SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6173-6180

JD-5006 and JD-5037: Peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities

(4) Chorvat, Robert J a Berbaum, Jennifer a Seriacki, Kristine a McElroy, John F a

a Jenrin Discovery (United States)

Author keywords

CB1 antagonist; CB1 receptor inverse agonist; Diabetes; Dyslipidemias; JD 5006; JD 5037; Liver diseases; Metabolic disorders; Obesity; Peripherally restricted cannabinoid 1 receptor blockers; Rimonabant; SLV 319

Indexed keywords

3 (4 CHLOROPHENYL) N' [(4 CHLOROPHENYL)SULFONYL] N (ACETAMIDE) 4 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOXAMIDINE; 3 (4 CHLOROPHENYL) N' [(4 CHLOROPHENYL)SULFONYL] N [(ISOPROPYL)ACETAMIDE] 4 PHENYL 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOXAMIDINE; CANNABINOID 1 RECEPTOR ANTAGONIST; IBIPINABANT; JD 5006; JD 5037; LIVER ENZYME; RIMONABANT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM DISEASE; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GLUCOSE TOLERANCE; INSULIN SENSITIVITY; LIVER WEIGHT; METABOLIC DISORDER; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL;

AMIDINES; BRAIN DISEASES, METABOLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866415138 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.004 Document Type: Article

Times cited : (78)

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