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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4794-4798

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity

(9) Lange, Jos H M a Van Stuivenberg, Herman H a Veerman, Willem a Wals, Henri C a Stork, Bob a Coolen, Hein K A C a McCreary, Andrew C a Adolfs, Tiny J P a Kruse, Chris G a

a Solvay Pharmaceuticals Inc (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO N [[3 (4 CHLOROPHENYL) 4 PHENYL 2 PYRAZOLIN 1 YL](METHYLAMINO)METHYLENE]BENZENESULFONAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; PYRAZOLINE DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LIPOPHILICITY; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; X RAY DIFFRACTION;

CANNABINOIDS; HUMANS; HYDROPHOBICITY; MOLECULAR STRUCTURE; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; X-RAY DIFFRACTION;

EID: 25144449195 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.07.054 Document Type: Article

Times cited : (60)

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