Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells

Cell Research

Volumn 21, Issue 10, 2011, Pages 1424-1435

  Wang, Quan ^a   Xu, Xinxiu ^b   Li, Jun ^c   Liu, Jing ^d   Gu, Haifeng ^a   Zhang, Ru ^b   Chen, Jiekai ^d   Kuang, Yin ^e   Fei, Jian ^e   Jiang, Cong ^f   Wang, Ping ^f   Pei, Duanqing ^d   Ding, Sheng ^c   Xie, Xin ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b TONGJI UNIVERSITY   (China)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e Shanghai Research Center for Biomodel Organism   (China)

^f EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

GSK3 ; histone demethylase; induced pluripotent stem cells; iPS; lithium; LSD1; Nanog

Indexed keywords

AOF2 PROTEIN, MOUSE; HISTONE DEMETHYLASE; HOMEODOMAIN PROTEIN; KDM1A PROTEIN, HUMAN; LITHIUM; N DEMETHYLASE; NANOG PROTEIN, HUMAN; NANOG PROTEIN, MOUSE; NEUROLEPTIC AGENT;

ANIMAL; ANIMAL EMBRYO; ARTICLE; CELL CULTURE; CELL DEDIFFERENTIATION; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; FIBROBLAST; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PLURIPOTENT STEM CELL; TRANSGENIC MOUSE; UMBILICAL VEIN;

ANIMALS; ANTIPSYCHOTIC AGENTS; CELL DEDIFFERENTIATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; ENDOTHELIAL CELLS; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HISTONE DEMETHYLASES; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LITHIUM; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; OXIDOREDUCTASES, N-DEMETHYLATING; UMBILICAL VEINS;

IPS;

EID: 80053633785     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.108     Document Type: Article

References (34)

1. Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature 2007;448:313-317. (Pubitemid 47080336)
2. Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920.
3. Zhao XY, Li W, Lv Z, et al. iPS cells produce viable mice through tetraploid complementation. Nature 2009;461:86-90.
4. Kim JB, Sebastiano V, Wu G, et al. Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136:411-419.
5. Gonzalez F, Barragan Monasterio M, Tiscornia G, et al. Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci USA 2009;106:8918-8922.
6. Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009;4:472-476.
7. Li W, Ding S. Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci 2010;31:36-45.
8. Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010;6:71-79.
9. Young W. Review of lithium effects on brain and blood. Cell Transplant 2009;18:951-975.
10. Silva AK, Yi H, Hayes SH, Seigel GM, Hackam AS. Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway. Mol Vis 2010;16:36-45.
11. Garcia-Gonzalo FR, Izpisua Belmonte JC. Albumin-associated lipids regulate human embryonic stem cell self-renewal. PLoS One 2008;3:e1384.
12. Chen J, Liu J, Han Q, et al. Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem 2010;285:31066-31072.
13. Zhu S, Li W, Zhou H, et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010;7:651-655.
14. Li Y, Zhang Q, Yin X, et al. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res 2011;21:196-204.
15. Chen J, Liu J, Yang J, et al. BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res 2011;21:205-212.
16. Jope RS. Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci 2003;24:441-443. (Pubitemid 37088166)
17. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10:55-63. (Pubitemid 38524699)
18. Silva J, Barrandon O, Nichols J, Kawaguchi J, Theunissen TW, Smith A. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 2008;6:e253.
19. Wu D, Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci 2010;35:161-168.
20. Harwood AJ. Lithium and bipolar mood disorder: the inositoldepletion hypothesis revisited. Mol Psychiatry 2005;10:117-126. (Pubitemid 40139592)
21. Chen RW, Chuang DM. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem 1999;274:6039-6042.
22. Kawamura T, Suzuki J, Wang YV, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009;460:1140-1144.
23. Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655. (Pubitemid 36694189)
24. Takao Y, Yokota T, Koide H. Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Biochem Biophys Res Commun 2007;353:699-705. (Pubitemid 46048726)
25. Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-956. (Pubitemid 41345211)
26. Pan G, Pei D. The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus. J Biol Chem 2005;280:1401-1407.
27. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem 2008;283:350-357.
28. Shi Y, Sawada J, Sui G, et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003;422:735-738. (Pubitemid 36514114)
29. You A, Tong JK, Grozinger CM, Schreiber SL. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc Natl Acad Sci USA 2001;98:1454-1458. (Pubitemid 32165520)
30. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R. A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci USA 2002;99:7420-7425. (Pubitemid 34568706)
31. Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004;119:941-953. (Pubitemid 40037608)
32. Gurvich N, Klein PS. Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol Ther 2002;96:45-66. (Pubitemid 35346617)
33. Pasquali L, Busceti CL, Fulceri F, Paparelli A, Fornai F. Intracellular pathways underlying the effects of lithium. Behav Pharmacol 2010;21:473-492.
34. Huangfu D, Maehr R, Guo W, et al. Induction of pluripotent stem cells by defined factors is greatly improved by smallmolecule compounds. Nat Biotechnol 2008;26:795-797. (Pubitemid 351961456)