IPSCs and small molecules: A reciprocal effort towards better approaches for drug discovery

Acta Pharmacologica Sinica

Volumn 34, Issue 6, 2013, Pages 765-776

  Zhang, Ru ^a   Zhang, Li Hong ^b   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

cell replacement therapy; disease modeling; drug development; drug screening; induced pluripotent stem cells (iPSCs); small molecules; toxicity evaluation

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALPHA SYNUCLEIN; BONE MORPHOGENETIC PROTEIN 4; CELL NUCLEUS RECEPTOR; CYCLIN DEPENDENT KINASE; GLUCOCORTICOID; LEUCINE RICH REPEAT KINASE 2; METHYL CPG BINDING PROTEIN 2; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCOUPLING PROTEIN 2;

AMYOTROPHIC LATERAL SCLEROSIS; ANAEROBIC GLYCOLYSIS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; DNA DAMAGE; DNA METHYLATION; DOPAMINERGIC NERVE CELL; DRUG DEVELOPMENT; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; DYSAUTONOMIA; ENVIRONMENTAL STRESS; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GLYCOLYSIS; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTELORISM; HYPERTROPHIC CARDIOMYOPATHY; LONG QT SYNDROME; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PLURIPOTENT STEM CELL; PULMONARY VALVE STENOSIS; RETT SYNDROME; REVIEW; SHORT QT SYNDROME; SPINAL MUSCULAR ATROPHY; SUDDEN CARDIAC DEATH;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG DISCOVERY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, BIOLOGICAL; SMALL MOLECULE LIBRARIES;

EID: 84881421194     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.21     Document Type: Review

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