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Volumn 217, Issue 2, 2011, Pages 432-438

Weight loss induced by rimonabant is associated with an altered leptin expression and hypothalamic leptin signaling in diet-induced obese mice

Author keywords

DIO mice; Food intake; Hypothalamus; Leptin; Rimonabant

Indexed keywords

AGOUTI RELATED PROTEIN; CANNABINOID 1 RECEPTOR; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; RIMONABANT;

EID: 78650420359     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.11.022     Document Type: Article
Times cited : (33)

References (52)
  • 1
    • 33747870163 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old
    • Adams K.F., Schatzkin A., Harris T.B., Kipnis V., Mouw T., Ballard-Barbash R., et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355:763-778.
    • (2006) N Engl J Med , vol.355 , pp. 763-778
    • Adams, K.F.1    Schatzkin, A.2    Harris, T.B.3    Kipnis, V.4    Mouw, T.5    Ballard-Barbash, R.6
  • 2
    • 0031016595 scopus 로고    scopus 로고
    • Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice
    • Ahren B., Simonsson E., Scheurink A.J., Mulder H., Myrsen U., Sundler F. Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice. Metabolism 1997, 46:97-106.
    • (1997) Metabolism , vol.46 , pp. 97-106
    • Ahren, B.1    Simonsson, E.2    Scheurink, A.J.3    Mulder, H.4    Myrsen, U.5    Sundler, F.6
  • 3
    • 58149214108 scopus 로고    scopus 로고
    • A critical review of the cannabinoid receptor as a drug target for obesity management
    • Akbas F., Gasteyger C., Sjodin A., Astrup A., Larsen T.M. A critical review of the cannabinoid receptor as a drug target for obesity management. Obes Rev 2009, 10:58-67.
    • (2009) Obes Rev , vol.10 , pp. 58-67
    • Akbas, F.1    Gasteyger, C.2    Sjodin, A.3    Astrup, A.4    Larsen, T.M.5
  • 4
    • 0037374766 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells
    • Bensaid M., Gary-Bobo M., Esclangon A., Maffrand J.P., Le Fur G., Oury-Donat F., et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 2003, 63:908-914.
    • (2003) Mol Pharmacol , vol.63 , pp. 908-914
    • Bensaid, M.1    Gary-Bobo, M.2    Esclangon, A.3    Maffrand, J.P.4    Le Fur, G.5    Oury-Donat, F.6
  • 5
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret S.G., Draper S.J., Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2003, 304:108-110.
    • (2003) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 7
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 0032541111 scopus 로고    scopus 로고
    • Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
    • Colombo G., Agabio R., Diaz G., Lobina C., Reali R., Gessa G.L. Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci 1998, 63:L113-117.
    • (1998) Life Sci , vol.63
    • Colombo, G.1    Agabio, R.2    Diaz, G.3    Lobina, C.4    Reali, R.5    Gessa, G.L.6
  • 10
    • 33646889517 scopus 로고    scopus 로고
    • Cannabinoids, opioids and eating behavior: the molecular face of hedonism?
    • Cota D., Tschop M.H., Horvath T.L., Levine A.S. Cannabinoids, opioids and eating behavior: the molecular face of hedonism?. Brain Res Rev 2006, 51:85-107.
    • (2006) Brain Res Rev , vol.51 , pp. 85-107
    • Cota, D.1    Tschop, M.H.2    Horvath, T.L.3    Levine, A.S.4
  • 11
    • 35548953757 scopus 로고    scopus 로고
    • CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health
    • Cota D. CB1 receptors: emerging evidence for central and peripheral mechanisms that regulate energy balance, metabolism, and cardiovascular health. Diabetes Metab Res Rev 2007, 23:507-517.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 507-517
    • Cota, D.1
  • 12
    • 43049094858 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in energy balance regulation and obesity
    • Cota D. Role of the endocannabinoid system in energy balance regulation and obesity. Front Horm Res 2008, 36:135-145.
    • (2008) Front Horm Res , vol.36 , pp. 135-145
    • Cota, D.1
  • 13
    • 67749101769 scopus 로고    scopus 로고
    • Food Intake-independent effects of CB1 antagonism on glucose and lipid metabolism
    • Cota D., Sandoval D.A., Olivieri M., Prodi E., D'Alessio D.A., Woods S.C., et al. Food Intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesità 2009, 17:1641-1645.
    • (2009) Obesità , vol.17 , pp. 1641-1645
    • Cota, D.1    Sandoval, D.A.2    Olivieri, M.3    Prodi, E.4    D'Alessio, D.A.5    Woods, S.C.6
  • 14
    • 27844463517 scopus 로고    scopus 로고
    • Effects of Rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Després J.P., Golay A., Sjostrom L. Effects of Rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005, 353:2121-2134.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Després, J.P.1    Golay, A.2    Sjostrom, L.3
  • 15
    • 61549116530 scopus 로고    scopus 로고
    • Lemieux I; ADAGIO-lipids investigators. Effect of rimonabant on the high-triglyceride/low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial
    • Després J.P., Ross R., Boka G., Alméras N. Lemieux I; ADAGIO-lipids investigators. Effect of rimonabant on the high-triglyceride/low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial. Arterioscler Thromb Vasc Biol 2009, 29:416-423.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 416-423
    • Després, J.P.1    Ross, R.2    Boka, G.3    Alméras, N.4
  • 16
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • Di Marzo V., Goparaju S.K., Wang L., Liu J., Batkai S., Jarai Z., et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001, 410:822-825.
    • (2001) Nature , vol.410 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3    Liu, J.4    Batkai, S.5    Jarai, Z.6
  • 17
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di Marzo V., Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005, 8:585-589.
    • (2005) Nat Neurosci , vol.8 , pp. 585-589
    • Di Marzo, V.1    Matias, I.2
  • 18
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: to enhance or reduce?
    • Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce?. Nat Rev Drug Discov 2008, 7:438-455.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di Marzo, V.1
  • 19
  • 20
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 21
    • 75949122654 scopus 로고    scopus 로고
    • Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant
    • Martín-García E., Burokas A., Martín M., Berrendero F., Rubí B., Kiesselbach C., et al. Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant. J Neurochem 2010, 112:1338-1351.
    • (2010) J Neurochem , vol.112 , pp. 1338-1351
    • Martín-García, E.1    Burokas, A.2    Martín, M.3    Berrendero, F.4    Rubí, B.5    Kiesselbach, C.6
  • 22
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese zucker fa/fa rats
    • Gary-Bobo M., Elachouri G., Gallas J.F., Janiak P., Marini P., Ravinet-Trillou C., et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese zucker fa/fa rats. Hepatology 2007, 46:122-129.
    • (2007) Hepatology , vol.46 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3    Janiak, P.4    Marini, P.5    Ravinet-Trillou, C.6
  • 23
    • 77952672353 scopus 로고    scopus 로고
    • The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant
    • Hansen H.H., Hansen G., Tang-Christensen M., Larsen P.J., Axel A.M., Raben A., et al. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol 2010, 636:88-95.
    • (2010) Eur J Pharmacol , vol.636 , pp. 88-95
    • Hansen, H.H.1    Hansen, G.2    Tang-Christensen, M.3    Larsen, P.J.4    Axel, A.M.5    Raben, A.6
  • 24
    • 27544511526 scopus 로고    scopus 로고
    • The neglected epidemic of chronic disease
    • Horton R. The neglected epidemic of chronic disease. Lancet 2005, 366:1514.
    • (2005) Lancet , vol.366 , pp. 1514
    • Horton, R.1
  • 25
    • 24644500204 scopus 로고    scopus 로고
    • The CB1 receptor antagonist Rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance
    • Jbilo O., Ravinet-Trillou C., Arnone M., Buisson I., Bribes E., Peleraux A., et al. The CB1 receptor antagonist Rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J 2005, 19:1567-1569.
    • (2005) FASEB J , vol.19 , pp. 1567-1569
    • Jbilo, O.1    Ravinet-Trillou, C.2    Arnone, M.3    Buisson, I.4    Bribes, E.5    Peleraux, A.6
  • 26
    • 0036293591 scopus 로고    scopus 로고
    • Leptin signaling, adiposity, and energy balance
    • Jequier E. Leptin signaling, adiposity, and energy balance. Ann NY Acad Sci 2002, 967:379-388.
    • (2002) Ann NY Acad Sci , vol.967 , pp. 379-388
    • Jequier, E.1
  • 27
    • 57049102251 scopus 로고    scopus 로고
    • End of the line for cannabinoid receptor 1 as an anti-obesity target?
    • Jones D. End of the line for cannabinoid receptor 1 as an anti-obesity target?. Nat Rev Drug Discov 2008, 7:961-962.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 961-962
    • Jones, D.1
  • 28
    • 77954694568 scopus 로고    scopus 로고
    • Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin
    • Jovanovic Z., Tung Y.C., Lam B.Y., O'Rahilly S., Yeo G.S. Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. J Neuroendocrinol 2010, 22:915-925.
    • (2010) J Neuroendocrinol , vol.22 , pp. 915-925
    • Jovanovic, Z.1    Tung, Y.C.2    Lam, B.Y.3    O'Rahilly, S.4    Yeo, G.S.5
  • 29
    • 0041859272 scopus 로고    scopus 로고
    • To eat or not to eat - how the gut talks to the brain
    • Korner J., Leibel R.L. To eat or not to eat - how the gut talks to the brain. N Engl J Med 2003, 349:926-928.
    • (2003) N Engl J Med , vol.349 , pp. 926-928
    • Korner, J.1    Leibel, R.L.2
  • 30
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
    • Lin S., Thomas T.C., Storlien L.H., Huang X.F. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 2000, 24:639-646.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 31
    • 33645517680 scopus 로고    scopus 로고
    • Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake
    • Matias I., Bisogno T., Di MarzoV. Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. Int J Obes 2006, 30:S7-S12.
    • (2006) Int J Obes , vol.30
    • Matias, I.1    Bisogno, T.2    Di, M.3
  • 32
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy balance
    • Matias I., Di Marzo V. Endocannabinoids and the control of energy balance. Trends Endocrinol Metab 2007, 18:27-37.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 33
    • 37349102663 scopus 로고    scopus 로고
    • Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins
    • Matias I., Vergoni A.V., Petrosino S., Ottani A., Pocai A., Bertolini A., et al. Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins. Neuropharmacology 2008, 54:206-212.
    • (2008) Neuropharmacology , vol.54 , pp. 206-212
    • Matias, I.1    Vergoni, A.V.2    Petrosino, S.3    Ottani, A.4    Pocai, A.5    Bertolini, A.6
  • 34
    • 58849113910 scopus 로고    scopus 로고
    • Adiponectin normalization: a clue to the anti-metabolic syndrome action of Rimonabant
    • Maynadier M., Basile I., Gary-Bobo M. Adiponectin normalization: a clue to the anti-metabolic syndrome action of Rimonabant. Drug Discovery Today 2009, 14:192-197.
    • (2009) Drug Discovery Today , vol.14 , pp. 192-197
    • Maynadier, M.1    Basile, I.2    Gary-Bobo, M.3
  • 35
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    • Osei-Hyiaman D., DePetrillo M., Pacher P., Liu J., Radaeva S., Bátkai S., et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005, 115:1298-1305.
    • (2005) J Clin Invest , vol.115 , pp. 1298-1305
    • Osei-Hyiaman, D.1    DePetrillo, M.2    Pacher, P.3    Liu, J.4    Radaeva, S.5    Bátkai, S.6
  • 36
    • 3843077611 scopus 로고    scopus 로고
    • Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats
    • Pfitzer T., Niederhoffer N., Szabo B. Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats. Br J Pharmacol 2004, 142:943-952.
    • (2004) Br J Pharmacol , vol.142 , pp. 943-952
    • Pfitzer, T.1    Niederhoffer, N.2    Szabo, B.3
  • 37
    • 32644441249 scopus 로고    scopus 로고
    • Effect of Rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    • Pi-Sunyer F.X., Aronne L.J., Heshmati H.M., Devin J., Rosenstock J. Effect of Rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 2006, 295:761-775.
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 40
    • 1842866963 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
    • Ravinet T.C., Delgorge C., Menet C., Arnone M., Soubrie P. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 2004, 28:640-648.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 640-648
    • Ravinet, T.C.1    Delgorge, C.2    Menet, C.3    Arnone, M.4    Soubrie, P.5
  • 41
    • 33745977406 scopus 로고    scopus 로고
    • Early tolerance to the hypophagic effect of the cannabinoid receptor antagonist SR141716 does not impede blockade of an orexigenic stimulus
    • Rigamonti A.E., Giordani C., Bonomo S.M., Cella S.G., Muller E.E. Early tolerance to the hypophagic effect of the cannabinoid receptor antagonist SR141716 does not impede blockade of an orexigenic stimulus. Eur J Pharmacol 2006, 542:116-120.
    • (2006) Eur J Pharmacol , vol.542 , pp. 116-120
    • Rigamonti, A.E.1    Giordani, C.2    Bonomo, S.M.3    Cella, S.G.4    Muller, E.E.5
  • 42
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • Rinaldi-Carmona M., Barth F., Heaulme M., Shire D., Calandra B., Congy C., et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 1994, 350:240-244.
    • (1994) FEBS Lett , vol.350 , pp. 240-244
    • Rinaldi-Carmona, M.1    Barth, F.2    Heaulme, M.3    Shire, D.4    Calandra, B.5    Congy, C.6
  • 43
    • 34347336422 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions
    • Salamone J.D., McLaughlin P.J., Sink K., Makriyannis A., Parker L.A. Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions. Physiol Behav 2007, 91:383-388.
    • (2007) Physiol Behav , vol.91 , pp. 383-388
    • Salamone, J.D.1    McLaughlin, P.J.2    Sink, K.3    Makriyannis, A.4    Parker, L.A.5
  • 44
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of Rimonabant in overweight or obese patients with type 2 diabetes: a randomized controlled study
    • Scheen A.J., Finer N., Hollander P., Jensen M.D., Van Gaal L.F. Efficacy and tolerability of Rimonabant in overweight or obese patients with type 2 diabetes: a randomized controlled study. Lancet 2006, 368:1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 45
    • 17644367480 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food
    • Thornton-Jones Z.D., Vickers S.P., Clifton P.G. The cannabinoid CB1 receptor antagonist SR141716A reduces appetitive and consummatory responses for food. Psychopharmacology 2005, 179:452-460.
    • (2005) Psychopharmacology , vol.179 , pp. 452-460
    • Thornton-Jones, Z.D.1    Vickers, S.P.2    Clifton, P.G.3
  • 46
    • 33746490030 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor inverse agonist, Rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake
    • Thornton-Jones Z.D., Kennett G.A., Benwell K.R., Revell D.F., Misra A., Sellwood D.M., et al. The cannabinoid CB1 receptor inverse agonist, Rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. Pharmacol Biochem Behav 2006, 84:353-359.
    • (2006) Pharmacol Biochem Behav , vol.84 , pp. 353-359
    • Thornton-Jones, Z.D.1    Kennett, G.A.2    Benwell, K.R.3    Revell, D.F.4    Misra, A.5    Sellwood, D.M.6
  • 47
    • 33644928428 scopus 로고    scopus 로고
    • Rimonabant: a cannabinoid receptor blocker for the treatment of metabolic and cardiovascular risk factors
    • Tonstad S. Rimonabant: a cannabinoid receptor blocker for the treatment of metabolic and cardiovascular risk factors. Nutr Metab Cardiovasc Dis 2006, 16:156-162.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , pp. 156-162
    • Tonstad, S.1
  • 48
    • 3042640680 scopus 로고    scopus 로고
    • Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake
    • Verty A.N., McFarlane J.R., McGregor I.S., Mallet P.E. Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology 2004, 145:3224-3231.
    • (2004) Endocrinology , vol.145 , pp. 3224-3231
    • Verty, A.N.1    McFarlane, J.R.2    McGregor, I.S.3    Mallet, P.E.4
  • 49
    • 58849117501 scopus 로고    scopus 로고
    • The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure
    • Verty A.N., Allen A.M., Oldfield B.J. The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure. Obesity 2009, 17:254-261.
    • (2009) Obesity , vol.17 , pp. 254-261
    • Verty, A.N.1    Allen, A.M.2    Oldfield, B.J.3
  • 50
    • 5744226870 scopus 로고    scopus 로고
    • WHO global strategy on diet, physical activity and health
    • Waxman A. WHO global strategy on diet, physical activity and health. Food Nutr Bull 2004, 25:292-302.
    • (2004) Food Nutr Bull , vol.25 , pp. 292-302
    • Waxman, A.1
  • 51
    • 70349299827 scopus 로고    scopus 로고
    • Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice
    • Yu Y., Deng C., Huang X.F. Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice. Behav Brain Res 2009, 205:50-56.
    • (2009) Behav Brain Res , vol.205 , pp. 50-56
    • Yu, Y.1    Deng, C.2    Huang, X.F.3
  • 52
    • 45149094904 scopus 로고    scopus 로고
    • Environmental stress, erythrocyte dysfunctions, inflammation, and the metabolic syndrome: adaptations to CO2 increases?
    • Zappulla D. Environmental stress, erythrocyte dysfunctions, inflammation, and the metabolic syndrome: adaptations to CO2 increases?. J Cardiometab Syndr 2008, 3:30-34.
    • (2008) J Cardiometab Syndr , vol.3 , pp. 30-34
    • Zappulla, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.