teronen O, Larmas M, Salo T (1999). The effect of MMP inhibitor metastat on fissure caries progression in rats. Am NY Acad Sci 878:686-688.
108. Uitto VJ, Suomalainen K, Sorsa T (1990). Salivary collagenase. Origin, characteristics and relationship to periodontal health. J Periodontal Res 25:135-142.
109. van Strijp AJ, van Steenbergen TJ, de Graaff J, ten Cate JM (1994). Bacterial colonization and degradation of demineralized dentin matrix in situ. Caries Res 28:21-27.
110. van Strijp AJ, van Steenbergen TJ, ten Cate JM (1997). Bacterial colonization of mineralized and completely demineralized dentine in situ. Caries Res 31:349-355.
111. van Strijp AJ, Jansen DC, DeGroot J, ten Cate JM, Everts V (2003). Host-derived proteinases and degradation of dentine collagen in situ. Caries Res 37:58-65.
112. Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, et al. (2000). Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 275:41263-41272.
113. Visse R, Nagase H (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92:827-839.
114. Waltimo J, Risteli L, Risteli J, Lukinmaa PL (1994). Altered collagen expression in human dentin: increased reactivity of type III and presence of type VI in dentinogenesis imperfecta, as revealed by immunoelectron microscopy. J Histochem Cytochem 42:1593-1601.
115. Waltregny D, Bellahcene A, Van Riet I, Fisher LW, Young M, Fernandez P, et al. (1998). Prognostic value of bone sialoprotein expression in clinically localized human prostate cancer. J Natl Cancer Inst 90:1000-1008.
116. Wojtowicz-Praga SM, Dickson RB, Hawkins MJ (1997). Matrix metalloproteinase inhibitors. Invest New Drugs 15:61-75.
117. Wu AJ, Lafrenie RM, Park C, Apinhasmit W, Chen ZJ, Birkedal-Hansen H, et al. (1997). Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line. J Cell Physiol 171:117-124.
118. Yu WH, Yu S, Meng Q, Brew K, Woessner JF Jr (2000). TIMP-3 binds to sulfated glycosaminoglycans of the extracellular matrix. J Biol Chem 275:31226-31232.