Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5711-5714

  Fulp, Alan ^a   Bortoff, Katherine ^a   Zhang, Yanan ^a   Seltzman, Herbert ^a   Snyder, Rodney ^a   Maitra, Rangan ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

Antagonist; Cannabinoid; CB1; Peripheral; Topological polar surface area

Indexed keywords

AM 6545; CANNABINOID 1 RECEPTOR ANTAGONIST; RIMONABANT; SULFANILAMIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; URB 447;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN;

ANIMALS; CELL LINE; CHO CELLS; CRICETINAE; DOGS; DRUG DESIGN; DRUG DISCOVERY; ENDOCANNABINOIDS; LIGANDS; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; PIPERIDINES; PROTEIN BINDING; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 80052592403     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.032     Document Type: Article

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