MMP inhibition in abdominal aortic aneurysms: Rationale for a prospective randomized clinical trial

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 159-178

  Thompson, Robert W ^a   Baxter, B Timothy ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE A; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; TETRACYCLINE DERIVATIVE;

ABDOMINAL AORTA ANEURYSM; ADULT; AGED; ANEURYSM SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ANIMALIA;

EID: 0032864506     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07682.x     Document Type: Conference Paper

References (83)

1. 1. Grange, J.J., V. Davis & B.T. Baxter. 1997. Pathogenesis of abdominal aortic aneurysm: update and look toward the future. Cardiovasc. Surg. 5: 256-265.
2. 2. Thompson, R.W. 1996. Basic science of abdominal aortic aneurysms: Emerging therapeutic strategies for an unresolved clinical problem. Curr. Opin. Cardiol. 11: 504-518.
3. 3. Bernstein, E.F., R.B. Dilley, L.E. Goldberger, B.B. Gosink & G.R. Leopold. 1976. Growth rates of small abdominal aortic aneurysms. Surgery 80: 765-773.
4. 4. Kremer, H., B. Weigold, W. Dobrinski, M.A. Schreiber & N. Zollner. 1984. Sonographische verlaufsbeobachtungen von bauchaortenaneurysmen. Klin. Wochenschr. 62: 1120-1125.
5. 5. Bernstein, E.F. & E.L. Chan. 1984. Abdominal aortic aneurysm in high-risk patients. Ann. Surg. 200: 255-263.
6. 6. Cronenwett, J.L., T.F. Murphy & G.B. Zelenock. 1985. Actuarial analysis of variables associated with the rupture of small abdominal aortic aneurysms. Surgery 98: 472-483.
7. 7. Delin, A., H. Ohlsen & J. Swedenborg. 1985. Growth rate of abdominal aortic aneurysms as measured by computed tomography. Br. J. Surg. 72: 530-532.
8. 8. Sterpetti, A.V., R.V. Schultz, R.J. Feldhaus, S.E. Cheng & D.J. Peetz. 1987. Factors influencing enlargement rate of small abdominal aortic aneurysms. J. Surg. Res. 43: 211-219.
9. 9. Nevitt, M.P., D.J. Ballard & J.W. Hallett. 1989. Prognosis of abdominal aortic aneurysms. N. Engl. J. Med. 321: 1009-1014.
10. 10. Limet, R., N. Sakalihassan & A. Albert. 1991. Determination of the expansion rate and incidence of rupture of abdominal aortic aneurysms. J. Vasc. Surg. 14: 540-548.
11. 11. Wilson, K.A., K.R. Woodburn, C.V. Ruckley & F.G.R. Fowkes. 1997. Expansion rates of abdominal aortic aneurysms: Current limitations in evaluation. Eur. J. Vasc. Endovasc. Surg. 13: 521-526.
12. 12. Hollier, L.H., L.M. Taylor & J. Ochsner. 1992. Recommended indications for operative treatment of abdominal aortic aneurysms. J. Vasc. Surg. 15: 1046-1056.
13. 13. Cole, C.W., G.B. Hill, J. Lindsay, W.P. Mickelson, C. Mills & D.T. Wigle. 1994. Proceedings of the workshop on the control of abdominal aortic aneurysm. Chronic Dis. Canada Suppl. 15: S1-S64.
14. 14. Alcorn, H.G., S.K. Wolfson, K. Sutton-Tyrrell, L.H. Kuller & D. O'Leary. 1996. Risk factors for abdominal aortic aneurysms in older adults enrolled in the Cardiovascular Health Study. Arterioscler. Thromb. Vasc. Biol. 16: 963-970.
15. 15. Lederle, F.A., G.R. Johnson, S.E. Wilson, E.P. Chute, F.N. Littooy, D. Bandyk, W.C. Krupski, G.W. Barone, C.W. Acher & D.J. Ballard (for the Aneurysm Detection and Management [ADAM] Veterans Affairs Cooperative Study Group). 1997. Prevalence and associations of abdominal aortic aneurysm detected through screening. Ann. Intern. Med. 126: 441-449.
16. 16. U.S. BUREAU OF THE CENSUS. 1996. Current Population Reports: P25-1130.
17. 17. Collin, J., L. Arauio & J. Walton. 1990. A community detection program for abdominal aortic aneurysm. Angiology 41: 53-58.
18. 18. Katz, D.A., B. Littenberg & J.L. Cronenwett. 1992. Management of small abdominal aortic aneurysms: early surgery vs. watchful waiting. JAMA 268: 2678-2686.
19. 19. Katz, D.A. & J.L. Cronenwett. 1994. The cost-effectiveness of early surgery versus watchful waiting in the management of small abdominal aortic aneurysms. J. Vasc. Surg. 19: 980-991.
20. 20. Small Aneurysm Trial Participants. 1995. The U.K. Small aneurysm trial: design, methods and progress. Eur. J. Vasc. Endovasc. Surg. 9: 42-48.
21. 21. Shah, P.K. 1997. Inflammation, metalloproteinases, and increased proteolysis: an emerging paradigm in aortic aneurysm. Circulation 96: 2115-2117.
22. 22. Pearce, W.H. & A.E. Koch. 1996. Cellular components and features of immune response in abdominal aortic aneurysms. Ann. N. Y. Acad. Sci. 800: 175-185.
23. 23. Brophy, C.M., J.M. Reilly, G.J.W. Smith & M.D. Tilson. 1991. The role of inflammation in nonspecific abdominal aortic aneurysm disease. Ann. Vasc. Surg. 5: 229-233.
24. 24. Zatina, M.A., C.K. Zarins, B.L. Gewertz & S. Glagov. 1984. Role of medial lamellar architecture in the pathogenesis of aneurysms. J. Vasc. Surg. 1: 442-448.
25. 25. Dobrin, P.B., W.H. Baker & W.C. Gley. 1984. Elastolytic and collagenolytic studies of arteries: Implications for the mechanical properties of aneurysms. Arch. Surg. 119: 405-409.
26. 26. Campa, J.S., R.M. Greenhalgh & J.T. Powell. 1987. Elastin degradation in abdominal aortic aneurysms. Atherosclerosis 65: 13-21.
27. 27. Baxter, B.T., G.S. McGee, V.P. Shively, I.A. Drummond, S.N. Dixit, M. Yamauchi & W.H. Pearce. 1992. Elastin content, cross-links, and mRNA in normal and aneurysmal human aorta. J. Vasc. Surg. 16: 192-200.
28. 28. White, J.V., K. Haas, S. Phillips & A.J. Comerota. 1993. Adventitial elastolysis is a primary event in aneurysm formation. J. Vasc. Surg. 17: 371-381.
29. 29. Chang, M.H. & M.R. Roach. 1994. The composition and mechanical properties of abdominal aortic aneurysms. J. Vasc. Surg. 20: 6-13.
30. 30. Dobrin, P.B. & R. Mrkvicka. 1994. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc. Surg. 2: 484-488.
31. 31. White, J.V. & S.D. Scovell. 1999. Etiology of abdominal aortic aneurysms: the structural basis for aneurysm formation. In Diagnosis and Treatment of Aortic and Peripheral Arterial Aneurysms. K.D. Calligaro, M.J. Dougherty & L.H. Hollier, Eds.: 3-12. W. B. Saunders, Philadelphia, PA.
32. 32. Vine, N. & J.T. Powell. 1991. Metalloproteinases in degenerative aortic disease. Clin. Sci. 81: 233-239.
33. 33. Herron, G.S., E. Unemori, M. Wong, J.H. Rapp, M.H. Hibbs & R.J. Stoney. 1991. Connective tissue proteinases and inhibitors in abdominal aortic aneurysms: Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms. Arterioscler. Thromb. 11: 1667-1677.
34. 34. Reilly, J.M., C.M. Brophy & M.D. Tilson. 1992. Characterization of an elastase from aneurysmal aorta which degrades intact aortic elastin. Ann. Vasc. Surg. 6: 499-502.
35. 35. Irizarry, E., K.M. Newman, R.H. Gandhi, G.B. Nackman, V. Halpern, S. Wishner, J.V. Scholes & M.D. Tilson. 1993. Demonstration of interstitial collagenase in abdominal aortic aneurysm disease. J. Surg. Res. 54: 571-574.
36. 36. Newman, K.M., A.M. Malon, R.D. Shin, J.V. Scholes, W.G. Ramey & M.D. Tilson. 1994. Matrix metalloproteinases in abdominal aortic aneurysm: Characterization, purification, and their possible sources. Conn. Tiss. Res. 30: 265-276.
37. 37. Newman, K.M., Y. Ogata, A.M. Malon, E. Irizarry, R.H. Gandhi, H. Nagase & M.D. Tilson. Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arterioscler. Thromb. 14: 1315-1320.
38. 38. Thompson, R.W., D.R. Holmes, R.A. Mertens, S. Liao, M.D. Botney, R.P. Mecham, H.G. Welgus & W.C. Parks. 1995. Production and localization of 92-kD gelatinase in abdominal aortic aneurysms: an elastolylic metalloproteinase expressed by aneurysm-infiltrating macrophages. J. Clin. Invest. 96: 318-326.
39. 39. McMillan, W.D., B.K. Patterson, R.R. Keen, V.P. Shively, M. Cipollone & W.H. Pearce. 1995. In situ localization and quantification of mRNA for 92-kD type IV collagenase and its inhibitor in aneurysmal, occlusive, and normal aorta. Arterioscler. Thromb. Vasc. Biol. 15: 1139-1144.
40. 40. Freestone, T., R.J. Turner, A. Coady, D.J. Higman, R.M. Greenhalgh & J.T. Powell. 1995. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 15: 1145-1151.
41. 41. McMillan, W.D., B.K. Patterson, R.R. Keen & W.H. Pearce. 1995. In situ localization and quantification of seventy-two-kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta. J. Vasc. Surg. 22: 295-305.
42. 42. Patel, M.I., J. Melrose, P. Ghosh & M. Appleberg. 1996. Increased synthesis of matrix metalloproteinases by aortic smooth muscle cells is implicated in the etiopathogenesis of abdominal aortic aneurysms. J. Vasc. Surg. 24: 82-92.
43. 43. Thompson, R.W. & W.C. Parks. 1996. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann. N.Y. Acad. Sci. 800: 157-174.
44. 44. Tamarina, N.A., W.D. McMillan, V.P. Shively & W.H. Pearce. 1997. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery 122: 264-271.
45. 45. Elmore, J.R., B.F. Keister, D.P. Franklin, J.R. Youkey & D.J. Carey. 1998. Expression of matrix metalloproteinases and TIMPs in human abdominal aortic aneurysms. Ann. Vasc. Surg. 12: 221-228.
46. 46. Davis, V., R. Persidskaia, L. Baca-Regen, Y. Itoh, H. Nagase, Y. Persidsky, A. Ghorpade & B.T. Baxter. 1998. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 18: 1625-1633.
47. 47. Curci, J.A., S. Liao, M.D. Huffman, S.D. Shapiro & R.W. Thompson. 1998. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102: 1900-1910.
48. 48. Lee, E., A.J. Grodzinsky, P. Libby, S.K. Clinton, M.W. Lark & R.T. Lee. 1995. Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture. Arterioscler. Thromb. 15: 2284-2289.
49. 49. Anidjar, S., J.L. Salzmann, D. Gentric, P. Lagneau, J.P. Camilleri & J.B. Michel. 1990. Elastase induced experimental aneurysms in rats. Circulation 82: 973-981.
50. 50. Anidjar, S., P.B. Dobrin, M. Eichorst, G.P. Graham & G. Chejfec. 1992. Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysm. J. Vasc. Surg. 16: 139-147.
51. 51. Gadowski, G.R., M.A. Ricci, E.D. Hendley & D.B. Pilcher. 1993. Hypertension accelerates the growth of experimental aortic aneurysms. J. Surg. Res. 54: 431-436.
52. 52. Gadowski, G.R., D.B. Pilcher & M.A. Ricci. 1994. Abdominal aortic aneurysm expansion rate: effect of size and beta-adrenergic blockade. J. Vasc. Surg. 19: 727-731.
53. 53. Halpern, V.J., G.B. Nackman, R.H. Gandhi, E. Irizarry, J.V. Scholes, W.G. Ramey & M.D. Tilson. 1994. The elastase infusion model of experimental aortic aneurysms: synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response. J. Vasc. Surg. 20: 51-60.
54. 54. Thompson, R.W., S. Liao, D. Petrinec, D.R. Holmes, J.M. Reilly, H.G. Welgus & W.C. Parks. 1995. Sequential expression of metallogelatinases during elastase-induced aneurysmal degeneration of the rat aorta: correlations with aortic dilatation and the destruction of medial elastin (abstract). FASEB Journal 9: A967.
55. 55. Ricci, M.A., G. Strindberg, J.M. Slaiby, R. Guibord, L.J. Bergersen, P. Nichols, E.D. Hendley & D.B. Pilcher. 1996. Anti-CD 18 monoclonal antibody slows experimental aortic aneurysm expansion. J. Vasc. Surg. 23: 301-307.
56. 56. Dobrin, P.B., N. Baumgartner, S. Anidjar, G. Chejfec & R. Mrkvicka. 1996. Inflammatory aspects of experimental aneurysms: effect of methylprednisolone and cyclosporin. Ann. N. Y. Acad. Sci. 800: 74-88.
57. 57. Holmes, D.R., D. Petrinec, W. Wester, R.W. Thompson & J.M. Reilly. 1996. Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat. J. Surg. Res. 63: 305-309.
58. 58. Petrinec, D., S. Liao, D.R. Holmes, J.M. Reilly, W.C. Parks & R.W. Thompson. 1996. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92-kD gelatinase. J. Vasc. Surg. 23: 336-346.
59. 59. Hingorani, A., E. Ascher, M. Scheinman, W. Yorkovich, P. Depippo, C.T. Ladoulis & S. Salles-Cunha. 1998. The effect of tumor necrosis factor binding protein and interleukin-1 receptor antagonist on the development of abdominal aortic aneurysms in a rat model. J. Vasc. Surg. 28: 522-526.
60. 60. Bigatel, D.A., J.R. Elmore, D.J. Carey, G. Cizmeci-Smith, D.P. Franklin & J.R. Youkey. 1999. The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. J. Vasc. Surg. 29: 130-138.
61. 61. Curci, J.A., D. Petrinec, S. Liao, L.M. Golub & R.W. Thompson. 1998. Pharmacologic suppression of experimental abdominal aortic aneurysms: a comparison of doxycycline and four chemically-modified tetracyclines. J. Vasc. Surg. 28: 1082-1093.
62. 62. Moore, G., S. Liao, J.A. Curci, B.C. Starcher, R.L. Martin, R.T. Hendricks, J.J. Chen & R.W. Thompson. 1999. Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908). J. Vasc. Surg. 29: 522-532.
63. 63. Miralles, M., W.N. Wester, G.A. Sicard, R.W. Thompson & J.M. Reilly. 1998. Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the COX2 isoform of cyclooxygenase. J. Vasc. Surg. In press.
64. 64. Pentland, A.P., S.D. Shapiro & H.G. Welgus. 1995. Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis. J. Invest. Dermatol. 104: 52-57.
65. 65. Golub, L.M., H.M. Lee, G. Lehrer, A. Nemiroff, T.F. Mcnamara, R. Kaplan & N.S. Ramamurthy. 1983. Minocycline reduces gingival collagenolytic activity during diabetes: Preliminary observations and a proposed new mechanism of action. J. Periodont. Res. 18: 516-526.
66. 66. Golub, L.M., T.F. Mcnamara, G.D'Angelo, R.A. Greenwald & N.S. Ramamurthy. 1987. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J. Dent. Res. 66: 1310-1314.
67. 67. Greenwald, R.A., L.M. Golub, N.S. Ramamurthy, M. Chowdhury, S.A. Moak & T. Sorsa. 1998. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: Relationship to bone and cartilage degradation. Bone 22: 33-38.
68. 68. Ryan, M.E., N.S. Ramamurthy & L.M. Golub. 1996. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr. Opin. Periodontol. 3: 85-96.
69. 69. Gearing, A.J., P. Beckett, M. Christodoulou, M. Churchill, J.M. Clements, M. Crimmin, A.H. Davidson, A.H. Drummond, W.A. Galloway & R. Gilbert. 1995. Matrix metalloproteinases and processing of pro-TNF-alpha. J. Leuk. Biol. 57: 774-777.
70. 70. Brown, P.D. 1998. Synthetic inhibitors of matrix metalloproteinases. In Matrix Metalloproteinases. W. C. Parks & R. P. Mecham, Eds. :243-261. Academic Press. San Diego, CA.
71. 71. Crout, R.J., H.M. Lee, K. Schroeder, H. Crout, N.S. Ramamurthy, M. Wiener & L.M. Golub. 1996. The "cyclic" regimen of low-dose doxycycline for adult periodontitis: a preliminary study. J Periodontol. 67: 506-514.
72. 72. Amin, A.R., M.G. Attur, G.D. Thakker, P.D. Patel, P.R. Vyas, R.N. Patel, I.R. Patel & S.B. Abramson. 1996. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc. Natl. Acad. Sci. USA 93: 14014-14019.
73. 73. Amin, A.R., R.N. Patel, G.D. Thakker, C.J. Lowenstein, M.G. Attur & S.B. Abramson. 1997. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett. 410: 259-264.
74. 74. D'Agostino, P., F. Arcoleo, C. Barbera, G. Di Bella, M. La Rosa, G. Misiano, S. Milano, M. Brai, G. Cammarata, S. Feo & E. Cillari. 1998. Tetracycline inhibits the nitric oxide synthase activity induced by endotoxin in cultured murine macrophages. Eur. J. Pharmacol. 346: 283-290.
75. 75. Rajagopalan, S., X.P. Meng, S. Ramasamy, D.G. Harrison & Z.S. Galis. 1996. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro: implications for atherosclerotic plaque stability. J. Clin. Invest. 98: 2572-2579.
76. 76. Uitto, V.J., J.D. Firth, L. Nip & L.M. Golub. 1994. Doxycycline and chemically modified tetracyclines inhibit gelatinase A (MMP-2) gene expression in human skin keratinocytes. Ann. N. Y. Acad. Sci. 732: 140-151.
77. 77. Hanemaauer, R., T. Sorsa, Y.T. Konttinen, Y. Ding, M. Sutinen, H. Visser, V.W. Van Hinsbergh, T. Helaakoski, T. Kainulainen, H. Ronka, H. Tschesche & T. Salo. 1997. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J. Biol. Chem. 272: 31504-31509.
78. 78. Jonat, C., F.Z. Chung, & V.M. Baragi. 1996. Transcriptional downregulation of stromelysin by tetracycline. J. Cell Biochem. 60: 341-347.
79. 79. Thompson, R.W., S. Liao & J.A. Curci. 1998. Therapeutic potential of tetracycline derivatives to suppress the growth of abdominal aortic aneurysms. Adv. Dent. Res. 12: 159-165.
80. 80. Hak, E., R. Balm, B.C. Eikelboom, G.J.M. Akkersdijk & Y. Van Der Graaf. 1996. Abdominal aortic aneurysm screening: an epidemiological point of view. Eur. J. Vasc. Endovasc. Surg. 11: 270-278.
81. 81. McMillan, W.D. & W.H. Pearce. 1999. Increased plasma levels of metalloproteinase-9 are associated with abdominal aortic aneurysms. J. Vasc. Surg. 29: 122-127.
82. 82. Juvonen, J., H.M. Surcel, J. Satta, A.M. Teppo, A. Bloigu, H. Syrjala, J. Airaksinen, M. Leinonen, P. Saikku & T. Juvonen. 1997. Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm. Arterioscler. Thromb. Vasc. Biol. 17: 2843-2847.
83. 83. Satta, J., T. Juvonen, K. Haukipuro, M. Juvonen & M.I. Kairaluoma. 1995. Increased turnover of collagen in abdominal aortic aneurysms, demonstrated by measuring the concentration of the aminoterminal propeptide of type III procollagen in peripheral and aortal blood samples. J. Vasc. Surg. 22: 155-160.