Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Cheng, Li Tao ^a,b   Nagata, Shogo ^a,c   Hirano, Kunio ^a   Yamaguchi, Shinpei ^a,c   Horie, Shigeo ^d   Ainscough, Justin ^e   Tada, Takashi ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TEIKYO UNIVERSITY   (Japan)

^e UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CHROMOSOME; CONTROLLED STUDY; DNA REPAIR; GENE DELETION; GENE FREQUENCY; GENE MUTATION; GENE PRODUCT; GENETIC RECOMBINATION; GENOTYPE; HETEROZYGOSITY; KIDNEY POLYCYSTIC DISEASE; MALE; MOUSE; NONHUMAN; PKD1 GENE; PLURIPOTENT STEM CELL; SOUTHERN BLOTTING; WILD TYPE; ANIMAL; CHIMERA; GENETICS; MUTATION; TREATMENT OUTCOME;

POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN;

ANIMALS; CELL TRANSPLANTATION; CHIMERA; DNA REPAIR; INDUCED PLURIPOTENT STEM CELLS; MICE; MUTATION; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; RECOMBINATION, GENETIC; TREATMENT OUTCOME; TRPP CATION CHANNELS;

EID: 84856805369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032018     Document Type: Article

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